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Over the past two decades, aspirin has emerged as a promising chemoprotective agent to prevent colorectal cancer (CRC). In 2016, the mounting evidence supporting its chemoprotective effect, from both basic science and clinical research, led the US Preventive Services Task Force to recommend regular use of low-dose aspirin in some subgroups of patients for whom the benefits are deemed to outweigh the risks. In contrast, data on the chemoprotective effect of aspirin against other cancers are less clear and remain controversial. Most data come from secondary analyses of cardiovascular prevention trials, with only a limited number reporting cancer outcomes as a prespecified endpoint, and overall unclear findings. Moreover, the potential chemoprotective effect of aspirin against other cancers has been recently questioned with the publication of 3 long-awaited trials of aspirin in the primary prevention of cardiovascular diseases reporting no benefit of aspirin on overall cancer incidence and cancer-related mortality. Data on the chemoprotective effects of other antiplatelet agents remain scarce and inconclusive, and further research to examine their benefit are warranted. In this narrative review, we summarize current clinical evidence and continuing controversies on the potential chemoprotective properties of antiplatelet agents against cancer.

Abstract Background The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute -funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level. Patients and methods NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15–30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors. Results Among 3,227 patients aged 15–30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) ( p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3–83.6) in AYA in RSC and 82.7% (95%CI 79.4–85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively). Conclusions This study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.

CLARK G. REYNOLDS. Navies in History. Annapolis: Naval Institute Press, 1998. Pp. xi, 267. $24.95 (US), paper. Reviewed by Joseph A. Maiolo PETER WHITFIELD. New Found Lands: Maps in the History of Exploration. London and New York: Routledge, 1998. Pp. viii, 200. $40.00 (US). Reviewed by Glyndwr William A. J. COATES. The Ethics of War. Manchester: Manchester University Press, 1997; dist. Vancouver: University of British Columbia Press. Pp. 314. $24.95 (US), paper. Reviewed by Noam J. Zohar JEREMY BLACK. Why Wars Happen. New York: New York University Press, 1998. Pp. 271. $30.00 (US); JEREMY BLACK. War and the World: Military Power and the Fate of Continents, 1450-2000. New Haven and London: Yale University Press, 1998. Pp. 334. $35.00 (US). Reviewed by Roger Beaumont ROBERT E. A. PALMER. Rome and Carthage at Peace. Stuttgart: Franz Steiner Verlag, 1997. Pp. 152. DM 68. Reviewed by Hans-Friedrich Mueller ROGER COLLINS. Charlemagne. Toronto: University of Toronto Press, 1998. 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Aristocratic Encounters: European Travelers and North American Indians. New York: Cambridge University Press, 1998. Pp. xi, 179. $49.95 (US). Reviewed by Ian K. Steele SYLVIANE A. DIOUF. Servants of Allah: African Muslims Enslaved in the Americas. New York: New York University Press, 1998. Pp. ix, 254. $18.50 (US), paper. Reviewed by Paul E. Lovejoy DESMOND GREGORY. No Ordinary General: Lt General Sir Henry Bunbury (1778-1860): The Best Soldier Historian. Cranbury: Fairleigh Dickinson University Press, 1999. Pp. 144. $32.50 (US). Reviewed by Neville Thompson JOHN GASCOIGNE. Science in the Service of the Empire: Joseph Banks, the British State, and the Uses of Science in the Age of Revolution. New York: Cambridge University Press, 1998. Pp. vii, 247. $64.95 (US). Reviewed by Larry Stewart PAUL WEBER. On the Road to Rebellion: The United Irishmen and Hamburg, 1796-1803. Dublin: Four Courts Press, 1997; dist. Portland: ISBS. Pp. 205. $45.00 (US). Reviewed by Daire Keogh JAC WELLER. 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Tauris, 1999; dist. New York: St Martin's Press. Pp. xiii, 230. $55.00 (US). Reviewed by Robert Olson MARTIN A. KLEIN. Slavery and Colonial Rule in French West Africa. New York: Cambridge University Press, 1998. Pp. xxi, 354. $54.95 (US), cloth; $19.95 (US), paper. Reviewed by William B. Cohen JAIME E. RODRÍGUEZ O. The Independence of Spanish America. New York: Cambridge University Press, 1998. Pp. xiii, 274. $59.95 (US). Reviewed by Timothy E. Anna CARL BENN. The Iroquois in the War of 1812. Toronto: University of Toronto Press, 1998. Pp. xi, 272. $21.95 (CDN), paper. Reviewed by K. David Milobar PHILIP D. CURTIN. Disease and Empire: The Health of European Troops in the Conquest of Africa. New York: Cambridge University Press, 1998. Pp. xiii, 256. $64.95 (US), cloth; $19.95 (US), paper. Reviewed by Daniel R. Headrick TIMOTHY E. ANNA. Forging Mexico, 1821-1835. Lincoln and London: University of Nebraska Press, 1998. Pp. xiii, 330. $40.00 (US). Reviewed by Claudia Agostoni GERALD STUDDERT-KENNEDY. Providence and the Raj: Imperial Mission and Missionary Imperialism. Walnut Creek, Calif.: AltaMira Press, 1998. Pp. 273. $44.95 (US). Reviewed by Penelope Carson JANE SAMSON. Imperial Benevolence: Making British Authority in the Pacific Islands. Honolulu: University of Hawaii Press, 1998. Pp. xv, 240. $35.00 (US). Reviewed by Hugh Laracy J. Y. WONG. Deadly Dreams: Opium, Imperialism, and the Arrow War (1856-1860) in China. New York: Cambridge University Press, 1998. Pp. xxx, 542. $69.95 (US). Reviewed by D. W. Clayton ELLIOTT WEST. The Contested Plains: Indians, Goldseekers, and the Rush to Colorado. Lawrence: University Press of Kansas, 1998. Pp. xxiv, 422. $34.95 (US). Reviewed by Francis Paul Prucha JACK L. HAMMERSMITH. Spoilsmen in a 'Flowery Fairyland': The Development of the US Legation in Japan, 1859-1906. Kent: Kent State University Press, 1998. Pp. xiv, 368. $49.00 (US). Reviewed by Antony Best PETER STANLEY. White Mutiny: British Military Culture in India. New York: New York University Press, 1998. Pp. xiv, 314. $40.00 (US). Reviewed by Hew Strachan JOHN C. G. RÖHL. Young Wilhelm: The Kaiser's Early Life, 1859-1888, trans. Jeremy Gaines and Rebecca Wallach. New York: Cambridge University Press, 1998. Pp. xxv, 979. $74.95 (US). Reviewed by Lamar Cecil DAVID MAYERS. Wars and Peace: The Future Americans Envisioned, 1861-1991. New York: St Martin's Press, 1998. Pp. viii, 184. $45.00 (US). Reviewed by Eileen P. Scully SAMUEL L. BAILY. Immigrants in the Lands of Promise: Italians in Buenos Aires and New York City, 1870-1914. Ithaca and London: Cornell University Press, 1999. Pp. xvii, 308. $45.00 (US). Reviewed by Donald S. Castro HIROAKI KUROMIYA. Freedom and Terror in the Donbas: A Ukrainian-Russian Borderland, 1870s-1990s. New York: Cambridge University Press, 1998. Pp. xiv, 357. $44.95 (US). Reviewed by David Saunders ANDREW LAMBERT. The Foundations of Naval History: John Knox Laughton, the Royal Navy, and the Historical Profession. London: Chatham Publishing, 1998. Pp. 256. £30.00. Reviewed by C. I. Hamilton H. RAHMAN. The Making of the Gulf War: Origins of Kuwait's Long-Standing Territorial Dispute with Iraq. Reading: Ithaca Press, 1997. Pp. xv, 378. £35.00. Reviewed by Peter Sluglett ROY MACLAREN, ed. African Exploits: The Diaries of William Stairs, 1887-1892. Montreal and Kingston: McGill-Queen's University Press, 1998. Pp. vi, 423. $49.95 (CDN); PETER HARRINGTON and FREDERIC A. SHARF, eds. Omdurman 1898: The Eye-Witnesses Speak: The British Conquest of the Sudan as Described by Participants in Letters, Diaries, Photos, and Drawings. London and Mechanicsburg: Greenhill Books and Stackpole Books, 1998. Pp. 236. £20.00. Reviewed by Philip Stigger MATTHEW S. SELIGMANN. Rivalry in Southern Africa, 1893-99: The Transformation of German Colonial Policy. New York: St Martin's Press, 1998. Pp. vii, 200. $65.00 (US). Reviewed by Robert Kubicek SALWA ALGHANIM. The Reign of Mubarak al-Sabah: Shaikh of Kuwait, 1896-1915. London and New York: I. B. Tauris, 1998; dist. New York: St Martin's Press. Pp. xiii, 242. $59.50 (US). Reviewed by Frederick F. Anscombe RISTO MARJOMAA. War on the Savannah: The Military Collapse of the Sokoto Caliphate under the Invasion of the British Empire, 1897-1903. Helsinki: Finnish Academy of Science and Letters, 1998. Pp. 305. FIM 140; $28.00 (US). Reviewed by A. S. Kanya-Forstner LOUIS A. PÉREZ, JR. The War of 1898: The United States and Cuba in History and Historiography. Chapel Hill and London: University of North Carolina Press, 1998. Pp. xvi, 171. $16.95 (US), paper. Reviewed by David Healy MARK MAZOWER. Dark Continent: Europe's Twentieth Century. London: Allen Lane, The Penguin Press, 1998. Pp. xv, 495. £20.00. Reviewed by William R. Keylor GUIDO MÜLLER, ed. Deutschland und der Westen: Internationale Beziehungen im 20. Jahrhundert: Festschrift fiir Klaus Schwabe zum 65. Geburtstag. Stuttgart: Franz Steiner Verlag, 1998. Pp. 381. DM 138, paper. Reviewed by Rennie W. Brantz NIALL FERGUSON. The Pity of War. New York: Basic Bo