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Visual landscape impacts on scenic and populated places are among significant factors affecting local acceptance of large-scale renewable energy projects. Through the combination of large-scale reverse viewshed and techno-economic energy system analyses, we assess their potential impacts for nationwide energy systems. In our case study of Germany, moderate consideration of visual impact by placing renewables out of sight of the most scenic and densely populated areas does not have a significant impact on future energy system costs and design. In contrast, in scenarios assuming high sensitivity to visual impacts, annual energy system costs would increase by up to 38% in 2045. The energy system’s resilience would also be compromised due to the increasing reliance on green hydrogen imports and the uncertain mass adoption of rooftop photovoltaics. Our analytical framework facilitates careful planning that considers the visual impact of renewable energy infrastructure, thus enabling socially acceptable deployment while understanding the implications for system costs and transformation pathways. Moderately reducing the visibility of renewable energy infrastructure in Germany is found to have a negligible impact on energy system costs and design. Strict visibility restrictions, however, may reduce the system’s resilience and increase costs by 38% in 2045.

Recent studies focusing on greenhouse gas emission reduction strategies indicate that material recycling has a significant impact on energy consumption and greenhouse gas emissions. The question arises how these effects can be quantified. Material recycling is not at all or insufficiently considered in energy system models, which are used today to derive climate gas mitigation strategies. To better assess and quantify the effects one option would be to couple energy system models and material flow models. The barriers and challenges of a successful coupling are addressed in this article. The greatest obstacles are diverging temporal horizons, the mismatching of system boundaries, data quality and availability, and the underrepresentation of industrial processes. A coupled model would enable access to more robust and significant results, a response to a greater variety of research questions and useful analyses. Further to this, collaborative models developed jointly by the energy system and material analysis communities are required for more cohesive and interdisciplinary assessments.

To achieve climate neutrality, synergies between circular economy and reduction of greenhouse gas emissions must be strengthened. Previously idle emission reduction potentials of resource efficiency are to be exploited. Since all potentially possible emission reduction measures are linked by interactions, the evaluation of a single measure in terms of cost efficiency, effectiveness, and compliance with climate protection targets is very complex and requires a model-based analysis that takes the entire energy system into account. This work advances an energy system model for Germany so that through comprehensive modeling of industrial processes and implementation of recycling options, the impact of recycling measures in the context of national greenhouse gas mitigation strategies can be analyzed. The scenario evaluation shows that different recycling strategies have large effects on the German energy system. Without recycling energy demand in 2050 will increase by more than 300 TWh and cost of transformation will rise by 85% compared to a reference scenario. On the other hand, if maximum recycling rates can be achieved, costs of transformation can be reduced by 26% until 2050. Recycling is an essential and cost-efficient greenhouse gas reduction strategy for future low-carbon energy system designs.

The determination of environmentally- and economically-optimal energy system designs and operations is complex. In particular, the integration of weather-dependent renewable energy technologies into energy system optimization models presents new challenges to computational tractability that cannot only be solved by advancements in computational resources. In consequence, energy system modelers must tackle the complexity of their models daily and introduce various methods to manipulate the underlying data and model structure, with the ultimate goal of finding optimal solutions. As which complexity reduction method is suitable for which research question is often unclear, herein we review some approaches to handling complexity. Thus, we first analyze the determinants of complexity and note that many drivers of complexity could be avoided a priori with a tailored model design. Second, we conduct a review of systematic complexity reduction methods for energy system optimization models, which can range from simple linearization performed by modelers to sophisticated multi-level approaches combining aggregation and decomposition methods. Based on this overview, we develop a guide for modelers who encounter computational limitations.

The actin cytoskeleton is a ubiquitous feature of eukaryotic cells, yet its complexity varies across different taxa. In the parasitic protist Trypanosoma brucei , a rudimentary actomyosin system consisting of one actin gene and two myosin genes has been retained despite significant investment in the microtubule cytoskeleton. The functions of this highly simplified actomyosin system remain unclear, but appear to centre on the endomembrane system. Here, advanced light and electron microscopy imaging techniques, together with biochemical and biophysical assays, were used to explore the relationship between the actomyosin and endomembrane systems. The class I myosin (TbMyo1) had a large cytosolic pool and its ability to translocate actin filaments in vitro was shown here for the first time. TbMyo1 exhibited strong association with the endosomal system and was additionally found on glycosomes. At the endosomal membranes, TbMyo1 colocalised with markers for early and late endosomes (TbRab5A and TbRab7, respectively), but not with the marker associated with recycling endosomes (TbRab11). Actin and myosin were simultaneously visualised for the first time in trypanosomes using an anti-actin chromobody. Disruption of the actomyosin system using the actin-depolymerising drug latrunculin A resulted in a delocalisation of both the actin chromobody signal and an endosomal marker, and was accompanied by a specific loss of endosomal structure. This suggests that the actomyosin system is required for maintaining endosomal integrity in T. brucei .

Objectives Early tumor shrinkage (ETS) quantifies the objective response at the first assessment during systemic treatment. In metastatic colorectal cancer (mCRC), ETS gains relevance as an early available surrogate for patient survival. The aim of this study was to increase the predictive accuracy of ETS by using semi-automated volumetry instead of standard diametric measurements. Methods Diametric and volumetric ETS were retrospectively calculated in 253 mCRC patients who received 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) combined with either cetuximab or bevacizumab. The association of diametric and volumetric ETS with overall survival (OS) and progression-free survival (PFS) was compared. Results Continuous diametric and volumetric ETS predicted survival similarly regarding concordance indices ( p > .05). In receiver operating characteristics, a volumetric threshold of 45% optimally identified short-term survivors. For patients with volumetric ETS ≥ 45% (vs < 45%), median OS was longer (32.5 vs 19.0 months, p < .001) and the risk of death reduced for the first and second year (hazard ratio [HR] = 0.25, p < .001, and HR = 0.39, p < .001). Patients with ETS ≥ 45% had a reduced risk of progressive disease only for the first 6 months (HR = 0.26, p < .001). These survival times and risks were comparable to those of diametric ETS ≥ 20% (vs < 20%). Conclusions The accuracy of ETS in predicting survival was not increased by volumetric instead of diametric measurements. Continuous diametric and volumetric ETS similarly predicted survival, regardless of whether patients received cetuximab or bevacizumab. A volumetric ETS threshold of 45% and a diametric ETS threshold of 20% equally identified short-term survivors. Key Points • ETS based on volumetric measurements did not predict survival more accurately than ETS based on standard diametric measurements. • Continuous diametric and volumetric ETS predicted survival similarly in patients receiving FOLFIRI with cetuximab or bevacizumab. • A volumetric ETS threshold of 45% and a diametric ETS threshold of 20% equally identified short-term survivors.

The actin cytoskeleton is a ubiquitous feature of eukaryotic cells, yet its complexity varies across different taxa. In the parasitic protist Trypanosoma brucei , a rudimentary actomyosin system consisting of one actin gene and two myosin genes has been retained despite significant investment in the microtubule cytoskeleton. The functions of this highly simplified actomyosin system remain unclear, but appear to centre on the endomembrane system. Here, advanced light and electron microscopy imaging techniques, together with biochemical and biophysical assays, were used to explore the relationship between the actomyosin and endomembrane systems. The class I myosin (TbMyo1) had a large cytosolic pool and its ability to translocate actin filaments in vitro was shown here for the first time. TbMyo1 exhibited strong association with the endosomal system and was additionally found on glycosomes. At the endosomal membranes, TbMyo1 colocalised with markers for early and late endosomes (TbRab5A and TbRab7, respectively), but not with the marker associated with recycling endosomes (TbRab11). Actin and myosin were simultaneously visualised for the first time in trypanosomes using an anti-actin chromobody. Disruption of the actomyosin system using the actin-depolymerising drug latrunculin A resulted in a delocalisation of both the actin chromobody signal and an endosomal marker, and was accompanied by a specific loss of endosomal structure. This suggests that the actomyosin system is required for maintaining endosomal integrity in T. brucei .

Crohn's disease is a chronic inflammatory disease of the intestine potentially affecting all parts of the intestine with predilection sites in the terminal ileum and proximal colon. Its prevalence in Western Europe is 20-40/100,000 with equal affection of both sexes and familiar accumulation. Histopathologically, it is characterized by a discontinuous, segmental manifestation and implication of all intestinal layers. Celiac disease, on the other hand, is defined by histologically proven villous atrophy associated with hyperplasia of crypts, lymphocytic infiltration and clinical improvement after a gluten-free diet. We report the case of a 52-year-old man presenting with long-term diarrhea and loss of weight associated with Crohn's disease. After interventional therapy for an unstable coronary artery syndrome and medical therapy for hyperthyroidism, the diarrhea stopped only after maintaining a gluten-free diet. A latent form of celiac disease (clinical symptoms, improvement after gluten-free diet, detection of anti-gliadin IgA antibodies, negative histology) was diagnosed. To our knowledge, this is the first report on the association of Crohn's disease and the latent form of celiac disease in the same patient. Whereas in most cases, Crohn's disease develops secondary to a pre-existing celiac disease, in our patient, latent celiac disease was diagnosed years after the onset of and therapy for Crohn's disease.

Nitrous oxide (N2O) is the fourth most important greenhouse gas in the atmosphere and is considered the most important current source gas emission for global stratospheric ozone depletion (O3). It has natural and anthropogenic sources, mainly as an unintended by-product of food production activities. This work examines the identification and quantification of trends in the N2O concentration from the middle troposphere to the middle stratosphere (MTMS) by in situ and remote sensing observations. The temporal variability of N2O is addressed using a comprehensive dataset of in situ and remote sensing N2O concentrations based on aircraft and balloon measurements in the MTMS from 1987 to 2018. We determine N2O trends in the MTMS, based on observations. This consistent dataset was also used to study the N2O seasonal cycle to investigate the relationship between abundances and its emission sources through zonal means. The results show a long-term increase in global N2O concentration in the MTMS with an average of 0.89 ± 0.07 ppb/yr in the troposphere and 0.96 ± 0.15 ppb/yr in the stratosphere, consistent with 0.80 ppb/yr derived from ground-based measurements and 0.799 ± 0.024 ppb/yr ACE-FTS (Atmospheric Chemistry Experiment Fourier Transform Spectrometer) satellite measurements.

Nitrous oxide (N[sub.2] O) is the fourth most important greenhouse gas in the atmosphere and is considered the most important current source gas emission for global stratospheric ozone depletion (O[sub.3] ). It has natural and anthropogenic sources, mainly as an unintended by-product of food production activities. This work examines the identification and quantification of trends in the N[sub.2] O concentration from the middle troposphere to the middle stratosphere (MTMS) by in situ and remote sensing observations. The temporal variability of N[sub.2] O is addressed using a comprehensive dataset of in situ and remote sensing N[sub.2] O concentrations based on aircraft and balloon measurements in the MTMS from 1987 to 2018. We determine N[sub.2] O trends in the MTMS, based on observations. This consistent dataset was also used to study the N[sub.2] O seasonal cycle to investigate the relationship between abundances and its emission sources through zonal means. The results show a long-term increase in global N[sub.2] O concentration in the MTMS with an average of 0.89 ± 0.07 ppb/yr in the troposphere and 0.96 ± 0.15 ppb/yr in the stratosphere, consistent with 0.80 ppb/yr derived from ground-based measurements and 0.799 ± 0.024 ppb/yr ACE-FTS (Atmospheric Chemistry Experiment Fourier Transform Spectrometer) satellite measurements.