Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
23,297
result(s) for
"Kumar, B"
Sort by:
Hesperidin, a citrus flavonoid, protects against l-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats
Context: Hesperidin (HSP), a flavanoglycone found in citrus fruits, has antioxidant, anti-inflammatory and neuroprotective properties.Objective: This study evaluates the protective effect of HSP on l-methionine-induced hyperhomocysteinemia (HHcy) in rats.Materials and methods: Male Wistar rats were randomly divided into seven groups as DMSO, l-methionine, HSP (25, 50 and 100 mg/kg), HSP-per se (100 mg/kg) and donepezil (0.1 mg/kg). HHcy was induced by oral administration of l-methionine (1.7 g/kg) for 32 days. From the 14th day of study HSP (25, 50 and 100 mg/kg) and donepezil was administered orally to l-methionine-treated rats. Cognitive impairment induced by HHcy was determined using the Morris water maze (MWM) and Y-maze on video tracking system (28th–32nd day). Different biomarkers of HHcy in serum and brain and vascular reactivity were evaluated and histopathology (thoracic aorta and brain) was done.Results: HSP (100 mg/kg) treatment in l-methionine-treated rats exhibited significant (p < 0.001) dose-dependent activity and reduced behavioural deficits, brain acetylcholinesterase (25.99 ± 2.36 versus 10.73 ± 1.26 μmoles/mg), brain lipid peroxidation (15.25 ± 1.65 versus 6.18 ± 0.74 nM/mg), serum homocysteine (Hcy) (22.37 ± 0.30 versus 11.01 ± 1.01 μg/mL) and serum cholesterol (182.7 ± 2.15 versus 101.5 ± 2.76 mg/dL) and increased brain antioxidant levels. HSP significantly (p < 0.001) reduced endothelial dysfunction (ED) by abolishing the effect of l-methionine on acetylcholine-induced endothelial-dependent relaxation and increased serum nitrite and vascular nitric oxide bioavailability along with the restoration of histological aberrations.Conclusion: HSP exerts a protective effect on HHcy by abrogating oxidative stress, ED and neurotoxicity.
Journal Article
DNA-based communication in populations of synthetic protocells
Developing molecular communication platforms based on orthogonal communication channels is a crucial step towards engineering artificial multicellular systems. Here, we present a general and scalable platform entitled ‘biomolecular implementation of protocellular communication’ (BIO-PC) to engineer distributed multichannel molecular communication between populations of non-lipid semipermeable microcapsules. Our method leverages the modularity and scalability of enzyme-free DNA strand-displacement circuits to develop protocellular consortia that can sense, process and respond to DNA-based messages. We engineer a rich variety of biochemical communication devices capable of cascaded amplification, bidirectional communication and distributed computational operations. Encapsulating DNA strand-displacement circuits further allows their use in concentrated serum where non-compartmentalized DNA circuits cannot operate. BIO-PC enables reliable execution of distributed DNA-based molecular programs in biologically relevant environments and opens new directions in DNA computing and minimal cell technology.Semipermeable proteinosome membranes allow complex DNA message communication through compartmentalization and protect the DNA circuits from degradation in a biological environment.
Journal Article
Ecological considerations in sustainable silvopasture design and management
Silvopastoral systems are sustainable production systems characterized by greater biodiversity and multifunctionality, compared with other livestock production methods. The complex functional dynamics, however, make silvopastoralism a difficult construct to design and study. The key design criterion for these complex land use practices is to optimize the use of spatial, temporal, and physical resources, by maximizing positive interactions (facilitation) and minimizing negative ones (competition) among the components, for which the principles of sustainable land use systems are relevant. In this paper we address the cardinal questions, how the general ecological principles common to complex natural systems apply to the design and management of silvopastoral systems and how sound management might be identified with the notion of sustained maximum yield. In particular, we explore (1) spatial and temporal heterogeneity for maximizing resource use efficiency, (2) competitive interactions in perennial systems, (3) structural and functional diversity for resource conservation, and (4) integration of the principles of disturbance ecology in silvopastoral system design.
Journal Article
Industrial automation and robotics : techniques and applications
\"This book discusses the radical technological changes occurring due to Industry 4.0, with a focus on offering a better understanding of the Fourth Industrial Revolution. It also presents a detailed analysis of interdisciplinary knowledge, numerical modeling and simulation, and the application of cyber-physical systems, where information technology and physical devices create synergic systems leading to unprecedented efficiency. The theoretical results, practical solutions, and guidelines presented are valuable for both researchers working in the area of engineering sciences and practitioners looking for solutions to industrial problems\"-- Provided by publisher.
BOOK
Optimizing sustainable energy management in grid connected microgrids using quantum particle swarm optimization for cost and emission reduction
The global shift towards decentralized energy systems, driven by the integration of distributed generation technologies and renewable energy sources, underscores the critical need for effective energy management strategies in microgrids. This study proposes a novel multi-objective optimization framework for grid-connected microgrids using quantum particle swarm optimization (QPSO) to address the dual challenges of minimizing operational costs and reducing environmental emissions. The microgrid configuration analyzed includes renewable energy sources like photovoltaic panels and wind turbines, along with conventional energy sources and battery storage. By incorporating quantum-inspired mechanics, QPSO overcomes limitations such as premature convergence and solution stagnation, often seen in traditional methods. Simulation results demonstrate that QPSO achieves a 9.67% reduction in operational costs, equating to savings of €158.87, and a 13.23% reduction in carbon emissions, lowering emissions to 513.70 kg of CO
2
equivalent in the economic scheduling scenario. In the environmentally constrained economic scheduling scenario, the method delivers a balanced solution with operational costs of €174.11 and emissions of 401.63 kg of CO
2
. The algorithm’s performance is validated across various microgrid configurations, including standard low-voltage setups. These results highlight QPSO’s potential as an efficient tool for optimizing microgrid energy management, promoting both economic and environmental sustainability. This study provides a robust framework for achieving practical solutions in real-world applications, emphasizing the role of advanced optimization techniques in sustainable energy systems.
Journal Article
Utilizing blockchain technologies in manufacturing and logistics management
\"The key objectives of the book are to explore the strengths of blockchain adaptation in manufacturing industries and logistics management, presenting different use cases of and future research trends\"-- Provided by publisher.
Book
Catalytic processing in ruthenium-based polyoxometalate coacervate protocells
The development of programmable microscale materials with cell-like functions, dynamics and collective behaviour is an important milestone in systems chemistry, soft matter bioengineering and synthetic protobiology. Here, polymer/nucleotide coacervate micro-droplets are reconfigured into membrane-bounded polyoxometalate coacervate vesicles (PCVs) in the presence of a bio-inspired Ru-based polyoxometalate catalyst to produce synzyme protocells (Ru
4
PCVs) with catalase-like activity. We exploit the synthetic protocells for the implementation of multi-compartmentalized cell-like models capable of collective synzyme-mediated buoyancy, parallel catalytic processing in individual horseradish peroxidase-containing Ru
4
PCVs, and chemical signalling in distributed or encapsulated multi-catalytic protocell communities. Our results highlight a new type of catalytic micro-compartment with multi-functional activity and provide a step towards the development of protocell reaction networks.
The development of microscale materials with cell-like functions and collective behaviors is an important milestone in bottom-up synthetic biology. Here the authors employ a bio-inspired inorganic synzyme to construct a micro-compartment with multi-functional activity providing a step towards the development of protocell reaction networks.
Journal Article