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Aim: The aim of this study was to evaluate the intracanal effectiveness of cryotherapy, curcumin irrigant, and normal saline as a final irrigant in reducing postendodontic pain in primary teeth. Materials and Methods: A total of 120 teeth between the ages of 4 and 7 years requiring pulpectomy in primary teeth were included in the study. The teeth were randomly assigned to one of the three treatment groups: intracanal cryotherapy using 2.5°C cold saline, curcumin irrigant, or normal saline. Following completion of chemomechanical preparation, final irrigation with 2.5°C cold saline, curcumin irrigant, and normal saline solution at room temperature were employed in the groups. Participants were asked to rate the severity of their postoperative pain on the Visual Analog Scale before, immediate postoperative after wearing of local anesthetic effect, and 24 h after the procedure. The results were analyzed statistically. Results: The differences in reduction of postendodontic pain between the three irrigating regimens were statistically not significant. Cryotherapy utilizing 2.5°C cold saline or curcumin irrigant can be used instead of normal saline as a final irrigant in pulpectomy of primary teeth. Conclusions: Cryotherapy can be a straightforward, cost-effective, and nontoxic treatment option for the management of postendodontic pain. Curcumin irrigant with its anti-inflammatory properties is also a better alternative as a final irrigant for reducing postoperative pain in primary teeth.

Objectives: The objective of this study was to compare ZrO2, polyether ether ketone (PEEK), and ZrO2-PEEK telescopic attachments in terms of retention of overdenture. Methodology: Forty-five acrylic resin models of the lower arch were divided into 3 groups of 15 each. In Group I, primary and secondary crowns were constructed from all zirconia (ZrO2), whereas all PEEK was used for Group II and Group III was made up of ZrO2 PEEK. Results: The mean retention value in Group I was 14.12 ± 3.4 N, in Group II was 15.86 ± 5.1, and in Group III was 22.40 ± 10.3 N. The mean final initial retention value in Group I was 14.50 ± 6.1 N, in Group II was 14.97 ± 8.2, and in Group III was 17.21 ± 9.3 N. A significant difference was observed in intergroup comparison (P < 0.05). Conclusion: Zirconia resulted in maximum retention as compared to other telescopic crown materials.

Several theories have been proposed to describe the formation of black hole seeds in the early Universe and to explain the emergence of very massive black holes observed in the first thousand million years after the Big Bang 1 – 3 . Models consider different seeding and accretion scenarios 4 – 7 , which require the detection and characterization of black holes in the first few hundred million years after the Big Bang to be validated. Here we present an extensive analysis of the JWST-NIRSpec spectrum of GN-z11, an exceptionally luminous galaxy at z  = 10.6, revealing the detection of the [Ne iv ] λ 2423 and CII* λ 1335 transitions (typical of active galactic nuclei), as well as semi-forbidden nebular lines tracing gas densities higher than 10 9  cm −3 , typical of the broad line region of active galactic nuclei. These spectral features indicate that GN-z11 hosts an accreting black hole. The spectrum also reveals a deep and blueshifted CIV λ 1549 absorption trough, tracing an outflow with velocity 800−1,000 km s −1 , probably driven by the active galactic nucleus. Assuming local virial relations, we derive a black hole mass of log ( M BH / M ⊙ ) = 6.2 ± 0.3 , accreting at about five times the Eddington rate. These properties are consistent with both heavy seeds scenarios and scenarios considering intermediate and light seeds experiencing episodic super-Eddington phases. Our finding explains the high luminosity of GN-z11 and can also provide an explanation for its exceptionally high nitrogen abundance. An extensive analysis of the JWST-NIRSpec spectrum of GN-z11 shows a supermassive black hole of a few million solar masses in a galaxy 440 million years after the Big Bang.

The first observations of the James Webb Space Telescope (JWST) have revolutionized our understanding of the Universe by identifying galaxies at redshift z  ≈ 13 (refs. 1 , 2 – 3 ). In addition, the discovery of many luminous galaxies at Cosmic Dawn ( z  > 10) has suggested that galaxies developed rapidly, in apparent tension with many standard models 4 , 5 , 6 , 7 – 8 . However, most of these galaxies lack spectroscopic confirmation, so their distances and properties are uncertain. Here we present JWST Advanced Deep Extragalactic Survey–Near-Infrared Spectrograph spectroscopic confirmation of two luminous galaxies at z = 14.32 − 0.20 + 0.08 and z  = 13.90 ± 0.17. The spectra reveal ultraviolet continua with prominent Lyman-α breaks but no detected emission lines. This discovery proves that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST. The most distant of the two galaxies is unexpectedly luminous and is spatially resolved with a radius of 260 parsecs. Considering also the very steep ultraviolet slope of the second galaxy, we conclude that both are dominated by stellar continuum emission, showing that the excess of luminous galaxies in the early Universe cannot be entirely explained by accretion onto black holes. Galaxy formation models will need to address the existence of such large and luminous galaxies so early in cosmic history. JWST–NIRSpec spectroscopic confirmation of two luminous galaxies is presented, proving that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST.

Local and low-redshift ( z  < 3) galaxies are known to broadly follow a bimodal distribution: actively star-forming galaxies with relatively stable star-formation rates and passive systems. These two populations are connected by galaxies in relatively slow transition. By contrast, theory predicts that star formation was stochastic at early cosmic times and in low-mass systems 1 – 4 . These galaxies transitioned rapidly between starburst episodes and phases of suppressed star formation, potentially even causing temporary quiescence—so-called mini-quenching events 5 , 6 . However, the regime of star-formation burstiness is observationally highly unconstrained. Directly observing mini-quenched galaxies in the primordial Universe is therefore of utmost importance to constrain models of galaxy formation and transformation 7 , 8 . Early quenched galaxies have been identified out to redshift z  < 5 (refs.  9 – 12 ) and these are all found to be massive ( M ⋆  > 10 10   M ⊙ ) and relatively old. Here we report a (mini-)quenched galaxy at z  = 7.3, when the Universe was only 700 Myr old. The JWST/NIRSpec spectrum is very blue ( U – V  = 0.16 ± 0.03 mag) but exhibits a Balmer break and no nebular emission lines. The galaxy experienced a short starburst followed by rapid quenching; its stellar mass (4–6 × 10 8   M ⊙ ) falls in a range that is sensitive to various feedback mechanisms, which can result in perhaps only temporary quenching. Analysis of the JWST/NIRSpec spectrum of the recently observed Lyman-break galaxy JADES-GS+53.15508-27.80178 revealed a redshift of z  = 7.3, a Balmer break and a complete absence of nebular emission lines, indicating that quenching occurred only 700 million years after the Big Bang.

Large dust reservoirs (up to approximately 10 8  M ⊙ ) have been detected 1 – 3 in galaxies out to redshift z  ≃ 8, when the age of the Universe was only about 600 Myr. Generating substantial amounts of dust within such a short timescale has proven challenging for theories of dust formation 4 , 5 and has prompted the revision of the modelling of potential sites of dust production 6 – 8 , such as the atmospheres of asymptotic giant branch stars in low-metallicity environments, supernova ejecta and the accelerated growth of grains in the interstellar medium. However, degeneracies between different evolutionary pathways remain when the total dust mass of galaxies is the only available observable. Here we report observations of the 2,175 Å dust attenuation feature, which is well known in the Milky Way and galaxies at z  ≲ 3 (refs. 9 – 11 ), in the near-infrared spectra of galaxies up to z  ≃ 7, corresponding to the first billion years of cosmic time. The relatively short timescale implied for the formation of carbonaceous grains giving rise to this feature 12 suggests a rapid production process, possibly in Wolf–Rayet stars or supernova ejecta. An (ultraviolet) dust attenuation feature at 2,175 Å, attributed to carbonaceous dust grains in the Milky Way and nearby galaxies, also exists in galaxies up to a redshift of 7.

Finding and characterizing the first galaxies that illuminated the early universe at cosmic dawn is pivotal to understand the physical conditions and the processes that led to the formation of the first stars. In the first few months of operations, imaging from the James Webb Space Telescope (JWST) has been used to identify tens of candidates of galaxies at redshift (z) greater than 10, less than 450 million years after the Big Bang. However, none of such candidates has yet been confirmed spectroscopically, leaving open the possibility that they are actually low-redshift interlopers. Here we present spectroscopic confirmation and analysis of four galaxies unambiguously detected at redshift 10.3 ≤ z ≤ 13.2, previously selected from JWST Near Infrared Camera imaging. The spectra reveal that these primeval galaxies are metal poor, have masses on the order of about 107–108 solar masses and young ages. The damping wings that shape the continuum close to the Lyman edge provide constraints on the neutral hydrogen fraction of the intergalactic medium from normal star-forming galaxies. These findings demonstrate the rapid emergence of the first generations of galaxies at cosmic dawn.As part of the JWST Advanced Deep Extragalactic Survey (JADES), NIRSpec has spectroscopically confirmed four young and metal-poor galaxies at redshift 10.3–13.2, from an early epoch of galaxy formation.

The most massive galaxies in the Universe stopped forming stars due to the time-integrated feedback from central supermassive black holes (SMBHs). However, the exact quenching mechanism is not yet understood, because local massive galaxies were quenched billions of years ago. Here we present JWST/NIRSpec integral-field spectroscopy observations of GS-10578, a massive, quiescent galaxy at redshift z = 3.064 ± 0.002. From its spectrum, we measure a stellar mass M ⋆  = 1.6 ± 0.2 × 10 11  M ⊙ and a dynamical mass M dyn  = 2.0 ± 0.5 × 10 11  M ⊙ . Half of its stellar mass formed at z  = 3.7–4.6, and the system is now quiescent, with a current star-formation rate of less than 19 M ⊙  yr −1 . We detect ionized- and neutral-gas outflows traced by [O iii ] emission and Na i absorption, with mass outflow rates 0.14–2.9 and 30–100 M ⊙  yr −1 , respectively. Outflow velocities reach v out  ≈ 1,000 km s −1 , comparable to the galaxy escape velocity. GS-10578 hosts an active galactic nucleus, evidence that these outflows are due to SMBH feedback. The neutral outflow rate is higher than the star-formation rate. Hence, this is direct evidence for ejective SMBH feedback, with a mass loading capable of interrupting star formation by rapidly removing its fuel. Stellar kinematics show ordered rotation, with spin parameter λ R e = 0.62 ± 0.07 , meaning GS-10578 is rotation-supported. This study presents direct evidence for ejective active galactic nucleus feedback in a massive, recently quenched galaxy, thus helping to clarify how SMBHs quench their hosts. The high value of λ R e implies that quenching can occur without destroying the stellar disk. A massive galaxy hosting an accreting supermassive black hole two billion years after the Big Bang shows fast neutral-gas outflows that are capable of stopping star formation by removing its fuel while the stars keep rotating in a disk.

The first observations of thejames Webb Space Telescope (JWST) have revolutionized our understanding of the Universe by identifying galaxies at redshift z ~ 13 (refs. 1-3). In addition, the discovery of many luminous galaxies at Cosmic Dawn (z > 10) has suggested that galaxies developed rapidly, in apparent tension with many standard models4 8. However, most of these galaxies lack spectroscopic confirmation, so their distances and properties are uncertain. Here we present JWST Advanced Deep Extragalactic Survey-Near-Infrared Spectrograph spectroscopic confirmation of two luminous galaxies at z = 14.32+0.08-0.20 and z = 13.90 ± 0.17. The spectra reveal ultraviolet continua with prominent Lyman-a breaks but no detected emission lines. This discovery proves that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected beforeJWST. The most distant of the two galaxies is unexpectedly luminous and is spatially resolved with a radius of260 parsecs. Considering also the very steep ultraviolet slope of the second galaxy, we conclude that both are dominated by stellar continuum emission, showing that the excess of luminous galaxies in the early Universe cannot be entirely explained by accretion onto black holes. Galaxy formation models will need to address the existence of such large and luminous galaxies so early in cosmic history.