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In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This phenomenon, known as the Warburg effect, provides a number of advantages in the survival of neoplastic cells, and its application is considered a potential strategy in the search for antitumor agents. With the aim of developing a promising platform for designing antitumor therapeutics, we synthesized a library of conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones. To gain insight into the determinants of the biological activity of the prepared compounds, we showed that the conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones, which are cytotoxic agents, demonstrate selective activity toward a number of tumor cell lines with glycolysis-inhibiting ability. Moreover, the results of molecular and in silico screening allowed us to identify these compounds as potential inhibitors of the pyruvate kinase M2 oncoprotein, which is the rate-determining enzyme of glycolysis. Thus, the results of our work indicate that the synthesized conjugates of 3,5-bis(arylidene)-4-piperidone and sesquiterpene lactones can be considered a promising platform for designing selective cytotoxic agents against the glycolysis process, which opens new possibilities for researchers involved in the search for antitumor therapeutics among compounds containing piperidone platforms.

The low rainfall and high temperatures of arid and semi-arid zones promote high salinity and this salinity has become an important factor limiting the growth of salt-sensitive plants. More than 800 million hectares of land throughout the world are salt affected including 39.2 million hectares in Russia, while in Kazakhstan, salinized soils occupy about 40% of the country’s area. Phytoremediation with the use of halophytes can be a cost-effective and environmentally sound technology for the remediation of salt-impacted sites. Halophytes could be valuable sources of novel endophytic isolates that can be used to overcome various biotic and abiotic stresses such as salinity. Endophytes can contribute to plant health impeded by salinity stress, by influencing phytohormonal levels and signaling, contributing to homeostasis maintenance of toxic ions under salinity stress, enhancing photosynthesis, and contributing to biomass production and allocation. The review is devoted to halophytic plants and endophytic microorganisms inhabiting them. Data on the possibility of using halophytes for remediation of saline soils are presented. The definitions of which plants can be considered halophytes are given, the mechanisms of adaptation of halophytes to salinity conditions are described. Data on the use of halophytes for the production of agricultural and other valuable products on saline soils are presented. The list of halophytes of practical value and promising for agricultural use on saline soils of Russia and Kazakhstan is given. Endophytic bacteria inhabiting halophytic plants are described and the results of their practical use for obtaining agricultural products on saline soils and phytoremediation of highly saline soils are presented. The selection of compatible and effective plant-microbial systems and their use to combat abiotic and biotic stresses of plants and produce agricultural products on saline soils is a promising scientific direction. This will make it possible to develop methodological approaches to solving one of the global problems of agricultural production—salinization and degradation of agricultural lands and obtaining products on them and to offer practical ways to implement it.

This study aims to analyzing scientific publications related to necrotizing pancreatitis and its mortality, identifying key areas and trends, and determining the leading research institutions, authors, countries, and journals actively working in this field. The Web of Science and Scopus databases were searched for articles on NP published between January 1, 2013, and April 22, 2024. Articles published before 2013, conference abstracts, and case reports were excluded. The articles were assessed based on various metrics, including the number of citations, publication dates, countries of origin, institutions, journals, and authors. A total of 929 articles were identified, of which 251 were deemed suitable for analysis after duplicates were removed. China contributed the most articles, followed by the United States and India. The most frequent publications appeared in specialized journals such as \"Pancreatology\" and \"Journal of Gastrointestinal Surgery.\" The primary research institutions were universities and medical centers. The highest-impact articles focused on minimally invasive treatment methods for NP. There has been a growing body of research in NP over the past decade, particularly in China and the United States. Despite advancements in medical science, the mortality rate associated with pancreatic necrosis remains high. This highlights the continued challenge in effectively addressing complications of acute pancreatitis. Researchers worldwide are actively exploring alternative therapeutic approaches to mitigate these complications and improve patient outcomes.