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The Getz region of West Antarctica is losing ice at an increasing rate; however, the forcing mechanisms remain unclear. Here we use satellite observations and an ice sheet model to measure the change in ice speed and mass balance of the drainage basin over the last 25-years. Our results show a mean increase in speed of 23.8 % between 1994 and 2018, with three glaciers accelerating by over 44 %. Speedup across the Getz basin is linear, with speedup and thinning directly correlated confirming the presence of dynamic imbalance. Since 1994, 315 Gt of ice has been lost contributing 0.9 ± 0.6 mm global mean sea level, with increased loss since 2010 caused by a snowfall reduction. Overall, dynamic imbalance accounts for two thirds of the mass loss from this region of West Antarctica over the past 25-years, with a longer-term response to ocean forcing the likely driving mechanism. The Getz region of West Antarctica is losing ice at an increasing rate; however, the forcing mechanisms remain unclear. Here we show for the first time that since 1994, widespread speedup has occurred on the majority of glaciers in the Getz drainage basin, with some glaciers speeding up by over 44 %.

In recent years, the Sentinel-1 satellites have provided a data archive of unprecedented volume, delivering C-band Synthetic Aperture Radar (SAR) acquisitions over most of the polar ice sheets with a repeat-pass period of 6–12 days using Interferometric Wide swath (IW) imagery acquired in Terrain Observation by Progressive Scans (TOPS) mode. Due to the added complexity of TOPS-mode interferometric processing, however, Sentinel-1 ice velocity measurements currently rely exclusively on amplitude offset tracking, which generates measurements of substantially lower accuracy and spatial resolution than would be possible with Differential SAR Interferometry (DInSAR). The main difficulty associated with TOPS interferometry lies in the spatially variable azimuth phase contribution arising from along-track motion within the scene. We present a Sentinel-1 interferometric processing chain, which reduces the azimuth coupling to the line-of-sight phase signal through a spatially adaptive coregistration refinement incorporating azimuth velocity measurements. The latter are based on available ice velocity mosaics, optionally supplemented by Burst-Overlap Multi-Aperture Interferometry. The DInSAR processing chain is demonstrated for a large drainage basin in Northeast Greenland, encompassing the Northeast Greenland Ice Stream (NEGIS), and integrated with state-of-the-art offset tracking measurements. In the ice sheet interior, the combined DInSAR and offset tracking ice velocity product provides a spatial resolution of 50 × 50 m and 1-sigma accuracies of 0.18 and 0.44 m/y in the x and y components respectively, compared to GPS.

The Northeast Greenland Ice Stream (NEGIS) extends around 600 km upstream from the coast to its onset near the ice divide in interior Greenland. Several maps of surface velocity and topography of interior Greenland exist, but their accuracy is not well constrained by in situ observations. Here we present the results from a GPS mapping of surface velocity in an area located approximately 150 km from the ice divide near the East Greenland Ice-core Project (EastGRIP) deep-drilling site. A GPS strain net consisting of 63 poles was established and observed over the years 2015–2019. The strain net covers an area of 35 km by 40 km, including both shear margins. The ice flows with a uniform surface speed of approximately 55 m a−1 within a central flow band with longitudinal and transverse strain rates on the order of 10−4 a−1 and increasing by an order of magnitude in the shear margins. We compare the GPS results to the Arctic Digital Elevation Model and a list of satellite-derived surface velocity products in order to evaluate these products. For each velocity product, we determine the bias in and precision of the velocity compared to the GPS observations, as well as the smoothing of the velocity products needed to obtain optimal precision. The best products have a bias and a precision of ∼0.5 m a−1. We combine the GPS results with satellite-derived products and show that organized patterns in flow and topography emerge in NEGIS when the surface velocity exceeds approximately 55 m a−1 and are related to bedrock topography.

The dynamics of the Greenland Ice Sheet are affected by surface meltwater reaching the base of the ice, altering ice contact with the bedrock. Lack of understanding of this evolution hampers the ability to predict the effects of increasing temperatures on the Greenland Ice Sheet mass balance. Here we present a unique high-resolution study of ice velocity response to surface melting based on data from a COSMO-SkyMed satellite campaign over Upernavik Isstrøm (Northwest Greenland) for two months around the end of the 2014 melt season. We show that the velocity variations, due to both short-term (days) and seasonal variations in surface melt rates, are increasing in relative strength farther from the glacier terminus. Furthermore, we observe how ice dynamic response to frontal retreat, reaching several kilometres inland, can obscure the meltwater-induced velocity change close to the terminus. Future studies should consider the flow velocity dependence on the distance to the terminus, and local geometry, to distinguish subglacial hydrologic system changes from frontal processes and local basal conditions.

We present the Programme for Monitoring of the Greenland Ice Sheet (PROMICE) Ice Velocity product (https://doi.org/10.22008/promice/data/sentinel1icevelocity/greenlandicesheet, Solgaard and Kusk, 2021), which is a time series of Greenland Ice Sheet ice velocity mosaics spanning September 2016 through to the present. The product is based on Sentinel-1 synthetic aperture radar data and has a 500 m grid spacing. A new mosaic is available every 12 d and spans two consecutive Sentinel-1 cycles (24 d). The product is made available within ∼ 10 d of the last acquisition and includes all possible 6 and 12 d pairs within the two Sentinel-1A cycles. We describe our operational processing chain from data selection, mosaicking, and error estimation to final outlier removal. The product is validated against in situ GPS measurements. We find that the standard deviation of the difference between satellite- and GPS-derived velocities (and bias) is 20 m yr−1 (−3 m yr−1) and 27 m yr−1 (−2 m yr−1) for the components in an eastern and northern direction, respectively. Over stable ground the values are 8 m yr−1 (0.1 m yr−1) and 12 m yr−1 (−0.6 m yr−1) in an eastern and northern direction, respectively. This is within the expected values; however, we expect that the GPS measurements carry a considerable part of this uncertainty. We investigate variations in coverage from both a temporal and spatial perspective. The best spatial coverage is achieved in winter due to the comprehensive data coverage by Sentinel-1 and high coherence, while summer mosaics have the lowest coverage due to widespread melt. The southeast Greenland Ice Sheet margin, along with other areas of high accumulation and melt, often has gaps in the ice velocity mosaics. The spatial comprehensiveness and temporal consistency make the product ideal both for monitoring and for studying ice-sheet-wide and glacier-specific ice discharge and dynamics of glaciers on seasonal scales.

Ice velocity is one of the products associated with the Ice Sheets Essential Climate Variable. This paper describes the intercomparison and validation of ice-velocity measurements carried out by several international research groups within the European Space Agency Greenland Ice Sheet Climate Change Initiative project, based on space-borne Synthetic Aperture Radar (SAR) data. The goal of this activity was to survey the best SAR-based measurement and error characterization approaches currently in practice. To this end, four experiments were carried out, related to different processing techniques and scenarios, namely differential SAR interferometry, multi aperture SAR interferometry and offset-tracking of incoherent as well as of partially-coherent data. For each task, participants were provided with common datasets covering areas located on the Greenland ice-sheet margin and asked to provide mean velocity maps, quality characterization and a description of processing algorithms and parameters. The results were then intercompared and validated against GPS data, revealing in several cases significant differences in terms of coverage and accuracy. The algorithmic steps and parameters influencing the coverage, accuracy and spatial resolution of the measurements are discussed in detail for each technique, as well as the consistency between quality parameters and validation results. This allows several recommendations to be formulated, in particular concerning procedures which can reduce the impact of analyst decisions, and which are often found to be the cause of sub-optimal algorithm performance.

Background Targeted delivery of nerve growth factor (NGF) has emerged as a potential therapy for Alzheimer’s disease (AD) due to its regenerative effects on basal forebrain cholinergic neurons. This hypothesis has been tested in patients with AD using encapsulated cell biodelivery of NGF (NGF-ECB) in a first-in-human study. We report our results from a third-dose cohort of patients receiving second-generation NGF-ECB implants with improved NGF secretion. Methods Four patients with mild to moderate AD were recruited to participate in an open-label, phase Ib dose escalation study with a 6-month duration. Each patient underwent stereotactic implant surgery with four NGF-ECB implants targeted at the cholinergic basal forebrain. The NGF secretion of the second-generation implants was improved by using the Sleeping Beauty transposon gene expression technology and an improved three-dimensional internal scaffolding, resulting in production of about 10 ng NGF/device/day. Results All patients underwent successful implant procedures without complications, and all patients completed the study, including implant removal after 6 months. Upon removal, 13 of 16 implants released NGF, 8 implants released NGF at the same rate or higher than before the implant procedure, and 3 implants failed to release detectable amounts of NGF. Of 16 adverse events, none was NGF-, or implant-related. Changes from baseline values of cholinergic markers in cerebrospinal fluid (CSF) correlated with cortical nicotinic receptor expression and Mini Mental State Examination score. Levels of neurofilament light chain (NFL) protein increased in CSF after NGF-ECB implant, while glial fibrillary acidic protein (GFAP) remained stable. Conclusions The data derived from this patient cohort demonstrate the safety and tolerability of sustained NGF release by a second-generation NGF-ECB implant to the basal forebrain, with uneventful surgical implant and removal of NGF-ECB implants in a new dosing cohort of four patients with AD. Trial registration ClinicalTrials.gov identifier: NCT01163825 . Registered on 14 Jul 2010.

In chemical regulation, e.g. the EU Water Framework Directive, REACH, or the Pesticide Directive, standardized ecotoxicological tests are applied to evaluate and rank the hazard of compounds and for deriving environmental quality standards (EQS). Standardized test methods prescribe fixed testing conditions e.g. specific temperature, pH, light intensity etc. However, environmental conditions under which the organisms live are rarely identical to the standard conditions. Thus, the ecotoxicity of compounds found in standard test is not only a function of the compounds inherent physico-chemical properties but is also affected by test conditions. It is therefore important to study the effect of changes in test conditions in order to get reliable input ecotoxicity data for assessing the potential risk posed by a compound. The objective of this study was to investigate the implications of changing test conditions on the toxicity of four sulfonylurea herbicides (SUs). The toxicity of the four SUs towards Lemna gibba was investigated at three pH levels (6, 7.5 and 9), at two temperatures (15 and 24 °C) and two light regimes (continuous and 12:12 h light:dark cycle) The EC50 increased twofold to tenfold for the four SUs when pH was increased from 6 to 9. Decreasing the temperature from 24 to 15 °C or introducing a dark:light cycle did not cause any trends in changes in toxicity. The results show that test conditions can have an effect on the toxicity and this should be considered when the standard test results are used for derivation of EQS.