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Background In Hungary, the mortality rate for testicular germ cell cancer (TGCC) is 0,9/100000 which is significantly higher than the EU average. We prospectively evaluated the effect of socioeconomic position on patient delay and therapy outcomes. Methods Questionnaires on subjective social status (MacArthur Subjective Status Scale), objective socioeconomic position (wealth, education, and housing data), and on patient’s delay were completed by newly diagnosed TGCC patients. Results Patients belonged to a relatively high socioeconomic class, a university degree was double the Hungarian average, Cancer-specific mortality in the highest social quartile was 1.56% while in the lowest social quartile 13.09% ( p  = 0.02). In terms of patient delay, 57.2% of deceased patients waited more than a year before seeking help, while this number for the surviving patients was 8.0% ( p  = 0.0000). Longer patient delay was associated with a more advanced stage in non-seminoma but not in seminoma, the correlation coefficient for non-seminoma was 0.321 ( p  < 0.001). For patient delay, the most important variables were the mother’s and patient’s education levels (r = − 0.21, p  = 0.0003, and r = − 0.20, p  = 0.0005), respectively. Since the patient delay was correlated with the social quartile and resulted in a more advanced stage in non-seminoma, the lower social quartile resulted in higher mortality in non-seminoma patients ( p  = 0.005) but not in seminoma patients ( p  = 0.36) where the patient delay was not associated with a more advanced stage. Conclusions Based on our result, we conclude that to improve survival, we should promote testicular cancer awareness, especially among the most deprived populations, and their health care providers.

Oncoplastic breast-conserving surgery (OBCS) comprises diverse techniques aimed at enhancing aesthetic outcomes and safety in breast cancer treatment. However, a knowledge gap exists in understanding the comprehensive assessment of safety factors and satisfaction rates associated with OBCS techniques. This systematic review and meta-analysis aim to compare volume displacement (VD) and volume replacement (VR) techniques concerning oncological safety, complication rates and patient satisfaction. A systematic literature search was conducted in three databases—PubMed, Embase, and Cochrane Library (CENTRAL)—up to November 2023. Original articles with quantitative satisfaction rates, recurrence, re-excision, margin status, and complications (hematoma, seroma, wound infection, fat necrosis). The systematic search identified 17,374 records, with 80 eligible studies and 46 providing quantitative data. Results showed comparable oncological safety between VD and VR techniques, including similar recurrence (Prop: 0.02; CI 0.02–0.03) and re-excision rates (Prop: 0.05; CI 0.04–0.07). VR techniques had a higher incidence of fat necrosis (Prop: 0.07; CI 0.04–0.12). Overall satisfaction was high (Prop: 0.83; CI 0.78–0.87), with VD yielding the highest satisfaction (Prop: 0.93; CI 0.85–0.97). Oncoplastic breast-conserving surgery emerges as a successful approach for treating early-stage breast cancer, characterized by low associated risks and high satisfaction rates.

The cold and thermal karst water resources of the Bükk Mountains play a significant role in the hydrogeological setting of northeastern Hungary. Although there is much geological and hydrogeological information available, the regional hydrogeology of the Bükk Mountains had not been described in a standalone study involving all this information. The drinking water supply of the city of Miskolc and some other neighboring cities is based on the cold karst water resources of the Bükk Mountains. The thermal water resources have been getting more important, in terms of balneology and geothermal energy production, in this region over the last decade. An evaluation of the measurements of a 27-year-old groundwater quantity and quality monitoring system was performed. As a result, several types of new field hydrogeology, meteorology and spring discharge measurements were added to the monitoring scheme to provide information for studying the tendencies connected to extreme weather conditions. This will help to achieve sustainable utilization of the karst water resources. The main conclusions drawn in this study underline the importance of the strict measures associated with the water management of the Bükk Mountains because of the limited natural recharge and the continuously increasing demands on the cold and thermal water resources. A success story is found in Miskolc, which demonstrates the sustainable utilization of the deep thermal karst water; Miskolc hosts the largest geothermal heating plant in Central Europe with 60 MWt capacity.

Manapság a vízadók és kapcsolatrendszereik minél alaposabb ismerete, ill. a hosszú távú mérési adatsorok folyamatos regisztrálása elengedhetetlenek a fenntartható vízgazdálkodás és a jövőbeli előrejelzések szempontjából. A Bükkben a Bükki Karsztvízszint Észlelő Rendszer által 25 éve szolgáltatott vízszint adatsorok szolgáltatják az alapot az ilyen irányú kutatásokhoz. A jelenleg zajló vizsgálatok több irányban zajlanak, melyek a következők: - Felhasználva a rendelkezésünkre álló korábbi információkat, azokat vízkémiai elemzésekkel kiegészítve új ismeretekkel bővült a tudásanyag a Garadna-forrás és vízgyűjtőjének rendszere tekintetében. Sikeres volt a hozam és vízszint adatsorok közötti megbízható matematikai összefüggés felállítása is. - Kidolgozásra került egy új típusú vízkészlet-becslési módszer, amit szintén vízkémiai eredmények felhasználásával egy karsztvíz-domborzati térkép létrehozására használunk. - A hosszú távú vízszint adatsorok alapján csökkenési jelleggörbéket állítottunk elő, melyek felhasználása sokrétű. Segítségükkel előre jelezhetőek a várható karsztvízszintek csapadékmentes időszakokra, továbbá a karsztos vízadók hidrogeológiai jellemzőire is következtethetünk. - Emellett vizsgáltuk, hogy milyen tendenciák, extrémitások jelentkeznek a hegységben csapadékok és vízszintek vonatkozásában az elmúlt évtizedekben, melyek akár a klímaváltozásra is utalhatnak.