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Background Due to the myriad of benefits of children’s outdoor play and time, there is increasing concern over its decline. This systematic review synthesized evidence on the correlates of outdoor play and outdoor time among children aged 3-12 years. Methods A total of 12 electronic databases in five different languages (Chinese, English, Korean, Spanish, Portuguese) were searched between October 28, 2019 and July 27, 2020. Covidence software was used for screening and Microsoft Excel with a predesigned coding form was used for data extraction. Evidence was synthesized and correlates were categorized using the socioecological model framework. Results Based on 107 studies representing 188,498 participants and 422 childcare centers from 29 countries, 85 studies examined potential correlates of outdoor play while 23 studies examined that of outdoor time (one examined both). The duration of outdoor play and outdoor time ranged between 60 and 165 min/d and 42-240 min/d, respectively. Out of 287 (outdoor play) and 61 (outdoor time) potential correlates examined, 111 correlates for outdoor play and 33 correlates for outdoor time were identified as significant correlates. Thirty-three variables were identified as key/common correlates of outdoor play/time, including eight correlates at the individual level (e.g., sex/gender, race/ethnicity, physical activity), 10 correlates at the parental level (e.g., parental attitude/support/behavior, parenting practice), nine at the microsystem level (e.g., proximal home/social environment such as residence type, peer influence), three at the macrosystem/community level (e.g., availability of space children can play), and three at the physical ecology/pressure for macrosystem change level (e.g., seasonality, rurality). No key correlates were found at the institutional level. Conclusions Individual, parental, and proximal physical (home) and social environments appear to play a role in children’s outdoor play and time. Ecological factors (i.e., seasonality, rurality) also appear to be related to outdoor play/time. Evidence was either inconsistent or lacking at institutional and macrosystem/community levels. Standardizing terminology and measures of outdoor play/time is warranted. Future work should investigate the interactions and processes of multiple variables across different levels of socioecological modelling to better understand the mechanisms through which outdoor play/time opportunities can be optimized for children while paying special attention to varying conditions in which children are born, live, and play.

The objective of this systematic review was to summarize the roles that religious communities played during the early stage of COVID-19 pandemic. Seven databases were searched and a total of 58 articles in English published between February 2020 and July 2020 were included in evidence synthesis. The findings of the literature showed diverse influences of religion as a double-edged sword in the context of COVID-19 pandemic. Religious communities have played detrimental and/or beneficial roles as a response to COVID-19 pandemic. A collaborative approach among religious communities, health science, and government is critical to combat COVID-19 crisis and future pandemics/epidemics.

Background Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess restorative properties for damaged skin, but the potential of microalgae extracts as skin protective agents remains unknown. Purpose This study aimed to analyze compound profiles from polar microalgae extracts, evaluate their potential as skin epithelial protective agents, and examine the underlying mechanisms. Methods Six different polar microalgae, Micractinium sp . (KSF0015 and KSF0041), Chlamydomonas sp . (KNM0029C, KSF0037, and KSF0134), and Chlorococcum sp. (KSF0003), were collected from the Antarctic or Arctic regions. Compound profiles of polar and non-polar microalgae extracts were analyzed using gas chromatography-mass spectrometry (GC-MS). The protective activities of polar microalgae extracts on human keratinocyte cell lines against oxidative stress, radiation, and psoriatic cytokine exposure were assessed. The potential anti-inflammatory mechanisms mediated by KSF0041, a polar microalga with protective properties against oxidative stress, ultraviolet (UV) B, and an inflammatory cytokine cocktail, were investigated using RNA-sequencing analysis. To evaluate the therapeutic activity of KSF0041, an imiquimod-induced murine model of psoriatic dermatitis was used. Results Polar microalgae contain components comparable to those of their non-polar counterparts, but also showed distinct differences, particularly in fatty acid composition. Polar microalgae extracts had a greater ability to scavenge free radicals than did non-polar microalgae and enhanced the viability of HaCaT cells, a human keratinocyte cell line, following exposure to UVB radiation or psoriatic cytokines. These extracts also reduced barrier integrity damage and decreased mRNA levels of inflammatory cytokines in psoriatic HaCaT cells. Treatment with KSF0041 extract altered the transcriptome of psoriatic HaCaT cells toward a more normal state. Furthermore, KSF0041 extract had a therapeutic effect in a mouse model of psoriasis. Conclusions Bioactive compounds from polar microalgae extracts could provide novel therapeutics for damaged and/or inflamed skin.

Background Physical activity (PA) participation during the COVID-19 pandemic may vary across different population groups. This study examined the associations between immigrant status, socioeconomic status (SES), and outdoor/indoor PA. Methods National-level, cross-sectional data from 4,383 Canadians aged 25 + yrs (51% women) who participated in the Canadian Perspective Survey Series–Impacts of COVID-19 were used. Exposure included immigrant status with potential effect modifiers—educational attainment, employment status, and financial impacts due to the COVID-19 pandemic. Outcome included outdoor and indoor PA. Covariates included sex, age, household size, presence of a child < 18 yrs, marital status, and changes in unhealthy behaviors (e.g., alcohol, tobacco, junk food, screen time) during the pandemic. Results About a quarter (24%) of the participants were immigrants who participated in less outdoor PA but more indoor PA than their Canadian-born counterparts (outdoor PA: 42% vs 70%; indoor PA: 68% vs 56%, respectively). Regardless of education, employment, and financial impacts, immigrants to Canada were far less likely to participate in outdoor PA than their Canadian-born counterparts during the COVID-19 pandemic. For indoor PA, immigrants, particularly those unemployed or financially impacted, were more likely to report participating in indoor PA than Canadian-born individuals. Among Canadian-born individuals, post-secondary education and employment status (employed but absent from work) have emerged as key correlates for both outdoor and indoor PA. Conclusions The findings highlight the importance of understanding the differential SES factors influencing outdoor and indoor PA participation among immigrants and Canadian-born individuals living in Canada. Future research should investigate ways that could equitably promote access to outdoor PA.

Science faculty who want to improve instructional strategies need to design appropriate methods for assessing and analyzing classroom data to determine the effectiveness of their approaches to learning. We used systematic strategies derived from methods of discipline-based science research to design problems to assess students' understanding of the carbon cycle in two introductory biology courses for science majors. Among typical misconceptions are the ideas that gaseous carbon dioxide is not respired during decomposition by organisms in the soil and that plants acquire carbon from the soil rather than from the air through leaves during photosynthesis. Diagnostic problems provided data on students' understanding and misconceptions. In-class instruction, problems, and laboratories were designed to focus on student misconceptions and provided formative assessment. After two semesters, results indicated that the majority of students responded accurately; however, 20 to 40 percent of the students maintained misconceptions even after instruction. Assessment strategies enabled us to collect, analyze, and report data that will influence future instruction.

ObjectivesTo investigate the effect of epithelial growth factor (EGF) with collagen matrix (CM) on the gain of KT for buccally positioned implants in dogs.Materials and methodsIn five dogs, four implants were placed buccally with the whole part of KT excision on the buccal side (two implants per each hemi-mandible). After one month, KT augmentation was performed: 1) free gingival grafts (FGG), 2) collagen matrix (CM) only, 3) CM soaked with 1 μg/g of EGF, and 4) CM soaked with 10 μg/g of EGF (n = 5 in each group). The experimental animals were sacrificed three months post-KT augmentation. Clinical, histologic, and histomorphometric analyses were performed.ResultsThe clinical KT zone was the highest in group FGG (5.16 ± 1.63 mm). Histologically, all groups presented buccal bony dehiscence. Regarding newly formed KT, no specific difference was found among the groups, but robust rete pegs formation in some specimens in group FGG. Histomorphometric KT height (4.66 ± 1.81 mm) and length (5.56 ± 2.25 mm) were the highest in group FGG, whereas similar increases were noted in the rest. The buccal soft tissue thickness at the coronal part of the implant did not exceed 2 mm in all groups.ConclusionAll groups presented increased KT zone, but FGG treatment was more favored. The addition of EGF to CM appeared not to enhance KT formation.Clinical relevanceFGG treatment was more favorable to re-establish the KT zone than other treatment modalities.

A 28-year-old male patient was referred from an otorhinolaryngologist for managing unilateral chronic maxillary sinusitis (MS). The patient had undergone 2 functional endoscopic sinus surgeries, although the MS was not resolved. Based on his dental history, endodontic treatment had been done on the symptomatic area. A leak of endodontic sealer and peri-apical lesion on tooth #14 was found on cone-beam computed tomographic examination. Extraction of tooth #14 and the modified Caldwell-Luc operation were performed to remove the endodontic sealer material and relevant inflammatory tissue. The sinus membrane lining was maintained as much as possible during the surgery. Implant placement was performed on the tooth extraction site. All clinical symptoms disappeared after the surgery. Radiographic and endoscopic examination revealed successful osseointegration of the implant and complete resolution of the MS. Functional endoscopic sinus surgery alone may not be sufficient to treat MS derived from dental origin. For unilateral MS, dental history should be carefully checked.

Background: Immune checkpoint inhibitors are ineffective in the majority of colorectal cancers (CRCs) that are microsatellite stable. However, the underlying reasons for their unresponsiveness and mechanisms of immune evasion are poorly understood. In the present study, we aimed to elucidate the mechanisms underlying the immune evasion driven by CRC cells. Methods: We performed single-cell RNA sequencing of tumor tissues from 30 CRC patients and syngeneic mice implanted with transformation-related protein 53 ( Trp53 ) knockout CT26 cells. Gene expression and correlations of individual tumor microenvironment (TME) components were analyzed, and their functional significance was investigated using syngeneic mouse models and cell line co-culture experiments. Results: CCAAT enhancer-binding protein beta ( CEBPB ) expression was increased in tumor protein 53 ( TP53 )-mutated CRCs. We confirmed that wild-type TP53 negatively regulated CEBPB expression in CRC cell lines. CEBPB expression was associated with decreased intratumoral T cell infiltration and negatively impacted survival in CRC patients. In the intercellular correlation analysis of gene expression, tumor epithelial cell CEBPB expression was significantly correlated with cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) expression in T cells, especially in regulatory and exhausted T cells. Cebpb overexpression promoted tumor growth in the immunocompetent syngeneic mouse models, which was accompanied by increased CTLA-4 expression in tumor-infiltrating CD4 + T cells. In vitro co-culture experiments also showed that tumor cell CEBPB overexpression increased CTLA4 in T cells. Conclusions: Tumor cell CEBPB expression, up-regulated by TP53 mutation, can increase CTLA4 expression in T cells and negatively affect patient outcomes. These findings suggested a central role of tumor cell CEBPB in shaping an immunosuppressive TME.

Online hate speech detection has become an important issue due to the growth of online content, but resources in languages other than English are extremely limited. We introduce K-MHaS, a new multi-label dataset for hate speech detection that effectively handles Korean language patterns. The dataset consists of 109k utterances from news comments and provides a multi-label classification using 1 to 4 labels, and handles subjectivity and intersectionality. We evaluate strong baseline experiments on K-MHaS using Korean-BERT-based language models with six different metrics. KR-BERT with a sub-character tokenizer outperforms others, recognizing decomposed characters in each hate speech class.