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A well-known and powerful convex optimization strategy is exploited to enhance the electromagnetic performance of the Square Kilometer Array Low-Frequency radio telescope. The proposed method minimizes the peak sidelobe level while ensuring full control of the receiving pattern across the entire angular domain. The approach is validated through full-wave simulations that incorporate realistic embedded element patterns, demonstrating significant improvements in sidelobe suppression despite the geometric constraints of the array structure. The achieved results underscore the method’s potential for high-performance beam synthesis in large-scale radio astronomy arrays.

The regional difference in the carbohydrate components of the ductus epididymis epithelium of a lizard was delineated by means of 13 lectins. Basal cells expressed only N-acetylglucosamine (GlcNAc). Throughout the ductus, the secretory cells showed oligosaccharides with terminal N-acetylneuraminic acid (Neu5Ac)α(2,6)galactose (Gal)/N-acetylgalactosamine (GalNAc) and internal mannose (Man) and/or glucose (Glc) in the whole cytoplasm, oligosaccharides terminating in Neu5Acα(2,6)Galβ(1,3)GalNAc, Neu5Acα(2,6)Galβ (1,4)GlcNAc, GalNAc, GlcNAc, and fucose (Fuc) in the supra-nuclear zone, and also glycans terminating in Neu5Acα(2,3)Galβ (1,4)GlcNAc, Neu5Acα(2,6)Galβ(1,3)GalNAc, Galβ (1,4)GlcNAc on the luminal surface. In the caput and corpus regions, the supra-nuclear cytoplasm was characterized by terminal Galβ(1,4)GlcNAc and αGalNAc, the luminal surface by αGalNAc and Gal. The Golgi zone, showing oligosaccharides with terminal Neu5Acα(2,3)Galβ (1,4)GlcNAc, Neu5Acα(2,6)Galβ (1,3)GalNAc, Neu5Acα(2,6)Galβ (1,4)GlcNAc, and internal GlcNAc, expressed terminal Galβ (1,4)GlcNAc and αGalNAc in the caput, and terminal β GalNAc in the corpus. The granules showed all the investigated carbohydrates in their peripheral zone except terminal βGalNAc and Fuc, whereas internal Man/Glc and terminal Gal were expressed in the central core, and Fuc throughout the ductus, terminal GlcNAc in the caput and corpus, and terminal αGalNAc only in the corpus.[PUBLICATION ABSTRACT]

This paper presents an innovative Direct Radiating Array (DRA) architecture exploiting aperiodic tilings of the plane. In particular, a pinwheel tiling has been selected in order to fix positions of the different radiating sources, which are constituted by properly shaped elements. Such a choice allows to achieve a good aperture efficiency and very low pseudo-grating lobes while using only two different kinds of radiating elements. Preliminary results are shown and discussed with reference to both cases wherein the single tiles are not fully populated and wherein ad-hoc sub-array radiators are used. The very encouraging results achieved leave open the way for further interesting possibilities.

Modern radio telescopes strongly rely on accurate computational electromagnetic tools for \"beam\" models. Especially for densely-packed aperture array radio telescopes, the only feasible way to produce accurate models of the individual embedded element patterns is by using electromagnetic codes. In this paper, the accuracy of two models computed by different commercial codes is evaluated for one station of the SKA-Low radio telescope. Except for a couple of critical frequencies, the amplitude and phase errors are low enough to allow a beamformer efficiency higher than 99%.

The low frequency component of the Square Kilometre Array (SKA1-Low) will be an aperture phased array located at the Murchison Radio-astronomy Observatory (MRO) site in Western Australia. It will be composed of 512 stations, each of them consisting of 256 log-periodic dual polarized antennas, and will operate in the low frequency range (50 MHz - 350 MHz) of the SKA bandwidth. The Aperture Array Verification System 2 (AAVS2), operational since late 2019, is the last full-size engineering prototype station deployed at the MRO site before the start of the SKA1-Low construction phase. The aim of this paper is to characterize the station performance through commissioning observations at six different frequencies (55, 70, 110, 160, 230 and 320 MHz) collected during its first year of activities. We describe the calibration procedure, present the resulting all-sky images and their analysis, and discuss the station calibratability and system stability. Using the difference imaging method, we also derive estimates of the SKA1-Low sensitivity for the same frequencies, and compare them to those obtained through electromagnetic simulations across the entire telescope bandwidth, finding good agreement (within \\(\\leq 13%\\)). Moreover, our estimates exceed the SKA1-Low requirements at all the considered frequencies, by up to a factor of \\(\\sim\\)2.3. Our results are very promising and allow an initial validation of the AAVS2 prototype station performance, which is an important step towards the upcoming SKA-Low telescope construction and science.

This report was submitted as part of the SKA Low Frequency Aperture Array Critical Design Review describing the design of the SKA1-LOW station that took place between 2013 and 2018. The SKA1 LOW field station is inscribed in a circular area having an effective station diameter (centre to centre) of 38 meters and has 256 SKALA4 elements. This document describes the electromagnetic design of the field station. In particular it describes the layout design and the electromagnetic modelling and characteristics of the station. This document describes the effects associated with the layout and array such as mutual coupling effects, side lobe pattern and beam shape (eg. smoothness, calibration models) and presents the state of the art of our ability to measure the array performance and validate the simulation work. The current LFAA field node requirements, derived from the SKA L1 requirements, have evolved over the last years since the LFAA PDR and the System Baseline Design. The SKA1 LOW field station has been designed to meet those requirements and has therefore tracked their evolution (eg. sensitivity requirements, array diameter, etc.). The aforementioned requirements represent a very tight space with a desire for very high sensitivity over a large frequency range (7 to 1) and wide field of view (90 degrees cone around zenith) while keeping the station diameter to a minimum, so as the filling factor but at the same time allowing for sufficient space between antennas to allow for easy maintenances, amongst many others. This results in a complex design.

Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in the last ten years, but there are still many obstacles to overcome for transfer to the clinic to become a reality. Although preclinical and first-in-human clinical evidence suggests that ultra-high dose rates (UHDRs) induce a sparing effect in normal tissue without modifying the therapeutic effect on the tumor, successful clinical translation of FLASH-RT depends on a better understanding of the biological mechanisms underpinning the sparing effect. Suitable in vitro studies are required to fully understand the radiobiological mechanisms associated with UHDRs. From a technical point of view, it is also crucial to develop optimal technologies in terms of beam irradiation parameters for producing FLASH conditions. This review provides an overview of the research progress of FLASH RT and discusses the potential challenges to be faced before its clinical application. We critically summarize the preclinical evidence and in vitro studies on DNA damage following UHDR irradiation. We also highlight the ongoing developments of technologies for delivering FLASH-compliant beams, with a focus on laser-driven plasma accelerators suitable for performing basic radiobiological research on the UHDR effects.

(1) Background: The aim of our study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables (epilepsy type, epilepsy duration, seizure number, antiseizure medications, comorbidities, efficacy, and adverse events). (2) Methods: We consecutively enrolled 36 children aged between 3 and 10 years who had been diagnosed with various types of drug-resistant epilepsy and who were in therapy with a ketogenic diet for better seizure control. A standardized neuropsychological questionnaire (Parenting Stress Index–PSI) was administered to the parents evaluating parental stress at baseline (T0), after 6 (T1) months, and after 12 months (T2). (3) Results: After 6 and 12 months of dietary treatment, Parental Distress and Total Stress mean scores were statistically significantly increased. Post hoc analysis showed no significant changes in the scores between T0 and T1, although there was a significant increase between T1 and T2. We did not find statistically significant relationships between parental stress and the other variables considered. (4) Conclusions: The ketogenic diet can be challenging for parents and can affect the perception of parental stress, especially in the long term. Parents may feel inadequate in their role; therefore, they should be helped and encouraged through additional supports in order to maximize the adherence to diet therapy.

Background Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is the organ playing the crucial role. So, it is necessary to evaluate fat mass and not simpler body mass index (BMI), because BMI leaves a portion of the obese population unrecognized. The aim is to evaluate the relationship between Percentage of Fat Mass (FM%) and immune-inflammatory response, after 10 days in Intensive Care Unit (ICU). Methods Prospective observational study of 22 adult patients, affected by COVID-19 pneumonia and admitted to the ICU and classified in two sets: (10) lean and (12) obese, according to FM% and age (De Lorenzo classification). Patients were analyzed at admission in ICU and at 10th day. Results Obese have steatosis, impaired hepatic function, compromise immune response and higher inflammation. In addition, they have a reduced prognostic nutritional index (PNI), nutritional survival index for ICU patients. Conclusion This is the first study evaluating FM% in COVID-19 patient. We underlined obese characteristic with likely poorly prognosis and an important misclassification of obesity. A not negligible number of patients with normal BMI could actually have an excess of adipose tissue and therefore have an unfavorable outcome such as an obese. Is fundamental personalized patients nutrition basing on disease phases.

The use of very high energy electron (VHEE) beams, with energies between 50 and 400 MeV, has drawn considerable interest in radiotherapy due to their deep tissue penetration, sharp beam edges, and low sensitivity to tissue density. VHEE beams can be precisely steered with magnetic components, positioning VHEE therapy as a cost-effective option between photon and proton therapies. However, the clinical implementation of VHEE therapy (VHEET) requires advances in several areas: developing compact, stable, and efficient accelerators; creating sophisticated treatment planning software; and establishing clinically validated protocols. In addition, the perspective of VHEE to access ultra-high dose–rate regime presents a promising avenue for the practical integration of FLASH radiotherapy of deep tumors and metastases with VHEET (FLASH-VHEET), enhancing normal tissue sparing while maintaining the inherent dosimetric advantages of VHEET. However, FLASH-VHEET systems require validation of time-dependent dose parameters, thus introducing additional technological challenges. Here, we discuss recent progress in VHEET research, focusing on both conventional and FLASH modalities, and covering key aspects including dosimetric properties, radioprotection, accelerator technology, beam focusing, radiobiological effects, and clinical outcomes. Furthermore, we comprehensively analyze initial VHEET in silico studies on coverage across various tumor sites.