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Background Schizophrenia is a debilitating psychiatric condition distinguished by a variety of cognitive, emotional, and behavioral manifestations. It affects an individual’s cognition, emotions, and actions, resulting in challenges in discerning reality from illusion. The objective of the current study was to assess the determinants and severity of symptoms in Moroccan patients hospitalized in Ar-Razi Hospital, Rabat, Morocco using Positive and Negative Syndromes scales (PANSS). Methods One hundred sixty-one schizophrenic patients were admitted to Ar-Razi Hospital in Sale. The PANSS scale, in conjunction with a sociodemographic questionnaire, is utilized as the assessment tool for symptoms. A chi-square test at a 5% error level and a Pearson correlation test were applied to investigate possible associations. Results The findings demonstrate a significant bias towards males (9:1), with 90% being unmarried, and 96.3% originating from urban settings. The breakdown of patients based on symptoms reveals a prevalence of 14.3% for the positive scale, 18% for the negative scale, and 11.2% for the psychopathological scale. The correlation analysis demonstrates a strong relationship between the three scales. The factors that were found to have a notable impact are gender ( p  < 0.000), functional ability ( p  < 0.032), socioeconomic status ( p  < 0.008), living environment ( p  < 0.05), and use of tobacco and cannabis. Conclusion Confronted with this scenario, healthcare professionals are required to evaluate the key factors in the timely detection of schizophrenia and advocate for the consistent utilization of the PANSS scale in the management and monitoring of patients.

Background Prodromal signs are a valuable factor, but they can be challenging to serve as predictive indicators in schizophrenia; meanwhile, other significant risk factors, like family history and cannabis use, are well-documented high-risk factors. Aim This present study aimed to examine the association between the age at onset of psychosis and prodromal signs, family history of psychosis, and cannabis use independently, as well as the impact of their interaction. Methods Our study employed a retrospective approach and recruited 200 Moroccan patients clinically diagnosed with schizophrenia with a mean age of 31.47 years (± 8.39) from the Ar-razi Psychiatric Center of ibn Sina Hospital. Clinical data were collected in the presence of a qualified psychiatrist via a structured questionnaire. Results we found that the more prodromal signs a patient had, the age at onset of psychosis was slightly lowered with a non-significant small effect [E= -0.04; CI(-0.69) – (0.61); p= 0.89], similarly effect was observed to the presence of family psychosis [E= -0.12; CI(-1.79) – (1.53); p= 0.87], however the cannabis users patients showed a statistically significant association with an earlier age at onset of psychosis by lowering it 2 years compared to non-cannabis users [E= -2.23; CI(-4.28) – (-0.18); p= 0.03], their interaction had also a small effect at the age at onset of psychosis by the presence of prodromal signs. Conclusion cannabis use was associated with an early age at onset of psychosis, and this trend was consistent among patients who exhibited more prodromal signs. Even though other risk factors were non-significant, they also had a small effect influenced by the presence of prodromal signs. BJMS, Vol. 25 No. 01 January’26 Page : 206-213  

Numerous studies have identified a correlation between autoimmune disorders and schizophrenia, indicating that various single-nucleotide polymorphisms (SNPs) associated with immune-related genes significantly implicated in common autoimmune conditions (rheumatoid arthritis, multiple sclerosis, and lupus erythematosus) may influence the risk of developing schizophrenia. The CLEC16A gene was identified as significant to those autoimmune pathologies associated with schizophrenia and a candidate gene for schizophrenia itself. For this study, 142 individuals diagnosed with schizophrenia were selected; the mean age was 32.5 ± 7 years, accompanied by 127 healthy controls of a mean age of 34.3 ± 10.3 years, all of Moroccan descent. For the first time, four SNPs within the CLEC16A gene were analyzed for their association with schizophrenia, the minor allele T (rs12928822) was found to be slightly elevated in SCZ patients compared to healthy controls, yielding an odds ratio of 1.554 (95% CI, 0.698–3.458); similarly with the minor allele A (rs2903692), with an odds ratio of 1.237 (95% CI, 0.848–1.805). However, no statistically significant association was observed for both variants and the disease ( p  = 0.28; p  = 0.27), similar to the haplotypes. The present investigation did not reveal a significant association between the analyzed single-nucleotide polymorphisms (SNPs) and schizophrenia within our Moroccan cohort; positive odds were identified, with no significance, advocating for additional research with an expanded sample size.

Suicide constitutes the greatest risk factor for mortality in individuals with schizophrenia. Although numerous risk factors have been suggested as important predictors of suicidality in schizophrenia, most studies have focused on Caucasian and Chinese patients. This study aimed to examine the prevalence of suicide attempts in schizophrenia patients in Rabat-Sale-Kenitra, Morocco, and to identify associated clinical and sociodemographic characteristics. A cross-sectional study was conducted at the Ar-RAZI Psychiatric Center of Ibn Sina Hospital in Rabat. We examined 175 Moroccan schizophrenic patients. The sociodemographic and clinical variables were analyzed based on the presence or absence of suicide attempts. The prevalence of suicide attempts among patients was 32%. 43% of them had reported multiple suicide attempts. The majority of those who attempted suicide were single, younger, and with a lower economic status. Visual hallucinations were significantly prevalent among attempter patients compared to non-attempters (p =0.032). Consequently, visual hallucinations could be a risk factor for suicide attempts in the Moroccan population. Understanding sociodemographic and clinical characteristics associated with suicide attempts can help identify patients at higher risk and provide appropriate support and interventions to prevent suicide among the Moroccan population.

Dans le but d'illustrer l'importance des manifestations psychiatriques du lupus érythémateux systémique, nous rapportons le cas d'une jeune patiente âgée de 32 ans, n'ayant pas d'antécédents psychiatriques. Elle est suivie depuis un an pour lupus érythémateux systémique. Elle a présenté depuis 2 à 3 mois des manifestations psychiatriques faisant évoquer un épisode dépressif majeur, qui s'est bien amélioré sous traitement. Dans le lupus érythémateux systémique, la prise en charge doit être d'emblée multidisciplinaire afin d'assurer une cohérence parfaite indispensable à l'adhérence de la patiente au projet de soin.

Objective: Over the past decade, and despite the increasing awareness of suicide attempts among adults in Morocco, there was no complete system of statistics. As a result, the sociodemographic profile of reported adult suicide attempts varied in some studies. The purpose of this study was to provide the sociodemographic and clinical profile of suicide attempts in adults in a Moroccan hospital. Methods: A retrospective study of a descriptive type carried out in Psychiatric University Hospital ArraziSalé during one and a half year (January 2016 to April 2017). The information was collected using a pre-established questionnaire based on medical records. The data entry and statistical evaluation were performed by the SPSS software (20.0). Results: A total of 62 patients were recruited, 32 women and 30 men who met the eligibility criteria. The profile of the suicidal attempters who must be kept in the hospital to prevent a suicidal recidivism is a young adult between the ages of 25 and 40, male, with psychiatric disorder: mood disorder, schizophrenia, anxiety disorder, borderline personality disorder, histrionic or psychopathic personality, alcohol or other psychoactive substance dependence, familial and emotional connectedness, material deprivation with previous suicide attempt that demonstrates the possibility of acting out because as we known that the risk of recidivism increases with the number of previous attempts. Conclusion: The development of repeated epidemiological surveys makes it possible to better understand the prevalence of suicide attempts in Morocco and to implement suicide prevention programs.

Brugada syndrome is a rare genetic disease, of autosomal dominant inheritance with low penetrance, manifested by ST-segment elevation at right precordial V1, V2, and V3, and right branch block aspect. to the electrocardiogram. It exposes to a high risk of ventricular arrhythmia that can cause syncope and even sudden death, on a structurally healthy heart.We report here the case of a young patient of 25 years who has a syndrome of Brugada induced by a neuroleptic. To our knowledge, this is the first reported case of Brugada syndrome induced by a neuroleptic Morocco. Therapeutic management is based on Amiodarone and beta-blockers. Regular monitoring of the ECG should, however, be performed on patients taking psychotropic drugs and also on associations.

Syphilis is a venereal disease. Morocco has witnessed syphilis since the fifteenth century and the treatment of this disease remained archaic until the Protectorate was established. With the establishment of the colonial system in Morocco, the phenomenon of prostitution spread. Protectorate authorities designated a particular place in Casablanca for such activity that developed: Bousbir district. The authorities' efforts failed to regulate and organize such activity because of the development of clandestine prostitution in relation to urban growth and the increase of employed, poor and downgraded urban population, especially among women who practice prostitution, and due to lack of a real social policy of the Protectorate concerning the policy of land-use planning or control that were a priority.