Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
18
result(s) for
"Labrecque, Ellen"
Sort by:
Implementation of Electronic Objective Structured Clinical Examination Evaluation in a Nurse Practitioner Program
The Objective Structured Clinical Examination (OSCE) is a valuable, yet resource-intensive method for evaluating clinical competence of students in health disciplines. Electronic OSCE (eOSCE) management programs have the potential to support evaluative efficiency and objectivity of OSCEs.
The processes for selecting, implementing, and evaluating use of an eOSCE management system in a Master of Nursing Primary Health Care Nurse Practitioner program are described.
Tailored selection and implementation of an eOSCE management system to fit program needs and available resources facilitated optimal use of eOSCE, promoting grading efficiency, ability to provide prompt feedback to students, and examiner objectivity. These advantages were found to outweigh the disadvantages of extra time and effort to initially learn the eOSCE program.
A program-centered approach to implementation of an eOSCE management system supports high-quality, efficient assessment of student clinical competencies. [J Nurs Educ. 2018;57(8):502-505.].
Journal Article
Strength : build muscles and climb high!
Why is strength important? How can you stay healthy? What are some fun, simple exercises we can all do to stay fit? Answer these questions and more with this simple and engaging text in the Exercise! series.
Book
Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood–brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting passage of circulating proinflammatory cytokines and depression-like behaviors. This effect is prominent within the nucleus accumbens, a brain region associated with mood regulation; however, the mechanisms involved are unclear. Moreover, compensatory responses leading to proper behavioral strategies and active resilience are unknown. Here we identify active molecular changes within the BBB associated with stress resilience that might serve a protective role for the neurovasculature. We also confirm the relevance of such changes to human depression and antidepressant treatment. We show that permissive epigenetic regulation of cldn5 expression and low endothelium expression of repressive cldn5-related transcription factor foxo1 are associated with stress resilience. Regionand endothelial cell-specific whole transcriptomic analyses revealed molecular signatures associated with stress vulnerability vs. resilience. We identified proinflammatory TNFα/NFκB signaling and hdac1 as mediators of stress susceptibility. Pharmacological inhibition of stress-induced increase in hdac1 activity rescued cldn5 expression in the NAc and promoted resilience. Importantly, we confirmed changes in HDAC1 expression in the NAc of depressed patients without antidepressant treatment in line with CLDN5 loss. Conversely, many of these deleterious CLDN5-related molecular changes were reduced in postmortem NAc from antidepressanttreated subjects. These findings reinforce the importance of considering stress-induced neurovascular pathology in depression and provide therapeutic targets to treat this mood disorder and promote resilience.
Journal Article
Deep oceans
\"Read this book to learn about one of Earth's last frontiers: deep oceans. Learn about the cold and dark depths of the ocean, where scientists find extreme landforms and unusual living things.\"--Provided by publisher.
Book
Arctic tundra
\"Read this book to learn about one of Earth's last frontiers: the arctic tundra. Learn about the harsh weather, extreme landforms, and unusual living things found in this habitat.\"--Publisher.
Book
Living in a desert
This book takes a simple look at what it means to live in a desert. It examines basic geographical features, why people choose to live there, and dangers people might have because of living in a desert, such as extreme weather conditions. The book also looks at how people adapt to living in deserts and the different things both adults and children do in their daily lives, from desert-specific jobs to home schooling, respectively.
Book