Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
13
result(s) for
"Laidlaw, Jill A"
Sort by:
Visit Egypt!
Introduces modern Egypt, describing its history, museums, and ancient sites and monuments.
Book
Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity
Seasonal epidemics of influenza virus result in ~36,000 deaths annually in the United States. Current vaccines against influenza virus elicit an antibody response specific for the envelope glycoproteins. However, high mutation rates result in the emergence of new viral serotypes, which elude neutralization by preexisting antibodies. T lymphocytes have been reported to be capable of mediating heterosubtypic protection through recognition of internal, more conserved, influenza virus proteins. Here, we demonstrate using a recombinant influenza virus expressing the LCMV GP33-41 epitope that influenza virus-specific CD8+ T cells and virus-specific non-neutralizing antibodies each are relatively ineffective at conferring heterosubtypic protective immunity alone. However, when combined virus-specific CD8 T cells and nonneutralizing antibodies cooperatively elicit robust protective immunity. This synergistic improvement in protective immunity is dependent, at least in part, on alveolar macrophages and/or other lung phagocytes. Overall, our studies suggest that an influenza vaccine capable of eliciting both CD8+ T cells and antibodies specific for highly conserved influenza proteins may be able to provide heterosubtypic protection in humans, and act as the basis for a potential \"universal\" vaccine.
Journal Article
Cities
\"Discusses the carbon footprint of cities and ways that the environmental impact can be reduced\"--Provided by the publisher.
Book
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repair of tissues.
Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor α-chain (CD25), IL-7 receptor α-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus.
Journal Article
Secret Lives of Children in the Digital Age
A 2023 SPE Outstanding Book Award Winner 2023 CHOICE Outstanding Academic Title Award Secret Lives of Children in the Digital Age: Disruptive Devices and Resourceful Learnersoffers an examination of the impact on children, their families and their teachers, as digital technologies and new literacy practices have rapidly transformed how children learn, play and communicate. While ease of access to enormous knowledge bases presents many benefits and advantages, mobile screen technologies are often perceived by parents and teachers as disruptive and worrisome. Developed from a wide range of the authors' research over the past decade to an examination of remote learning during the COVID 19 pandemic, this book posits that while teachers, parents and governments are focused on protecting children, what is often neglected is children's own agency and capacity to engage with mobile technologies in ways that support them in pursuing their own interests, pleasures and learning. This text works to disrupt boundaries in research, policy and practice, between home and school, and across virtual and actual worlds, positioning children as both users of media texts and coproducers of digitally mediated knowledge, with peers, family and teachers. Secret Lives of Children in the Digital Agecontributes to research on digital literacies, and offers a pedagogical examination of digital possibilities for bringing playfulness and innovation into learning.
eBook
Foundation Year 2 doctors’ reasons for leaving UK medicine: an in-depth analysis of decision-making using semistructured interviews
ObjectivesTo explore the reasons that doctors choose to leave UK medicine after their foundation year two posts.SettingAll four regions of Scotland.ParticipantsFoundation year two doctors (F2s) working throughout Scotland who were considering leaving UK medicine after foundation training were recruited on a volunteer basis. Maximum variation between participants was sought.Primary and secondary outcome measuresSemistructured interviews were coded using template analysis. Six perspectives, described by Feldman and Ng, were used as the initial coding template. The codes were then configured to form a framework that explores the interplay of factors influencing Foundation Year 2 (F2) doctors’ decisions to leave UK medicine.ResultsSeventeen participants were interviewed. Six perspectives were explored. Structural influences (countrywide and worldwide issues) included visas, economic and political considerations, structure of healthcare systems and availability of junior doctor jobs worldwide. Organisational influences (the National Health Service (NHS) and other healthcare providers) included staffing and compensation policies, the working environment and the learning environment. Occupational influences (specific to being a junior doctor) comprised the junior doctor contract, role and workload, pursuit of career interests and the structure of training. Work group influences (relationships with colleagues) included support at work, task interdependence and use of locums. Personal life influences consisted of work-life balance, and support in resolving work-life conflict. The underlying theme of ‘taking a break’ recurred through multiple narratives.ConclusionsF2s give reasons similar to those given by any professional considering a change in their job. However, working within the NHS as an F2 doctor brought specific challenges, such as a need to make a choice of specialty within the F2 year, exposure to workplace bullying and difficulties in raising concerns. Despite these challenges, most F2s did not view their decision to leave as a permanent job change, but as a temporary break from their current working lives.
Journal Article
Roman city guidebook
Introduces the architecture, city life, cuisine, entertainment, religion, and technology of ancient Rome.
Book
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus.
Journal Article