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A city's infrastructure influences the daily life of residents, neighborhoods, and businesses. But uniting the hard infrastructure of roads and bridges with the soft infrastructure of parks and public art creates significant political challenges. Planners at all stages must work at an intersection of public policy, markets, and aesthetics--while also accounting for how a project will work in both the present and the future. The latest volume in the Urban Agenda series looks at pressing infrastructure issues discussed at the 2017 UIC Urban Forum. Topics include: competing notions of the infrastructure ideal; what previous large infrastructure programs can teach the Trump Administration; how infrastructure influences city design; the architecture of the cities of tomorrow; who benefits from infrastructure improvements; and evaluations of projects like the Chicago Riverwalk and grassroots efforts to reclaim neighborhood parks from gangs. Contributors: Philip Ashton, Beverly S. Bunch, Bill Burton, Charles Hoch, Sean Lally, and Sanjeev Vidyarthi

Family farming operations in the United States are the backbone of the American agricultural economy. Yet, these farms are continually threatened by corporate encroachment and sector wide intergenerational transition of ownership and the uncertainty of succession outcomes. The current study uses a set of theoretical constructs (centralization, formalization, interconnectedness, organizational slack, size) from Rogers’s (2003) Innovation Diffusion Model of Structural Characteristics and Organizational Innovativeness to guide a qualitative exploration of the implications of intergenerational family farming dynamics in California’s San Joaquin Valley. The findings revealed three phenomena - generational leadership positioning, formalization and centralization, and interconnectedness and ingenuity—that stand to inform more proactive approaches to the integration of innovation adoption with intergenerational family farming dynamics.

Transportation and communication are the two revolutionary precursors that predate what Paul Virilio would characterize as the third revolution: transplantation. Advancements in these two precursors are synonymous with increased speed and collapsing of distances, as goods, people, and information travel faster. These revolutions have even extended beyond our terrestrial territory, producing an escape velocity that enabled Voyager 1, launched thirty-five years ago, to recently leave our solar system into interstellar space. The progression of velocity and collapsing of distance are responsible for both the growth and the demise of cities, as trade routes reorganize, new methods of travel emerge (trains,

Evolution is accepted by virtually the entire community of scientists. It is as central to biology as relativity is to physics or atomic theory is to chemistry. Removing it from biology or presenting it as mere conjecture misrepresents its explanatory and predictive power, while erasing its dramatic success over the past 150 years.

Coastal margins are important areas of materials flux that link terrestrial and marine ecosystems. Consequently, climate-mediated changes to coastal terrestrial ecosystems and hydrologic regimes have high potential to influence nearshore ocean chemistry and food web dynamics. Research from tightly coupled, high-flux coastal ecosystems can advance understanding of terrestrial–marine links and climate sensitivities more generally. In the present article, we use the northeast Pacific coastal temperate rainforest as a model system to evaluate such links. We focus on key above- and belowground production and hydrological transport processes that control the land-to-ocean flow of materials and their influence on nearshore marine ecosystems. We evaluate how these connections may be altered by global climate change and we identify knowledge gaps in our understanding of the source, transport, and fate of terrestrial materials along this coastal margin. Finally, we propose five priority research themes in this region that are relevant for understanding coastal ecosystem links more broadly.

With new emerging diseases such as COVID-19 and an increasing incidence of cancer, there remains a significant need for investigating new therapeutic options to treat a wide range of ailments and disorders. Peppermint (Mentha × piperita) and white snakeroot (Ageratina altissima) have been used medicinally by native people in the Midwestern United States for centuries. However, the antiproliferative and antimicrobial properties of the aqueous extracts of these plants remain unclear. In this study, we evaluate the therapeutic potential of peppermint and white snakeroot aqueous leaf extracts by examining their activity against mammalian cancer cells, bacteria, and viruses. Both peppermint and snakeroot extracts showed no reductions in viability at concentrations lower than 25 mg/mL and 10 mg/mL, respectively, in two different cancer lines, HEp-2 and DBT-9 cells, in vitro. While treatment with the snakeroot extract resulted in significant disruption to cytoskeletal organization in HEp-2 cells at a concentration of 10 mg/mL, peppermint and snakeroot extracts did not have a major impact on the viability or proliferation of the cancer cell lines tested. Peppermint and snakeroot were then evaluated for antibacterial activity against four different bacterial pathogens. Significant inhibition of bacterial replication was observed for E. coli (at concentrations greater than 0.1 mg/mL) and S. aureus (at concentrations greater than 1 mg/mL) treated with either peppermint or snakeroot extracts. No significant activity was observed against the bacterial strains P. aeruginosa and S. pyogenes. Peppermint (EC50 = 2.36 mg/mL) and snakeroot (EC50 = 2.64 mg/mL) significantly reduce infectivity and replication (at concentrations above 0.2 mg/mL) of the major human pathogen, human respiratory syncytial virus (hRSV). However, testing for antiviral activity against a mouse coronavirus (murine hepatitis virus, MHV) showed no impact on replication at concentrations up to 2.5 mg/mL. Lastly, chemical analysis of the extracts identified several prominent compounds, which were subsequently evaluated for their biological contributions to the observed plant extract phenotypes. Two of the identified compounds, 1,8-cineole (Eucalyptol) and menthol, show significant antimicrobial activity. We report that aqueous extracts of peppermint and white snakeroot exhibit specific antibacterial and antiviral activities that support further investigation for therapeutic potential.

The Brothers say their departure is unrelated to the various controversies on child abuse. It is, they insist, a response to the huge decline in the number of Brothers. Many of those who remain are well past retirement age. In all, 109 second-level and 29 primary schools will pass from the control of the Brothers to a new charitable trust (the Edmund Rice Schools Trust - ERST). The schools will continue to be run by boards of management which in future will be appointed by the trust. Br John Heneghan, director of the ERST project, said it was hoped to have the new structures in place and to have got approval for them from Church and State before the end of 2007. Preparation and consultations on the plan have been taking place over the past two years with parents, teachers, pupils and other relevant parties, he said.

With new emerging diseases such as COVID-19 and an increasing incidence of cancer, there remains a significant need for investigating new therapeutic options to treat a wide range of ailments and disorders. Peppermint (Mentha × piperita) and white snakeroot (Ageratina altissima) have been used medicinally by native people in the Midwestern United States for centuries. However, the antiproliferative and antimicrobial properties of the aqueous extracts of these plants remain unclear. In this study, we evaluate the therapeutic potential of peppermint and white snakeroot aqueous leaf extracts by examining their activity against mammalian cancer cells, bacteria, and viruses. Both peppermint and snakeroot extracts showed no reductions in viability at concentrations lower than 25 mg/mL and 10 mg/mL, respectively, in two different cancer lines, HEp-2 and DBT-9 cells, in vitro. While treatment with the snakeroot extract resulted in significant disruption to cytoskeletal organization in HEp-2 cells at a concentration of 10 mg/mL, peppermint and snakeroot extracts did not have a major impact on the viability or proliferation of the cancer cell lines tested. Peppermint and snakeroot were then evaluated for antibacterial activity against four different bacterial pathogens. Significant inhibition of bacterial replication was observed for E. coli (at concentrations greater than 0.1 mg/mL) and S. aureus (at concentrations greater than 1 mg/mL) treated with either peppermint or snakeroot extracts. No significant activity was observed against the bacterial strains P. aeruginosa and S. pyogenes. Peppermint (EC[sub.50] = 2.36 mg/mL) and snakeroot (EC[sub.50] = 2.64 mg/mL) significantly reduce infectivity and replication (at concentrations above 0.2 mg/mL) of the major human pathogen, human respiratory syncytial virus (hRSV). However, testing for antiviral activity against a mouse coronavirus (murine hepatitis virus, MHV) showed no impact on replication at concentrations up to 2.5 mg/mL. Lastly, chemical analysis of the extracts identified several prominent compounds, which were subsequently evaluated for their biological contributions to the observed plant extract phenotypes. Two of the identified compounds, 1,8-cineole (Eucalyptol) and menthol, show significant antimicrobial activity. We report that aqueous extracts of peppermint and white snakeroot exhibit specific antibacterial and antiviral activities that support further investigation for therapeutic potential.

The short-term clinical outcomes from a multicenter prospective randomized trial of laparoscopic Nissen versus anterior 90 degrees partial fundoplication have been reported previously. These demonstrated a high level of satisfaction with the overall outcome following anterior 90 degrees fundoplication. However, the results of postoperative objective tests and specific clinical symptoms are not always consistent with an individual patient's functional status and general well being following surgery, and quality of life (QOL) is also an important outcome to consider following surgery for reflux. Hence, QOL information was collected in this trial to investigate the hypothesis: improvements in QOL following laparoscopic antireflux surgery are greater after anterior 90 degrees partial fundoplication than after Nissen fundoplication. Patients undergoing a laparoscopic fundoplication for gastro-esophageal reflux at one of nine university teaching hospitals in six major cities in Australia and New Zealand were randomized to undergo either laparoscopic Nissen or anterior 90 degrees partial fundoplication. Quality of life before and after surgery was assessed using validated questionnaires - the Short Form 36 general health questionnaire (SF36) and an Illness Behavior Questionnaire (IBQ). Patients were asked to complete these questionnaires preoperatively and at 3, 6, 12 and 24 months postoperatively. One hundred and twelve patients were randomized to undergo a Nissen fundoplication (52) or a 90 degrees anterior fundoplication (60). Patients who underwent anterior fundoplication reported significant improvements in eight of the nine SF36 scales compared to four of the nine following a Nissen fundoplication. The majority of these improvements occurred early in the postoperative period. With respect to the illness behavior data, there were no significant differences between the two procedures. Both groups had a significant improvement in disease conviction scores at all time points compared to their preoperative scores. Patients undergoing laparoscopic anterior 90 degrees partial fundoplication reported more QOL improvements in the early postoperative period than patients undergoing a Nissen fundoplication. However, the QOL outcome for both procedures was similar at later follow-up.