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"Lamothe, Matt"
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The exquisite book : 100 artists play a collaborative game
One hundred indie artists play a version of the Exquisite Corpse drawing game. Each artist adorns a page with artwork having seen only the page of the artist immediately prior and using a single horizon line to connect the two. The book's ten chapters reside on a ten-page accordion pull-out, allowing readers to view the art continuously.
Book
The debate over gay marriage: Con
Since same-sex marriage inevitably brings nothing to society, yet goes against the beliefs of the majority of this country, almost all major religions and the state of nature, it should not be recognized or legalized.
Newsletter
The debate over gay marriage: Con
Since same-sex marriage inevitably brings nothing to society, yet goes against the beliefs of the majority of this country, almost all major religions and the state of nature, it should not be recognized or legalized.
Newsletter
The debate over gay marriage: Con
Since same-sex marriage inevitably brings nothing to society, yet goes against the beliefs of the majority of this country, almost all major religions and the state of nature, it should not be recognized or legalized.
Newsletter
E3 Ubiquitin Ligase Activity of Arabidopsis PLANT U-BOX17 and Its Functional Tobacco Homolog ACRE276 Are Required for Cell Death and Defense
Previous analysis of transcriptional changes after elicitation of Cf-9 transgenic tobacco (Nicotiana tabacum) by Avr9 peptide revealed a rapidly upregulated gene, ACRE276. We show that ACRE276 is transiently induced in wounded leaves within 15 min, but upon Avr9 elicitor treatment, this upregulation is enhanced and maintained until cell death onset in Cf-9 tobacco. ACRE276 RNA interference (RNAi) silencing in tobacco results in loss of hypersensitive response (HR) specified by Cf resistance genes. ACRE276 RNAi plants are also compromised for HR mediated by the tobacco mosaic virus defense elicitor p50. Silencing tomato (Lycopersicon esculentum) ACRE276 leads to breakdown of Cf-9-specified resistance against Cladosporium fulvum leaf mold. We confirmed that tobacco ACRE276 is an E3 ubiquitin ligase requiring an intact U-box domain. Bioinformatic analyses revealed Arabidopsis thaliana PLANT U-BOX17 (PUB17) and Brassica napus ARC1 as the closest homologs of tobacco ACRE276. Transiently expressing PUB17 in Cf-9 tobacco silenced for ACRE276 restores HR, while mutant PUB17 lacking E3 ligase activity fails to do so, demonstrating that PUB17 ligase activity is crucial for defense signaling. Arabidopsis PUB17 knockout plants are compromised in RPM1- and RPS4-mediated resistance against Pseudomonas syringae pv tomato containing avirulence genes AvrB and AvrRPS4, respectively. We identify a conserved class of U-box ARMADILLO repeat E3 ligases that are positive regulators of cell death and defense across the Solanaceae and Brassicaceae.
Journal Article
