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Feebly-interacting particles represent an alternative paradigm with respect to the traditional strongly-coupled Beyond the Standard Model physics explored at the LHC and can provide an answer to many fundamental open questions in particle physics. This document presents the state of the art of searches for feebly-interacting particles at accelerator-based experiments including projects proposed at CERN and currently discussed in the European Strategy for Particle Physics update.

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.

With the establishment and maturation of the experimental programs searching for new physics with sizeable couplings at the LHC, there is an increasing interest in the broader particle and astrophysics community for exploring the physics of light and feebly-interacting particles as a paradigm complementary to a New Physics sector at the TeV scale and beyond. FIPs 2020 has been the first workshop fully dedicated to the physics of feebly-interacting particles and was held virtually from 31 August to 4 September 2020. The workshop has gathered together experts from collider, beam dump, fixed target experiments, as well as from astrophysics, axions/ALPs searches, current/future neutrino experiments, and dark matter direct detection communities to discuss progress in experimental searches and underlying theory models for FIPs physics, and to enhance the cross-fertilisation across different fields. FIPs 2020 has been complemented by the topical workshop “Physics Beyond Colliders meets theory”, held at CERN from 7 June to 9 June 2020. This document presents the summary of the talks presented at the workshops and the outcome of the subsequent discussions held immediately after. It aims to provide a clear picture of this blooming field and proposes a few recommendations for the next round of experimental results.

SHADOWS [1, 2] is an intended future beam dump experiment in the CERN North Area, aiming to search for feebly interacting particles (FIPs) [3] created in 400 GeV/c proton interactions. Due to its proposed off-axis location alongside the K12 beamline [4], the SHADOWS detector can be placed potentially very close to the beam dump, enabling it to search for FIPs in unexplored parts of the parameter space. In order to guarantee good quality of a potential signal, it is crucial to reduce any backgrounds of Standard Model particles as much as possible. The dominant background downstream the beam dump is caused by muons [1]. This introduces the need of a dedicated muon sweeping system consisting of magnetised iron blocks (MIBs) to actively mitigate this background component. We present the conceptional design studies in the framework of the Conventional Beams Working Group of the Physics Beyond Colliders Initiative at CERN [5, 6].

Background Rhabdomyosarcoma (RMS), which can be classified as embryonal RMS (ERMS) and alveolar RMS (ARMS), represents the most frequent soft tissue sarcoma in the pediatric population; the latter shows greater aggressiveness and metastatic potential with respect to the former. Epigenetic alterations in cancer include DNA methylation changes and histone modifications that influence overall gene expression patterns. Different tumor subtypes are characterized by distinct methylation signatures that could facilitate early disease detection and greater prognostic accuracy. Methods A genome-wide approach was used to examine methylation patterns associated with different prognoses, and DNA methylome analysis was carried out using the Agilent Human DNA Methylation platform. The results were validated using bisulfite sequencing and 5-aza-2′deoxycytidine treatment in RMS cell lines. Some in vitro functional studies were also performed to explore the involvement of a target gene in RMS tumor cells. Results In accordance with the Intergroup Rhabdomyosarcoma Study (IRS) grouping, study results showed that distinct methylation patterns distinguish RMS subgroups and that a cluster of protocadherin genes are hypermethylated in metastatic RMS. Among these, PCDHA4, whose expression was decreased by DNA methylation, emerged as a down-regulated gene in the metastatic samples. As PCDHA4 -silenced cells have a significantly higher cell proliferation rate paralleled by higher cell invasiveness, PCDHA4 seems to behave as a tumor suppressor in metastatic RMS. Conclusion Study results demonstrated that DNA methylation patterns distinguish between metastatic and non-metastatic RMS and suggest that epigenetic regulation of specific genes could represent a novel therapeutic target that could enhance the efficiency of RMS treatments.

Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2-knockout or -overexpressing primary proliferating or differentiating myoblasts, we found an inverse correlation between Ankrd2 levels and the expression of proinflammatory genes and identified Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF- κ B repressor subunit p50. In particular, we identified Gsk3 β as a novel direct target of the p50/Ankrd2 repressosome dimer and found that the recruitment of p50 by Ankrd2 is dependent on Akt2-mediated phosphorylation of Ankrd2 upon oxidative stress during myogenic differentiation. Surprisingly, the absence of Ankrd2 in slow muscle negatively affected the expression of cytokines and key calcineurin-dependent genes associated with the slow-twitch muscle program. Thus, our findings support a model in which alterations in Ankrd2 protein and phosphorylation levels modulate the balance between physiological and pathological inflammatory responses in muscle.

A bstract The NA62 experiment at CERN, designed to study the ultra-rare decay K + → π + ν ν ¯ , has also collected data in beam-dump mode. In this configuration, dark photons may be produced by protons dumped on an absorber and reach a decay volume beginning 80 m downstream. A search for dark photons decaying in flight to μ + μ − pairs is reported, based on a sample of 1 . 4 × 10 17 protons on dump collected in 2021. No evidence for a dark photon signal is observed. A region of the parameter space is excluded at 90% CL, improving on previous experimental limits for dark photon masses between 215 and 550 MeV /c 2 .

A bstract A sample of 2 . 8 × 10 4 K + → π + μ + μ − candidates with negligible background was collected by the NA62 experiment at the CERN SPS in 2017–2018. The model-independent branching fraction is measured to be (9 . 15 ± 0 . 08) × 10 − 8 , a factor three more precise than previous measurements. The decay form factor is presented as a function of the squared dimuon mass. A measurement of the form factor parameters and their uncertainties is performed using a description based on Chiral Perturbation Theory at O ( p 6 ).

The NA62 experiment at CERN has the capability to collect data in a beam-dump mode, where 400 GeV protons are dumped on an absorber. In this configuration, New Physics particles, including dark photons, dark scalars, and axion-like particles, may be produced in the absorber and decay in the instrumented volume beginning approximately 80 m downstream of the dump. A search for these particles decaying in flight to hadronic final states is reported, based on an analysis of a sample of 1.4 × 10 17 protons on dump collected in 2021. No evidence of a New Physics signal is observed, excluding new regions of parameter spaces of multiple models.

A bstract A measurement of the K + → π + ν ν ¯ decay by the NA62 experiment at the CERN SPS is presented, using data collected in 2021 and 2022. This dataset was recorded, after modifications to the beamline and detectors, at a higher instantaneous beam intensity with respect to the 2016–2018 data taking. Combining NA62 data collected in 2016–2022, a measurement of B K + → π + ν ν ¯ = 13.0 − 3.0 + 3.3 × 10 − 11 is reported. With 51 signal candidates observed and an expected background of 18 − 2 + 3 events, B K + → π + ν ν ¯ becomes the smallest branching ratio measured with a signal significance above 5 σ .