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Caught dead : a Rick Van Lam mystery
\"Mary Le Vu, wife of a poor grocery-store owner, is gunned down in a drive-by. Her twin sister insists dutiful Mary 'wouldn't be caught dead' in that drug-infested zone. The police rule it an unlucky accident. Skeptics hire private eye Rick Van Lam to get to the truth. Amerasian Rick-- his father an unknown US soldier--is Rick Van Lam to get to the truth. Amerasian Rick-his father an unknown US soldier- one of the Bui Doi, children of the dust, so often rejected by Vietnamese culture cults young sidekick, Hank Nguyen, a pureblood Vietnamese, can help Rick navigate the closed world of Little Saigon.\"--Back cove.
Book
A TNF region haplotype offers protection from typhoid fever in Vietnamese patients
The genomic region surrounding the TNF locus on human chromosome 6 has previously been associated with typhoid fever in Vietnam (Dunstan et al. in J Infect Dis 183:261-268, 2001). We used a haplotypic approach to understand this association further. Eighty single nucleotide polymorphisms (SNPs) spanning a 150 kb region were genotyped in 95 Vietnamese individuals (typhoid case/mother/father trios). A subset of data from 33 SNPs with a minor allele frequency of >4.3% was used to construct haplotypes. Fifteen SNPs, which tagged the 42 constructed haplotypes were selected. The haplotype tagging SNPs (T1-T15) were genotyped in 380 confirmed typhoid cases and 380 Vietnamese ethnically matched controls. Allelic frequencies of seven SNPs (T1, T2, T3, T5, T6, T7, T8) were significantly different between typhoid cases and controls. Logistic regression results support the hypothesis that there is just one signal associated with disease at this locus. Haplotype-based analysis of the tag SNPs provided positive evidence of association with typhoid (posterior probability 0.821). The analysis highlighted a low-risk cluster of haplotypes that each carry the minor allele of T1 or T7, but not both, and otherwise carry the combination of alleles *12122*1111 at T1-T11, further supporting the one associated signal hypothesis. Finally, individuals that carry the typhoid fever protective haplotype *12122*1111 also produce a relatively low TNF-alpha response to LPS.
Journal Article
Child of my winter
Rick van Lam is bui doi , \"a child of dust,\" as the Vietnamese scornfully called a mixed-blood kid whose father was an unknown American GI. But Rick was lucky; in time he was sent to America. And he's ended up in Hartford, Connecticut, where he's made a life as a private eye after leaving a career as a cop at the NYPD. Rick is also teaching a part-time course at Farmington College where brainy Vietnamese student Dustin Trang, a scholarship student with no social skills and an oddly hostile family, is scorned and bullied. It reminds Rick of his own miserable days in a Saigon orphanage and he reaches out. But Dustin rebuffs him. One night as a blizzard strikes, a professor is shot down in the campus parking lot. The man had befriended Dustin, but their relationship had visibly soured. Dustin is everyone's hot suspect for the murder, but Rick believes the boy is innocent. Oddly, Dustin seems indifferent to others' suspicion that he's a killer. And he seems resistant to helping his case. Rick knows he owes who he has become to the loving support of his friend, Hank Nguyen, and Hank's multigenerational family. To pay it forward for Dustin, Rick persuades Hank, a state cop, and some of his circle of Hartford friends to dig into Dustin's dysfunctional world, interviewing faculty and students, relatives, and a busy congregation that seems to be a focal point for the fractured Trang family. As the investigation stalls and the cops close in, Rick realizes he has to break though a web of lies, anger, and betrayals, and force Justin to reveal whatever it is he fears more than arrest for murder.
Book