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One-dimensional (1D) interacting electronic systems exhibit distinct properties when compared to their counterparts in higher dimensions. We report Coulomb drag measurements between vertically integrated quantum wires separated by a barrier only 15 nanometers wide. The temperature dependence of the drag resistance is measured in the true 1D regime where both wires have less than one 1D subband occupied. As a function of temperature, an upturn in the drag resistance is observed below a temperature T* ∼ 1.6 kelvin. This crossover in Coulomb drag behavior is consistent with Tomonaga-Luttinger liquid models for the 1D-1D drag between quantum wires.

Psychiatric comorbidities and suicide attempts are highly prevalent in Bipolar Disorders (BD). We examined the associations between childhood maltreatment, psychiatric comorbidities, and suicide attempts, in terms of lifetime prevalence, sequence of onset, and current symptoms. We assessed 3,047 individuals with BD for suicide attempts, anxiety disorders, substance use disorders, and eating disorders. Participants completed a self-report for the assessment of childhood maltreatment. Associations between childhood maltreatment and characteristics of comorbidities (lifetime prevalence, current symptoms, and age at onset) were examined using logistic regressions and network analyses. Psychiatric comorbidities were frequent with a mean number per individual of 1.23 (SD = 1.4). Most comorbidities occurred prior to the onset of BD. Participants who reported higher levels of childhood maltreatment had more frequent and multiple comorbidities, which were also more currently active at inclusion. Childhood maltreatment did not decrease the age of onset of comorbidities, but was associated with a faster accumulation of comorbidities prior to the onset of BD. Logistic regression and network analyses showed that emotional abuse and sexual abuse might play a prominent role in the lifetime prevalence of psychiatric comorbidities and suicide attempts. Childhood maltreatment was associated with suicide attempts, and with frequent, multiple, and persistent psychiatric comorbidities that accumulated more rapidly prior to the onset of BD. Hence, childhood maltreatment should be systematically assessed in individuals with BD, in particular when the course of the disorder is characterized by a high comorbid profile or by a high suicidality.

Glaucoma is a leading cause of preventable blindness, yet nearly half of those affected are unaware of their diagnosis. Individuals with glaucoma may present with \"normal\" or \"lower\" intraocular pressure (IOP) compared to typical glaucoma thresholds, due in large part to many of these individuals having thin corneas. Conversely, many with elevated IOP and thicker corneas may not necessarily have glaucoma. In this article, we review the importance of central corneal thickness (CCT) and corneal pachymetry devices in eye care. Additionally, we review the role of corneal thickness as a risk factor for glaucoma and glaucoma progression. PubMed and Web of Science databases were searched for articles and reviews on corneal pachymetry and its use in glaucoma, corneal biomechanics and refractive surgery, and glaucoma screening. The results of this review revealed that CCT is a risk factor for development of glaucoma, and in eyes suspected of glaucoma, corneal pachymetry can be performed by trained technicians to provide important information related to the risk of acquiring glaucoma and/or having other ocular diseases. Additionally, a lower CCT is associated with an increased risk of progression and faster rates of visual field loss in eyes with glaucoma. This review will provide evidence regarding the importance of performing corneal pachymetry on all persons over the age of 50 as part of a comprehensive eye examination to better identify those patients who have glaucoma or are glaucoma suspects.

The Hydrus Microstent has been shown to be efficacious in the treatment of Open-angle Glaucoma. We previously reported 1-year results of the Hydrus Microstent in Black and Afro-Latino patients. Here we report two-year results of the Hydrus Microstent in Black and Afro-Latino patients with mild to moderate open-angle glaucoma. This was a retrospective, nonrandomized study that was carried out at two private practices in Harlem, NY and Queens, NY. This study consisted of Black and Afro Latino patients who had a Hydrus Microstent implanted for the treatment of glaucoma. The evaluated parameters were intraocular pressure (IOP), reductions in the number of medications, mean deviation on visual field test and visual acuity. We excluded persons with advanced glaucoma and incomplete data. We included those with mild to moderate glaucoma and had complete two-year follow-up data. The study consisted of 86 patients and 86 eyes. The mean age was 69. The mean pre-op IOP was 14.1 on 2.17 medications. At two years the mean IOP was 14 (p = 0.651) on 0.42 medications (p = 0.000003); 88% of patients were medication free (p = 0.651), The MD on the visual field changed little from -5.73 preoperatively to -5.21 at two years. There were 3 intraocular pressure spikes and 1 case of hyphema that were treated and had complete resolution. No patients required secondary surgery. Our results show that at two years the Hydrus Microstent can maintain low intraocular pressures, reduce medication burden and, in aggregate, experienced little change in visual field Mean Deviation in Black and Afro Latino patients with mild to moderate glaucoma.

To assess the validity of a novel, low-cost glaucoma screening calculator in determining glaucoma risk in high-risk New York communities. This prognostic community-based study was conducted in New York City neighborhoods from 2022 to 2024 among participants aged 40 years and older. Glaucoma screenings were held at community gatherings including local fairs, senior citizen homes, places of worship, and in the lobby of medical offices. The screenings were conducted by trained non-physician medical personnel comprised medical students and medical assistants working under physician supervision. Participants' intraocular pressure (IOP) and central corneal thickness (CCT) were measured in both eyes with a handheld tonometer and pachymeter, respectively. Participants then completed a comprehensive eye exam by an ophthalmologist to confirm glaucoma status. Statistical analysis was completed using MedCalc version 22.023 (MedCalc Software Ltd. Ostend, Belgium) with 95% confidence intervals. Of the 823 study participants, 716 (mean age 62.9 ± 11.9 years) were eligible to participate and completed the comprehensive follow-up exam. 68% identified as Black, 6.7% identified as Hispanic/Latino, and 52.5% identified as female. The Laroche glaucoma calculator had a sensitivity of 93.5% (CI 89.1-96.5%), specificity of 91.3% (CI 88.5-93.6%), positive predictive value of 80.5% (CI 75.7-84.6%), negative predictive value of 97.3% (CI 95.5-98.4%) and accuracy of 91.9% (CI 89.6-93.8%). The Laroche glaucoma calculator shows high sensitivity, specificity, positive predictive value, negative predictive value, and accuracy using affordable screening methods to determine glaucoma risk.

Electron interactions in and between wires become increasingly complex and important as circuits are scaled to nanometre sizes, or use reduced-dimensional conductors 1 such as carbon nanotubes 2 , 3 , 4 , 5 , 6 , nanowires 7 , 8 , 9 , 10 and gated high-mobility two-dimensional electron systems 11 , 12 , 13 . This is because the screening of the long-range Coulomb potential of individual carriers is weakened in these systems, which can lead to phenomena such as Coulomb drag, where a current in one wire induces a voltage in a second wire through Coulomb interactions alone. Previous experiments have demonstrated Coulomb electron drag in wires separated by a soft electrostatic barrier of width ≳80 nm (ref.  12 ), which was interpreted as resulting entirely from momentum transfer. Here, we measure both positive and negative drag between adjacent vertical quantum wires that are separated by ∼15 nm and have independent contacts, which allows their electron densities to be tuned independently. We map out the drag signal versus the number of electron sub-bands occupied in each wire, and interpret the results both in terms of momentum-transfer and charge-fluctuation induced transport models. For wires of significantly different sub-band occupancies, the positive drag effect can be as large as 25%. A quantum wire induces both positive and negative electron drag in another wire 15 nm away, changing the voltage across the second wire by up to 25%.

The clinical evaluation of patients in hip osteoarthritis is often done using patient questionnaires. While this provides important information it is also necessary to continue developing objective measures. In this work we further investigate the studies concerning the use of 3D gait analysis to attain this goal. The gait analysis was associated with machine learning methods in order to provide a direct measure of patient control gait discrimination. The applied machine learning method was the support vector machine (SVM). Applying the SVM on all the measured kinematic trajectories, we were able to classify individual patient and control gait cycles with a mean success rate of 88%. With the use of an ROC curve to establish the threshold number of cycles necessary for a subject to be identified as a patient, this allowed for an accuracy of higher than 90% for discriminating patient and control subjects. We then went on to determine the importance of each trajectory. By ranking the capacity of each trajectory for this discrimination, we provided a guide on their order of importance in evaluating patient severity. In order to be clinically relevant, any measure of patient deficit must be compared with clinically validated scores of functional disability. In the case of hip osteoarthritis (OA), the WOMAC scores are currently one of the most widely accepted clinical scores for quantifying OA severity. The kinematic trajectories that provided the best patient–control discrimination with the SVM were found to correlate well but imperfectly with the WOMAC scores, hence indicating the presence of complementary information in the two. •Gait analysis can be used to discriminate hip OA patients and controls through the use of an SVM.•The SVM can rank the discrimination capacities of the kinematic variables.•The thigh, shank and foot sagittal angles and the foot frontal angles were the most discriminatory.•Three dimensional gait analysis and WOMAC scores provide complementary information

Quantum Hall ferromagnetic transitions are typically achieved by increasing the Zeeman energy through in-situ sample rotation, while transitions in systems with pseudo-spin indices can be induced by gate control. We report here a gate-controlled quantum Hall ferromagnetic transition between two real spin states in a conventional two-dimensional system without any in-plane magnetic field. We show that the ratio of the Zeeman splitting to the cyclotron gap in a Ge two-dimensional hole system increases with decreasing density owing to inter-carrier interactions. Below a critical density of ~2.4 × 10 10  cm −2 , this ratio grows greater than 1, resulting in a ferromagnetic ground state at filling factor ν  = 2. At the critical density, a resistance peak due to the formation of microscopic domains of opposite spin orientations is observed. Such gate-controlled spin-polarizations in the quantum Hall regime opens the door to realizing Majorana modes using two-dimensional systems in conventional, low-spin-orbit-coupling semiconductors.

Background The Frail’BESTest was developed in order to include frail older adults when they are using the BESTest. Recently, psychometrics properties (internal coherence, systems usefulness, complementarity and inter-rater reliability) of the Frail’BESTest were tested. To complete these analyses, this study will aim the assessment of its concurrent validity, responsiveness, predictive validity on falls occurrence, and slower walkers detection. Methods The correlation between the Frail’BESTest and the Gait Speed Test permitted to assess concurrent validity. The variation between the initial test score and the score obtained after the completion of a rehabilitation program was used to evaluate responsiveness with MANOVA analysis and standard response mean (SRM) calculation. Predictive validity was assessed with receiver-operating characteristic curves and area under the curve (AUC) analysis regarding falls occurrence. Slower walkers detection thresholds were computed by receiver-operating characteristic curves for the Frail’BESTest and the Tinetti test. Results The concurrent validity of the test was good (r = 0.74; p  < 0.001). The Standard Error of measurement was at 2.81 points and the Minimal Detectable Change at 7.79 points for the total score of the Frail’BESTest. The SRM was at 0.41 for the Tinetti test and 0.56 for the Frail’BESTest. The AUC, computed according to fall occurrence, was at 0.71 for the Gait Speed test, 0.673 for the Tinetti test and 0.693 for the Frail’BESTest. Both the Tinetti (AUC = 0.87) and the Frail’BESTest (AUC = 0.88) were found suitable for tracking slower walkers. Conclusion Concurrent validity and responsiveness of the Frail’BESTest were good. As for the Tinetti and the Frail’BESTest, they were unable to predict efficiently falls occurrence in the tested sample. The Frail’BESTest seems enough sensitive to spot the slower walkers efficiently, using a 15/20 threshold method. The Frail’BESTest was found to be a valid and responsive clinical test, therefore it can be recommended as an outcome measure in clinical practice.

The Balance Evaluation System Test (BESTest) and the Mini-BESTest were developed to assess the complementary systems that contribute to balance function. These tests include functional tasks involving several high-level exercises to assess the balance function, which may be even more difficult in case of frailty. The Frail'BESTest has been developed to make it possible to include frail older adults in systemic assessment. In this first paper, the objective is to present the Frail'BESTest and to describe the usefulness and complementarity of each system and to test the inter-rater reliability of the score measurements in two health centers. In the first center, 192 frail and non-frail older patients were enrolled to test I) the contribution of each system, II) internal consistency, and III) the threshold and ceiling effects. The scores of 32 patients from center 1 and 32 patients recruited in another center (center 2) were used to measure the inter-rater reliability of the measurements by means of Kendall's tau coefficients. The internal consistency was moderate to good for five systems and limited for \"biomechanical constraints\". The distribution of the Frail'BESTest was more centered than that of the Tinetti and Mini-Motor tests. The Kendall's tau showed strong concordance in center 1 for all systems and only for 4 on 6 systems in center 2. Completing a systemic evaluation, the therapist may prioritize the patient's needs identifying the most challenging systems. This paper presents the Frail'BESTest and confirms the psychometric properties at a first step level.