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About a third of the sediment delivery of the Mekong River is shown to be associated with rainfall generated by tropical cyclones, suggesting that future delta stability will be strongly moderated by changes to tropical cyclone intensity, frequency and track. Cyclones shaping tropical mega-deltas The delivery of sediment to deltas is crucial for their survival, especially when faced with rising sea levels. Human activities, such as dam building and land-cover alterations, can affect sediment supply, but Stephen Darby et al . show that, for the Mekong River, about a third of the sediment delivered is associated with rainfall generated by tropical cyclones. More than half of the decline in suspended sediment supply to the delta between 1981 and 2005 arose from shifts in tropical-cyclone climatology, suggesting that future delta stability will also be strongly moderated by additional changes to tropical-cyclone intensity and track. The world’s rivers deliver 19 billion tonnes of sediment to the coastal zone annually 1 , with a considerable fraction being sequestered in large deltas, home to over 500 million people. Most (more than 70 per cent) large deltas are under threat from a combination of rising sea levels, ground surface subsidence and anthropogenic sediment trapping 2 , 3 , and a sustainable supply of fluvial sediment is therefore critical to prevent deltas being ‘drowned’ by rising relative sea levels 2 , 3 , 4 . Here we combine suspended sediment load data from the Mekong River with hydrological model simulations to isolate the role of tropical cyclones in transmitting suspended sediment to one of the world’s great deltas. We demonstrate that spatial variations in the Mekong’s suspended sediment load are correlated ( r  = 0.765, P  < 0.1) with observed variations in tropical-cyclone climatology, and that a substantial portion (32 per cent) of the suspended sediment load reaching the delta is delivered by runoff generated by rainfall associated with tropical cyclones. Furthermore, we estimate that the suspended load to the delta has declined by 52.6 ± 10.2 megatonnes over recent years (1981–2005), of which 33.0 ± 7.1 megatonnes is due to a shift in tropical-cyclone climatology. Consequently, tropical cyclones have a key role in controlling the magnitude of, and variability in, transmission of suspended sediment to the coast. It is likely that anthropogenic sediment trapping in upstream reservoirs is a dominant factor in explaining past 5 , 6 , 7 , and anticipating future 8 , 9 , declines in suspended sediment loads reaching the world’s major deltas. However, our study shows that changes in tropical-cyclone climatology affect trends in fluvial suspended sediment loads and thus are also key to fully assessing the risk posed to vulnerable coastal systems.

Climate change poses critical threats to water-related safety and sustainability in the Mekong River basin. Hydrological impact signals from earlier Coupled Model Intercomparison Project phase 3 (CMIP3)-based assessments, however, are highly uncertain and largely ignore hydrological extremes. This paper provides one of the first hydrological impact assessments using the CMIP5 climate projections. Furthermore, we model and analyse changes in river flow regimes and hydrological extremes (i.e. high-flow and low-flow conditions). In general, the Mekong's hydrological cycle intensifies under future climate change. The scenario's ensemble mean shows increases in both seasonal and annual river discharges (annual change between +5 and +16 %, depending on location). Despite the overall increasing trend, the individual scenarios show differences in the magnitude of discharge changes and, to a lesser extent, contrasting directional changes. The scenario's ensemble, however, shows reduced uncertainties in climate projection and hydrological impacts compared to earlier CMIP3-based assessments. We further found that extremely high-flow events increase in both magnitude and frequency. Extremely low flows, on the other hand, are projected to occur less often under climate change. Higher low flows can help reducing dry season water shortage and controlling salinization in the downstream Mekong Delta. However, higher and more frequent peak discharges will exacerbate flood risks in the basin. Climate-change-induced hydrological changes will have important implications for safety, economic development, and ecosystem dynamics and thus require special attention in climate change adaptation and water management.

The Mekong River Basin in Southeast Asia is experiencing extensive hydropower development. Concerns have been raised about the consequences of the development for the ecosystems, livelihoods and food security in the region. The largest planned hydropower dam cascade in the basin, the Lancang-Jiang cascade, is currently under construction and already partly built into the Upper Mekong Basin, China. In this paper we assess the impact of the Lancang-Jiang cascade on downstream hydrology by using a combination of a hydrological model and a reservoir cascade optimization model. The hydrological changes were quantified in detail at the Chiang Saen gauging station in Thailand, the first gauge station downstream from the cascade, and in lesser detail at four other downstream locations in the Mekong mainstream. We found that on average the Lancang-Jiang cascade increased the December–May discharge by 34–155 % and decreased the July–September discharge by 29–36 % at Chiang Saen. Furthermore, the Lancang-Jiang cascade reduced (increased) the range of hydrological variability during the wet season (dry season) months. The dry season hydrological changes were significant also in all downstream gauging stations, even as far as Kratie in Cambodia. Thus the Mekong’s hydrological regime has been significantly altered by the Lancang-Jiang cascade, but what the consequences are for ecosystems and livelihoods, needs further study.

The effect of the grid cell size on a distributed hydrological model performance was investigated using five grid resolutions (1, 5, 10, 20 and 50 km) in a model for the Mekong Basin in Southeast Asia. Two main factors affecting computation results and related to topography and the grid cell size were identified: the terrain slope decreases and the computed drainage network gets shorter with the increasing grid cell size. The decrease of terrain slope induced a rise of the ground water table, increase in saturation overflow, slight increase in evapotranspiration and slower outflow from soil to river network. The shortening of the drainage network induced more peaked response to high discharge events. To compensate the effect of coarse grid cell size, new correction parameters were introduced to the model. The new parameterisation method improved goodness of fit to measured discharges with all coarse resolution model grids. However, almost the same level of improvement was obtained by modifying existing soil water conductivity parameters. Nevertheless, the proposed parameterisation decreases the dependence of soil water conductivity parameterisation from slope and improves the transferability of model parameterisation between different grid scales.

Background In familial pulmonary fibrosis (FPF) at least two biological relatives are affected. Patients with FPF have diverse clinical features. Research question We aimed to characterize demographic and clinical features, re-evaluate high-resolution computed tomography (HRCT) scans and histopathology of surgical lung biopsies, assess survival and investigate the suitability of risk prediction models for FPF patients. Study design A retrospective cohort study. Methods FPF data ( n = 68) were collected from the medical records of Oulu University Hospital (OUH) and Oulaskangas District Hospital between 1 Jan 2000 and 11 Jan 2023. The inclusion criterion was pulmonary fibrosis (PF) (ICD 10-code J84.X) and at least one self-reported relative with PF. Clinical information was gathered from hospital medical records. HRCT scans and histology were re-evaluated. Results Thirty-seven (54.4%) of the patients were men, and 31 (45.6%) were women. The mean ages of the women and men were 68.6 and 61.7 years, respectively ( p = 0.003). Thirty-seven (54.4%) patients were nonsmokers. The most common radiological patterns were usual interstitial pneumonia (UIP) (51/75.0%), unclassifiable (8/11.8%) and nonspecific interstitial pneumonia (NSIP) (3/4.4%). Pleuroparenchymal fibroelastosis (PPFE) was observed as a single or combined pattern in 13.2% of the patients. According to the 2022 guidelines for idiopathic pulmonary fibrosis (IPF), the patients were categorized as UIP (31/45.6%), probable UIP (20/29.4%), indeterminate for UIP (7/10.3%) or alternative diagnosis (10/14.7%). The histopathological patterns were UIP (7/41.2%), probable UIP (1/5.9%), indeterminate for UIP (8/47.2%) and alternative diagnosis (1/5.9%). Rare genetic variants were found in 9 patients; these included telomerase reverse transcriptase ( TERT , n = 6), telomerase RNA component ( TERC , n = 2) and regulator of telomere elongation helicase 1 ( RTEL1 , n = 1). Half of the patients died ( n = 29) or underwent lung transplantation ( n = 5), with a median survival of 39.9 months. The risk prediction models composite physiology index (CPI), hazard ratio (HR) 1.07 (95.0% CI 1.04–1.10), and gender-age-physiology index (GAP) stage I predicted survival statistically significantly ( p <0.001) compared to combined stages II and III. Conclusions This study confirmed the results of earlier studies showing that FPF patients’ radiological and histopathological patterns are diverse. Moreover, radiological and histological features revealed unusual patterns and their combinations.

Determining the structures of nanoparticles at atomic resolution is vital to understand their structure–property correlations. Large metal nanoparticles with core diameter beyond 2 nm have, to date, eluded characterization by single-crystal X-ray analysis. Here we report the chemical syntheses and structures of two giant thiolated Ag nanoparticles containing 136 and 374 Ag atoms (that is, up to 3 nm core diameter). As the largest thiolated metal nanoparticles crystallographically determined so far, these Ag nanoparticles enter the truly metallic regime with the emergence of surface plasmon resonance. As miniatures of fivefold twinned nanostructures, these structures demonstrate a subtle distortion within fivefold twinned nanostructures of face-centred cubic metals. The Ag nanoparticles reported in this work serve as excellent models to understand the detailed structure distortion within twinned metal nanostructures and also how silver nanoparticles can span from the molecular to the metallic regime. The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag 136 and Ag 374 nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Background Bronchoalveolar lavage fluid (BAL) cell differential count analysis is a common diagnostic tool in interstitial lung diseases (ILD), but studies of the BAL cell profile in familial pulmonary fibrosis (FPF) are sparse. In this retrospective cohort study, we aimed to determine BAL cell profile in patients with FPF and to compare findings to those with idiopathic pulmonary fibrosis (IPF) or asbestosis. We also investigated BAL cell profile according to clinical features, radiological usual interstitial pneumonia (UIP) patterns, survival and additionally in the subgroups of the patients with pathogenic gene variants and histological investigations. Methods Data were collected from medical records between 1 January 2000 and 30 September 2024. The inclusion criterion was pulmonary fibrosis (PF) (ICD 10-code J84.X), with at least one self-reported relative with PF and BAL data available. High-resolution computer tomography (HRCT) scans and histology were re-evaluated. Results The BAL results of 49 FPF patients were compared with 72 IPF and 90 asbestosis cases. Differences in BAL cell profile were revealed between groups of FPF, IPF, and asbestosis. Furthermore, we found differences in BAL cell profile between smoking habits and radiological UIP patterns. The BAL results of the patients with pathogenic gene variants were variable. Moreover, BAL eosinophils associated with survival in FPF and familial IPF. Conclusions As a novel finding, a high proportion of BAL eosinophils is associated with shortened survival of patients with FPF, thus emphasising the need to further investigate the role of eosinophils in the pathogenesis of FPF.

Background Biological databases contain large amounts of data concerning the functions and associations of genes and proteins. Integration of data from several such databases into a single repository can aid the discovery of previously unknown connections spanning multiple types of relationships and databases. Results Biomine is a system that integrates cross-references from several biological databases into a graph model with multiple types of edges, such as protein interactions, gene-disease associations and gene ontology annotations. Edges are weighted based on their type, reliability, and informativeness. We present Biomine and evaluate its performance in link prediction, where the goal is to predict pairs of nodes that will be connected in the future, based on current data. In particular, we formulate protein interaction prediction and disease gene prioritization tasks as instances of link prediction. The predictions are based on a proximity measure computed on the integrated graph. We consider and experiment with several such measures, and perform a parameter optimization procedure where different edge types are weighted to optimize link prediction accuracy. We also propose a novel method for disease-gene prioritization, defined as finding a subset of candidate genes that cluster together in the graph. We experimentally evaluate Biomine by predicting future annotations in the source databases and prioritizing lists of putative disease genes. Conclusions The experimental results show that Biomine has strong potential for predicting links when a set of selected candidate links is available. The predictions obtained using the entire Biomine dataset are shown to clearly outperform ones obtained using any single source of data alone, when different types of links are suitably weighted. In the gene prioritization task, an established reference set of disease-associated genes is useful, but the results show that under favorable conditions, Biomine can also perform well when no such information is available. The Biomine system is a proof of concept. Its current version contains 1.1 million entities and 8.1 million relations between them, with focus on human genetics. Some of its functionalities are available in a public query interface at http://biomine.cs.helsinki.fi , allowing searching for and visualizing connections between given biological entities.

Background Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma. Methods Questionnaires were sent to 8000 randomly selected recipients aged 20–69 years in Finland in 2016. The response rate was 52.3% ( n  = 4173). The questionnaire included questions on e.g. atopic status, asthma and age at asthma diagnosis. Asthma was classified allergic if also a physician-diagnosed allergic rhinitis was reported. Results The prevalence of physician-diagnosed asthma and allergic rhinitis were 11.2 and 17.8%, respectively. Of the 445 responders with physician-diagnosed asthma, 52% were classified as allergic and 48% as non-allergic. Median ages at diagnosis of allergic and non-allergic asthma were 19 and 35 years, respectively. Among subjects with asthma diagnosis at ages 0–9, 10–19, 20–29, 30–39, 40–49, 50–59 and 60–69 years, 70, 62, 58, 53, 38, 19 and 33%, respectively, were allergic. For non-allergic asthma, the incidence rate was lowest in children and young adults (0.7/1000/year). It increased after middle age and was highest in older age groups (2.4/1000/year in 50–59 years old). Conclusions The incidence of allergic asthma is highest in early childhood and steadily decreases with advancing age, while the incidence of non-allergic asthma is low until it peaks in late adulthood. After approximately 40 years of age, most of the new cases of asthma are non-allergic.

In Finland, there is an ongoing adoption and learning process considering the cultivation of cover crops (CCs). The primary aim is to claim the benefits of CCs for agricultural production and ecosystems, which are both appreciated by Finnish farmers. A farmer survey with 1130 respondents was carried out to build an up-to-date understanding of how farmers have succeeded with CCs and whether they intend to continue with the use of CCs and to collect farmers’ views on knowledge gaps that should be filled by research or better knowledge sharing. The studied groups were farmers who had selected CCs as a registered measure in 2020 to receive agricultural payments. Data came from the Finnish Food Authority. Organic farmers were slightly more positive: they have had longer experience with CCs, but organic production is also more dependent on the ecosystem services provided by CCs. A high share of respondents agreed that their experiences with CCs have improved over time and were confident that CCs had become a permanent element of their production systems. Most of the farmers also agreed that the area under CCs would expand significantly in Finland and considered the cultivation of CCs as an effective measure to improve soil conditions. They often considered that challenges in adopting CCs were exaggerated and disagreed that bad experiences prevented them from expanding or continuing the use of CCs. The agricultural payment available for Finnish farmers to support the cultivation of CCs is quite reasonable (EUR 97 + EUR 50 per hectare) to compensate for any economic risks of CCs. Free word answers from the farmers highlighted research needs (in descending order) in the following areas: crop protection, sowing practices, the use of diverse CCs and their mixtures, and impacts on yield and profitability. Many of these are universal, i.e., have been reported elsewhere. Younger farmers (≤50 years) highlighted profitability, which is, in many European countries, a key barrier to the deployment of CCs. Farmers from the east and north regions, where the growing season is short, highlighted alternative CC choices as a knowledge gap.