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In Just Like Us: Digital Debates on Feminism and Fame, Caitlin E. Lawson examines the rise of celebrity feminism, its intersections with digital culture, and its complicated relationships with race, sexuality, capitalism, and misogyny. Through in-depth analyses of debates across social media and news platforms, Lawson maps the processes by which celebrity culture, digital platforms, and feminism transform one another. As she analyzes celebrity-centered stories ranging from \"The Fappening\" and the digital attack on actress Leslie Jones to stars' activism in response to #MeToo, Lawson demonstrates how celebrity culture functions as a hypervisible space in which networked publics confront white feminism, assert the value of productive anger in feminist politics, and seek remedies for women's vulnerabilities in digital spaces and beyond. Just Like Us asserts that, together, celebrity culture and digital platforms form a crucial discursive arena where postfeminist logics are unsettled, opening up more public, collective modes of holding individuals and groups accountable for their actions.

r/fundiesnarkuncensored is a Reddit community that monitors and critiques fundamentalist Christian, namely evangelical, content creators. Many members of the community were formerly conservative Christians who have since deconstructed some or all of their beliefs. This study approaches “fundie snarkers,” particularly those who have deconstructed, through the lenses of anti-fandom and affect theory, to deepen our understanding of anti-fandom as a simultaneously ideological and affective phenomenon. Through individual, semi-structured interviews with 20 members of r/fundiesnarkuncensored, we explore the role that “fundie snarking” plays in members’ deconstruction journeys and vice versa. Participants organized content on the subreddit into three categories based on their affective and intellectual responses to that content: petty snark, or superficial critiques that participants find both guiltily pleasurable and frustratingly rude; structural snark, or systemic critiques of fundamentalism that participants universally esteem; and dark snark, or content that participants find too distressing to engage. Taken together, this “structure of snark” reveals the ambiguity of their anti-fandom by emphasizing that participants have empathy for the fundies they criticize and see the subreddit’s ideal purpose as a tool for deconstruction. Ultimately, through our discussion of the gratifications participants obtain through their engagement with the subreddit, we propose an additional form of anti-fandom: cathartic anti-fandom. Cathartic anti-fandom involves the dislike and critique of ideologies, practices, and communities in which the anti-fan formerly participated and/or by which they were harmed. By filtering fundamentalist Christian teaching through critical commentary and making these ideologies laughable, r/fundiesnarkuncensored provides an accessible and enjoyable space for members to unlearn harmful ideologies.

Background Individuals with familial adenomatous polyposis (FAP) harbor numerous polyps with inevitable early progression to colon cancer. Complex microbiotic-tumor microenvironment perturbations suggest a dysbiotic relationship between polyp and microbiome. In this study, we performed comprehensive analyses of stool and tissue microbiome of pediatric FAP subjects and compared with unaffected cohabiting relatives through 16S V4 region amplicon sequencing and machine learning platforms. Results Within our FAP and control patient population, Firmicutes and Bacteroidetes were the predominant phyla in the tissue and stool samples, while Proteobacteria dominated the polyp/non-polyp mucosa. A decline in Faecalibacterium in polyps contrasted with a decline in Bacteroides in the FAP stool. The alpha- and beta-diversity indices differed significantly within the polyp/non-polyp groups, with a concurrent shift towards lower diversity in polyps. In a limited 3-year longitudinal study, the relative abundance of Proteobacteria and Fusobacteria was higher in polyps compared to non-polyp and stool specimens over time. Through machine learning, we discovered that Archaeon_enrichment_culture_clone_A13 , Micrococcus_luteus, and Eubacterium_hallii in stool and PL-11B10, S1-80, and Blastocatellaceae in tissues were significantly different between patients with and without polyps. Conclusions Detection of certain bacterial concentrations within stool or biopsied polyps could serve as adjuncts to current screening modalities to help identify higher-risk patients.

Familial adenomatous polyposis (FAP) is a hereditary condition with a near 100 % lifetime risk of colorectal cancer without prophylactic colectomy. Most patients with FAP have a mutation in the adenomatous polyposis coli gene on chromosome 5q22. This condition frequently presents in children with polyps developing most frequently in the second decade of life and surveillance colonoscopy is required starting at age ten. Polyps are found not only in the colon, but in the stomach and duodenum. Knowledge of the natural history of FAP is important as there are several extra-colonic sequelae which also require surveillance. In infants and toddlers, there is an increased risk of hepatoblastoma, while in teenagers and adults duodenal carcinomas, desmoid tumors, thyroid cancer and medulloblastoma are more common in FAP than in the general population. Current chemopreventive strategies include several medications and natural products, although to this point there is no consensus on the most efficacious and safe agent. Genetic counseling is an important part of the diagnostic process for FAP. Appropriate use and interpretation of genetic testing is best accomplished with genetic counselor involvement as many families also have concerns regarding future insurability or discrimination when faced with genetic testing.

The management of pediatric Peutz–Jeghers Syndrome (PJS) focuses on the prevention of intussusception complicating small intestinal (SI) polyposis. This hinges on the accurate appraisal of the polyp burden to tailor therapeutic interventions. Video Capsule Endoscopy (VCE) is an established tool to study SI polyps in children, but an in-depth characterization of polyp burden in this population is lacking. Methods: We performed a retrospective longitudinal cross-sectional analysis of VCE studies in pediatric PJS patients at our institution (CMKC) from 2010 to 2020. Demographic, clinical, and VCE findings reported by three reviewers in tandem were accrued. Polyp burden variables were modeled as functions of patient and study characteristics using linear mixed models adjusted for clustering. Results: The cohort included 15 patients. The total small bowel polyp count and largest polyp size clustered under 30 polyps and <20 mm in size. Luminal occlusion correlated closely with the estimated polyp size. Polyp distribution favored proximal (77%) over distal (66%) small bowel involvement. The adjusted largest polyp size was greater in males. Double Balloon Enteroscopy was associated with a decreased polyp burden. Conclusions: The polyp burden in pediatric PJS patients favors the proximal third of the small intestine, with relatively small numbers and a polyp size amenable to resection through enteroscopy. Male gender and older age were related to an increased polyp burden.

Transition of care (TOC) in adolescents and young adults (AYAs) with chronic gastrointestinal disorders has received increased attention, especially in those with inflammatory bowel disease. AYAs with hereditary polyposis syndromes are a heterogeneous group of patients with overlapping and complex medical needs. These patients are particularly vulnerable because of the risk of loss of continuity of care and subsequent poor disease outcomes. The Pediatric Committee of the American College of Gastroenterology commissioned a report with recommendations on TOC in AYAs with hereditary polyposis syndromes. This report aims at achieving best practice by both pediatric and adult gastroenterologists despite the paucity of published evidence in this population reflected in the included PRISMA report. Therefore, the group extrapolated findings from the literature related to other chronic gastrointestinal disorders, and a high degree of expert consensus was scored for all recommendations. The report addresses TOC through identifying shared domains followed by specific recommendations in disease management, including models of care, providers and patient and socioeconomic factors relevant to TOC. Areas of strong emphasis include the need for early planning, flexibility in the transition process to maintain continuity during major surgical procedures, patient and family psychological readiness, liaison among team members addressing transition, and changing insurance coverage in this population.

BackgroundRare variants in hundreds of genes have been implicated in developmental delay (DD), intellectual disability (ID) and neurobehavioural phenotypes. TNRC6B encodes a protein important for RNA silencing. Heterozygous truncating variants have been reported in three patients from large cohorts with autism, but no full phenotypic characterisation was described.MethodsClinical and molecular characterisation was performed on 17 patients with TNRC6B variants. Clinical data were obtained by retrospective chart review, parent interviews, direct patient interaction with providers and formal neuropsychological evaluation.ResultsClinical findings included DD/ID (17/17) (speech delay in 94% (16/17), fine motor delay in 82% (14/17) and gross motor delay in 71% (12/17) of subjects), autism or autistic traits (13/17), attention deficit and hyperactivity disorder (ADHD) (11/17), other behavioural problems (7/17) and musculoskeletal findings (12/17). Other congenital malformations or clinical findings were occasionally documented. The majority of patients exhibited some dysmorphic features but no recognisable gestalt was identified. 17 heterozygous TNRC6B variants were identified in 12 male and five female unrelated subjects by exome sequencing (14), a targeted panel (2) and a chromosomal microarray (1). The variants were nonsense (7), frameshift (5), splice site (2), intragenic deletions (2) and missense (1).ConclusionsVariants in TNRC6B cause a novel genetic disorder characterised by recurrent neurocognitive and behavioural phenotypes featuring DD/ID, autism, ADHD and other behavioural abnormalities. Our data highly suggest that haploinsufficiency is the most likely pathogenic mechanism. TNRC6B should be added to the growing list of genes of the RNA-induced silencing complex associated with ID/DD, autism and ADHD.

Familial adenomatous polyposis (FAP) is a cancer predisposition syndrome that causes early-onset polyposis and is associated with an increased risk for hepatoblastoma. There is currently a lack of consensus on when to order APC ( adenomatous polyposis coli ) gene testing or implement surveillance for hepatoblastoma. An online questionnaire was completed by 62 genetic counselors to capture their current practices regarding these questions. Extracolonic findings associated with FAP that were most likely to prompt APC testing in an otherwise asymptomatic 10 year-old child with a negative family history were multiple desmoid tumors, congenital hypertrophy of the retinal pigment epithelium (CHRPE), jaw osteomas, and hepatoblastoma. For hepatoblastoma screening, the majority did recommend this in children less than age five years with known APC mutations. An interval of every 3–6 months was most commonly suggested; however, responses extended to screening on a less than annual basis. These results highlight the need for further investigation into why some genetic counselors do not recommend APC testing in young at-risk children and what factors influence views about the ideal age and indication for APC testing. Studies of these issues would help to define the best clinical practice model for genetic testing and hepatoblastoma screening in pediatric patients with FAP.

Platform Feminism: Celebrity Culture and Activism in the Digital Age tells the story of digital platforms' role in the feminist movement during the early 21st century. Taking celebrity culture as a potent site at which to analyze the new visibilities of feminism and its responses to a new wave of conservative and deeply reactionary politics, I explore the ways in which networked publics coalesce around celebrity events and, in discussing, analyzing, and critiquing various actors within these events, engage in boundary work around what it means to “be a feminist.” From responses to celebrity harassment to hashtag campaigns supporting celebrity feminism to critiques of imperfect feminist celebrities, this dissertation explores the contentious debates about feminism that arise around celebrity culture within digital spaces. To analyze these discourses, this project draws together literature from three often-disparate academic subfields: platform studies, feminist media studies, and celebrity studies. Using a case study approach, each chapter draws on intersectional feminist theory to examine a celebrity event from 2014-2016 that incited controversy across a variety of media platforms around issues of gender, sexuality, race, and class. I track each event across online and legacy media outlets and engage in multiplatform critical technocultural discourse analysis to analyze how discussions amongst issue publics that coalesce around each event both reflect and further define contemporary feminist discourses in ways that are often distinctly shaped by the digital platforms on which they emerge (Burgess & Matamoros-Fernández 2016, Brock 2016). In contrast to prior feminist media studies research that argues popular culture is largely postfeminist, I demonstrate that feminism, amplified by the famous voices that espouse it and the broad reach of the digital spaces in which it appears, has increased its discursive power so greatly that many aspects of popular culture no longer take for granted the gains of the feminist movement but rather feminism itself. Further, the iteration of feminism that is ideologically dominant espouses the importance of intersectionality, calling out the limitations of white liberal feminism and foregrounding the importance of a feminist platform that interrogates racial, sexual, and class differences. Overall, I argue that digital platforms have emerged as a major techno-cultural infrastructure for the dissemination and negotiation of the positions, goals, and actions of the contemporary feminist movement, which experienced a resurgence in the wake of the crisis of neoliberalism. While established media institutions continue to inform popular understandings of feminism, it is the recirculation, re-mediation, and conversations around print, film, and television media images and discourses on digital platforms that are driving the ongoing shifts in the feminist movement. More specifically, I contend that celebrity culture is a potent site at which the very category of “feminism” is being challenged in these digital spaces. Together, digital platforms and celebrity culture form a crucial discursive arena where postfeminist logics are unsettled, opening up the possibility of a more radical, intersectional, and activist popular feminism.