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Patients with resectable non–small-cell lung cancer had a greater response and longer event-free survival with preoperative durvalumab plus chemotherapy and adjuvant durvalumab than with chemotherapy alone.

Objective To determine the effectiveness of phase-change-material mattress (PCM) during transportation of newborns with hypoxic ischemic encephalopathy (HIE). Study design Randomized controlled trial of newborns with HIE from June 2016 to December 2019. Patients were randomized to transport with PCM or without PCM (control) when transferred to a cooling center in northern Vietnam. Primary outcome measure was mortality rate, secondary outcomes including temperature control and adverse effects. Result Fifty-Two patients in PCM-group and 61 in control group. Median rectal temperature upon arrival was 34.5 °C (IQR 33.5–34.8) in PCM-group and 35.1 °C (IQR 34.5–35.9) in control group ( p  = 0.023). Median time from birth to reach target temperature was 5.0 ± 1.4 h and 5.5 ± 1.2 h in the respective groups ( p  = 0.065). 81% of those transported with PCM versus 62% of infants transported without ( p  = 0.049) had reached target temperature within the 6-h timeframe. There was no record of overcooling (< 32 °C) in any of the groups. The was no difference in mortality rate between the two groups (33% and 34% respectively ( p  > 0.05)). Conclusion Phase-change-material can be used as a safe and effective cooling method during transportation of newborns with HIE in low-resource settings. Trial registration The study was retro-prospectively registered in Clinical Trials (04/05/2022, NCT05361473).

Every year, Hanoi suffers from several episodes (periods with daily concentration of PM 2.5 higher than 50 µg m −3 during at least two consecutive days). These episodes are of health concern because of the high concentration of PM 2.5 and/or PM 0.1 and the presence of PM-bound toxic components, such as, PAHs. In this study, the concentrations of PAHs bound to PM 2.5 and PM 0.1 in night-time and day-time samples during episode and non-episode periods in December 2021 were determined. The concentrations of PAHs bound to PM 2.5 were found to increase significantly from day-time samples of 3.24 ± 0.83 ng m −3 to night-time samples of 10.8 ± 4.45 ng m −3 in episode periods. However, PAHs bound to PM 0.1 increased slightly from day-time samples of 0.58 ± 0.12 ng m −3 to night-time samples of 0.89 ± 0.30 ng m −3 in episode periods. Diagnostic ratios of PAHs indicate that biomass/coal combustion and vehicular emission are the primary sources of PAHs. The incremental lifetime cancer risk was estimated to vary from 8.7E-09 to 2.5E-08 for children and 6.7E-08 to 2.2E-07 for adults, respectively. Accordingly, loss of life expectancy was estimated at 0.11 min and 0.82 min for children and adults, respectively. These findings imply that the carcinogenic impact induced by PAHs via inhalation is negligible during the episode period.

Particulate Matter (PM) pollution is one of the most important air quality concerns in Vietnam. In this study, we integrate ground-based measurements, meteorological and satellite data to map temporal PM concentrations at a 10 × 10 km grid for the entire of Vietnam. We specifically used MODIS Aqua and Terra data and developed statistically-significant regression models to map and extend the ground-based PM concentrations. We validated our models over diverse geographic provinces i.e., North East, Red River Delta, North Central Coast and South Central Coast in Vietnam. Validation suggested good results for satellite-derived PM2.5 data compared to ground-based PM2.5 (n = 285, r2 = 0.411, RMSE = 20.299 g m−3 and RE = 39.789%). Further, validation of satellite-derived PM2.5 on two independent datasets for North East and South Central Coast suggested similar results (n = 40, r2 = 0.455, RMSE = 21.512 g m−3, RE = 45.236% and n = 45, r2 = 0.444, RMSE = 8.551 g m−3, RE = 46.446% respectively). Also, our satellite-derived PM2.5 maps were able to replicate seasonal and spatial trends of ground-based measurements in four different regions. Our results highlight the potential use of MODIS datasets for PM estimation at a regional scale in Vietnam. However, model limitation in capturing maximal or minimal PM2.5 peaks needs further investigations on ground data, atmospheric conditions and physical aspects.

Haze is a well-known air pollution phenomenon linked to the severe and persistent particulate matter (PM) episodes in Southeast Asia (SEA), which significantly impacts the environment, health, and economy. This work reviewed for the first time the characteristics of haze episodes in terms of PM concentrations, chemical compositions, and the causes of haze in both Lower (Maritime) and Upper (Mainland) SEA. In addition, we carried out a systematic comparison of the frequency and intensity of haze events through SEA regions in recent years. Our finding indicated that the different trend of haze frequency and intensity between SEA cities are not only due to local air pollution sources such as biomass burning (BB) but also meteorology and long-range transport. Other sources such as secondary aerosols also play an important role in haze formation, but they have not been comprehensively investigated in previous studies. Due to the complicated formation mechanisms and the transportations of haze and its impacts on SEA’s human health and economy, more sophisticated and specific policies are needed to deal with haze issues not only for individual countries but also on a regional scale.

Background The Expanded Program on Immunization currently considers offering Human Papilomavirus vaccine on a routine basis in Vietnam. However, as the current available vaccine can prevent only two types HPV 16 and 18, before implementing a large-scale vaccine campaign we need information about the prevalence of infection with only HPV 16 and 18 in Viet Nam. This study was done in 5 large cities in Vietnam to estimate the prevalence of HPV 16 and/or 18 infections and to explore the distribution of other high risk types of HPV among married women in these provinces. Methods The study employed a cross-sectional design with multistage sampling. The sample size included 4500 married women in two rounds (aged ranged from 18-69 years old, median age: 40 year old). Participant were randomly selected, interviewed and given gynaecological examinations. HPV infection status (by real-time PCR kit using TaqMan probe) and HPV genotyping test (by Reverse dot blot) were done for all participants. Results The prevalence of cervical infection with HPV type 16 and/or 18 among married women in this study ranged from 3.1% to 7.4%. Many positive HPV cases (ranged from 24.5% to 56.8%) were infected with other type of high risk HPV which can lead to cervical cancer and cannot prevented by currently available vaccines. In addition to HPV 16 and/or 18, most common types of high risk HPV were types 58, 52, 35 and 45. Awareness about HPV and HPV vaccines was still low in the study samples. Discussion While it is relevant to implement an HPV vaccine campaign in Viet Nam, it is important to note that one can be infected with multiple types of HPV. Vaccination does not protected against all type of high risk HPV types. Future vaccine campaigns should openly disclose this information to women receiving vaccines. Conclusion High prevalence of infection with HPV high risk types was observed in this study. As HPV infection has a high correlation with cervical cancer, this study emphasizes the need for both primary prevention of cervical cancer with HPV vaccines as well as secondary prevention with screening.

The study aims to determine the concentration, size distribution and analyze the relationship of indoor and outdoor particles in urban area, in Vietnam. One thousand two hundred daily samples of PM 0.1 , PM 0.1-0.5 , PM 0.5-1 , PM 1-2.5 , PM 2.5-10 , PM >10 were taken simultaneously at four residential houses in summer and winter by nano sampler (Model 3182, Kinomax). The average concentrations of indoor PM 0.1 , PM 0.5 , PM 1 , PM 2.5 and PM 10 were in range of 5.3-8.9 μg/m 3 ; 10.8-20.1μg/m 3 ; 20.5-47.6 μg/m 3 ; 33.7-105.9 μg/m 3 and 44.7-135.0 μg/m 3 among four houses, respectively. The concentrations of outdoor PM 2.5 , PM 10 were considerately higher than those of indoor PM, whereas negligible differences on concentrations of PM 0.1 , PM 0.5 and PM 1 were observed. The significantly seasonal variation was observed for indoor PM 1 , PM 2.5 and PM 10 , but not for PM 0.1 and PM 0.5 . Majority of indoor fractions were origin from outdoor sources. Unimodal distributions of indoor particles determined the super-micron size (1 to 2.5 μm) with highest concentration and PM <0.5 and PM >10 with lowest concentration. Fine particles with interval sizes (PM 0.5-1 and PM 1-2.5 ) contributed to the predominance to coarse particles in both indoors and outdoors, suggesting serious threat on human health.

Treebanks are important resources for researchers in natural language processing. They provide training and testing materials so that different algorithms can be compared. However, it is not a trivial task to construct high-quality treebanks. We have not yet had a proper treebank for such a low-resource language as Vietnamese, which has probably lowered the performance of Vietnamese language processing. We have been building a consistent and accurate Vietnamese treebank to alleviate such situations. Our treebank is annotated with three layers: word segmentation, part-of-speech tagging, and bracketing. We developed detailed annotation guidelines for each layer by presenting Vietnamese linguistic issues as well as methods of addressing them. Here, we also describe approaches to controlling annotation quality while ensuring a reasonable annotation speed. We specifically designed an appropriate annotation process and an effective process to train annotators. In addition, we implemented several support tools to improve annotation speed and to control the consistency of the treebank. The results from experiments revealed that both inter-annotator agreement and accuracy were higher than 90%, which indicated that the treebank is reliable.

In this paper, δ -dual codes over finite commutative semi-simple rings are defined as a generalization of dual codes over finite commutative semi-simple rings. Some properties of δ -dual codes are given. We present necessary and sufficient conditions for a λ -constacyclic code of length n to be δ -self-dual, δ -self-orthogonal, δ -dual-containing, δ -LCD over finite commutative semi-simple rings. We also study the δ -dual of skew Θ - λ -constacyclic codes over finite commutative semi-simple rings. Among others, we also give necessary and sufficient conditions for a skew Θ - λ -constacyclic code of any length n to be δ -self-dual, δ -self-orthogonal, δ -dual-containing, δ -LCD over finite commutative semi-simple rings.

•Less than 50% of patients completed their intramuscular vaccine regimen despite vaccine availability.•Low completion rates were observed among high-risk individuals and patients living in high rabies burden provinces.•Patients who received eRIG had lower odds of completing their vaccine regimen compared to those patients that did not. Adhering to post-exposure prophylaxis (PEP): wound treatment, vaccine, and rabies immunoglobulin (RIG) is a crucial step in preventing rabies mortality. When PEP is widely available, a lack of adherence to the recommended treatment guidelines can also lead to death. Our objective was to understand characteristics associated with adherence to the vaccine regimen and RIG in Vietnam. We obtained individual-level data on PEP adherence from registries at 10 sites located in five provinces. From these registries, we extracted epidemiologic characteristics of patients including the timing of PEP initiation and completion. We used descriptive analyses and logistic regression to examine patient characteristics associated with initiation and completion of RIG and vaccine. Based on reported rabies mortality, the government defined provincial rabies burden as medium-burden (<5 and >2 deaths) and high-burden (≥5 deaths). During 2014–2016, 15,646 patients received PEP in our study. Among 14,296 vaccinated patients, only 41.4% (5847) completed their five-dose intramuscular (IM) injections and 81.6% (133) of patients completed their eight-dose intradermal (ID) injections. Approximately 26% of patients received RIG. Patient characteristics associated with vaccine completion were females (44%), <15 years of age (44%), category 1 exposure (68%, bite location on leg (46%), bite from bat (56%), bite from a healthy animal (45%), high-burden province (86%), and district preventive center (49%). Disparities were revealed among provinces, with high-burden provinces having highest (86%) and lowest (7%) vaccine completion rates. Vietnam has made tremendous progress towards reducing the burden of rabies. However, despite the wide availability of PEP, we found relatively low rates of vaccine completion. Our findings suggest provider training and patient education is needed to ensure appropriate treatment is completed. Moreover, our data suggest changes to information reported through the national surveillance system for monitoring good clinical practice for rabies prevention and control.