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Sanitary landfill is still considered as one of the most significant and least expensive methods of waste disposal. It is essential to consider environmental impacts while selecting a suitable landfill site. Thus, the site selection for sanitary landfill is a complex and time-consuming task needing an assessment of multiple criteria. In the present study, a decision support system (DSS) was prepared for selecting a landfill site in a growing urban region. This study involved two steps of analysis. The first step of analysis involved the application of spatial data to prepare the thematic maps and derive their weight. The second step employed a fuzzy multicriteria decision-making (FMCDM) technique for prioritizing the identified landfill sites. Thus, initially, the analytic hierarchy process (AHP) was used for weighting the selected criteria, while the fuzzy technique for order of preference by similarity to ideal solution (FTOPSIS) was applied for addressing the uncertainty associated with decision-making and prioritizing the most suitable site. A case study was conducted in the city of Memari Municipality. The main goal of this study was the initial evaluation and acquisition of landfill candidate sites by utilizing GIS and the following decision criteria: (1) environmental criteria consisting of surface water, groundwater, land elevation, land use land cover, distance from urban residence and buildup, and distance from sensitive places; and (2) socioeconomic criteria including distance from the road, population density, and land value. For preparing the final suitability map, the integration of GIS layers and AHP was used. On output, 7 suitable landfill sites were identified which were further ranked using FTOPSIS based on expert’s views. Finally, candidate site-7 and site-2 were selected as the most suitable for proposing new landfill sites in Memari Municipality. The results from this study showed that the integration of GIS with the MCDM technique can be highly applied for site suitability. The present study will be helpful to local planners and municipal authorities for proposing a planning protocol and suitable sites for sanitary landfill in the near future.

To establish and maintain organ structure and function, tissues need to balance stem cell proliferation and differentiation rates and coordinate cell fate with position. By quantifying and modelling tissue stress and deformation in the mammalian epidermis, we find that this balance is coordinated through local mechanical forces generated by cell division and delamination. Proliferation within the basal stem/progenitor layer, which displays features of a jammed, solid-like state, leads to crowding, thereby locally distorting cell shape and stress distribution. The resulting decrease in cortical tension and increased cell–cell adhesion trigger differentiation and subsequent delamination, reinstating basal cell layer density. After delamination, cells establish a high-tension state as they increase myosin II activity and convert to E-cadherin-dominated adhesion, thereby reinforcing the boundary between basal and suprabasal layers. Our results uncover how biomechanical signalling integrates single-cell behaviours to couple proliferation, cell fate and positioning to generate a multilayered tissue. Mechanics of epidermal differentiation Miroshnikova et al. find that during embryonic development, epidermal basal layer crowding generates local changes in cell shape, cortical tension, and adhesion that initiate differentiation and delamination

This article presents a multi-band right-hand circularly polarized antenna designed for the Cube Satellite (CubeSat). Based on a quadrifilar structure, the antenna provides circular polarization radiation suitable for satellite communication. Moreover, the antenna is designed and fabricated using two 1.6 mm thickness FR4-Epoxy boards connected by metal pins. In order to improve the robustness, a ceramic spacer is placed in the centerboard, and four screws are added at the corners to fix the antenna to the CubeSat structure. These additional parts reduce antenna damage caused by vibrations in the launch vehicle lift-off stage. The proposal has a dimension of 77 × 77 × 10 mm3 and covers the LoRa frequency bands at 868 MHz, 915 MHz, and 923 MHz. According to the measurements in the anechoic chamber, antenna gains with the values of 2.3 dBic and 1.1 dBic are obtained for the 870 MHz and 920 MHz, respectively. Finally, the antenna is integrated into a 3U CubeSat that was launched by a Soyuz launch vehicle in September 2020. The terrestrial-to-space communication link was measured, and the antenna performance was confirmed in a real-life scenario.

Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings presented in the published literature are inconsistent. Therefore, we conducted a PRISMA systematic review and meta-analysis. 14 studies were identified and meta-analyzed. Vaccinations studied comprised Bacillus Calmette-Guérin (BCG) vaccine, Triple vaccine, Hepatitis B vaccine (HBV), Polio, Measles, Rubella, Mumps, trivalent MMR vaccine and Haemophilus influenza type B (HiB) vaccine. We observed a protective association between any vaccination in the first year of life and risk of childhood leukemia (summary odds ratio (OR) 0.58 [95% confidence interval (CI) 0.36–0.91]). When individual vaccines were analysed, some evidence of an association was seen only for BCG (summary OR 0.73 [95% CI 0.50–1.08]). In conclusion, early vaccination appears to be associated with a reduced risk of childhood leukemia. This finding may be underpinned by the association observed for BCG. Given the relatively imprecise nature of the results of this meta-analysis, our findings should be interpreted cautiously and replicated in future studies.

Rice ( Oryza sativa L.) is a staple food for half of the world’s population, and its biofortification is a key factor in fighting micronutrient malnutrition. However, harmful heavy metals tend to accumulate in rice grains due to soil and water contamination. Therefore, it is important to improve beneficial micronutrient contents and reduce the accumulation of undesirable metals in rice grain. To better characterize the genetic control of mineral accumulation in rice, we conducted association genetics on the ion contents of white and brown grains using a collection of 184 Vietnamese rice landraces. In total, 27 significant associations were identified and delimited into quantitative trait loci associated with macronutrients such as phosphorus, potassium or calcium; micronutrients such as iron or zinc; or toxic heavy metals such as arsenic and cadmium. Several genes related to ion homeostasis or ion transport were identified in the different quantitative trait loci. LOC_Os10g30610 , present in qRAs10-1 associated with arsenic content in brown rice, encodes an ABC transporter (OsABCG25), which is involved in the silicon-induced formation of the Casparian strip in the rice exodermis and could act as a barrier restricting As diffusion within the root cortex. LOC_Os05g04330 , present in qRP5-1 and associated with phosphorus content in brown rice, encodes a CHH methylation maintenance protein, and its expression is downregulated in roots in the presence of the phosphorus uptake 1 ( Pup1 ), suggesting a role for epigenetics in the regulation of phosphorus uptake and accumulation in grain. These findings reveal novel quantitative trait loci associated with grain ion content and candidate genes that are potentially valuable for breeding programs aimed at rice grain biofortification and reducing toxic metal accumulation.

This study aims to assess the livelihood vulnerability to climate change of ethnic minority communities in Yen Bai province, a typical mountainous region in northern Vietnam. Utilizing the Livelihood Vulnerability Index (LVI) framework developed by Hahn et al. (2009), in combination with the IPCC vulnerability structure, the research analyzes eight components related to household characteristics, health, food, water, housing and productive land, social and financial networks, livelihood strategies, and exposure to climate shocks. Data were collected through a combination of desk study and survey with 480 households from two major ethnic groups: Tay and Thai.The results indicate that the Thai group has a higher overall LVI score (0.43) compared to the Tay group (0.37), reflecting greater livelihood vulnerability. The main factors contributing to this difference are limited livelihood diversification, lower educational attainment, weaker access to healthcare, and higher dependency on climate-sensitive resources. Although both groups are highly exposed to climate-related hazards such as flash floods, landslides, and droughts, the Thai group demonstrates greater sensitivity and lower adaptive capacity. This research contributes theoretically by adapting and refining the LVI framework to suit the context of upland ethnic communities, and practically by providing empirical evidence to inform climate adaptation policies. The study highlights the need for differentiated and context-specific strategies that prioritize ethnic minority communities with high vulnerability, focusing on improving education, livelihood diversification, healthcare access, and institutional support mechanisms.

Objective We report the safety and efficacy of combined radiofrequency ablation and cementoplasty in treating painful neoplastic bone lesions. Materials and Methods Fifty-three combined radiofrequency ablation and cementoplasty procedures were completed in 36 patients. Thirty-four vertebrae (20 lumbar, 14 thoracic), 14 acetabulae, 3 sacra, 1 pubic symphysis, and 1 humerus were treated. Patient age ranged from 34 to 81 years (mean 57.6 years, SD = 12.6). Primary malignancies included: 12 breast, 5 lung, 6 multiple myeloma, 2 prostate, 2 renal cell carcinoma, 1 synovial sarcoma, 1 endometrial, 1 oral squamous cell carcinoma, 1 lymphoma, 1 colon, 1 transitional cell carcinoma, 1 colorectal, 1 cholangiocarcinoma, and 1 pheochromocytoma. Primary neoplasm location, pain levels pre- and post-procedure (as assessed using the Visual Analog Scale), number of radiofrequency (RF) treatments and any extravasation were documented. Results Combined radiofrequency ablation (RFA) and cementoplasty procedures were performed with 100% technical success (53 out of 53). The mean pre-procedure and post-procedure pain, as measured by the Visual Analog Scale (VAS), was 7.2/10 and 3.4/10 respectively. Symptomatic complications included one case of self-resolving transient thermal sciatic neurapraxia following RFA and acetabuloplasty. Two cases of transient pain following epidural leaks during treatment of thoracic vertebrae and breast metastases also occurred. Non-symptomatic complications, from a variety of cases, included cement emboli to the lung, incidental, non-symptomatic leaks into the needle track, spinal canal, draining veins, disc spaces, and an intra-articular leak into the hip joint. Conclusion Combined RFA and cementoplasty appears to be safe, practical and effective in the palliative treatment of painful neoplastic lesions.

This article presents a reconfigurable antenna using digitally tuneable capacitors (DTCs). Mounted on a 120 × 200 mm2 ground plane, the radiating element has very compact dimensions of 0.06λg × 0.016λg × 0.0016λg (with λg being the wavelength at 585 MHz). The proposed structure could be operated in the white-space frequency band from 470 to 700 MHz. The antenna system is composed of two radiated elements that are placed at the corner of the board. The active components were soldered onto the antennas and controlled by an embedded microcontroller via the I2C interface. Antenna impedances were simulated and evaluated by measurement with an impedance-matching bandwidth of 39.32% (470–700 MHz) for an S11 less than −6 dB. Furthermore, the numerical results show a realized maximal gain ranging from −2.2 dBi at 470 MHz to 1.87 dBi at 700 MHz. Lastly, the diversity gains based on the radiation pattern of two resonators were calculated. The results show envelope correlation coefficient (ECC) values lower than 0.5 for the different configurations.

Background. Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue. Balapiravir is a prodrug of a nucleoside analogue (called R1479) and an inhibitor of hepatitis C virus replication in vivo. Methods. We conducted in vitro experiments to determine the potency of balapiravir against dengue viruses and then an exploratory, dose-escalating, randomized placebo-controlled trial in adult male patients with dengue with <48 hours of fever. Results. The clinical and laboratory adverse event profile in patients receiving balapiravir at doses of 1500 mg (n = 10) or 3000 mg (n = 22) orally for 5 days was similar to that of patients receiving placebo (n = 32), indicating balapiravir was well tolerated. However, twice daily assessment of viremia and daily assessment of NS1 antigenemia indicated balapiravir did not measurably alter the kinetics of these virological markers, nor did it reduce the fever clearance time. The kinetics of plasma cytokine concentrations and the whole blood transcriptional profile were also not attenuated by balapiravir treatment. Conclusions. Although this trial, the first of its kind in dengue, does not support balapiravir as a candidate drug, it does establish a framework for antiviral treatment trials in dengue and provides the field with a clinically evaluated benchmark molecule. Clinical Trials Registration. NCT01096576.

This study investigates the determinants of household-level adaptation strategies to climate variability and saltwater intrusion in the coastal regions of Central Vietnam. Using a Multinomial Logistic Regression (MNL) model, the analysis is based on a cross-sectional survey of 356 farming households, focusing on four primary adaptation measures: vegetable production, shrimp farming, adoption of salt-tolerant rice varieties, and the lotus-fish farming model. The results reveal that socio-economic, demographic, environmental, and institutional factors significantly influence the adoption of specific adaptation strategies. Key determinants include gender, education, age, farming experience, household income, land characteristics, access to information, credit services, membership in civic organizations, and participation in training programs. Male-headed households and those with greater access to climate information and social networks were more likely to adopt diverse and complex adaptation strategies. In contrast, households with limited land resources, lower incomes, or lacking institutional support were less adaptive. The findings highlight the heterogeneity of adaptive behaviors and the need for tailored interventions. From a policy perspective, enhancing institutional capacity—especially through targeted training, increased access to subsidized credit, and support for community-based organizations—can significantly strengthen farmers’ adaptive capacities. Moreover, the study contributes to filling key research gaps in the Southeast Asian context by integrating socio-economic and environmental variables into a unified analytical framework. These insights are critical for designing inclusive and effective climate adaptation policies aimed at safeguarding rural livelihoods and promoting sustainable agricultural development in climate-vulnerable regions.