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"Leahy, William"
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Neural Interactome: Interactive Simulation of a Neuronal System
Connectivity and biophysical processes determine the functionality of neuronal networks. We, therefore, developed a real-time framework, called Neural Interactome
, to simultaneously visualize and interact with the structure and dynamics of such networks. Neural Interactome is a cross-platform framework, which combines graph visualization with the simulation of neural dynamics, or experimentally recorded multi neural time series, to allow application of stimuli to neurons to examine network responses. In addition, Neural Interactome supports structural changes, such as disconnection of neurons from the network (ablation feature). Neural dynamics can be explored on a single neuron level (using a zoom feature), back in time (using a review feature), and recorded (using presets feature). The development of the Neural Interactome was guided by generic concepts to be applicable to neuronal networks with different neural connectivity and dynamics. We implement the framework using a model of the nervous system of
(
) nematode, a model organism with resolved connectome and neural dynamics. We show that Neural Interactome assists in studying neural response patterns associated with locomotion and other stimuli. In particular, we demonstrate how stimulation and ablation help in identifying neurons that shape particular dynamics. We examine scenarios that were experimentally studied, such as touch response circuit, and explore new scenarios that did not undergo elaborate experimental studies.
Journal Article
‘the dreamscape of nostalgia’: Shakespearean Biography: Too Much Information (but not about Shakespeare)
Shakespearean biography has a long and colourful history, with a new edition of the life of the world’s greatest ever poet published at least once a year. Yet, the records are hardly full with details of his life and are indeed almost non-existent with regard to his writing life. If this is the case, then what are these various biographies made up of? What are they constituted by given that, it seems, their basic foundations are absent? This essay considers these questions in the context of the most important intervention in the field of Shakespearean biography in recent years, Brian Cummings’ essay ‘Shakespeare, Biography and Anti-Biography’. The conclusion it reaches is that the entire sub-genre can be regarded as ‘the dreamscape of nostalgia’, constituted by works of fictional narcissism.
Journal Article
Elizabethan Triumphal Processions
Until now, scholarly analysis of Elizabethan processions has always regarded them as having been successful in their function as propaganda, and has always found them to have effectively 'won over' the common people - that group of the population at whom they were chiefly aimed. Both her Royal entries and progresses were regarded as effective public relations exercises, the population gaining access to the Queen and thus being encouraged to remain loyal subjects. This book represents a new approach to this subject by investigating whether this was actually the case - that is, whether the common people were actually won over by these spectacular rituals. By examining original documents that have thus far been ignored, as well as re-examining others from the perspective of the common people, the book casts a new light on Elizabethan processions.
Contents: Introduction: 'Triumphal processions'; Theorising processions; 'Her spiritual, mystical, transforming power': Elizabeth on procession and the common audience; 'Tyme hath brought me hether': readings of Elizabeth on procession; Conclusion: 'The true picture of the past flits by': re-reading a procession painting; Appendices; Bibliography; Index.
William Leahy is Director of Studies in the Department of English at Brunel University, UK.
eBook
Biophysical Insights into the Binding Interactions of Inhibitors (ICA-1S/1T) Targeting Protein Kinase C-ι
The overexpression of atypical protein kinase C-iota (PKC-ι) is a biomarker for carcinogenesis in various cell types, such as glioma, ovarian, renal, etc., manifesting as a potential drug target. In previous in vitro studies, ICA-1S and ICA-1T, experimental candidates for inhibiting PKC-ι, have demonstrated their specificity and promising efficacy against various cancers. Moreover, the in vivo studies have demonstrated low toxicity levels in acute and chronic murine models. Despite these prior developments, the binding affinities of the inhibitors were never thoroughly explored from a biophysical perspective. Here, we present the biophysical characterizations of PKC-ι in combination with ICA-1S/1T. Various methods based on molecular docking, light scattering, intrinsic fluorescence, thermal denaturation, and heat exchange were applied. The biophysical characteristics including particle sizing, thermal unfolding, aggregation profiles, enthalpy, entropy, free energy changes, and binding affinity (Kd) of the PKC-ι in the presence of ICA-1S were observed. The studies indicate the presence of domain-specific stabilities in the protein–ligand complex. Moreover, the results indicate a spontaneous reaction with an entropic gain, resulting in a possible entropy-driven hydrophobic interaction and hydrogen bonds in the binding pocket. Altogether, these biophysical studies reveal important insights into the binding interactions of PKC-ι and its inhibitors ICA-1S/1T.
Journal Article
Shakespeare and his authors : critical perspectives on the authorship question
The Shakespeare Authorship question - the question of who wrote Shakespeare's plays and who the man we know as Shakespeare was - is a subject which fascinates millions of people the world over and can be seen as a major cultural phenomenon. However, much discussion of the question exists on the very margins of academia, deemed by most Shakespearean academics as unimportant or, indeed, of interest only to conspiracy theorists. Yet, many academics find the Authorship question interesting and worthy of analysis in theoretical and philosophical terms. This collection brings together leading literary and cultural critics to explore the Authorship question as a social, cultural and even theological phenomenon and consider it in all its rich diversity and significance.
eBook
Introduction
To some extent, the likes of Sinfield and Dollimore's Political Shakespeare as well as the Alternative Shakespeares series could be seen to be of that ilk, though it is true to say that much of the work contained in these important texts has rather become the new but merely reconstituted orthodoxy in Shakespeare studies.2 That so many of the authors of essays which appeared in these collections have subsequently seen fit to publish work every bit as conventional as those Shakespeareans they originally set out to criticize is a sobering sight for anyone who harboured thoughts of a radical departure from the traditional forms of Shakespeare criticism.3 Despite this fact, there is work currently being carried out which, though it would not wish to place itself in any way on the margins of Shakespeare studies, certainly exists within the parameters of this kind of oppositional criticism. In the first essay, Roger Stritmatter and Lynne Kositsky continue their important work on the problematic dating of Shakespeare's Tempest that recently began in the Review of English Studies.6 According to the authors, a comprehensive review of early modern travel narratives and relevant literary texts reveals the unprecedented influence on Tempest of Peter Martyr's De Orbe Novo decades cum Legatione Babylonica (1516), translated into English with supplemental extracts from Gonzalo Ferdinandez Oviedo's The History of the West Indies (173v-214) andAntonio Pygafetta's Brief Declaration of the Voyage or Navigation Made About the World (216v-232v) and published under the title The Decades of the New Worlde (1555) by Richard Eden. [...]Barber's essay demonstrates that primary source evidence of authorship doubt not only exists, but by approaching early modern material from an unorthodox perspective, new information of significant interest to orthodox scholars can be unearthed.Adopting such a perspective, Barber shows that passages in Gabriel Harvey's Pierces Supererogation suggest that Harvey, and not Richard Stonley is the earliest documented reader of Venus and Adonis. In addition to establishing that the questioning of Shakespeare's authorship began with the very first work published under that name, Barber believes that decoding Harvey's prose reveals information of interest to all early modern literary scholars, including evidence that the dedication to the Earl of Southampton is already present when Venus and Adonis is registered, a full character description for Marlowe's accuser Richard Baines, and an earlier provenance for the Baines Note.
Journal Article