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American Sign Language for dummies
\"Grasp the rich culture and language of the Deaf community To see people use American Sign Language (ASL) to share ideas is remarkable and fascinating to watch. Now, you have a chance to enter the wonderful world of sign language. American Sign Language For Dummies offers you an easy-to-access introduction so you can get your hands wet with ASL, whether you're new to the language or looking for a great refresher. Used predominantly in the United States, ASL provides the Deaf community with the ability to acquire and develop language and communication skills by utilizing facial expressions and body movements to convey and process linguistic information. With American Sign Language For Dummies, the complex visual-spatial and linguistic principles that form the basis for ASL are broken down, making this a great resource for friends, colleagues, students, education personnel, and parents of Deaf children. Grasp the various ways ASL is communicated Get up to speed on the latest technological advancements assisting the Deaf Understand how cultural background and regionalism can affect communication Practice signing with videos online If you want to get acquainted with Deaf culture and understand what it's like to be part of a special community with a unique shared and celebrated history and language, American Sign Language For Dummies gets you up to speed on ASL fast.\"--Amazon.com description.
Book
Emotion and motion: Toward emotion recognition based on standing and walking
Emotion recognition is key to interpersonal communication and to human–machine interaction. Body expression may contribute to emotion recognition, but most past studies focused on a few motions, limiting accurate recognition. Moreover, emotions in most previous research were acted out, resulting in non–natural motion, which is unapplicable in reality. We present an approach for emotion recognition based on body motion in naturalistic settings, examining authentic emotions, natural movement, and a broad collection of motion parameters. A lab experiment using 24 participants manipulated participants’ emotions using pretested movies into five conditions: happiness, relaxation, fear, sadness, and emotionally–neutral. Emotion was manipulated within subjects, with fillers in between and a counterbalanced order. A motion capture system measured posture and motion during standing and walking; a force plate measured center of pressure location. Traditional statistics revealed nonsignificant effects of emotions on most motion parameters; only 7 of 229 parameters demonstrate significant effects. Most significant effects are in parameters representing postural control during standing, which is consistent with past studies. Yet, the few significant effects suggest that it is impossible to recognize emotions based on a single motion parameter. We therefore developed machine learning models to classify emotions using a collection of parameters, and examined six models: k-nearest neighbors, decision tree, logistic regression, and the support vector machine with radial base function and linear and polynomial functions. The decision tree using 25 parameters provided the highest average accuracy (45.8%), more than twice the random guess for five conditions, which advances past studies demonstrating comparable accuracies, due to our naturalistic setting. This research suggests that machine learning models are valuable for emotion recognition in reality and lays the foundation for further progress in emotion recognition models, informing the development of recognition devices (e.g., depth camera), to be used in home-setting human–machine interactions.
Journal Article
Value from Regulatory Construal Fit: The Persuasive Impact of Fit between Consumer Goals and Message Concreteness
This research investigates the relationship between regulatory focus and construal level. The findings indicate that promotion‐focused individuals are more likely to construe information at abstract, high levels, whereas those with a prevention focus are more likely to construe information at concrete, low levels (experiments 1 and 2). Further, such fit (vs. nonfit) between an individual’s regulatory focus and the construal level at which information is represented leads to more favorable attitudes (experiments 3 and 4) and enhances performance on a subsequent task (experiment 3). These outcomes occur because fit enhances engagement that in turn induces processing fluency and intensifies reactions.
Journal Article
Looking into the Future: A Match between Self-View and Temporal Distance
Representing an event in abstract (vs. concrete) terms and as happening in the distant (vs. proximal) future has been shown to have important consequences for cognition and motivation. Less is known about factors that influence construal level and perceived temporal distance. The present research identifies one such factor and explores the implications for persuasion. Four studies show that an independent self-view is associated with abstract representations of future events and with perceiving these events as happening in the more distant future, whereas an interdependent self-view is associated with concrete representations of future events and with perceiving these events as happening in the more proximal future. Furthermore, a match (vs. mismatch) between the temporal frame of an advertisement and the self-view of the recipient leads to systematic changes in advertisement effectiveness and product appeal. These results add to the construal level theory and the self literatures and have practical implications for advertisers.
Journal Article
Feeling Mixed but Not Torn: The Moderating Role of Construal Level in Mixed Emotions Appeals
This research examines how construal level (i.e., how abstractly or concretely people represent information in memory) affects consumers’ responses to mixed emotions appeals. The results of five studies show that, consistent with prior research, participants experienced discomfort when they encountered mixed emotions appeals and developed less favorable attitudes toward the ad relative to pure positive emotional appeals, but this was the case only for those who construed information at a concrete, low level. Participants who construed information at an abstract, high level did not experience much discomfort; hence, they found mixed emotions and pure positive emotional appeals equally persuasive. We further demonstrate that the chronic construal level associated with people’s age and cultural background underlies the moderating effects of age and culture on consumers’ attitudes toward mixed emotions appeals documented in prior research.
Journal Article
It’s Time to Vote: The Effect of Matching Message Orientation and Temporal Frame on Political Persuasion
What political candidates say during their campaign and when they say it are critical to their success. In three experiments, we show that abstract, “why”‐laden appeals are more persuasive than concrete, “how”‐laden appeals when voters’ decision is temporally distant; the reverse is true when the decision is imminent, and these results are strongest among those who are politically uninformed. These effects seem to be driven by a match between temporal distance and the abstractness of the message that leads to perceptions of fluency, and the ensuing “feels right” experience yields enhanced evaluations of the focal stimulus.
Journal Article
Palmitoylation Regulates Epidermal Homeostasis and Hair Follicle Differentiation
Palmitoylation is a key post-translational modification mediated by a family of DHHC-containing palmitoyl acyl-transferases (PATs). Unlike other lipid modifications, palmitoylation is reversible and thus often regulates dynamic protein interactions. We find that the mouse hair loss mutant, depilated, (dep) is due to a single amino acid deletion in the PAT, Zdhhc21, resulting in protein mislocalization and loss of palmitoylation activity. We examined expression of Zdhhc21 protein in skin and find it restricted to specific hair lineages. Loss of Zdhhc21 function results in delayed hair shaft differentiation, at the site of expression of the gene, but also leads to hyperplasia of the interfollicular epidermis (IFE) and sebaceous glands, distant from the expression site. The specific delay in follicle differentiation is associated with attenuated anagen propagation and is reflected by decreased levels of Lef1, nuclear beta-catenin, and Foxn1 in hair shaft progenitors. In the thickened basal compartment of mutant IFE, phospho-ERK and cell proliferation are increased, suggesting increased signaling through EGFR or integrin-related receptors, with a parallel reduction in expression of the key differentiation factor Gata3. We show that the Src-family kinase, Fyn, involved in keratinocyte differentiation, is a direct palmitoylation target of Zdhhc21 and is mislocalized in mutant follicles. This study is the first to demonstrate a key role for palmitoylation in regulating developmental signals in mammalian tissue homeostasis.
Journal Article
Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models
In atrial fibrillation (AF), atrial biomechanics are altered, reducing atrial movement. It remains unclear whether these changes are due to altered anatomy, myocardial stiffness, or constraints from surrounding structures. Understanding the causes of changed atrial deformation in AF could enhance tissue characterization and inform AF diagnosis, stratification, and treatment. We created patient-specific anatomical models of the left atrium (LA) from CT images. Passive LA biomechanics were simulated using finite deformation continuum mechanics equations. LA stiffness was represented by the Guccione material law, where α scaled the anisotropic stiffness parameters. Regional passive stiffness parameters were calibrated to peak regional deformation during the reservoir phase and validated against deformation transients derived from retrospective gated CT images during the reservoir and conduit phase. Physiological LA deformation varies regionally, with the roof deforming significantly less than other regions during the reservoir phase. The fitted model matched peak patient deformations globally and regionally with an average error of 0.90 ± 0.39 mm over our cohort. We compared deformation transients through the reservoir and conduit phases and found that the simulated deformation transients were within an average of ± 0.38 mm per unit time of the CT-derived deformation transients. Regional stiffness varied across the atria with average α values of 1.8, 1.6, 2.2, 1.6 and 2.1 across the cohort in the anterior, posterior, septum, lateral and roof regions respectively. Using mixed effect models, we found no correlation between regional patient LA deformation and regional estimates of wall thickness or regional volumes of epicardial adipose tissue. We found a significant correlation between regionally calibrated stiffness and CT-derived LA biomechanics ( p = 0.023). We have shown that regional heterogeneity in stiffness contributes to regional LA biomechanics, while anatomical features appeared less important. These findings provide insight into the underlying causes of altered LA biomechanics in AF.
Journal Article
Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype
To date, genome-wide association studies (GWAS) have identified at least 32 novel loci for obesity and body mass-related traits. However, the causal genetic variant and molecular mechanisms of specific susceptibility genes in relation to obesity are yet to be fully confirmed and characterised. Here, we examined whether the candidate gene NEGR1 encoding the neuronal growth regulator 1, also termed neurotractin or Kilon, accounts for the obesity association. To characterise the function of NEGR1 for body weight control in vivo, we generated two novel mutant mouse lines, including a constitutive NEGR1-deficient mouse line as well as an ENU-mutagenised line carrying a loss-of-function mutation (Negr1-I87N) and performed metabolic phenotypic analyses. Ablation of NEGR1 results in a small but steady reduction of body mass in both mutant lines, accompanied with a small reduction in body length in the Negr1-I87N mutants. Magnetic resonance scanning reveals that the reduction of body mass in Negr1-I87N mice is due to a reduced proportion of lean mass. Negr1-I87N mutants display reduced food intake and physical activity while normalised energy expenditure remains unchanged. Expression analyses confirmed the brain-specific distribution of NEGR1 including strong expression in the hypothalamus. In vitro assays show that NEGR1 promotes cell-cell adhesion and neurite growth of hypothalamic neurons. Our results indicate a role of NEGR1 in the control of body weight and food intake. This study provides evidence that supports the link of the GWAS candidate gene NEGR1 with body weight control.
Journal Article
Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
While exposure to nicotine during developmental periods can significantly affect brain development, studies examining the association between maternal smoking and autism spectrum disorder (ASD) in offspring have produced conflicting findings, and prior meta-analyses have found no significant association. Our meta-analysis used a novel approach of investigating population-level smoking metrics as moderators. The main meta-analysis, with 22 observational studies comprising 795,632 cases and 1,829,256 control participants, used a random-effects model to find no significant association between maternal smoking during pregnancy and ASD in offspring (pooled odds ratio (OR) = 1.16, 95% CI: 0.97–1.40). However, meta-regression analyses with moderators were significant when we matched pooled ORs with adult male smoking prevalence (
z
= 2.55,
p
= 0.01) in each country, using World Health Organization data. Our study shows that using population-level smoking metrics uncovers significant relationships between maternal smoking and ASD risk. Correlational analyses show that male smoking prevalence approximates secondhand smoke exposure. While we cannot exclude the possibility that our findings reflect the role of paternal or postnatal nicotine exposure, as opposed to maternal or
in utero
nicotine exposure, this study underlines the importance of investigating paternal and secondhand smoking in addition to maternal smoking in ASD.
Journal Article