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"Lee, Byong-Hoon"
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New Insights on the Use of Polyphenols as Natural Preservatives and Their Emerging Safety Concerns
Polyphenols are natural high-valued secondary metabolites of plant that demonstrate strong antimicrobial potential as natural preservatives besides their well-established health promoting benefits. This review highlights the challenges, novel strategies to achieve industrial production of polyphenols and their safe use as potential alternative natural preservative. Since plant extraction presents considerable limitations of high cost due to excessive energy and solvent requirements, climate and long growth cycles, microbial biosynthesis using highly advanced omics techniques and metabolic engineering tools could provide superior alternative for commercial production of environmentally sustainable and cost-effective high-value metabolites in a short time. In spite of the many beneficial effects, some plant metabolites and polyphenol compounds at high dosage are found to be pro-oxidant or mutagenic with toxicity. Due to the controversial findings from sub-chronic and oral toxicity studies, more detailed safety and efficacy studies are needed to substantiate findings. Furthermore, extensive research efforts are required to ascertain optimal dosage for safe use in various foods to avoid potential harmful side effects.
Journal Article
Maltoheptaose and maltooctaose as the superior aroma encapsulating agents
Maltoheptaose (G7) and maltooctaose (G8) were examined as potential encapsulating agents for aroma compounds and compared with commercially available maltodextrins with the dextrose equivalent (DE) 10 and 18. Solutions of each encapsulating agent were homogenized with aromas and spray dried. The initial amounts of aroma compounds retained in each encapsulating agent were as follows: G7
Journal Article
Health Impact and Therapeutic Manipulation of the Gut Microbiome
Recent advances in microbiome studies have revealed much information about how the gut virome, mycobiome, and gut bacteria influence health and disease. Over the years, many studies have reported associations between the gut microflora under different pathological conditions. However, information about the role of gut metabolites and the mechanisms by which the gut microbiota affect health and disease does not provide enough evidence. Recent advances in next-generation sequencing and metabolomics coupled with large, randomized clinical trials are helping scientists to understand whether gut dysbiosis precedes pathology or gut dysbiosis is secondary to pathology. In this review, we discuss our current knowledge on the impact of gut bacteria, virome, and mycobiome interactions with the host and how they could be manipulated to promote health.
Journal Article