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Decrease in processing speed due to increased resistance and capacitance delay is a major obstacle for the down-scaling of electronics 1 – 3 . Minimizing the dimensions of interconnects (metal wires that connect different electronic components on a chip) is crucial for the miniaturization of devices. Interconnects are isolated from each other by non-conducting (dielectric) layers. So far, research has mostly focused on decreasing the resistance of scaled interconnects because integration of dielectrics using low-temperature deposition processes compatible with complementary metal–oxide–semiconductors is technically challenging. Interconnect isolation materials must have low relative dielectric constants ( κ values), serve as diffusion barriers against the migration of metal into semiconductors, and be thermally, chemically and mechanically stable. Specifically, the International Roadmap for Devices and Systems recommends 4 the development of dielectrics with κ values of less than 2 by 2028. Existing low- κ materials (such as silicon oxide derivatives, organic compounds and aerogels) have κ values greater than 2 and poor thermo-mechanical properties 5 . Here we report three-nanometre-thick amorphous boron nitride films with ultralow κ values of 1.78 and 1.16 (close to that of air, κ = 1) at operation frequencies of 100 kilohertz and 1 megahertz, respectively. The films are mechanically and electrically robust, with a breakdown strength of 7.3 megavolts per centimetre, which exceeds requirements. Cross-sectional imaging reveals that amorphous boron nitride prevents the diffusion of cobalt atoms into silicon under very harsh conditions, in contrast to reference barriers. Our results demonstrate that amorphous boron nitride has excellent low- κ dielectric characteristics for high-performance electronics. Thin films of amorphous boron nitride are mechanically and electrically robust, prevent diffusion of metal atoms into semiconductors and have ultralow dielectric constants that exceed current recommendations for high-performance electronics.

Nα-terminal acetylation (Nt-acetylation) occurs very frequently and is found in most proteins in eukaryotes. Despite the pervasiveness and universality of Nt-acetylation, its general functions in terms of physiological outcomes remain largely elusive. However, several recent studies have revealed that Nt-acetylation has a significant impact on protein stability, activity, folding patterns, cellular localization, etc. In addition, Nt-acetylation marks specific proteins for degradation by a branch of the N-end rule pathway, a subset of the ubiquitin-mediated proteolytic system. The N-end rule associates a protein’s in vivo half-life with its N-terminal residue or modifications on its N-terminus. This review provides a current understanding of intracellular proteolysis control by Nt-acetylation and the N-end rule pathway. Protein Nα-terminal acetylation: Regulating stability The addition of an acetyl group to amino acids at the start of a protein (known as the Nα-terminal end) is crucial for maintaining protein homeostasis and cellular health. Hwang and colleagues review the effects of Nα-terminal acetylation (Nt-acetylation) on protein function and stability. This modification occurs in over 50% of proteins in eukaryotic organisms and when mis-regulated can lead to cancer, hypertension, neurodegeneration etc. Nt-acetylation not only targets proteins for degradation through a specific signaling pathway, but also regulates protein folding, cellular localization and activity. This seemingly irreversible modification can also protect proteins against other mechanisms of degradation and represents a potential therapeutic target. Inhibiting Nt-acetylation-dependent protein interactions could be a useful strategy for regulating protein stability.

Over time, the vegetation of abandoned rice paddy fields is succeeded by communities of willow (Salix pierotii Miq.). This study was carried out to confirm the potential for future carbon farming by evaluating the carbon absorption capacity of willow communities restored passively in abandoned rice paddy fields. The net primary productivity (NPP) of willow communities established in abandoned rice paddy fields in three areas of central Korea (Cheongju, Andong, and Buyeo) was determined. The NPP was obtained by combining the diameter growth of willow individuals and the density of willow stands, yielding 24.36, 19.74, and 38.69 tons·ha−1·yr−1, respectively, and the average NPP of the three sites was 27.62 tons·ha−1·yr−1. The carbon-based NPP calculated from the average NPP at the three sites was 13.81 tons·C·ha−1·yr−1, and the amount of heterotrophic respiration, which is the respiration of microorganisms and animals in the soil, measured in abandoned rice paddy fields in Cheongju was 5.25 tons·C·ha−1·yr−1. As a result, the net ecosystem production (NEP) of the willow communities established in the abandoned rice paddy fields was calculated as 8.56 tons·C·ha−1·yr−1. By substituting this NEP value into the area of abandoned rice paddy fields so far, the carbon dioxide absorption capacity of abandoned rice paddy fields was estimated to exceed 19 million·tons·yr−1. This amount is high enough to account for 77% of the total forecasted carbon absorption capacity in 2050, which is the year Korea aims to achieve carbon neutrality. In this regard, carbon farming using abandoned rice paddy fields is evaluated as a promising project.

Rhododenol (RD), a whitening cosmetic ingredient, was withdrawn from the market due to RD-induced leukoderma (RIL). While many attempts have been made to clarify the mechanism underlying RIL, RIL has not been fully understood yet. Indeed, affected subjects showed uneven skin pigmentation, but the features are different from vitiligo, a skin hypopigmentary disorder, alluding to events more complex than simple melanocyte cytotoxicity. Here, we discovered that rhododenol treatment reduced the number of melanocytes in a pigmented 3D human skin model, Melanoderm™, confirming the melanocyte toxicity of RD. Of note, melanocytes that survived in the RD treated tissues exhibited altered morphology, such as extended dendrites and increased cell sizes. Consistently with this, sub-cytotoxic level of RD increased cell size and elongated dendrites in B16 melanoma cells. Morphological changes of B16 cells were further confirmed in the immunocytochemistry of treated cells for actin and tubulin. Even more provoking, RD up-regulated the expression of tyrosinase and TRP1 in the survived B16 cells. Evaluation of mRNA expression of cytoskeletal proteins suggests that RD altered the cytoskeletal dynamic favoring cell size expansion and melanosome maturation. Collectively, these results suggest that RD not only induces cytotoxicity in melanocytes but also can lead to a profound perturbation of melanocyte integrity even at sub-cytotoxic levels.

Achieving carbon neutrality requires a comprehensive understanding of terrestrial carbon dynamics, particularly the capacity of ecosystems to act as carbon sinks. This study quantified the temporal and spatial variability of net primary production (NPP) and net ecosystem production (NEP) across South Korea from 2010 to 2024, assessing long-term carbon sink trends and their implications for carbon neutrality and nature-based solutions (NbSs). Using the Carnegie–Ames–Stanford Approach (CASA) model driven by Moderate Resolution Imaging Spectroradiometer (MODIS) satellite data and climate variables, we estimated ecosystem carbon fluxes at high spatial and temporal resolutions. In 2024, national NPP totaled 78.63 Mt CO2 yr−1, with a mean value of 1956.63 t CO2 ha−1 yr−1. High productivity was concentrated in upland forests of Gangwon-do, Mt. Jirisan, and northern Gyeongsangbuk-do, where favorable vegetation indices and climatic conditions enhanced photosynthesis. Lower productivity occurred in urbanized areas and intensively farmed lowlands. Heterotrophic respiration (RH) was estimated at 15.35 Mt CO2 yr−1, with elevated rates in warm, humid lowlands and reduced values in high-elevation forests. The resulting NEP in 2024 was 63.29 Mt CO2 yr−1, with strong sinks along the Baekdudaegan Range and localized negative NEP pockets in lowlands dominated by urban development or agriculture. From 2010 to 2024, the spatially averaged NPP increased from 1170 to 1543 g C m−2 yr−1, indicating a general upward trend in ecosystem productivity. However, interannual variability was influenced by climatic fluctuations, land-cover changes, and data masking adjustments. These findings provide critical insights into the spatiotemporal dynamics of terrestrial carbon sinks in South Korea, offering essential baseline data for national greenhouse gas inventories and the strategic integration of NbSs into carbon-neutral policies.

Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, the expression mechanism of S100A9 in colonic epithelial cells (CECs) remains elusive. We investigated the role of IL-6 in S100A9 expression in CECs using a colitis model. IL-6 and S100A9 expression, signal transducer and activator of transcription 3 (STAT3) phosphorylation, and infiltration of immune cells were analyzed in mice with dextran sulfate sodium (DSS)-induced colitis. The effects of soluble gp130-Fc protein (sgp130Fc) and S100A9 small interfering (si) RNA (si-S100A9) on DSS-induced colitis were evaluated. The molecular mechanism of S100A9 expression was investigated in an IL-6-treated Caco-2 cell line using chromatin immunoprecipitation assays. IL-6 concentrations increased significantly in the colon tissues of DSS-treated mice. sgp130Fc or si-S100A9 administration to DSS-treated mice reduced granulocyte infiltration in CECs and induced the down-regulation of S100A9 and colitis disease activity. Treatment with STAT3 inhibitors upon IL-6 stimulation in the Caco-2 cell line demonstrated that IL-6 mediated S100A9 expression through STAT3 activation. Moreover, we found that phospho-STAT3 binds directly to the S100A9 promoter. S100A9 may recruit immune cells into inflamed colon tissues. Elevated S100A9 expression in CECs mediated by an IL-6/STAT3 signaling cascade may play an important role in the development of colitis.

The Najeoer Pond was created in a rice paddy as a part of a plan to build the National Institute of Ecology. To induce the establishment of various plants, the maximum depth of the pond was 2.0 m, and diverse depths were created with a gentle slope on the pond bed. When introducing vegetation, littoral and emergent vegetation were first introduced to stabilize the space secured for the creation of the pond, whereas the introduction of other vegetation was allowed to develop naturally. In this pond, floating, emergent, wetland, and littoral plants have been established to various degrees, reflecting the water depth and water table. As a result of stand ordination, based on vegetation data obtained from the created Najeoer Pond and a natural lagoon selected as the reference site, the species’ composition resembled that of the reference site. Diversity, based on vegetation type, community, and species, tended to be higher than that of the reference site. The proportion of exotic species increased due to the disturbance that occurred during the pond creation process but continued to decrease as the vegetation introduced during the creation of the pond became established. Considering these results comprehensively, the restorative treatment served to increase both the biological integrity and ecological stability of the pond and, thus, achieved the creation goal from the viewpoint of the pond structure.

Climate change is rapidly progressing as the carbon budget balance is broken due to excessive energy and land use. This study was conducted to find and quantify new carbon sinks to implement the carbon neutrality policy prepared by the international community to solve these problems. To reach this goal, an allometric equation of the willow community, which dominates riparian vegetation, was developed and applied to calculate the net primary productivity of the willow community. Furthermore, after the amount of carbon emitted via soil respiration was quantified, the net ecosystem production was calculated by subtracting the amount of soil respiration from the net primary productivity. In comparisons of the results obtained via this process with those obtained from forest vegetation, the willow community, representative of riparian vegetation, showed a much higher carbon sequestration rate than forest vegetation. Considering these results comprehensively, the willow community could be a new and significant carbon absorption source. In this context, proper river restoration should be realized to contribute to carbon neutrality and secure various ecosystem service functions.

The difference in the leaf unfolding date of Mongolian oak obtained through MODIS image analysis between the urban center and the outskirts of Seoul was found to be seven days. The difference in the flowering date of cherry obtained through field observations was also found to be seven days between the urban center and the outskirts. The frequency of the abnormal shoot of Korean red pine differed by 71% between the urban center and the outskirts, and the length growth differed by 8.6 cm. There was a statistically significant correlation between the leaf unfolding date of Mongolian oak, the flowering date of the cherry, and the spatial difference in the frequency and length of the abnormal shoot of the Korean red pine. The temperature difference between the urban center and the outskirts of Seoul based on the mean temperature over the past 30 years was about 5 °C. The spatial difference in plant phenology showed a statistically significant negative relationship with the spatial difference in temperature. On the other hand, the spatial difference in temperature showed a statistically significant positive relationship with the spatial difference in the urbanization rate. These results are interpreted as the result of excessive land use during urbanization causing the heat island phenomenon, and the resulting temperature difference is reflected in the phenology of plants. These results are evidence that urbanization, which uses excessive land and energy, has a very significant impact on climate change. In addition, it is also evidence that sustainable land use could be an important means to achieve climate change adaptation and further solve climate change problems.

An ubiquinone derivative, pseudoalteromone A (1), has been isolated from two marine-derived Pseudoalteromonas spp., APmarine002 and ROA-050, and its anti-melanogenesis activity was investigated. The anti-melanogenic capacity of pseudoalteromone A was demonstrated by assessing the intracellular and extracellular melanin content and cellular tyrosinase activity in the B16 cell line, Melan-a mouse melanocyte cell line, and MNT-1 human malignant melanoma cell line. Treatment with pseudoalteromone A (40 μg/mL) for 72 h reduced α-melanocyte-stimulating hormone (α-MSH)-induced intracellular melanin production by up to 44.68% in B16 cells and 38.24% in MNT-1 cells. Notably, pseudoalteromone A induced a concentration-dependent reduction in cellular tyrosinase activity in B16 cell, and Western blot analyses showed that this inhibitory activity was associated with a significant decrease in protein levels of tyrosinase and tyrosinase-related protein 1 (Tyrp-1), suggesting that pseudoalteromone A exerts its anti-melanogenesis activity through effects on melanogenic genes. We further evaluated the skin-whitening effect of pseudoalteromone A in the three-dimensional (3D) pigmented-epidermis model, MelanoDerm, and visualized the 3D distribution of melanin by two-photon excited fluorescence imaging in this human skin equivalent. Collectively, our findings suggest that pseudoalteromone A inhibits tyrosinase activity and expression and that this accounts for its anti-melanogenic effects in melanocytes.