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"Lee, James"
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A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
Detection of extracellular vesicle (EV)-associated RNAs with low expression levels in early-stage cancer remains a challenge and is highly valuable. Here, we report a nanoparticle-based biochip that could capture circulating EVs without isolation, brighten encapsulated RNAs, and amplify fluorescence signals in situ in a single step. We confine catalyzed hairpin DNA circuit (CHDC) in cationic lipid-polymer hybrid nanoparticles (LPHNs) that are tethered on a chip. LPHN features a core-shell-corona structure that facilitates the transfer and mixing of CHDC with EV-associated RNAs when forming the LPHN–EV nanocomplex. CHDC is triggered upon target RNA binding and quickly generate amplified signals. The signal amplification efficiency of LPHN–CHDC is demonstrated in artificial EVs, cancer cells, and cancer cell-derived EVs. We show that LPHN–CHDC biochip with signal amplification capability could selectively and sensitively identify low expression glypican-1 mRNA in serum EVs, distinguishing patients with early- and late-stage pancreatic cancer from healthy donors and patients with benign pancreatic disease.
Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patients.
Journal Article
Swan Peak : a Dave Robicheaux novel
Detective Dave Robicheaux returns in another adventure--only this time, he travels from New Iberia Parish to the wilds of Montana to solve the mysterious murder of a University of Montana coed and her boyfriend.
Book
Protonic Capacitor: Elucidating the biological significance of mitochondrial cristae formation
For decades, it was not entirely clear why mitochondria develop cristae? The work employing the transmembrane-electrostatic proton localization theory reported here has now provided a clear answer to this fundamental question. Surprisingly, the transmembrane-electrostatically localized proton concentration at a curved mitochondrial crista tip can be significantly higher than that at the relatively flat membrane plane regions where the proton-pumping respiratory supercomplexes are situated. The biological significance for mitochondrial cristae has now, for the first time, been elucidated at a protonic bioenergetics level: 1) The formation of cristae creates more mitochondrial inner membrane surface area and thus more protonic capacitance for transmembrane-electrostatically localized proton energy storage; and 2) The geometric effect of a mitochondrial crista enhances the transmembrane-electrostatically localized proton density to the crista tip where the ATP synthase can readily utilize the localized proton density to drive ATP synthesis.
Journal Article
Creole belle
Dave Robicheaux was recovering in a New Orleans hospital from a near-fatal bullet wound. Immobilized and heavily medicated by morphine, he was visited there by a beautiful Creole woman named Tee Jolie Melton. After she's gone, his fond, hazy remembrances of her are rekindled by one song on his iPod that she left behind. Now obsessed by the song and thoughts of her, he goes in search of her, but finds instead the frozen corpse of her sister floating at sea. As he grapples with that mystery, another oil rig explodes on the Gulf, bringing with it a fresh sense of the frailty of things.
Book
Combating Anti-Asian Sentiment — A Practical Guide for Clinicians
On top of the social, emotional, and psychological effects of the Covid pandemic, many Asian American patients are feeling the stress of increased anti-Asian sentiment. Physicians can take practical steps to tailor their practices to meet this moment.
Journal Article
Crusader's cross : a Dave Robicheaux novel
A deathbed confession from an old schoolmate resurrects a story of injustice, the murder of a young woman, and a time in Dave Robicheaux's life he had tried to forget.
Book
The New Iberia blues
Detective Dave Robicheaux's world isn't filled with too many happy stories, but Desmond Cormier's rags-to-riches tale is certainly one of them. Robicheaux first met Cormier on the streets of New Orleans, when the young, undersized boy had foolish dreams of becoming a Hollywood director. Twenty-five years later, when Robicheaux knocks on Cormier's door, it isn't to congratulate him on his Golden Globe and Academy Award nominations. Robicheaux has discovered the body of a young woman who's been crucified, wearing only a small chain on her ankle. She disappeared near Cormier's Cyrpemort Point estate, and Robicheaux, along with young deputy, Sean McClain, are looking for answers. Neither Cormier nor his enigmatic actor friend Antoine Butterworth are saying much, but Robicheaux knows better. As always, Clete Purcel and Davie's daughter, Alafair, have Robicheaux's back. Clete witnesses the escape of Texas inmate, Hugo Tillinger, who may hold the key to Robicheaux's case. As they wade further into the investigation, they end up in the crosshairs of the mob, the deranged Chester Wimple, and the dark ghosts Robicheaux has been running from for years. Ultimately, it's up to Robicheaux to stop them all, but he'll have to summon a light he's never seen or felt to save himself, and those he loves.
Book
Topologically Protected States in One-Dimensional Systems
We study a class of periodic Schrödinger operators, which in distinguished cases can be proved to have linear band-crossings or
“Dirac points”. We then show that the introduction of an “edge”, via adiabatic modulation of these periodic potentials by a domain wall,
results in the bifurcation of spatially localized “edge states”. These bound states are associated with the topologically protected
zero-energy mode of an asymptotic one-dimensional Dirac operator. Our model captures many aspects of the phenomenon of topologically
protected edge states for two-dimensional bulk structures such as the honeycomb structure of graphene. The states we construct can be
realized as highly robust TM-electromagnetic modes for a class of photonic waveguides with a phase-defect.
eBook