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"Lee, Jennifer"
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The fortune cookie chronicles : adventures in the world of Chinese food
\"A woman's search for the world's greatest Chinese restaurant proves that egg rolls are as American as apple pie\"--Provided by publisher.
Book
The diversity paradox
African Americans grappled with Jim Crow segregation until it was legally overturned in the 1960s. In subsequent decades, the country witnessed a new wave of immigration from Asia and Latin America—forever changing the face of American society and making it more racially diverse than ever before. In The Diversity Paradox, authors Jennifer Lee and Frank Bean take these two poles of American collective identity—the legacy of slavery and immigration—and ask if today’s immigrants are destined to become racialized minorities akin to African Americans or if their incorporation into U.S. society will more closely resemble that of their European predecessors. They also tackle the vexing question of whether America’s new racial diversity is helping to erode the tenacious black/white color line. The Diversity Paradox uses population-based analyses and in-depth interviews to examine patterns of intermarriage and multiracial identification among Asians, Latinos, and African Americans. Lee and Bean analyze where the color line—and the economic and social advantage it demarcates—is drawn today and on what side these new arrivals fall. They show that Asians and Latinos with mixed ancestry are not constrained by strict racial categories. Racial status often shifts according to situation. Individuals can choose to identify along ethnic lines or as white, and their decisions are rarely questioned by outsiders or institutions. These groups also intermarry at higher rates, which is viewed as part of the process of becoming “American” and a form of upward social mobility. African Americans, in contrast, intermarry at significantly lower rates than Asians and Latinos. Further, multiracial blacks often choose not to identify as such and are typically perceived as being black only—underscoring the stigma attached to being African American and the entrenchment of the “one-drop” rule. Asians and Latinos are successfully disengaging their national origins from the concept of race—like European immigrants before them—and these patterns are most evident in racially diverse parts of the country. For the first time in 2000, the U.S. Census enabled multiracial Americans to identify themselves as belonging to more than one race. Eight years later, multiracial Barack Obama was elected as the 44th President of the United States. For many, these events give credibility to the claim that the death knell has been sounded for institutionalized racial exclusion. The Diversity Paradox is an extensive and eloquent examination of how contemporary immigration and the country’s new diversity are redefining the boundaries of race. The book also lays bare the powerful reality that as the old black/white color line fades a new one may well be emerging—with many African Americans still on the other side.
eBook
Educate the heart : screen-free activities for grades PreK-6 to inspire authentic learning
\"This book includes 180 creatively designed screen-free activities teachers can implement to maximize authentic hands-on learning in their classroom. Chapter topics include promoting peace by empowering students to handle conflict through kindness, literacy centers, STEM challenges, and ways to build connections beyond the classroom door\"-- Provided by publisher.
Book
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
A cellular feature of Parkinson’s disease is cytosolic accumulation and amyloid formation of α-synuclein (α-syn), implicating a misregulation or impairment of protein degradation pathways involving the proteasome and lysosome. Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease for α-syn clearance; however, the protease alone only generates amyloidogenic C terminal-truncated species (e.g., 1–94, 5–94), implying that other proteases and/or environmental factors are needed to facilitate degradation and to avoid α-syn aggregation in vivo. Using liquid chromatography–mass spectrometry, to our knowledge, we report the first peptide cleavage map of the lysosomal degradation process of α-syn. Studies of purified mouse brain and liver lysosomal extracts and individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L (CtsL). Both CtsB and CtsL cleave α-syn within its amyloid region and circumvent fibril formation. For CtsD, only in the presence of anionic phospholipids can this protease cleave throughout the α-syn sequence, suggesting that phospholipids are crucial for its activity. Taken together, an interplay exists between α-syn conformation and cathepsin activity with CtsL as the most efficient under the conditions examined. Notably, we discovered that CtsL efficiently degrades α-syn amyloid fibrils, which by definition are resistant to broad spectrum proteases. This work implicates CtsB and CtsL as essential in α-syn lysosomal degradation, establishing groundwork to explore mechanisms to enhance their cellular activity and levels as a potential strategy for clearance of α-syn.
Journal Article
ملخص كتاب بناء عملك بالطريقة الصحيحة
تساعد جينيفر لي من خلال كتابها \"بناء عملك بالطريقة الصحيحة\" أولئك الذين هم في المراحل الأولى من بناء أعمالهم، بدءا من العثور على العملاء والاحتفاظ بهم، والعمل مع الموظفين والبائعين، وتحديد الأهداف وبناء العلامة التجارية، والتوسع، وحتى تخصيص الوقت للاحتفال ومعرفة متى يجب عليهم الابتعاد وترتكز على تحقيق النجاح المستدام لرجل الأعمال المبدع.
Book
Racialized Assimilation of Asian Americans
Because of the generally high socioeconomic attainments and high intermarriage rates of Asian Americans, it has been suggested that Asian Americans are reaching parity with whites and are assimilating to mainstream American society. However, other research shows the continued significance of race for Asian Americans regardless of their socioeconomic status and levels of acculturation. This article provides a review of recent research on socioeconomic attainment and intermarriage among Asian Americans as well as an overview of research on less studied but increasingly important indicators: residential outcomes, political participation, and mental health. We argue that Asian Americans are assimilating but in ways that differ from their European predecessors. In this process, racial ethnic boundaries between Asians and whites may be solidified rather than dissolved, thus maintaining the significance of race for Asian Americans. We suggest that a racialized assimilation framework may best characterize the experiences of contemporary Asian Americans.
Journal Article
Fire drill
In this story told in brief rhyming text, students in a class follow the proper procedures during a fire drill.
Book
Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane
Parkinson’s disease is associated with α-synuclein (α-syn), a cytosolic protein enriched in presynaptic terminals. The biological function of α-syn remains elusive; however, increasing evidence suggests that the protein is involved in the regulation of synaptic vesicle fusion, signifying the importance of α-syn–lipid interactions. We show that α-syn preferentially binds to GM1-rich, liquid-ordered lipid domains on cytoplasmic membranes by using unroofed cells, which encapsulates lipid complexity and cellular topology. Moreover, proteins (Rab3a, syntaxin-1A, and VAMP2) involved in exocytosis also localize with α-syn, supporting its proposed functional role in exocytosis. To investigate how these lipid/protein interactions influence α-syn at the residue level, α-syn was derivatized with an environmentally sensitive fluorophore (7-nitrobenz-2-oxa-1,3-diazol-4-yl [NBD]) at different N- and C-terminal sites. Measurements of NBD fluorescence lifetime distributions reveal that α-syn adopts a multitude of membrane-bound conformations, which were not recapitulated in simple micelle or vesicle models, indicating an exquisite sensitivity of the protein to the complex lipid environment. Interestingly, these data also suggest the participation of the C terminus in membrane localization, which is generally overlooked and thus emphasize the need to use cellularly derived and biologically relevant membranes for biophysical characterization. Collectively, our results demonstrate that α-syn is more conformationally dynamic at the membrane interface than previously appreciated, which may be important for both its physiological and pathological functions.
Journal Article
