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There is no Planet B : a handbook for the make or break years
\"Almost every year since records began, our species has had more energy at its disposal than it had the year before. For the last 50 years, the growth rate has averaged 2.4% per year, more than tri-pling in total over that time. For the century before that it was more like 1% per year, and as we go back through history, the growth rate looks lower still but nevertheless positive, give or take the odd blip. We have been getting continually more powerful, not just by growing our energy supply, but by using it with ever more efficiency and inventiveness. In doing so, we have been increas-ingly affecting our world, through a mixture of accident and de-sign. The restorative powers of our planet, meanwhile, have re-mained broadly the same, so the balance of power has been shift-ing - and it has now tipped. Throughout history, the dominant cultures have treated the planet as a big and robust place, compared to everything we could throw at it--and that approach has not, generally speaking, come back to bite us.\"-- Provided by publisher.
Book
Dried Blood Spots
This book covers the fundamentals, experimental procedures, and applications of dried blood spot (DBS) sampling in combination with various qualitative and quantitative analytical techniques. This includes sample collection, storage, transportation, and sample preparation for various analysis. Experimental examples in newborn screening, toxicokinetics and pharmacokinetics, and forensics are also given. Finally, the book provides an overview of trends in quantitative and qualitative analysis of DBS samples as well as future perspectives
eBook
The school carnival from the Black Lagoon
Every class has to come up with an idea for a booth at the school carnival. Too bad your class has chosen your idea -- a dunking booth and they want you to be the one who gets dunked!
Book
Design of Dielectric Resonator Antenna Using Dielectric Paste
In this publication, the use of a dielectric paste for dielectric resonator antenna (DRA) design is investigated. The dielectric paste can serve as an alternative approach of manufacturing a dielectric resonator antenna by subsequently filling a mold with the dielectric paste. The dielectric paste is obtained by mixing nanoparticle sized barium strontium titanate (BST) powder with a silicone rubber. The dielectric constant of the paste can be adjusted by varying the BST powder content with respect to the silicone rubber content. The tuning range of the dielectric constant of the paste was found to be from 3.67 to 18.45 with the loss tangent of the mixture being smaller than 0.044. To demonstrate the idea of the dielectric paste approach, a circularly polarized DRA with wide bandwidth, which is based on a fractal geometry, is designed. The antenna is realized by filling a 3D-printed mold with the dielectric paste material, and the prototype was found to have an axial ratio bandwidth of 16.7% with an impedance bandwidth of 21.6% with stable broadside radiation.
Journal Article
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Lahl and colleagues characterize human gut DC populations and define their relationship to previously described human and mouse DCs.
Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Here we characterized human gut DC populations and defined their relationship to previously studied human and mouse DCs. CD103
+
Sirpα
−
DCs were related to human blood CD141
+
DCs and to mouse intestinal CD103
+
CD11b
−
DCs and expressed markers of cross-presenting DCs. CD103
+
Sirpα
+
DCs aligned with human blood CD1c
+
DCs and mouse intestinal CD103
+
CD11b
+
DCs and supported the induction of regulatory T cells. Both CD103
+
DC subsets induced the T
H
17 subset of helper T cells, while CD103
−
Sirpα
+
DCs induced the T
H
1 subset of helper T cells. Comparative analysis of transcriptomes revealed conserved transcriptional programs among CD103
+
DC subsets and identified a selective role for the transcriptional repressors Bcl-6 and Blimp-1 in the specification of CD103
+
CD11b
−
DCs and intestinal CD103
+
CD11b
+
DCs, respectively. Our results highlight evolutionarily conserved and divergent programming of intestinal DCs.
Journal Article
Master of mirrors!
When the Flash follows three mirror image thieves through a shiny storefront window, he enters a different dimension controlled by the Mirror Master, and finds he needs the help of the princess Oriana to counter the supervillain's hypnotic tricks.
Book
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing
High endothelial vessels (HEVs) provide the conduit for blood-borne leukocytes to enter lymph nodes. Butcher and colleagues report transcriptional profiles of various endothelial cell populations that can explain functional differences of homing-molecule modifications.
Lymphocytes are recruited from blood by high-endothelial venules (HEVs). We performed transcriptomic analyses and identified molecular signatures that distinguish HEVs from capillary endothelium and that define tissue-specific HEV specialization. Capillaries expressed gene programs for vascular development. HEV-expressed genes showed enrichment for genes encoding molecules involved in immunological defense and lymphocyte migration. We identify capillary and HEV markers and candidate mechanisms for regulated recruitment of lymphocytes, including a lymph node HEV–selective transmembrane mucin; transcriptional control of functionally specialized carbohydrate ligands for lymphocyte L-selectin; HEV expression of molecules for transendothelial migration; and metabolic programs for lipid mediators of lymphocyte motility and chemotaxis. We also elucidate a carbohydrate-recognition pathway that targets B cells to intestinal lymphoid tissues, defining CD22 as a lectin-homing receptor for mucosal HEVs.
Journal Article
Clock King's time bomb
When, on New Year's eve, the Clock King sets off a time bomb that interferes with all technology that depends on clocks, it is up to the Flash to find the villain and his device and undo the chaos it is causing.
Book
Microsampling: considerations for its use in pharmaceutical drug discovery and development
There is growing interest in the implementation of microsampling approaches for the quantitation of circulating concentrations of analytes in biological samples derived from nonclinical and clinical studies involved in drug development. This interest is partly due to the ethical advantages of taking smaller blood volumes, particularly for studies in rodents, children and the critically ill. In addition, these technologies facilitate sampling to be performed in previously intractable locations and occasions. Further, they enable the collection of samples for additional purposes (extra time points, biomarkers, sampling during a clinical event, etc). This article gives a comprehensive insight to the utilization of these approaches in drug discovery and development, and provides recommendations for best practice for nonclinical, clinical and bioanalytical aspects.
Journal Article