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"Lee, Sun-Young"
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كوريا في نصوص الدراسات الاجتماعية في المصادر التعليمية بالدول العربية
يتناول كتاب (كوريا في نصوص الدراسات الاجتماعية في المصادر التعليمية بالدول العربية) والذي قام بتحريره (د. لي تشان-هي) في حوالي (76) صفحة من القطع المتوسط موضوع (التعليم في كوريا الجنوبية) مستعرضا المحتويات التالية : مراجعة المحتويات الخاصة بكوريا في نصوص الدراسات الاجتماعية في الدول العربية، تقديم موضوعات متعلقة بالمجتمع الإسلامي في الكتب المدرسية الابتدائية والإعدادية.
Book
Osteoclast-secreted SLIT3 coordinates bone resorption and formation
Coupling is the process that links bone resorption to bone formation in a temporally and spatially coordinated manner within the remodeling cycle. Several lines of evidence point to the critical roles of osteoclast-derived coupling factors in the regulation of osteoblast performance. Here, we used a fractionated secretomic approach and identified the axon-guidance molecule SLIT3 as a clastokine that stimulated osteoblast migration and proliferation by activating β-catenin. SLIT3 also inhibited bone resorption by suppressing osteoclast differentiation in an autocrine manner. Mice deficient in Slit3 or its receptor, Robo1, exhibited osteopenic phenotypes due to a decrease in bone formation and increase in bone resorption. Mice lacking Slit3 specifically in osteoclasts had low bone mass, whereas mice with either neuron-specific Slit3 deletion or osteoblast-specific Slit3 deletion had normal bone mass, thereby indicating the importance of SLIT3 as a local determinant of bone metabolism. In postmenopausal women, higher circulating SLIT3 levels were associated with increased bone mass. Notably, injection of a truncated recombinant SLIT3 markedly rescued bone loss after an ovariectomy. Thus, these results indicate that SLIT3 plays an osteoprotective role by synchronously stimulating bone formation and inhibiting bone resorption, making it a potential therapeutic target for metabolic bone diseases.
Journal Article
Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control
Glucagon-like peptide-1 (GLP-1) is an incretin hormone mainly secreted from intestinal L cells in response to nutrient ingestion. GLP-1 has beneficial effects for glucose homeostasis by stimulating insulin secretion from pancreatic beta-cells, delaying gastric emptying, decreasing plasma glucagon, reducing food intake, and stimulating glucose disposal. Therefore, GLP-1-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase-4, which is a GLP-1 inactivating enzyme, have been developed for treatment of type 2 diabetes. In addition to glucose-lowering effects, emerging data suggests that GLP-1-based therapies also show anti-inflammatory effects in chronic inflammatory diseases including type 1 and 2 diabetes, atherosclerosis, neurodegenerative disorders, nonalcoholic steatohepatitis, diabetic nephropathy, asthma, and psoriasis. This review outlines the anti-inflammatory actions of GLP-1-based therapies on diseases associated with chronic inflammation in vivo and in vitro, and their molecular mechanisms of anti-inflammatory action.
Journal Article
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b
+
F4/80
low
hepatic infiltrating macrophages, but not CD11b
+
F4/80
high
Kupffer cells, generate ROS via dynamin-mediated endocytosis of TLR4 and NOX2, independently from MyD88 and TRIF. We demonstrate that differently from LPS-mediated dimerization of the TLR4–MD2 complex, palmitate binds a monomeric TLR4–MD2 complex that triggers endocytosis, ROS generation and increases pro-interleukin-1β expression in macrophages. Palmitate-induced ROS generation in human CD68
low
CD14
high
macrophages is strongly suppressed by inhibition of dynamin. Furthermore,
Nox2
-deficient mice are protected against high-fat diet-induced hepatic steatosis and insulin resistance. Therefore, endocytosis of TLR4 and NOX2 into macrophages might be a novel therapeutic target for non-alcoholic fatty liver disease.
Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.
Journal Article
Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells
Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated the role of exosomes in NAFLD progression. Exosomes were isolated from a human hepatoma cell line treated with palmitic acid (PA) and their miRNA profiles examined by microarray. The human hepatic stellate cell (HSC) line (LX-2) was then treated with exosome isolated from hepatocytes. Compared with controls, PA-treated hepatocytes displayed significantly increased CD36 and exosome production. The microarray analysis showed there to be distinctive miRNA expression patterns between exosomes from vehicle- and PA-treated hepatocytes. When LX-2 cells were cultured with exosomes from PA-treated hepatocytes, the expression of genes related to the development of fibrosis were significantly amplified compared to those treated with exosomes from vehicle-treated hepatocytes. In conclusion, PA treatment enhanced the production of exosomes in these hepatocytes and changed their exosomal miRNA profile. Moreover, exosomes derived from PA-treated hepatocytes caused an increase in the expression levels of fibrotic genes in HSCs. Therefore, exosomes may have important roles in the crosstalk between hepatocytes and HSCs in the progression from simple steatosis to NASH.
Journal Article
Effective Ransomware Detection Using Entropy Estimation of Files for Cloud Services
A variety of data-based services such as cloud services and big data-based services have emerged in recent times. These services store data and derive the value of the data. The reliability and integrity of the data must be ensured. Unfortunately, attackers have taken valuable data as hostage for money in attacks called ransomware. It is difficult to recover original data from files in systems infected by ransomware because they are encrypted and cannot be accessed without keys. There are cloud services to backup data; however, encrypted files are synchronized with the cloud service. Therefore, the original file cannot be restored even from the cloud when the victim systems are infected. Therefore, in this paper, we propose a method to effectively detect ransomware for cloud services. The proposed method detects infected files by estimating the entropy to synchronize files based on uniformity, one of the characteristics of encrypted files. For the experiment, files containing sensitive user information and system files for system operation were selected. In this study, we detected 100% of the infected files in all file formats, with no false positives or false negatives. We demonstrate that our proposed ransomware detection method was very effective compared to other existing methods. Based on the results of this paper, we expect that this detection method will not synchronize with a cloud server by detecting infected files even if the victim systems are infected with ransomware. In addition, we expect to restore the original files by backing up the files stored on the cloud server.
Journal Article
Circulating miRNA is a useful diagnostic biomarker for nonalcoholic steatohepatitis in nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis (NASH) is considered as a progressive form of nonalcoholic fatty liver disease (NAFLD). To distinguish NASH from nonalcoholic fatty liver (NAFL), we evaluated the diagnostic value of circulating miRNAs. Small RNA sequencing was performed on 12 NAFL patients and 12 NASH patients, and the miRNA expression was compared. After selecting miRNAs for the diagnosis of NASH, we analyzed the diagnostic accuracy of each miRNA and the combination of miRNAs. External validation was performed using quantitative reverse transcription PCR. Among the 2,588 miRNAs, 26 miRNAs significantly increased in the NASH group than in the NAFL group. Among the 26 elevated miRNAs in the NASH group, 8 miRNAs were selected, and in silico analysis was performed. Only four miRNAs (miR-21-5p, miR-151a-3p, miR-192-5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis. The combination of the four miRNAs showed satisfactory diagnostic accuracy for NASH (AUC 0.875; 95% CI 0.676–0.973). External validation revealed similar diagnostic accuracy for NASH (AUC 0.874; 95% CI 0.724–0.960). NASH represents significantly distinct miRNA expression profile compared with NAFL. The combination of serum circulating miRNAs can be used as a novel biomarker for the NASH diagnosis in NAFLD.
Journal Article
Neutralization Method of Ransomware Detection Technology Using Format Preserving Encryption
Ransomware is one type of malware that involves restricting access to files by encrypting files stored on the victim’s system and demanding money in return for file recovery. Although various ransomware detection technologies have been introduced, existing ransomware detection technologies have certain limitations and problems that affect their detection ability. Therefore, there is a need for new detection technologies that can overcome the problems of existing detection methods and minimize the damage from ransomware. A technology that can be used to detect files infected by ransomware and by measuring the entropy of files has been proposed. However, from an attacker’s point of view, neutralization technology can bypass detection through neutralization using entropy. A representative neutralization method is one that involves decreasing the entropy of encrypted files by using an encoding technology such as base64. This technology also makes it possible to detect files that are infected by ransomware by measuring entropy after decoding the encoded files, which, in turn, means the failure of the ransomware detection-neutralization technology. Therefore, this paper derives three requirements for a more sophisticated ransomware detection-neutralization method from the perspective of an attacker for it to have novelty. These requirements are (1) it must not be decoded; (2) it must support encryption using secret information; and (3) the entropy of the generated ciphertext must be similar to that of plaintext. The proposed neutralization method satisfies these requirements, supports encryption without decoding, and applies format-preserving encryption that can adjust the input and output lengths. To overcome the limitations of neutralization technology using the encoding algorithm, we utilized format-preserving encryption, which could allow the attacker to manipulate the entropy of the ciphertext as desired by changing the expression range of numbers and controlling the input and output lengths in a very free manner. To apply format-preserving encryption, Byte Split, BinaryToASCII, and Radix Conversion methods were evaluated, and an optimal neutralization method was derived based on the experimental results of these three methods. As a result of the comparative analysis of the neutralization performance with existing studies, when the entropy threshold value was 0.5 in the Radix Conversion method, which was the optimal neutralization method derived from the proposed study, the neutralization accuracy was improved by 96% based on the PPTX file format. The results of this study provide clues for future studies to derive a plan to counter the technology that can neutralize ransomware detection technology.
Journal Article
Barrier coatings with various types of cellulose nanofibrils and their barrier properties
Needs for biodegradable packaging materials are growing to reduce the negative environmental impact of petroleum-based polymer packaging. Barrier paper packaging is in demand as environmentally-friendly barrier coating materials to improve biodegradability and recyclability. Cellulose nanofibril (CNF) is considered an alternative to conventional polymers for barrier coatings due to the barrier properties of its films. In this work, various types of CNFs were prepared and coated on linerboard and wood-free paper to evaluate the barrier properties of these papers against air, liquid water, water vapor, oxygen, and grease, and the major factors of the barrier performance of the CNFs-based coatings were investigated. A coat weight of at least 10 g/m2 was desirable to impart efficient the barrier properties to papers. The average fibril size and hydrophobicity were strongly related to the barrier properties. CNFs with smaller fibril sizes are beneficial for enhancing barrier properties, and hydrophobization improves the water resistance. Hydrophobic functional groups with sufficient chain lengths decreased the water vapor barrier properties. The average fibril diameter of CNFs may be related to the air resistance, oxygen barrier properties, and grease resistance.Graphic abstract
Journal Article