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"Lee, T."
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Epigenetic Regulation by Long Noncoding RNAs
Recent studies show that transcription of the mammalian genome is not only pervasive but also enormously complex. It is estimated that an average of 10 transcription units, the vast majority of which make long noncoding RNAs (lncRNAs), may overlap each traditional coding gene. These lncRNAs include not only antisense, intronic, and intergenic transcripts but also pseudogenes and retrotransposons. Do they universally have function, or are they merely transcriptional by-products of conventional coding genes? A glimpse into the molecular biology of multiple emerging lncRNA systems reveals the \"Wild West\" landscape of their functions and mechanisms and the key problems to solve in the years ahead toward understanding these intriguing macromolecules.
Journal Article
The development of the American public accountancy profession : Scottish chartered accountants and the early American public accountancy profession
\"This book presents a unique series of research biographies of professional accountants who immigrated to the United States and developed their careers there in the late nineteenth, and early twentieth, century. Until now, little has been written about the positive impact of immigrant professionals on American life.\"--Jacket.
Book
Quantum spin liquids unveil the genuine Mott state
The localization of charge carriers by electronic repulsion was suggested by Mott in the 1930s to explain the insulating state observed in supposedly metallic NiO. The Mott metal–insulator transition has been subject of intense investigations ever since1–3—not least for its relation to high-temperature superconductivity4. A detailed comparison to real materials, however, is lacking because the pristine Mott state is commonly obscured by antiferromagnetism and a complicated band structure. Here we study organic quantum spin liquids, prototype realizations of the single-band Hubbard model in the absence of magnetic order. Mapping the Hubbard bands by optical spectroscopy provides an absolute measure of the interaction strength and bandwidth—the crucial parameters that enter calculations. In this way, we advance beyond conventional temperature–pressure plots and quantitatively compose a generic phase diagram for all genuine Mott insulators based on the absolute strength of the electronic correlations. We also identify metallic quantum fluctuations as a precursor of the Mott insulator–metal transition, previously predicted but never observed. Our results suggest that all relevant phenomena in the phase diagram scale with the Coulomb repulsion U, which provides a direct link to unconventional superconductivity in cuprates and other strongly correlated materials.
Journal Article
Everything here is beautiful
\"Two sisters--Miranda, the older, responsible one, always her younger sister's protector; Lucia, the headstrong, unpredictable one, whose impulses are huge and, often, life changing. When their mother dies and Lucia starts hearing voices, it is Miranda who must find a way to reach her sister. But Lucia impetuously plows ahead, marrying a bighearted, older man only to leave him, suddenly, to have a baby with a young Latino immigrant. She moves her new family from the States to Ecuador and back again, but the bitter constant is that she is, in fact, mentally ill. Lucia lives life on a grand scale, until, inevitably, she crashes to earth. Miranda leaves her own self-contained life in Switzerland to rescue her sister again--but only Lucia can decide whether she wants to be saved. The bonds of sisterly devotion stretch across oceans--but what does it take to break them? Told in alternating points of view, Everything Here Is Beautiful is, at its heart, the story of a young woman's quest to find fulfillment and a life unconstrained by her illness. But it's also an unforgettable, gut-wrenching story of the sacrifices we make to truly love someone--and when loyalty to one's self must prevail over all\"-- Provided by publisher.
Book
Isotopic constraint on the twentieth-century increase in tropospheric ozone
Tropospheric ozone (O
3
) is a key component of air pollution and an important anthropogenic greenhouse gas
1
. During the twentieth century, the proliferation of the internal combustion engine, rapid industrialization and land-use change led to a global-scale increase in O
3
concentrations
2
,
3
; however, the magnitude of this increase is uncertain. Atmospheric chemistry models typically predict
4
–
7
an increase in the tropospheric O
3
burden of between 25 and 50 per cent since 1900, whereas direct measurements made in the late nineteenth century indicate that surface O
3
mixing ratios increased by up to 300 per cent
8
–
10
over that time period. However, the accuracy and diagnostic power of these measurements remains controversial
2
. Here we use a record of the clumped-isotope composition of molecular oxygen (
18
O
18
O in O
2
) trapped in polar firn and ice from 1590 to 2016
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, as well as atmospheric chemistry model simulations, to constrain changes in tropospheric O
3
concentrations. We find that during the second half of the twentieth century, the proportion of
18
O
18
O in O
2
decreased by 0.03 ± 0.02 parts per thousand (95 per cent confidence interval) below its 1590–1958
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mean, which implies that tropospheric O
3
increased by less than 40 per cent during that time. These results corroborate model predictions of global-scale increases in surface pollution and vegetative stress caused by increasing anthropogenic emissions of O
3
precursors
4
,
5
,
11
. We also estimate that the radiative forcing of tropospheric O
3
since 1850
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is probably less than +0.4 watts per square metre, consistent with results from recent climate modelling studies
12
.
Isotope data from polar firn and ice are used to constrain the increase in tropospheric ozone between 1850 and 2005
ad
.
Journal Article
The healing art of tai chi : becoming one with nature
\"Is tai chi a stretching exercise, deep-breathing program, martial art, dance or prayer? Yes, it's all those and more. Tai chi, like many ancient Eastern practices, does not fit strict Western categories. Tai chi, together with the extraordinary self-healing method developed by Dr Lee, offers relief for stress, breathing disorders, muscular ailments, chronic headaches, and a variety of modern office- and sports-related complaints, as well as for deep emotional distress. Few today are as well positioned to explain the healing powers of tai chi as Dr. Martin Lee, a renowned engineering physicist and tai chi master. He and his wife, Emily, also a tai chi master, are the only Americans to have studied with Yu Pen-Shih, one of China's foremost ch'i kung masters. Dr. Lee has developed a groundbreaking practical program that combines Eastern and Western approaches to wellness, which he calls \"physical philosophy.\" Its goal is to help people become \"one with nature,\" a Buddhist term for the natural restoration of true health. The rewards of one-with-nature tai chi are inner happiness, self-control, self-realization, and self-healing. Each one of these benefits receives individual attention, complete with the 64 tai chi forms, thoroughly illustrated with photographs and diagrams. The central focus is on the flow of energy -- the chi, or \"inner breath\" -- that tai chi evokes through Lee's four basic instructions: Relax. Breathe. Feel the earth. Do nothing extra. Here is a valuable health, exercise, and meditation program that combines ancient spiritual insights with advanced scientific knowledge and important original discoveries\"-- Provided by publisher.
Book
Identifying and Interrupting Superspreading Events—Implications for Control of Severe Acute Respiratory Syndrome Coronavirus 2
It appears inevitable that severe acute respiratory syndrome coronavirus 2 will continue to spread. Although we still have limited information on the epidemiology of this virus, there have been multiple reports of superspreading events (SSEs), which are associated with both explosive growth early in an outbreak and sustained transmission in later stages. Although SSEs appear to be difficult to predict and therefore difficult to prevent, core public health actions can prevent and reduce the number and impact of SSEs. To prevent and control of SSEs, speed is essential. Prevention and mitigation of SSEs depends, first and foremost, on quickly recognizing and understanding these events, particularly within healthcare settings. Better understanding transmission dynamics associated with SSEs, identifying and mitigating high-risk settings, strict adherence to healthcare infection prevention and control measures, and timely implementation of nonpharmaceutical interventions can help prevent and control severe acute respiratory syndrome coronavirus 2, as well as future infectious disease outbreaks.
Journal Article
Potential crosstalk of oxidative stress and immune response in poultry through phytochemicals — A review
Phytochemicals which exist in various plants and fungi are non-nutritive compounds that exert numerous beneficial bioactive actions for animals. In recent years following the restriction of antibiotics, phytochemicals have been regarded as a primal selection when dealing with the challenges during the producing process in the poultry industry. The selected fast-growing broiler breed was more fragile when confronting the stressors in their growing environments. The disruption of oxidative balance that impairs the production performance in birds may somehow be linked to the immune system since oxidative stress and inflammatory damage are multi-stage processes. This review firstly discusses the individual influence of oxidative stress and inflammation on the poultry industry. Next, studies related to the application of phytochemicals or botanical compounds with the significance of their antioxidant and immunomodulatory abilities are reviewed. Furthermore, we bring up nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor kappa B (NF-κB) for they are respectively the key transcription factors involved in oxidative stress and inflammation for elucidating the underlying signal transduction pathways. Finally, by the discussion about several reports using phytochemicals to regulate these transcription factors leading to the improvement of oxidative status, heme oxygenase-1 gene is found crucial for Nrf2-mediated NF-κB inhibition.
Journal Article