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"Lee, Young Kyung"
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Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte Sonchus brachyotus DC
There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated from the halophyte Sonchus brachyotus DC. The structures of the compounds were determined using spectroscopic methods, including 1D and 2D NMR spectra, MS data, and optical rotation values. Compounds 4 and 5 were characterized by the position of p-hydroxyphenylacetyl group in the sugar moiety. In the evaluation of anti-inflammatory effects on LPS-activated RAW264.7 macrophages, compound 1, 5α,6βH-eudesma-3,11(13)-dien-12,6α-olide, potently suppressed the expression of iNOS and COS-2, as well as the production of TNF-α, IL-6, and IL-10. Treatment of 1 regulates the Nrf2/HO-1 pathway.
Journal Article
A Study on the Factors Influencing Residents’ Intention of Continuous Residence in Innovation Cities: The Case of South Korea
This study examined the relationship between residential environment satisfaction, neighbor relations, and the intention of continuous residence. Previous research has not comprehensively analyzed the combined effects of these factors. Accordingly, this study investigated the influence of residential environment satisfaction on the intention of continuous residence and analyzed the mediating role of neighbor relations. Residential environments were categorized into commercial facilities, medical facilities, childcare/educational facilities, and cultural facilities. Respondents aged 20 years and above were selected from Innovation Cities where public institution relocation had been completed. Data were collected from 1606 participants through an online survey. Hypotheses were tested using mediation analysis. The results showed that residential environment satisfaction positively influenced the intention of continuous residence, with satisfaction with medical facilities having the strongest effect. In addition, neighbor relations had both direct and indirect positive effects on the intention of continuous residence, underscoring their importance in encouraging residents to remain. In many developing countries where the private market is less developed, state-owned enterprises play a crucial role in the national economy, and development is often concentrated around their locations. In the long term, relocating public institutions could serve as a strategy to address regional disparities. The findings of this study thus offer important policy implications.
Journal Article
Residential environmental satisfaction, social capital, and place attachment: the case of Seoul, Korea
This study examines the relationship between residential environmental satisfaction, social capital, and place attachment. Previous studies on place attachment and residential environments have not fully considered the components of residential environments or executed an integrated analysis. This study includes diverse aspects of residential environmental satisfaction such as accessibility, comfort, and safety, which permits a comparison of the influence of each element. Furthermore, this study examined the mediating effect of social capital between residential environments and place attachment. Online surveys were conducted with 750 residents in the metropolitan city of Seoul, Korea, and mediation regression analysis as employed. The results indicated that residential environmental satisfaction had a positive effect on place attachment. In particular, accessibility had the greatest effect on place attachment. Furthermore, social capital had a mediating effect on all sub-components of residential environments. Today, many countries, including China and India, pursue and experience rapid urbanization much like Seoul, which has undergone it over several decades. However, this causes a variety of urban problems that might hinder long-term sustainable development. Therefore, this study suggests that the importance of qualitative development for sustainability should be recognized and incorporated together with quantitative development.
Journal Article
Factors Influencing Urban Livability in Seoul, Korea: Urban Environmental Satisfaction and Neighborhood Relations
This study examines the correlations between urban environmental satisfaction, neighborhood relations, and livability. Previous studies on livability have insufficiently dealt with urban environments and neighborhood relations and have failed to conduct an integrated analysis that considers the causal relationships between these factors. To fill these knowledge gaps, this study includes urban environmental satisfaction and neighborhood relations as factors affecting livability. Moreover, this study verified the mediating effect of neighborhood relations between urban environmental satisfaction and livability. Online surveys were carried out with 750 residents in Seoul, South Korea, and the structural equation model (SEM) was employed. The results indicated that a higher level of urban environmental satisfaction affected livability positively. In particular, the accessibility had the greatest effect on livability. In addition, neighborhood relations had a mediating effect on the pleasantness and safety of urban environments. Today, many developing countries are undergoing rapid urbanization, as Seoul has experienced in the past. However, this can cause a number of simultaneous side effects, which lower livability. Furthermore, this leads to population decline which might hinder urban sustainability. Therefore, this study suggests important policy implications for achieving urban sustainability by improving livability.
Journal Article
Relationship between Physical Environment Satisfaction, Neighborhood Satisfaction, and Quality of Life in Gyeonggi, Korea
This study examined the relationship between physical environment satisfaction, neighborhood satisfaction, and quality of life (QoL) in Gyeonggi, Korea. As previous QoL studies have rarely dealt with residential environments or examined the interactions between the physical and social factors in residential environments, to close these knowledge gaps, this study took physical and social environment satisfaction factors as relevant influences on QoL. This study also verified the moderating effect of neighborhood satisfaction on QoL through physical environment satisfaction. This study analyzed a Quality of Life Survey that was conducted in Gyeonggi, Korea. The total number of samples in the survey was 20,000, covering all 31 districts in Gyeonggi Province. In addition, multistage stratified sampling based on the number of household members and housing types was applied to the sample design. This increases the representation of the data. As a result, it was found that higher satisfaction with the physical and neighborhood factors positively affected QoL, with satisfaction with the facilities having the most obvious effect. Neighborhood satisfaction was found to have a moderating effect between safety satisfaction and QoL. Many developing countries have tended to pursue quantitative growth with a focus on economic aspects, which has undermined overall urban sustainability. However, recent urban management has also emphasized qualitative growth, such as resident QoL, as being just as important for urban sustainability. Therefore, this study’s results have important policy implications for qualitative urban growth.
Journal Article
Perception of Community Environment, Satisfaction with Local Government, and Quality of Life: The Case of Gyeonggi, Korea
This study examined the relationship between the perception of community environment, local government, and quality of life (QoL). Previous studies on QoL have not comprehensively analyzed factors related to community environments or local governments. Consequently, this study examined the influence of the perception of community environment on QoL and simultaneously analyzed the mediating effect of satisfaction with local government. Furthermore, this study divided the community environment into facility, safety, medical, and social environments, which enables comparisons to be made between the influences of each factor. This study analyzed the “2020 Residents’ Quality of Life Survey in Gyeonggi, Korea”. The survey included all 31 districts in Gyeonggi Province, and the total number of samples was 16,000. Moreover, a multilevel stratified sampling method was applied on the basis of the 31 districts and the number of households. Thus, the survey properly reflects the regional characteristics of Gyeonggi Province. The analysis results were as follow: First, perception of community environment had a positive influence on QoL. In particular, the safety environment had the greatest effect on QoL. Therefore, it is necessary to focus more on improving the safety environment in the community. Second, satisfaction with local government had a mediating effect between facility environment, medical environment, social environment, and QoL. This means that satisfaction with local government is an important factor in increasing residents’ QoL. Presently, developing countries such as China, the Philippines, and Myanmar are still pursuing “rapid urbanization” while focusing only on quantitative development. However, this can generate various problems regarding social sustainability. Thus, this study provides important implications for these developing countries.
Journal Article
Antibiofilm Activity of Phorbaketals from the Marine Sponge Phorbas sp. against Staphylococcus aureus
Biofilm formation by Staphylococcus aureus plays a critical role in the persistence of chronic infections due to its tolerance against antimicrobial agents. Here, we investigated the antibiofilm efficacy of six phorbaketals: phorbaketal A (1), phorbaketal A acetate (2), phorbaketal B (3), phorbaketal B acetate (4), phorbaketal C (5), and phorbaketal C acetate (6), isolated from the Korean marine sponge Phorbas sp. Of these six compounds, 3 and 5 were found to be effective inhibitors of biofilm formation by two S. aureus strains, which included a methicillin-resistant S. aureus. In addition, 3 also inhibited the production of staphyloxanthin, which protects microbes from reactive oxygen species generated by neutrophils and macrophages. Transcriptional analyses showed that 3 and 5 inhibited the expression of the biofilm-related hemolysin gene hla and the nuclease gene nuc1.
Journal Article
Relationship between Public Service Satisfaction and Intention of Continuous Residence of Younger Generations in Rural Areas: The Case of Jeonbuk, Korea
This study examines the population decline of younger generations in rural areas, the factors that influence the intention of continuous residence, and how these influences differ based on regional economic potential. Previous studies on intention of continuous residence lack some discussion of the role of local governments. Therefore, satisfaction with public services provided by local governments was considered as a main factor. Specifically, this study analyzed the effect of public service satisfaction on intention of continuous residence and compared this influence according to regional economic potential. This study selected respondents aged between 25 and 49 years in Jeonbuk Province, Korea. Data were collected from 980 people through an online survey, and multistage stratified sampling based on the number of residents by district and resident ages was applied to the sample design. To test the hypothesis, the study conducted a moderating effect analysis using the categorical moderator reflected by regional economic potential. The empirical analysis shows that housing support and residential environment management of public service satisfaction had positive effects on intention of continuous residence. Housing support services in particular had a stronger influence. In addition, the effect of housing support on intention of continuous residence was further strengthened in regions with low economic potential. The results of this study provide policy implications for developing countries facing a population decline in rural areas due to regional disparities between urban and rural areas.
Journal Article
The continuation and recommendation intention of artificial intelligence-based voice assistant systems (AIVAS): the influence of personal traits
PurposeBased on the post-acceptance model of information system continuance (PAMISC), this study investigates the influence of the early-stage users' personal traits (specifically personal innovativeness and technology anxiety) and ex-post instrumentality perceptions (specifically price value, hedonic motivation, compatibility and perceived security) on social diffusion of smart technologies measured by the intention to recommend artificial intelligence-based voice assistant systems (AIVAS) to others.Design/methodology/approachSurvey data from 400 US AIVAS users were collected and analyzed with Statistical Product and Service Solutions (SPSS) 18.0 and the partial least square technique using advanced analysis of composites (ADANCO) 2.1.FindingsAIVAS technology is presently at the early stage of market penetration (about 25% of market penetration in the USA). A survey of AIVAS technology users reveals that personal innovativeness is directly and indirectly (through confirmation and continuance) associated with a stronger intention to recommend the use of the device to others. Confirmation is associated with all four ex-post instrumentality perceptions (hedonic motivation, compatibility, price value and perceived security). Among the four, however, only hedonic motivation and compatibility are significant predictors of satisfaction, which lead to use continuance and, eventually, intention to recommend. Finally, technology anxiety is found to be indirectly (but not directly) associated with a lower intention to recommend.Originality/valueThis is the first study conducted on the early-stage AIVAS users that evaluates the influence of both personal traits and ex-post instrumentality perceptions on users' intention for continuance and recommendation to others.
Journal Article