Explore the vast range of titles available.

Objective: To review the accuracy and coverage of Department of Health returns on provision of mental health residential accommodation. Design: Department of Health returns on provision of mental health residential accommodation in seven English Districts were compared with 'true provision' in these districts. Setting: Seven English Health Districts. Subjects: Two data sets of residential facilities with places for those with mental health problems: (a) official returns to the Department of Health compiled by Local and Health Authorities; (b) data collected by health districts using criteria defined by the Royal College of Psychiatrists' Research Unit. Main outcome measures: The completeness of the Department of Health returns and variations between districts. Results: Department of Health returns fail to identify 55% of facilities (n =130)which contain 51% of all mental health places. Of these 130 facilities not identified, 89 (68%) were omitted because they do not meet criteria for inclusion.

The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h2=0.53–0.90, p<10−5), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests that the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application. •Data from 488 HCP subjects were processed using ENIGMA-DTI protocols.•Heritability in HCP sample was compared to ENIGMA-DTI joint-analytical estimates.•Estimates from HCP and ENIGMA-DTI were highly correlated.•Genetic contribution to white matter integrity is consistent across populations.•Defines common genetic search space for future gene-discovery studies

Integration of diverse synaptic inputs is a basic neuronal operation that relies on many neurocomputational principles, one of which is neural summation. However, we lack empirical understanding of neuronal summation in the human brains in vivo. Here, we explored the effect of neural summation on the motor cortex using two subthreshold pulses of transcranial magnetic stimulation (TMS), each with intensities ranging from 60 to 95 % of the resting motor threshold (RMT) and interstimulus interval (ISI) varying from 1 to 25 ms. We found that two subthreshold TMS pulses can produce suprathreshold motor response when ISIs were less than 10 ms, most prominent at 1, 1.5 and 3 ms. This facilitatory, above-threshold response was evident when the intensity of the subthreshold pulses was above 80 % of RMT but was absent as the intensity was 70 % or below. Modeling of the summation data across intensity suggested that they followed an exponential function with excellent model fitting. Understanding the constraints for inducing summation of subthreshold stimulations to generate above-threshold response may have implications in modeling neural operations and potential clinical applications.

A study reviewed the accuracy and coverage of UK Department of Health (DOH) returns on provision of mental health residential accommodation. DOH returns fail to identify 55% of facilities which contain 51% of all mental health places, and of these 130 facilities not identified, 68% were omitted because they do not meet criteria for inclusion.