Explore the vast range of titles available.

\"Decades from now, the man who was Wolverine endured the deaths of his fellow heroes, the slaughter of his family by the hillbilly Hulk Gang, and the murder of his closest friend, Hawkeye. So when Old Man Logan wakes up in the present to discover a world not yet gone to hell, he's determined to kill whomever it takes to ensure the Wasteland he knew never comes to pass!\"--Page [4] of cover, volume 1.

Outdoor play is a fundamental part of childhood. Children's participation in outdoor play connects them to nature and the land, and supports their role in the natural world. Early learning and child care (ELCC) centers provide opportunities for outdoor play; however, barriers toward the provision of outdoor play exist, including educator attitudes, policies and procedures, outdoor space limitations, and adverse weather conditions. The Promoting Early Childhood Outside (PRO-ECO) 2.0 study is a community-based research partnership with Indigenous Knowledge Keepers and Elders, Indigenous and early childhood organizations, early childhood education faculty, ELCC centers, and families, aiming to expand outdoor play in ELCC centers. This paper provides an overview of the community-based design process, guided by the 5 R's-Respect, Relevance, Responsibility, Reciprocity, and Relationship-and the resulting study protocol for the mixed methods waitlist control cluster randomized trial. This study considered a 5 R's research approach from its inception, beginning with the formation of a Steering Committee and over a year of relationship building before formal study activities commenced. A key early focus was collaboratively identifying project values through an iterative process. Collectively, we worked to promote equity, disrupt power dynamics, and embed Indigenous data sovereignty principles into research agreements, marking a significant departure from traditional Western research processes. The PRO-ECO program and study protocol are implemented in partnership with 10 ELCC centers delivering licensed full-day, year-round care to children aged 2.5-6 years in rural and urban areas of British Columbia, Canada. The PRO-ECO program includes 4 components to address common barriers to outdoor play in ELCC settings. Primary outcome measures include the proportion and diversity of observed nature play behavior during dedicated outdoor times at ELCC centers as measured through observational behavior mapping. Secondary outcomes include changes in educator attitudes, quality of ELCC outdoor play space, and children's perspectives of their experiences at ELCC centers. Outcome data are collected at baseline, and 6 months and 12 months post baseline. The community's perspectives (educators, children, and families) on the project are assessed qualitatively to understand the acceptability of the PRO-ECO program. Mixed-effect models will test the effect of the PRO-ECO program on quantitative outcomes. Qualitative data will support the interpretation of quantitative findings and provide evidence on project acceptability. Participant recruitment for this study began in August 2023, and data collection was completed in March 2025. A total of 229 children, 91 staff and early childhood educators, and 40 family members were recruited to participate in this study. The PRO-ECO 2.0 study uses a rigorous experimental design within a community-based research project. The 5 R's approach grounded our work in shared values, disrupting traditional academic power relations and weaving together Indigenous and Western worldviews in the context of academic research. ClinicalTrials.gov NCT05626595; https://clinicaltrials.gov/study/NCT05626595. DERR1-10.2196/77956.

\"Oliver Queen thought he had it all figured out. As the heroic archer Green Arrow, he'd finally found a sense of purpose, friends to aid him, even a place on the Justice League of America. But now, he's not even sure where he came from... or who he came from. As Green Arrow discovers that his stranding on a desert island was more than just an accident, there seem to be more sinister forces at work behind all these sudden revelations. The Queen family is embroiled in a war generations old. A war of clans. A war of outsiders. Acclaimed creative team Jeff Lemire (ANIMAL MAN) and Andrea Sorrentino (I, VAMPIRE) take Green Arrow on his most challenging adventure yet. Collects GREEN ARROW #17-34, GREEN ARROW FUTURES END #1, and GREEN ARROW SECRET ORIGINS\"-- Provided by publisher.

\"Oliver Queen thought he had it all figured out. As the heroic archer Green Arrow, he'd finally found a sense of purpose, friends to aid him, even a place on the Justice League of America. But now he's not even sure where he came from... or whom he came from. As Green Arrow discovers that his stranding on a desert island was more than just an accident, there seem to be more sinister forces at work behind all these sudden revelations. The Queen family is embroiled in a war generations old. A war of clans. A war of outsiders.\"-- Provided by publisher.

The research comes from the Early Development Instrument from the Human Early Learning Partnership at UBC, the Child Friendly Survey results from DeltaKids, and Is \"Good\", Good Enough? A report on the health well-being of children youth in BC from Child Health BC and the BC Ministry.

Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene expression atlas of the Drosophila larval central nervous system composed of 131,077 single cells across three developmental stages (1 h, 24 h and 48 h after hatching). We identify 67 distinct cell clusters based on the patterns of gene expression. These include 31 functional mature larval neuron clusters, 1 ring gland cluster, 8 glial clusters, 6 neural precursor clusters, and 13 developing immature adult neuron clusters. Some clusters are present across all stages of larval development, while others are stage specific (such as developing adult neurons). We identify genes that are differentially expressed in each cluster, as well as genes that are differentially expressed at distinct stages of larval life. These differentially expressed genes provide promising candidates for regulating the function of specific neuronal and glial types in the larval nervous system, or the specification and differentiation of adult neurons. The cell transcriptome Atlas of the Drosophila larval nervous system is a valuable resource for developmental biology and systems neuroscience and provides a basis for elucidating how genes regulate neural development and function.

Background Risk-reducing mastectomy (RRM) is offered to women with a BRCA1 or BRCA2 pathogenic variant, however, there are limited data on the impact on breast cancer mortality. Methods Participants were identified from a registry of women with BRCA1/2 pathogenic variants. We used a pseudo-randomised trial design and matched one woman with a RRM to one woman without a RRM on year of birth, gene, and country. We estimated the hazard ratio (HR) and 95% confidence intervals (CI) for dying of breast cancer in the follow-up period. Results There were 1654 women included; 827 assigned to the RRM arm and 827 assigned to the control arm. After a mean follow-up of 6.3 years, there were 20 incident breast cancers (including 15 occult cancers) and two breast cancer deaths in the RRM arm, and 100 incident breast cancers and 7 breast cancer deaths in the control arm (HR = 0.26; 95% CI 0.05–1.35; p  = 0.11). The probability of dying of breast cancer within 15 years after RRM was 0.95%. Conclusions In women with a BRCA1 or BRCA2 pathogenic variant, RRM reduces the risk of breast cancer, and the probability of dying of breast cancer is low.

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI , SPZ1 , MUTYH , MAP2K4 , FETUB , and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR = 0.42, 95% CI: 0.21–0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21–1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features. Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.