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"Lemoine, M."
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Joining the blunt and the pointy end of the spear: towards a common framework of joint action, human–machine cooperation, cooperative guidance and control, shared, traded and supervisory control
To introduce this special issue of shared and cooperative control, we will look into history of tools in cooperation between humans and aim to unify the plethora of related concepts and definitions that have been proposed in recent years, such as shared control, human–machine cooperation and cooperative guidance and control. Concretely, we provide definitions to relate these concepts and sketch a unifying framework of shared and cooperative control that sees the different concepts as different perspectives or foci on a common design space of shared intentionality, control and cooperation between humans and machines. One working hypothesis which the article explores is that shared control can be understood as cooperation at the control layer, while human–machine cooperation can include shared control, but can also extend towards cooperation at higher layers, e.g., of guidance and navigation, of maneuvers and goals. The relationship between shared control and human–machine cooperation is compared to the relationship between the sharp, pointy tip and the (blunt) shaft of a spear. Shared control is where cooperation comes sharply into effect at the control layer, but to be truly effective it should be supported by cooperation on all layers beyond the operational layer, e.g., on the tactical and strategic layer. A fourth layer addresses the meta-communication about the cooperation and supports the other three layers in a traversal way.
Journal Article
Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD
Background
Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are understudied.
Methods
The National Health and Nutrition Examination Survey (NHANES), with a focus on dietary assessment, provides a unique opportunity to explore relationships between omega-3 intake and morbidity in respiratory diseases marked by inflammation in the United States (US) population. We investigated relationships between ALA or EPA + DHA intake and respiratory symptoms among US adults with COPD, as well as variation in relationships based on personal characteristics or exposures.
Results
Of 878 participants, mean age was 60.6 years, 48% were current smokers, and 68% completed high school. Omega-3 intake was, 1.71 ± 0.89 g (ALA), and 0.11 ± 0.21 g (EPA + DHA). Logistic regression models, adjusting for age, gender, race, body mass index, FEV
1
, education, smoking status, pack-years, total caloric intake, and omega-6 (linoleic acid, LA) intake demonstrated no primary associations between omega-3 intake and respiratory symptoms. Interaction terms were used to determine potential modification of relationships by personal characteristics (race, gender, education) or exposures (LA intake, smoking status), demonstrating that at lower levels of LA intake, increasing ALA intake was associated with reduced odds of chronic cough (p
int
= 0.015) and wheeze (p
int
= 0.037). EPA + DHA, but not ALA, was associated with reduced symptoms only among current smokers who did not complete high school.
Conclusions
Individual factors should be taken into consideration when studying the association of fatty acid intake on respiratory diseases, as differential responses may reveal susceptible subgroups.
Journal Article
Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients
The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers. In non-small cell lung cancer (NSCLC), we have previously showed that a high density of B cells within TLS (TLS-B cells) is positively correlated with tumor antigen-specific antibody responses and increased intratumor CD4 + T cell clonality. Here, we investigated the relationship between the presence of TLS-B cells and CD4 + T cell profile in NSCLC patients. The expression of immune-related genes and proteins on B cells and CD4 + T cells was analyzed according to their relationship to TLS-B density in a prospective cohort of 56 NSCLC patients. We observed that tumor-infiltrating T cells showed marked differences according to TLS-B cell presence, with higher percentages of naïve, central-memory, and activated CD4 + T cells and lower percentages of both immune checkpoint (ICP)-expressing CD4 + T cells and regulatory T cells (Tregs) in the TLS-B high tumors. A retrospective study of 538 untreated NSCLC patients showed that high TLS-B cell density was even able to counterbalance the deleterious impact of high Treg density on patient survival, and that TLS-B high Treg low patients had the best clinical outcomes. Overall, the correlation between the density of TLS-B high tumors with early differentiated, activated and non-regulatory CD4 + T cell cells suggest that B cells may play a central role in determining protective T cell responses in NSCLC patients.
Journal Article
Monthly mobility inferred from isoscapes and laser ablation strontium isotope ratios in caprine tooth enamel
Strontium isotopic analysis of sequentially formed tissues, such as tooth enamel, is commonly used to study provenance and mobility of humans and animals. However, the potential of 87Sr/86Sr in tooth enamel to track high-frequency movements has not yet been established, in part due to the lack of data on modern animals of known movement and predictive model of isotope variation across the landscape. To tackle this issue, we measured the 87Sr/86Sr in plant samples taken from a 2000 km2 area in the Altai Mountains (Mongolia), and the 87Sr/86Sr in tooth enamel of domestic caprines whose mobility was monitored using GPS tracking. We show that high-resolution, sequential profiles of strontium isotope composition of tooth enamel reliably reflect the high-frequency mobility of domestic livestock and that short-term residency of about 45 days can be resolved. This offers new perspectives in various disciplines, including forensics, ecology, palaeoanthropology, and bioarchaeology.
Journal Article
Land water storage variability over West Africa estimated by Gravity Recovery and Climate Experiment (GRACE) and land surface models
Land water storage plays a fundamental role in the West African water cycle and has an important impact on climate and on the natural resources of this region. However, measurements of land water storage are scarce at regional and global scales and especially in poorly instrumented endorheic regions, such as most of the Sahel, where little useful information can be derived from river flow measurements and basin water budgets. The Gravity Recovery and Climate Experiment (GRACE) satellite mission provides an accurate measurement of the terrestrial gravity field variations from which land water storage variations can be derived. However, their retrieval is not straightforward, and different methods are employed, which results in different water storage GRACE products. On the other hand, water storage can be estimated by land surface modeling forced with observed or satellite‐based boundary conditions, but such estimates can be highly model dependent. In this study, land water storage by six GRACE products and soil moisture estimations by nine land surface models (run within the framework of the African Monsoon Multidisciplinary Analysis Land Surface Intercomparison Project (ALMIP)) are evaluated over West Africa, with a particular focus on the Sahelian area. The water storage spatial distribution, including zonal transects, its seasonal cycle, and its and interannual variability, are analyzed for the years 2003–2007. Despite the nonnegligible differences among the various GRACE products and among the different models, a generally good agreement between satellite and model estimates is found over the West Africa study region. In particular, GRACE data are shown to reproduce well the water storage interannual variability over the Sahel for the 5 year study period. The comparison between satellite estimates and ALMIP results leads to the identification of processes needing improvement in the land surface models. In particular, our results point out the importance of correctly simulating slow water reservoirs as well as evapotranspiration during the dry season for accurate soil moisture modeling over West Africa. Key Points GRACE interannual variability of TWS over the Sahel Importance of slow water reservoirs and dry season evapotraspiration in LSM Zonal distribution: comparison between GRACE and ALMIP
Journal Article
Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion
Chronic exposure to environmental pollutants is often associated with systemic inflammation. As such, cigarette smoking contributes to inflammation and lung diseases by inducing senescence of pulmonary cells such as pneumocytes, fibroblasts, and endothelial cells. Yet, how smoking worsens evolution of chronic inflammatory disorders associated with Th17 lymphocytes, such as rheumatoid arthritis, psoriasis, Crohn’s disease, and multiple sclerosis, is largely unknown. Results from human studies show an increase in inflammatory CD4
+
Th17 lymphocytes at blood- and pulmonary level in smokers. The aim of the study was to evaluate the sensitivity of CD4
+
Th17 lymphocytes to cigarette smoke-induced senescence. Mucosa-homing CCR6
+
Th17- were compared to CCR6
neg
-and regulatory T peripheral lymphocytes after exposure to cigarette smoke extract (CSE). Senescence sensitivity of CSE-exposed cells was assessed by determination of various senescence biomarkers (β-galactosidase activity, p16
Ink4a
- and p21 expression) and cytokines production. CCR6
+
Th17 cells showed a higher sensitivity to CSE-induced senescence compared to controls, which is associated to oxidative stress and higher VEGFα secretion. Pharmacological targeting of ROS- and ERK1/2 signalling pathways prevented CSE-induced senescence of CCR6
+
Th17 lymphocytes as well as VEGFα secretion. Altogether, these results identify mechanisms by which pro-oxidant environmental pollutants contribute to pro-angiogenic and pathogenic CCR6
+
Th17 cells, therefore potential targets for therapeutic purposes.
Journal Article
The Mexican bean beetle (Epilachna varivestis) regurgitome and insights into beetle-borne virus specificity
For nearly 400 million years, insects and plants have been embattled in an evolutionary arms race. Insects have developed diverse feeding strategies and behaviors in an effort to circumvent and overcome an extensive collection of plant defense tactics. Sap-sucking insects often inject saliva into hosts plants, which contains a suite of effector proteins and even microbial communities that can alter the plant's defenses. Lacking salivary glands, leaf-feeding beetles represent an interesting group of phytophagous insects. Feeding beetles regurgitate onto leaf surfaces and it is thought that these oral secretions influence insect-plant interactions and even play a role in virus-vector specificity. Since the molecular and biological makeup of the regurgitant is virtually unknown, we carried out RNA sequencing and 16S rDNA analysis on a major soybean pest, Epilachna varivestis, to generate the first ever beetle \"regurgitome\" and characterize its microbiome. Interestingly, the regurgitant is comprised of a rich molecular assortment of genes encoding putative extracellular proteins involved in digestion, molting, immune defense, and detoxification. By carrying out plant inoculation assays, we reinforced the fundamental role of the regurgitant in beetle-borne virus specificity. Ultimately, these studies begin to characterize the importance of regurgitant in virus transmission and beetle-plant interactions.
Journal Article
Risk factors, stroke rates and aspirin prescribing trends in the Canadian Fabry disease initiative cohort
Background
Fabry disease (FD) is an X-linked disorder caused by deleterious variants in
GLA.
Cardiovascular disease (CVD) causes premature mortality in FD. Hope for aspirin (acetylsalicylic acid, ASA) to reduce CVD risks in FD as primary prevention may have been tempered by the 2018 ARRIVE, ASCEND, and ASPREE clinical trials. It is unclear how new ASA guidance applies to FD patients, who have a high rate of young-onset, small vessel stroke compared with the general population.
Methods
Longitudinal data spanning 2007–2023 from patients in the Canadian Fabry Disease Initiative (CFDI) were analyzed retrospectively. Incident stroke and transient ischemic attack (TIA), other CVD events, FD-specific risk factors, and ASA/antiplatelet (“ASA/AP”) prescription before and after 2018 were compared between groups who never had an event (“primary prevention group”) to those who had incident stroke/TIA during the study. Stroke/TIA rates were compared within CFDI by sex and
GLA
variant severity, and in the CFDI compared to Canadian statistics by sex. Ten-year atherosclerotic CVD (ASCVD) risk was calculated using the 2013 ACC/AHA risk calculator. ASA/AP prescription rate was compared before and after 2018.
Results
Out of 641 patients, 57 had an incident stroke/TIA during the study, and 193 with complete data remained in the primary prevention group. Stroke/TIA rates were significantly higher among male patients (0.026 events per patient-year) than females (0.0098 events per patient-year), and higher among patients with severe
GLA
variants (males: 0.031 events per patient-year, females: 0.0096 events per patient-year) compared to those with attenuated variants (males: 0.011 events per patient-year, females: 0.0088 events per patient-year). No patients under 60 years at their incident stroke/TIA had high (≥ 10%) calculated 10-year ASCVD risk. Fewer patients were prescribed ASA/AP for primary prevention after 2018.
Conclusions
There was a high incidence of stroke/TIA in the younger CFDI cohort compared to the general Canadian population, despite low levels of traditional vascular risk factors as represented in 10-year estimated ASCVD risk. Primary prevention use of ASA has declined.
Journal Article