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Water manipulation is crucial for a wide range of engineering applications, such as microfluidics, heat transfer, desalination, and water harvesting. Despite scientific achievements in the past few decades, it remains challenging to achieve efficient and well‐controllable droplet transport in practical applications. In nature, creatures have evolved ingenious wisdom to manipulate water to adapt to their environments. Learning from nature and combining bioinspirations with advanced manufacturing technology are promising to fabricate excellent materials for directional water transport. In this review, we summarize the mechanisms of water droplet manipulation on various biological surfaces and review the recent progress in fabricating hydrophilic surfaces, hybrid hydrophilic/hydrophobic surfaces, and slippery lubricant‐infused porous surfaces (SLIPSs) with bioinspiration for water manipulation. These novel bioinspired materials have great potential in many fields, especially for water harvesting. Finally, current challenges and future perspectives in this field are proposed. We review the water manipulation mechanisms of creatures in nature and the recent progress of their bioinspired materials in three parts, hydrophilic surfaces, wettability‐patterned surfaces, and slippery lubricant‐infused porous surfaces.

Diabetes mellitus (DM), a chronic metabolic disease with a high global prevalence, has increasingly been recognized for its adverse effects on the male reproductive system, particularly spermatogenesis. This review systematically summarizes the multifaceted impacts of diabetes on spermatogenesis, encompassing molecular mechanisms such as oxidative stress, endocrine disruption, dysregulated gene expression, metabolic imbalance, apoptosis, microcirculation impairment, and chronic inflammation, as revealed by recent studies. The intricate effects of these mechanisms on sperm quality, reproductive function, and offspring health are also thoroughly explored. A key innovation of this review lies in integrating recent advances, especially those highlighting the roles of epigenetic modifications, mitochondrial dysfunction, and insulin resistance (IR)-related pathways in spermatogenesis. Furthermore, the review evaluates the potential of personalized interventions, including glycemic control, antioxidant therapies, and lifestyle modifications, providing a scientific foundation for the development of more effective preventive and therapeutic strategies. This comprehensive analysis offers forward-looking guidance for future research and clinical interventions addressing diabetes-associated male infertility.

Several challenges persist in China’s ginseng industry. Phoxim, chlorpyrifos, quintozene—unregistered pesticides primarily used as soil insecticides and fungicides—may pose high dietary risks. This study performed a thorough screening of potential pesticides used in Chinese ginseng cultivation, evaluated the long-term dietary risks for the ginseng-consuming group, and used the primary risk factors for ginseng in China and South Korea to compare the two nations’ pesticide usage scenarios. From 2020 to 2022, 325 pesticides and related compounds were screened in 15 major ginseng-producing counties and 3 commercial markets in Northeast China, and 39 pesticides and 3 metabolites were identified using gas chromatography–tandem mass spectrometry and liquid chromatography–tandem mass spectrometry, including allylmorph, pyrimethanil, pyraclostrobin, and other contaminants in Northeast China. Acute and chronic dietary risk assessment was performed using 0.009 kg as the maximum daily intake and 0.005 kg as the average daily intake, with adults as the exposed population. Based on these findings and reliable toxicological data, acute and chronic dietary risk quotients for ginseng were assessed, considering dietary intake and population exposure. The results indicate that ginseng products are generally safe and manageable, with acute and long-term dietary risks remaining within acceptable limits.

The simultaneous determination of 166 pesticides using dispersive liquid–liquid micro extraction combined with gas chromatography–tandem mass spectrometry and ultra-high performance liquid chromatography–tandem mass spectrometry (DLLME–GC-MS/MS+LC-MS/MS) is presented here. In this work, DLLME was extended to complex residues in the ginseng wine matrix. This study first focused on the selection of an appropriate solvent that enabled the dissolution of analytes from ginseng wine. The matrix-matched calibration curves showed good linearity in the range of 2–100 µg L−1 for all pesticides, with coefficients of determination of 0.977–1. The mean recoveries were in the range of 3–124%, with 133 pesticides in the range of 60–130%, and the relative standard deviations (RSDs) were between 0.4% and 31.4%. The limits of detection (LOD) and limits of quantitation (LOQ) were within the ranges of 0.14–140 and 0.5–470 ng L−1, respectively. Therefore, this analytical method contributes to residue analyses of 133 pesticides for the routine laboratory testing of ginseng wine. Research was also carried out by soaking the pesticide-positive samples in ginseng wine to monitor the migration and degradation of pesticides. The results showed that, the migration rates of thifluzamidewaslower than 60%, cyprodinil was 73.7, while azoxystrobin, pyrimethanil, carbendazim, dimethomorph, difenoconazole, pyraclostrobin, propiconazole, quintozene, pentachloroaniline, tebuconazole and phoximwere between 75% and 95%. Quintozene was more easily degraded into pentachloroaniline in the wine.

Superoxide dismutase 1 (SOD1) modulates intestinal barrier integrity and intestinal homeostasis as an antioxidant enzyme. Intestinal homeostasis is maintained by the intestinal stem cells (ISCs). However, whether and how SOD1 regulates ISCs is unknown. In this study, we established intestinal organoids from tamoxifen–inducible intestinal epithelial cell–specific Sod1 knockout ( Sod1 f/f ; Vil-creERT2 ) mice. We found that loss of Sod1 in organoids suppressed the proliferation and survival of cells and Lgr5 gene expression. SOD1 is known for nearly half a century for its canonical role as an antioxidant enzyme. We identified its enzyme-independent function in ISC: inhibition of SOD1 enzymatic activity had no impact on organoid growth, and enzymatically inactive Sod1 mutants could completely rescue the growth defects of Sod1 deficient organoids, suggesting that SOD1-mediated ISC growth is independent of its enzymatic activity. Moreover, Sod1 deficiency did not affect the ROS levels of the organoid, but induced the elevated WNT signaling and excessive Paneth cell differentiation, which mediates the occurrence of growth defects in Sod1 deficient organoids. In vivo, epithelial Sod1 loss induced a higher incidence of apoptosis in the stem cell regions and increased Paneth cell numbers, accompanied by enhanced expression of EGFR ligand Epiregulin (EREG) in the stromal tissue, which may compensate for Sod1 loss and maintain intestinal structure in vivo. Totally, our results show a novel enzyme-independent function of SOD1 in ISC growth under homeostasis.

To ascertain whether COVID-19 infection affects sperm quality and measure the scale of the effects. A cross sectional study and a longitudinal study were conducted during the SARS-CoV-2 pandemic (from September 7th 2022 to late January 2023) in China. 604 patients participated in the cross sectional study; 140 in the longitudinal study with 149 unaffected natural controls. The cross sectional study included participants who produce semen sample after COVID-19. The longitudinal study included COVID-19 positive participants who could provide semen samples before and after the infection. In addition, patients unaffected by the infection who could provide two consecutive semen samples over the same period were included as controls for the longitudinal study. Conventional sperm quality parameters including sperm count, motility, morphology and more recent parameters such as sperm DNA fragmentation index (DFI) and sperm chromatin immaturity were observed. In the cross sectional study, the exposure group demonstrated significantly lower total sperm count (159.58 × 10 6 vs. 185.42 × 10 6 , P  = 0.042), lower percentage of grade A sperms (5.37% vs. 8.45%, P  = 0.009), lower progressive motility (24.74 ± 14.96% vs. 28.73 ± 16.65%, P  = 0.023), lower total motility (32.04 ± 18.03% vs. 36.91 ± 20.86%, P  = 0.022), and higher sperm DFI (17.50% vs. 11.75%, P  = 0.030) than the controls. In the longitudinal study, after the infection, patients showed lower total sperm count (131.80 × 10 6 vs. 173.63 × 10 6 , Δd = -20.49 × 10 6 , P  = 0.018 ), lower percentage of grade A sperms ( 2.61% vs. 8.50%, Δd = -3.18%, P  < 0.001), lower progressive motility (19.82 ± 13.68% vs. 24.88 ± 14.97%, Δd = -5.07 ± 11.94%, P  < 0.001) and lower total motility (26.64 ± 17.35% vs. 32.25 ± 18.69%, Δd = -5.62 ± 14.30%, P  < 0.001) and higher DFI (32.10 ± 21.30% vs. 26.49 ± 18.54%, Δd = 5.61 ± 13.71%, P  < 0.039) than before the infection, while the negative controls showed the opposite changes. Finally, in the longitudinal study, after the infection, 59.29% of the COVID-19 positive patients showed deteriorated sperm concentration, 57.86% deteriorated total sperm count, 71.43% Grade A sperm, 65.00% progressive motility, 69.29% total motility, and 75.00% sperm DFI, while the changes in negative controls were all less than 40% ( P  < 0.002). COVID-19 was associated with poor sperm quality. The findings would be useful for clinicians to manage men with fertility problems who suffered COVID-19.

Moisture‐responsive actuators are widely used as energy‐harvesting devices due to their excellent ability to spontaneously and continuously convert external energy into kinetic energy. However, it remains a challenge to sustainably synthesize moisture‐driven actuators. Here, we present a sustainable zero‐waste emission methodology to prepare soft actuators using carbon nano‐powders and biodegradable polymers through a water evaporation method. Due to the water solubility and recyclability of the matrixes employed here, the entire synthetic process achieves zero‐waste emission. Our composite films featured strong figures of merit and capabilities with a 250° maximum bending angle under 90% relative humidity. Programmable motions and intelligent bionic applications, including walkers, smart switches, robotic arms, flexible excavators, and hand‐shaped actuators, were further achieved by modulating the geometry of the actuators. This sustainable method for actuators’ fabrication has great potential in large‐scale productions and applications due to its advantages of zero‐waste emission manufacturing, excellent recyclability, inherent adaptive integration, and low cost. Graphical : A sustainable zero‐waste emission methodology is developed to prepare soft actuators using carbon nano‐powders and biodegradable polymers. The entire synthetic process achieves zero‐waste emission due to the water solubility and recyclability of matrixes. The geometries of composite film could be designed and modulated for programmable motions and specific applications, including walkers, smart switches, robotic arms, flexible excavators, and hand‐shaped actuators.

Nucleic acid oxidation plays an important role in the pathophysiology progress of a variety of diseases. 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA oxidation, were the most widely used indicators for oxidative stress. The study investigated the relation between 8-oxo-dGsn, 8-oxo-Gsn, and CKD. 146 patients with CKD were divided into five disease stages, and their fasting blood and morning urine were collected. The levels of 8-oxo-dGsn and 8-oxo-Gsn in plasma and urine were quantified by LC-MS/MS. The ratio of urinary 8-oxo-Gsn to creatinine increased from stages 1 to 4 corresponding to the increased severity of CKD, but it decreased in stage 5. And plasma 8-oxo-Gsn gradually increased with the decline of renal function. In particular, the increased ratio of plasma and urine 8-oxo-Gsn in stage 5 exceeded the concentration of creatinine. This trend was similar to the estimated glomerular filtration rate (eGFR), which indicates that 8-oxo-Gsn could be an appropriate indicator for renal function. Our finding indicates that as the disease progresses, RNA oxidation is increased. The significant increase in the ratio of plasma and urinary 8-oxo-Gsn is a novel evaluation index of end-stage renal disease.

Abstract STUDY QUESTION Are dietary fat and fatty acid (FA) intakes related to the odds of asthenozoospermia? SUMMARY ANSWER Plant-based fat consumption was associated with decreased asthenozoospermia odds, while the consumption of animal-based monounsaturated fatty acid (MUFA) was positively related to asthenozoospermia odds. WHAT IS KNOWN ALREADY Dietary fat and FA are significant ingredients of a daily diet, which have been demonstrated to be correlated to the reproductive health of men. However, to date, evidence on fat and FA associations with the odds of asthenozoospermia is unclear. STUDY DESIGN, SIZE, DURATION The hospital-based case–control study was performed in an infertility clinic from June 2020 to December 2020. Briefly, 549 asthenozoospermia cases and 581 controls with normozoospermia were available for final analyses. PARTICIPANTS/MATERIALS, SETTING, METHODS We collected dietary data through a verified food frequency questionnaire of 110 food items. Asthenozoospermia cases were ascertained according to the World Health Organization guidelines. To investigate the correlations of dietary fat and FA consumptions with the odds of asthenozoospermia, we calculated the odds ratios (ORs) and corresponding 95% CIs through unconditional logistic regression models. MAIN RESULTS AND THE ROLE OF CHANCE Relative to the lowest tertile of consumption, the highest tertile of plant-based fat intake was inversely correlated to the odds of asthenozoospermia (OR = 0.68, 95% CI = 0.50–0.91), with a significant dose–response relation (OR = 0.85, 95% CI = 0.75–0.97, per standard deviation increment). Inversely, animal-based MUFA intake (OR = 1.49, 95% CI = 1.04–2.14) was significantly correlated to increased odds of asthenozoospermia, and an evident dose–response relation was also detected (OR = 1.24, 95% CI = 1.05-1.45, per standard deviation increment). Subgroup analyses showed similar patterns of associations to those of the primary results. Moreover, we observed significant interactions on both multiplicative and additive scales between animal-based MUFA and cigarette smoking. LIMITATIONS, REASONS FOR CAUTION Selection bias and recall bias were unavoidable in any of the observational studies. As we failed to obtain the information of trans-fatty acid (TFA) consumption, the relation of TFA intake and asthenozoospermia odds was unclear. WIDER IMPLICATIONS OF THE FINDINGS This study indicated that different sources of fat and FAs might exert different effects on the etiology of asthenozoospermia, and cigarette smoking could exacerbate the adverse effect of high animal-based MUFA intake on asthenozoospermia. Our findings provide novel evidence pertaining to the fields of prevention of asthenozoospermia through decreasing animal-derived fat and FA consumptions and smoking cessation. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the JieBangGuaShuai Project of Liaoning Province, Natural Science Foundation of Liaoning Province, Clinical Research Cultivation Project of Shengjing Hospital, and Outstanding Scientific Fund of Shengjing Hospital. All authors have no conflict of interest to declare. TRIAL REGISTRATION NUMBER N/A.