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"Levey, Jon"
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Variant of TREM2 Associated with the Risk of Alzheimer's Disease
This study shows that a variant of
TREM2
, which encodes a protein that suppresses inflammation, causes susceptibility to Alzheimer's disease. Although the variant is rare, its effect on the risk of disease is similar to that of the ε4 allele of apolipoprotein E.
Alzheimer's disease, the most common form of dementia in the elderly, is a neurodegenerative disorder that is characterized by a slow but progressive loss of cognitive function. Extracellular amyloid plaques, intracellular neurofibrillary tangles, and loss of neurons and synapses resulting in brain atrophy are the main pathological hallmarks of Alzheimer's disease.
1
Disease onset is usually after the age of 70 years, although the prevalence increases exponentially with age after the age of 65 years and exceeds 25% in those over the age of 90 years.
2
The vast majority of variants in the sequence of the genome that have been shown . . .
Journal Article
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Stacy Steinberg, Hreinn Stefansson, Thorlakur Jonsson and colleagues found that rare variants predicted to alter the function of ABCA7 are associated with risk of Alzheimer's disease. The association was found in Iceland and replicated in northern Europe and the United States.
We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in
ABCA7
confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12,
P
= 2.2 × 10
−13
) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03,
P
= 6.8 × 10
−15
).
Journal Article
Asian-Pacific Transfer Pricing Update 2007
Transfer pricing has significantly refined itself in recent years in the Asia-Pacific region. Although transfer pricing regimes are more developed in some countries than others, it is clear that issues stemming from related-party, cross-border transactions have caught the attention of tax authorities in the region. This can be demonstrated by the growing number of transfer pricing audits, increasing prevalence of advance pricing agreement programs, tax officials' increased appetite for information, and expanding experience of tax officials with transfer pricing matters. However, the spread of transfer pricing regulation in the region has been far from a homogenous affair. The growth of transfer pricing has produced an array of differing responses from countries in the region with each government seemingly adopting its own approach to compliance and enforcement. Australia, China, Japan, Korea, and India have developed full-fledged transfer pricing regime with extensively trained transfer pricing specialists, government databases, and advance pricing agreement programs. However, each country has different characteristics and approaches. Tax audits are ever increasing. The diversity in transfer pricing practices among nine Asian-Pacific countries is examined at length by members of Baker & McKenzie and affiliated law firms who participated in Baker & McKenzie's 22nd Annual Asia-Pacific Tax Conference held in November 2006 in Beijing.
Trade Publication Article
In ricordo di Francis Haskell
English A series of essays in tribute to art historian Francis Haskell: \"I primi incontri a Cambridge e Venezia,\" by Alessandro Bettagno; \"Francis Haskell all'Ermitage,\" by Irina Artemieva; \"Sulla edizione del 1809 della \"Storia pittorica della Italia\" di Luigi Lanzi,\" by Paola Barocchi; \"Ricordo di Francis,\" by Gaetano Cozzi; \"Memoria de Francis,\" by Enzo Crea; \"Tradurre se stessi,\" by Carlo Ginzburg; \"Francis Haskell come maestro,\" by Charles Hope; \"Les préfaces Françaises de Francis Haskell,\" by André Jammes; \"En France avec Francis Haskell,\" by Michel Laclotte; \"Francis Haskell and eighteenth-century Venice,\" by Michael Levey; \"Francis Haskell: i primi anni Romani,\" by Alessandro Marabottini; \"Un incontro a Oxford,\" by Giorgio Marini; \"Francis Haskell: a personal recollection,\" by Alfred Moir; \"Ultimi incontri alla scuola normale di Pisa,\" by Tomaso Montanari; \"A drink in Walton Street,\" by Nicholas Penny; \"Per ricordare Francis Haskell,\" by Terisio Pignatti; \"Nel segno di Haskell,\" by Lionello Puppi; and \"Francis and the department of the history of art in Oxford,\" by Jon Whiteley.
Journal Article