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"Levine, Charles (Charles G.)"
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Identity formation, youth, and development : a simplified approach
\"Identity, Youth, and Human Development: An Introduction is the first text to address identity formation in a format appropriate for students being introduced to identity-related issues for the first time. Although a significant area of interest for many students and youth, identity formation has been a field of study largely inaccessible to anyone outside of the academy. To address this, authors James E. C
Book
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia
Marshall Horwitz, Charles Mullighan, Kenneth Offit and colleagues report the identification of a recurrent germline
PAX5
mutation in families with pre–B cell acute lymphoblastic leukemia. They also identify sporadic cases of this leukemia with the same mutation that arose somatically.
Somatic alterations of the lymphoid transcription factor gene
PAX5
(also known as
BSAP
) are a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL)
1
,
2
,
3
, but inherited mutations of
PAX5
have not previously been described. Here we report a new heterozygous germline variant, c.547G>A (p.Gly183Ser), affecting the octapeptide domain of PAX5 that was found to segregate with disease in two unrelated kindreds with autosomal dominant B-ALL. Leukemic cells from all affected individuals in both families exhibited 9p deletion, with loss of heterozygosity and retention of the mutant
PAX5
allele at 9p13. Two additional sporadic ALL cases with 9p loss harbored somatic
PAX5
substitutions affecting Gly183. Functional and gene expression analysis of the
PAX5
mutation demonstrated that it had significantly reduced transcriptional activity. These data extend the role of
PAX5
alterations in the pathogenesis of pre-B cell ALL and implicate
PAX5
in a new syndrome of susceptibility to pre-B cell neoplasia.
Journal Article
Identity, Formation, Agency, and Culture
The goal of Identity, Formation, Agency, and Culture is to lay the basis of a theory with which to better understand the difficulties and complexities of identity formation. It provides an extensive understanding of identity formation as it relates to human striving (agency) and social organization (culture). James E. Côté and Charles G. Levine have compiled state-of-the-art psychological and sociological theory and research into a concise synthesis. This volume utilizes a vast, interdisciplinary literature in a reader-friendly style. Playing the role of narrators, the authors take readers through the most important theories and studies of self and identity, focusing on pragmatic issues of identity formation--those things that matter most in people's lives.
Identity, Formation, Agency, and Culture is intended for identity-related researchers in the behavioral and social sciences, as well as clinicians, counselors, and social workers dealing with identity-related disorders. It also serves as a main or supplemental text in advanced courses on identity, identity and human development, social development, moral development, personality, the sociology of identity, and the individual and society taught in departments of psychology, sociology, human development, and family studies.
Contents: Preface. Part I: A Critical Analysis of Approaches to Self and Identity. Identity Theory in Perspective. Psychological Approaches to the Concepts of Self and Identity. The Identity Concept in Sociology. Integrating Sociological and Psychological Perspectives on Identity: Toward a Social Psychology of Identity. Issues in Definition and Critique. Part II: A Return to a Formal Theory of Ego Identity Formation. Erikson Revisited: The Basis of a Formal Theory of Identity Formation. Identity, Agency, and Social Structure. Part III: Theoretical and Empirical Elaborations for a Social Psychology of Identity in Late Modernity. Identity Capital. Assessing the Adequacy of Identity Stage Resolution in Late Modernity. Identity and Late Modern Society: Ongoing Concerns and Future Research.
eBook
Critical period regulation across multiple timescales
Brain plasticity is dynamically regulated across the life span, peaking during windows of early life. Typically assessed in the physiological range of milliseconds (real time), these trajectories are also influenced on the longer timescales of developmental time (nurture) and evolutionary time (nature), which shape neural architectures that support plasticity. Properly sequenced critical periods of circuit refinement build up complex cognitive functions, such as language, from more primary modalities. Here, we consider recent progress in the biological basis of critical periods as a unifying rubric for understanding plasticity across multiple timescales. Notably, the maturation of parvalbumin-positive (PV) inhibitory neurons is pivotal. These fast-spiking cells generate gamma oscillations associated with critical period plasticity, are sensitive to circadian gene manipulation, emerge at different rates across brain regions, acquire perineuronal nets with age, and may be influenced by epigenetic factors over generations. These features provide further novel insight into the impact of early adversity and neurodevelopmental risk factors for mental disorders.
Journal Article
Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children
Acute gastroenteritis is a common illness, and treatment with probiotics is common. In a double-blind, placebo-controlled trial, treatment with
Lactobacillus rhamnosus
GG was found to afford no benefit in reducing symptoms associated with acute gastroenteritis in children.
Journal Article