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4,630 result(s) for "Lewis, Eric"
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Dust Devil: The Life and Times of the Fungus That Causes Valley Fever
  Coccidioides' most recent common ancestor underwent gene family expansions for proteases and keratinases, membrane biology genes, and toxin production, all likely utilized for survival in animal tissues and morphological changes; and a loss of genes associated with degradation of plant tissue, such as tannases, cellulases, and cutinases [1]. Both Coccidioides species have similar biology, with a well-characterized asexual life cycle with distinct saprobic and parasitic stages, and only molecular evidence of a sexual cycle (Fig 1). [...]analysis at a single 10-meter square area in Tucson, Arizona, revealed multiple genotypes present in a single environmental location [11].
Hyderabad, British India, and the world : Muslim networks and minor sovereignty, c. 1850-1950
\"This examination of the formally autonomous state of Hyderabad in a global comparative framework challenges the idea of the dominant British Raj as the sole sovereign power in the late colonial period. Beverley argues that Hyderabad's position as a subordinate yet sovereign 'minor state' was not just a legal formality, but that in exercising the right to internal self-government and acting as a conduit for the regeneration of transnational Muslim intellectual and political networks, Hyderabad was indicative of the fragmentation of sovereignty between multiple political entities amidst empires. By exploring connections with the Muslim world beyond South Asia, law and policy administration along frontiers with the colonial state and urban planning in expanding Hyderabad City, Beverley presents Hyderabad as a locus for experimentation in global and regional forms of political modernity. This book recasts the political geography of late imperialism and historicises Muslim political modernity in South Asia and beyond\"-- Provided by publisher.
Beyond colonial urbanism: state power, global connections and fragmented land regimes in twentieth-century Hyderabad city
Urban histories of modern South Asia have centred on British Indian cities and the reign of colonial urbanism, with dependence on metropolitan imperatives and models regarded as givens. Focusing on Hyderabad, one of the subcontinent's five largest cities and capital of an autonomous princely state throughout the colonial era, this article establishes the analytical utility of princely urbanism as a framework for writing the history of South Asian cities. Characterized by state-directed planning, transnational urbanist networks and multiple overlapping property regimes, this mode of city development and its resonance points to hidden genealogies of modern urbanism.
Preaching Outside the Temple: On the Literary Witness of James Baldwin as the Word Made Public
It was the late Bishop Ithiel Conrad Clemmons, former minister of the First Church of God in Christ of Brooklyn, New York, who said of the late famed novelist/essayist James Baldwin that “he was America’s inside eye on the Black Holiness and Pentecostal Churches”. Though Baldwin admitted that the culture and ethos of the African-American Pentecostal church were “highly significant and indelibly imprinted upon him”, according to Baldwin, his faith community’s “naiveté about life appalled him and drove him away”. While Baldwin left behind the church of his youth, never to return, for the remainder of his writing career, the “backslidden” minister’s literary musings continued to be informed (in both style and content) by the formative religious tradition that he left behind. Though several studies have been undertaken that examine Baldwin’s significance to various aspects of the study of African-American religion and culture, precious little has been written regarding Baldwin’s continuing engagement of the idiom of African-American preaching, the idiom which cultural critic Michael Eric Dyson has nominated as the “jewel in the crown of Black Sacred Rhetoric”. While many studies of Baldwin include the fact that Baldwin was a preacher’s son and that Baldwin himself preached for a time during his youth, the account is yet to be given of how Baldwin’s writings continued to employ the rhythms, grammar, tones, and textures of the Black sacred rhetorical tradition, especially from beyond the borders of the African-American church. This essay seeks to expose not only how Baldwin self-consciously continued to stand in the rhetorical trajectory of the African-American preaching tradition, but the attempt is also to reveal how the writer secularizes the idiom, providing the Black Holiness preacher a hearing from beyond the church. Through a focus on Baldwin as a Black sacred rhetorician, sermonizing from beyond the church, this essay participates in the nearly 100-year-old conversation instigated by the early African-American literary and cultural critic James Weldon Johnson in God’s Trombones: Seven Negro Sermons in Verse (1927), regarding the neglected significance of the sermon and the preacher in African-American literature and Black expressive cultures. Baldwin’s sermonic is here examined as a highly distinctive mode of Black public theologizing.
Comparing in vitro and in vivo virulence phenotypes of Burkholderia pseudomallei type G strains
Burkholderia pseudomallei (Bpm) is a saprophytic rod-shaped gram-negative bacterium and the causative agent of melioidosis. This disease has previously been described as endemic in areas such as northern Australia and Southeast Asia, but, more recently, a better understanding of the epidemiology of melioidosis indicated that the disease is distributed worldwide, including regions of the Americas and Africa. A 16S-23S rDNA internal transcribed spacer (ITS) typing system has been developed for Bpm and has revealed that ITS types C, E, and hybrid CE are mainly associated with Australia and Southeast Asia while type G strains are more associated with cases of melioidosis in the Western Hemisphere. The purpose of the current study was to determine the in vitro and in vivo virulence profiles of the understudied Bpm type G strains Ca2009, Ca2013a, Mx2013, and 724644 and compared such phenotypes to the commonly studied Bpm type C strain K96243. We evaluated virulence by measuring invasion/uptake and survival of these Bpm strains in murine respiratory epithelial LA-4 cells and alveolar macrophage MH-S cells using different multiplicity of infections (MOIs of 1 and 10). We also calculated the lethal dose 50 values (LD50) in BALB/c mice that were inoculated intranasally with either Ca2009, Ca2013a, or Mx2013. Overall, the virulence and lethality phenotypes of Bpm type G strains were similar to the Bpm type C strain K96243. Additional comparative analyses between the Bpm ITS types may lead to a better understanding of the contribution of the ITS type to the epidemiology and ecology of Bpm strains.
The art of persistence—the secrets to Burkholderia chronic infections
The Gram-negative proteobacteria genus Burkholderia encompasses multiple bacterial species that are pathogenic to humans and other vertebrates. Two pathogenic species of interest within this genus are Burkholderia pseudomallei (Bpm) and the B. cepacia complex (Bcc); the former is the causative agent of melioidosis in humans and other mammals, and the latter is associated with pneumonia in immunocompromised patients. One understudied and shared characteristic of these two pathogenic groups is their ability to persist and establish chronic infection within the host. In this review, we will explore the depth of knowledge about chronic infections caused by persistent Bpm and Bcc. We examine the host risk factors and immune responses associated with more severe chronic infections. We also discuss host adaptation and phenotypes associated with persistent Burkholderia species. Lastly, we survey how other intracellular bacteria associated with chronic infections are combatted and explore possible future applications to target Burkholderia. Our goal is to highlight understudied areas that should be addressed for a more thorough understanding of chronic Burkholderia infections and how to combat them. This work explores the depth of knowledge about chronic infections caused by persistent Burkholderia pseudomallei and B. cepacia complex. Graphical Abstract Figure. This work explores the depth of knowledge about chronic infections caused by persistent Burkholderia pseudomallei and B. cepacia complex.