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"Lewis, J."
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National Geographic book of animal poetry : 200 poems with photographs that squeak, soar, and roar!
Combines photography with lyrical text celebrating the animal world, in a compilation that includes works by such poets as Emily Dickinson, Robert Frost and Rudyard Kipling.
Book
Period Functions for Maass Wave Forms and Cohomology
We construct explicit isomorphisms between spaces of Maass wave forms and cohomology groups for discrete cofinite groups
In the case that
We introduce the concepts of
For spaces of Maass cusp forms we also describe isomorphisms to parabolic cohomology groups with smooth
coefficients and standard cohomology groups with distribution coefficients. We use the latter correspondence to relate the Petersson
scalar product to the cup product in cohomology.
eBook
Perfect : Don Larsen's miraculous World Series game and the men who made it happen
Don Larsen's perfect game in the 1956 World Series between the New York Yankees and the Brooklyn Dodgers remains the only no-hit game in World Series history. Drawing upon oral histories, contemporaneous articles, and dozens of interviews with commentators and players (including all of the surviving players for the Dodgers and Yankees), Lew Paper brings that extraordinary event to life with a pitch-by-pitch narrative that incorporates profiles of the 19 players who were on the field that day.
Book
A comprehensive study of the rare diseases and conditions targeted by orphan drug designations and approvals over the forty years of the Orphan Drug Act
Background
Rare diseases affect more than 30 million Americans. The passage of the Orphan Drug Act (ODA) in the United States in 1983 represented a launching point for a rare disease drug development revolution for these patients. Financial incentives provided by the ODA through its Orphan Drug Designation Program, in addition to remarkable scientific advances over the past 40 years, have led to hundreds of drug approvals for rare diseases. Our research examines the rare diseases that have been targeted by orphan drug designations and subsequent approvals since the law was enacted.
Methods
Using an internal FDA database, we classified and analyzed all orphan drug designations and approvals from 1983 to 2022 by disease and therapeutic area.
Results
Over the 40 years of the ODA, 6,340 orphan drug designations were granted, representing drug development for 1,079 rare diseases. Additionally, 882 of those designations resulted in at least one FDA approval for use in 392 rare diseases. Much of this development has been concentrated in oncology as seven of the top ten most designated and approved diseases were rare cancers.
Conclusions
Researchers have estimated that there may be 7000–10,000 rare diseases that have been identified and described. Based on our study, we can conclude that around 5% of rare diseases have an FDA-approved drug and up to 15% of rare diseases have at least one drug that has been developed and shown promise in their treatment, diagnosis or prevention. Funding of basic and translational science for rare disease drug development should continue in order to bring therapies to the millions of affected patients who remain without treatment options.
Journal Article
Monumental verses
A collection of poems about various famous monuments, bridges and buildings, such as Stonehenge and the Golden Gate Bridge.
Book
Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?
The brain and the immune system are not fully formed at birth, but rather continue to mature in response to the postnatal environment. The two-way interaction between the brain and the immune system makes it possible for childhood psychosocial stressors to affect immune system development, which in turn can affect brain development and its long-term functioning. Drawing from experimental animal models and observational human studies, we propose that the psychoneuroimmunology of early-life stress can offer an innovative framework to understand and treat psychopathology linked to childhood trauma. Early-life stress predicts later inflammation, and there are striking analogies between the neurobiological correlates of early-life stress and of inflammation. Furthermore, there are overlapping trans-diagnostic patterns of association of childhood trauma and inflammation with clinical outcomes. These findings suggest new strategies to remediate the effect of childhood trauma before the onset of clinical symptoms, such as anti-inflammatory interventions and potentiation of adaptive immunity. Similar strategies might be used to ameliorate the unfavorable treatment response described in psychiatric patients with a history of childhood trauma.
Journal Article
Identifying Shocks via Time-Varying Volatility
I propose to identify an SVAR, up to shock ordering, using the autocovariance structure of the squared innovations implied by an arbitrary stochastic process for the shock variances. These higher moments are available without parametric assumptions on the variance process. In contrast, previous approaches exploiting heteroskedasticity rely on the path of innovation covariances, which can only be recovered from the data under specific parametric assumptions on the variance process. The conditions for identification are testable. I compare the identification scheme to existing approaches in simulations and provide guidance for estimation and inference. I use the methodology to estimate fiscal multipliers peaking at 0.86 for tax cuts and 0.75 for government spending. I find that tax shocks explain more variation in output at longer horizons. The empirical implications of my estimates are more consistent with theory and the narrative record than those based on some leading approaches.
Journal Article
Conceiving God : the cognitive origin and evolution of religion
This book is a controversial exploration of the origin of religion in the neurology of the human brain. The author first describes how science developed within the cocoon of religion and then shows how the natural functioning of the human brain creates experiences that can lead to belief in a supernatural realm, beings, and interventions. Once people have these experiences, they formulate beliefs about them, and thus creeds are born. Forty thousand years ago, people were leaving traces in the archaeological record of activities that we can label religious, and the author discusses in detail the evidence preserved in the Volp Caves in France. He also shows that mental imagery produced by the functioning of the human brain can be detected in widely separated religious communities such as Hildegard of Bingen's in medieval Europe or the San hunters of southern Africa.
Book
Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage
In a trial of minimally invasive cerebral hematoma removal within 24 hours after onset of hemorrhage, functional outcomes were better with surgery than with medical treatment, particularly among patients with lobar hemorrhages.
Journal Article