Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
7,027
result(s) for
"Lewis, Mark"
Sort by:
Between Scylla and Charybdis — Oncologic Decision Making in the Time of Covid-19
As the deaths from Covid-19 have mounted, many patients with cancer struggle to process the case fatality rate in the context of all the other statistics their oncologists cite. Chemotherapy, hardly desirable at the best of times, may never have been less appealing.
Journal Article
Animal models for COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Journal Article
China between empires : the northern and southern dynasties
After the collapse of the Han dynasty in the third century CE, China divided along a north-south line. Mark Lewis traces the changes that both underlay and resulted from this split in a period that saw the geographic redefinition of China, more engagement with the outside world, and the introduction of new religions.
Book
Correlates of protection against SARS-CoV-2 in rhesus macaques
Recent studies have reported the protective efficacy of both natural
1
and vaccine-induced
2
–
7
immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (
Macaca mulatta
) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8
+
T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2.
Journal Article
A critique of the principle of error correction as a theory of social change
This article assesses the historical failures and limits of the dominant ‘error correction’ approach within sociolinguistics. The error correction approach supposes that social change can be achieved when knowledge is shared by researchers with the public or figures of institutional authority. This article reviews reflections on sociolinguists’ work toward social change, especially those of Labov, through scholarship in language ideologies and critical race theory. From a language ideological and critical race perspective, error correction is limited in its engagement with marginalizing representations of language because it does not jointly address material conditions and social positions supported by these representations. Exemplifying these limitations, sociolinguistic error-correction efforts that address the evaluation of language practices racialized as Black may have unfortunately distracted from social change agendas that confront material and institutionalized racism directly. To address these limitations, this article highlights existing critical reflexive scholarship that explicitly interrogates disciplinary assumptions. (Critical race theory, error correction, language ideologies, social change, critical reflexivity)*
Journal Article
Introduction to programming and problem-solving using Scala
Written by an expert in the field, this text teaches programming with Scala, one of a new generation of languages that combine the best from the procedural, functional, and object-oriented paradigms of programming.
Book
Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure
Restricted, repetitive behaviors are common symptoms in neurodevelopmental disorders including autism spectrum disorder. Despite being associated with poor developmental outcomes, repetitive behaviors remain poorly understood and have limited treatment options. Environmental enrichment attenuates the development of repetitive behaviors, but the exact mechanisms remain obscure. Using the C58 mouse model of repetitive behavior, we performed diffusion tensor imaging to examine microstructural alterations associated with the development of repetitive behavior and its attenuation by environmental enrichment. The C57BL/6 mouse strain, which displays little or no repetitive behavior, was used as a control group. We observed widespread differences in diffusion metrics between C58 mice and C57BL/6 mice. In juvenile C58 mice, repetitive motor behavior displayed strong negative correlations with fractional anisotropy in multiple gray matter regions, whereas in young adult C58 mice, high repetitive motor behavior was most strongly associated with lower fractional anisotropy and higher radial diffusivity in the striatum. Environmental enrichment increased fractional anisotropy and axial diffusivity throughout gray matter regions in the brains of juvenile C58 mice and overlapped predominantly with cerebellar and sensory regions associated with repetitive behavior. Our results suggest environmental enrichment reduces repetitive behavior development by altering gray matter microstructure in the cerebellum, medial entorhinal cortex, and sensory processing regions in juvenile C58 mice. Under standard laboratory conditions, early pathology in these regions appears to contribute to later striatal and white matter dysfunction in adult C58 mice. Future studies should examine the role these regions play in the development of repetitive behavior and the relationship between sensory processing and cerebellar deficits and repetitive behavior.
Journal Article