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"Lewis, Oliver"
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A planet is a poem
\"How does life survive on Earth? Why is Pluto no longer considered a planet? And just how big is Jupiter, really? The answers to these questions and more are explored in this innovative non-fiction book featuring 14 beautifully written poems about space. Every object in our solar system is paired with a different kind of poem, from lyrical sonnets to bouncy rhyming couplets, twisty sestinas to joyful free verse. As they explore the solar system, readers will learn about what makes each object, from the tiny paired-dwarf planets Pluto and Charon to the vast Kuiper Belt, special. Each unique poem by Amanda West Lewis is stunningly illustrated with dreamy artwork by Oliver Averill that celebrates the vast darkness of space and brings to life familiar space objects such as sunspots, comets, Saturn's rings and more. Every spread features a flap that opens to extend the illustration and offer readers easy-to-understand science sidebars as well as short explanations of each poetic form. This highly original, lavishly illustrated book is the perfect blend of science and poetry, and a marvelous pick for all budding astronomers.\"-- Provided by publisher.
Book
Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor
G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still unclear. Using
13
C methyl methionine and
19
F NMR, we investigate the agonist-bound active state of β
1
AR and its ternary complexes with different G proteins in solution. We find the receptor in the ternary complexes adopts very similar conformations. In contrast, the full agonist-bound receptor active state assumes a conformation differing from previously characterised activation intermediates or from β
1
AR in ternary complexes. Assessing the kinetics of binding for the agonist-bound receptor with different G proteins, we find the increased affinity of β
1
AR for G
s
results from its much faster association with the receptor. Consequently, we suggest a kinetic-driven selectivity gate between canonical and secondary coupling which arises from differential favourability of G protein binding to the agonist-bound receptor active state.
The authors show G protein subtype selectivity at the β
1
-adrenergic receptor is driven by the binding kinetics of ternary complex formation. Bound to G protein, the receptor adopts conformations that differ from its agonist-bound solution states.
Journal Article
Human rights violations of people with mental and psychosocial disabilities: an unresolved global crisis
This report reviews the evidence for the types of human rights violations experienced by people with mental and psychosocial disabilities in low-income and middle-income countries as well as strategies to prevent these violations and promote human rights in line with the UN Convention on the Rights of Persons with Disabilities (CRPD). The article draws on the views, expertise, and experience of 51 people with mental and psychosocial disabilities from 18 low-income and middle-income countries as well as a review of English language literature including from UN publications, non-governmental organisation reports, press reports, and the academic literature.
Journal Article
Global Mental Health 6: Human rights violations of people with mental and psychosocial disabilities: an unresolved global crisis
This report reviews the evidence for the types of human rights violations experienced by people with mental and psychosocial disabilities in low-income and middle-income countries as well as strategies to prevent these violations and promote human rights in line with the UN Convention on the Rights of Persons with Disabilities (CRPD). The article draws on the views, expertise, and experience of 51 people with mental and psychosocial disabilities from 18 low-income and middle-income countries as well as a review of English language literature including from UN publications, non-governmental organisation reports, press reports, and the academic literature. [PUBLICATION ABSTRACT]
Journal Article
The World Psychiatric Association's \Bill of Rights\: A curious contribution to human rights
In 2016 the World Psychiatric Association (WPA) published a \"Bill of Rights.\" This article considers and analyzes what is at stake in a global professional clinical organization developing such a document that purports to support its efforts to tackle the social injustices experienced by people with mental health issues globally. It critically examines the text of the Bill and suggests that, while the document promises serious engagement with human rights (as distinct from ethics), it fails to meet existing international human rights standards. For the WPA to be a present and engaged partner in the implementation of international human rights standards it should not merely encourage governments to take action, but start with inward-facing tasks. These include establishing minimum human rights-based criteria for its own members and holding them to account, so as to nudge psychiatrists towards a human rights-based approach that would benefit people with mental health issues around the world.
Journal Article
A New Method of Measuring Atmospheric Refractivity
This thesis explores a new source of atmospheric refractivity information by measuring the refraction of radio transmissions broadcast by commercial aircraft. Detailed measurements of atmospheric humidity in the lower atmosphere are currently difficult and expensive to obtain. For this reason, there is interest in the development of low-cost, high-volume opportunistic technologies to acquire measurements of tropospheric humidity. The angle-of-arrival (AoA) of the 1090 MHz Automatic Dependent Surveillance-Broadcast (ADS-B) radio transmission can be measured using vertically-orientated, two-element interferometers. Atmospheric refraction is strongly influenced by changes in humidity, and refractivity observations have proved to be an effective source of humidity information for numerical weather prediction models. This thesis shows the derivation of novel inversion algorithms to retrieve refractivity structure from AoA measurements using gradient-free and adjoint-based techniques. The initial experimental results from a prototype interferometer installed on the Clee Hill weather radar tower in Shropshire, United Kingdom are shown. The inversion algorithms are applied to observational data and vertical profiles of refractivity were retrieved. The principal sources of observational uncertainties and methods to mitigate their impacts were explored through simulations and experiments. The observations obtained were significantly impacted by multipath contamination, where multiple signals from the same source mutually interfere at the receiver. Variations in atmospheric refractivity structure on mesoscale (∼10-100 km) and ∼15-minute spatial and temporal scales respectively were detected with the prototype ADS-B interferometer. The proposed technique is relatively low cost (∼€10k), requiring off the shelf equipment and making use of freely available software. The results from this thesis encourage further exploration and research into this new remote sensing technique. Future work would benefit from simulated and real assimilation experiments using observational data.
Dissertation
Binding kinetics drive G protein subtype selectivity at the β 1 -adrenergic receptor
G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still unclear. Using
C methyl methionine and
F NMR, we investigate the agonist-bound active state of β
AR and its ternary complexes with different G proteins in solution. We find the receptor in the ternary complexes adopts very similar conformations. In contrast, the full agonist-bound receptor active state assumes a conformation differing from previously characterised activation intermediates or from β
AR in ternary complexes. Assessing the kinetics of binding for the agonist-bound receptor with different G proteins, we find the increased affinity of β
AR for G
results from its much faster association with the receptor. Consequently, we suggest a kinetic-driven selectivity gate between canonical and secondary coupling which arises from differential favourability of G protein binding to the agonist-bound receptor active state.
Journal Article
Lea Valley Drift: paths, objects and the creation of urban narratives
This article considers the legacies of place revealed by critical walking journeys through the city and the potential for transforming their interpretation through the distribution of new forms of map. As Francesco Careri implies in Walkscapes: Walking as an Aesthetic Practice, walking pre-dates the city and nomadism is the original condition of civilised living. Put simply, settlement is the process of civilisation becoming static.
Journal Article
Anticipated and experienced stigma and discrimination in the workplace among individuals with major depressive disorder in 35 countries: qualitative framework analysis of a mixed-method cross-sectional study
ObjectivesWorkplace stigmatisation and discrimination are significant barriers to accessing employment opportunities, reintegration and promotion in the workforce for people with mental illnesses in comparison to other disabilities. This paper presents qualitative evidence of anticipated and experienced workplace stigma and discrimination among individuals with major depressive disorder (MDD) in 35 countries, and how these experiences differ across countries based on their Human Development Index (HDI) level.DesignMixed-method cross-sectional survey.Participants, setting and measuresThe qualitative data were gathered as part of the combined European Union Anti-Stigma Programme European Network and global International Study of Discrimination and Stigma Outcomes for Depression studies examining stigma and discrimination among individuals with MDD across 35 countries. Anticipated and experienced stigma and discrimination were assessed using the Discrimination and Stigma Scale version 12 (DISC-12). This study used responses to the open-ended DISC-12 questions related to employment. Data were analysed using the framework analysis method.ResultsThe framework analysis of qualitative data of 141 participants identified 6 key ‘frames’ exploring (1) participants reported experiences of workplace stigma and discrimination; (2) impact of experienced workplace stigma and discrimination; (3) anticipated workplace stigma and discrimination; (4) ways of coping; (5) positive work experiences and (6) contextualisation of workplace stigma and discrimination. In general, participants from very high HDI countries reported higher levels of anticipated and experienced discrimination than other HDI groups (eg, less understanding and support, being more avoided/shunned, stopping themselves from looking for work because of expectation and fear of discrimination). Furthermore, participants from medium/low HDI countries were more likely to report positive workplace experiences.ConclusionsThis study makes a significant contribution towards workplace stigma and discrimination among individuals with MDD, still an under-researched mental health diagnosis. These findings illuminate important relationships that may exist between countries/contexts and stigma and discrimination, identifying that individuals from very high HDI countries were more likely to report anticipated and experienced workplace discrimination.
Journal Article
Remarks by Oliver Lewis
When the Tribunal issued its July 2016 Award in the Philippines-China arbitration, the United States announced that the decision is an important contribution to the shared goal of a peaceful resolution to disputes in the South China Sea. The United States strongly supports the rule of law and efforts to resolve disputes in the South China Sea peacefully, including through arbitration. As provided in Article 296 of the UN Convention on the Law of the Sea (UNCLOS), the decision is “final and shall be complied with” by both parties to the dispute.
Journal Article