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"Li, Bingqian"
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البحار والمحيطات
يتناول كتاب \"البحار والمحيطات\" والذي قاما بتأليفه \"هان كيدي، وانغ بينشيان\" في حوالي (185) صفحة من القطع المتوسط موضوع (البحار والمحيطات)، هذا الكتاب من ضمن كتب سلسلة مئة ألف لماذا وهي مجموعة من الكتب العلمية التي نشرتها دار نشر الأطفال عام 1961 وعلى مدار نصف قرن تم إصدار هذه الكتب واحد تلو الآخر في خمس طبعات، تتضمن السلسلة مجموعة من المواد المثبتة علميا لأجيال الأطفال، بحيث تروج هذه السلسلة لنشر الروح العلمية، وتنشر المعرفة العلمية بين العقول الناشئة، وتعزز الجودة والمعلومات العلمية للأطفال. وهذا الكتاب يتحدث بلغة سهلة ويسيرة حيث يقدم معلومات كثيرة حول البحار والمحيطات في العالم.
BOOK
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review
Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.
Journal Article
Quality Assessment and Application Scenario Analysis of AGRI Land Aerosol Product from the Geostationary Satellite Fengyun-4B in China
The Advanced Geostationary Radiation Imager (AGRI) sensor on board the geostationary satellite Fengyun-4B (FY-4B) is capable of capturing particles in different phases in the atmospheric environment and acquiring aerosol observation data with high spatial and temporal resolution. To understand the quality of the Land Aerosol (LDA) product of AGRI and its application prospects, we conducted a comprehensive evaluation of the AGRI LDA AOD. Using the 550 nm AGRI LDA AOD (550 nm) of nearly 1 year (1 October 2022 to 30 September 2023) to compare with the Aerosol Robotic Network (AERONET), MODIS MAIAC, and Himawari-9/AHI AODs. Results show the erratic algorithmic performance of AGRI LDA AOD, the correlation coefficient (R), mean error (Bias), root mean square error (RMSE), and the percentage of data with errors falling within the expected error envelope of ±(0.05+0.15×AODAERONET) (within EE15) of the LDA AOD dataset are 0.55, 0.328, 0.533, and 34%, respectively. The LDA AOD appears to be overestimated easily in the southern and western regions of China and performs poorly in the offshore areas, with an R of 0.43, a Bias of 0.334, a larger RMSE of 0.597, and a global climate observing system fraction (GCOSF) percentage of 15% compared to the inland areas (R = 0.60, Bias = 0.163, RMSE = 0.509, GCOSF = 17%). Future improvements should focus on surface reflectance calculation, water vapor attenuation, and more suitable aerosol model selection to improve the algorithm’s accuracy.
Journal Article
Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects. The strong antitumor effect of bufadienolides has attracted considerable attention in recent years, but the clinical application of bufadienolides is limited due to their low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored, such as structural modification, solid dispersion, cyclodextrin inclusion, microemulsion and nanodrug delivery systems, etc. In this review, we have tried to summarize the pharmacological activities and structure–activity relationship of bufadienolides. Furthermore, the strategies for solubility and bioavailability enhancement of bufadienolides also are discussed. This review can provide a basis for further study on bufadienolides.
Journal Article
Lightweight YOLOv8-based real-time detection of pine wilt disease from drone imagery
A core bottleneck of forestry remote sensing lies in accurate, real-time pine wilt disease monitoring on UAV-borne edge hardware, which suffers from constrained computing capacity and complicated field forest backgrounds. To fill this technical gap, we developed an ultra-lightweight real-time detection architecture named Edge-Forest YOLO in this work.
Methods: Built upon the baseline YOLOv8n network, three targeted optimizations were embedded into the proposed model: (1) a domain-adaptive data augmentation workflow to mitigate poor generalization induced by variable illumination and uneven lesion sizes in complex woodland; (2) scale-aware asymmetric channel redistribution, cutting 37.5% shallow channels and expanding 75% deep channels to remove redundant spatial features and strengthen high-level pathological feature extraction; (3) Cross-layer ECA attention adopting 1D convolution to capture inter-channel correlation and concentrate on diseased regions with minimal computation overhead. All model validation was performed on the public high-resolution UAV pine wilt PDT dataset.
Edge-Forest YOLO only occupies 2.31 M storage with mAP@0.5 up to 92.7%. Its single-image inference costs 4.2 ms on regular computing equipment and runs at around 26 FPS on the Jetson Nano edge platform. Compared with YOLOv8s and customized YOLO-DP, our model cuts over half parameter quantity while retaining competitive detection precision.
The proposed lightweight detector supplies a low-power, practically deployable solution for on-board UAV real-time forest disease monitoring, supporting rapid in-field pine wilt diagnosis and facilitating scientific decision-making for forest health management and disease prevention.
Journal Article
Fully 3D printed flexible, conformal and multi-directional tactile sensor with integrated biomimetic and auxetic structure
Tactile sensors play a crucial role in the development of biologically inspired robotic prostheses, particularly in providing tactile feedback. However, existing sensing technology still falls short in terms of sensitivity under high pressure and adaptability to uneven working surfaces. Furthermore, the fabrication of tactile sensors often requires complex and expensive manufacturing processes, limiting their widespread application. Here we develop a conformal tactile sensor with improved sensing performance fabricated using an in-house 3D printing system. Our sensor detects shear stimuli through the integration of an auxetic structure and interlocking features. The design enables an extended sensing range (from 0.1 to 0.26 MPa) and provides sensitivity in both normal and shear directions, with values of 0.63 KPa
−1
and 0.92 N
−1
, respectively. Additionally, the sensor is capable of detecting temperature variations within the range of 40−90 °C. To showcase the feasibility of our approach, we have printed the tactile sensor directly onto the fingertip of an anthropomorphic robotic hand, the proximal femur head, and lumbar vertebra. The results demonstrate the potential for achieving sensorimotor control and temperature sensing in artificial upper limbs, and allowing the monitoring of bone-on-bone load.
Yuyang Wei and colleagues use 3D printing to fabricate tactile sensors with an auxetic structure design capable of detecting both forces and temperature for use in prosthetics and other robotic applications.
Journal Article
Temperature Distribution Research on Liquid Packaging Structure of Deep UV LEDs
By showing a packaged device model with 2×2 chips, the effects of packaging material, device height, chip spacing, thermal conductivity, and viscosity of silicone oil on temperature distribution of deep ultraviolet (UV) light-emitting diodes (LEDs) were investigated by finite element simulation. The results showed that similar temperature distributions in the horizontal and vertical directions were obtained using different packaging materials including gas, solid, and liquid. The lowest maximum temperature (131.7°C) was obtained with liquid packaging compared to the gas packaging (140.8°C) and solid packing (132.5°C). Accompanied by increasing the device height, the maximum temperature of the liquid packaging structure revealed a more significant drop compared to solid packaging. However, that of gas packaging exhibited a rise and saturation. Larger chip spacing and higher thermal conductivity of silicone oil will dramatically reduce the maximum temperature of the liquid packaging device, and a lower maximum temperature and more uniform temperature distribution were obtained by using a lower viscosity packaging material. Therefore, considering the feasibility of the device process, appropriate liquid packaging structures can be optimized, and the maximum temperature of the liquid packaging structure of 102.8°C has been achieved. Liquid packaging may have a certain impact on the reliability of device sealing due to the current immature technology. For high-power light sources, there may also be a certain impact on their lifespan.
Journal Article
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and no antivirals or vaccines are available. Here, we assess the anti-norovirus activity of new peptidomimetic aldehydes related to the protease inhibitor rupintrivir. The early hit compound 4 inhibited the replication of murine norovirus (MNV) and the HuNoV GI.1 replicon in vitro (EC50 ~1 µM) and swiftly cleared the HuNoV GI.1 replicon from the cells. Compound 4 still inhibits the proteolytic activity. We selected a resistant GI.1 replicon, with a mutation (I109V) in a highly conserved region of the viral protease, conferring a low yield of resistance against compound 4 and rupintrivir. After testing new derivatives, compound 10d was the most potent (EC50 nanomolar range). Molecular docking indicated that the aldehyde group of compounds 4 and 10d bind with Cys139 in the HuNoV 3CL protease by a covalent linkage. Finally, compound 10d inhibited the replication of HuNoV GII.4 in infected zebrafish larvae, and PK studies in mice showed an adequate profile.
Journal Article
Coagulation of trace arsenic and cadmium from drinking water using titanium potassium oxalate
Coagulation is a simple and cost-effective water treatment method that does not work well in removing multiple cationic and anionic heavy metals simultaneously from drinking water. Titanium potassium oxalate (K
2
TiO(C
2
O
4
)
2
), a fur tanning reagent, was found to be able to efficiently remove arsenite (As(III)), arsenate (As(V)), and Cd simultaneously. A dose of 120 µmol/L K
2
TiO(C
2
O
4
)
2
could remove more than 90% of As and Cd to meet the drinking water standards when their initial concentrations were 10 times their maximum concentration limits, whereas traditional coagulants, such as Fe
2
(SO
4
)
3
and Al
2
(SO
4
)
3
, failed to meet the drinking water standards. Additionally, K
2
TiO(C
2
O
4
)
2
coagulation consumes natural water hardness (Ca
2+
/Mg
2+
) to produce softer water and releases healthy K
+
as a by-product. The mechanism study indicated that K
2
TiO(C
2
O
4
)
2
reacted with natural calcium ions in drinking water to form calcium oxalate, while residual titanium was hydrolyzed with water to form hydrous titanium oxide. Arsenic was removed primarily via complexation with hydrous titanium oxide, while Cd was removed via the combined effect of adsorption by hydrous titanium oxide and mixed-crystal formation by calcium oxalate. This study provides an efficient coagulant for removing multiple heavy metals simultaneously, which can be applied in water treatment to provide safe and healthy drinking water.
Journal Article
Revaluating coal permeability-gas pressure relation under various gas pressure differential conditions
Identifying changes in coal permeability with gas pressure and accurately codifying mean effective stresses in laboratory samples are crucial in predicting gas-flow behavior in coal reservoirs. Traditionally, coal permeability to gas is assessed using the steady-state method, where the equivalent gas pressure in the coal is indexed to the average of upstream and downstream pressures of the coal, while ignoring the nonlinear gas pressure gradient along the gas flow path. For the flow of a compressible gas, the traditional method consistently underestimates the length/volume-averaged pressure and overestimates mean effective stress. The higher the pressure differential within the sample, the greater the error between the true mean pressure for a compressible fluid and that assumed as the average between upstream and downstream pressures under typical reservoir conditions. A correction coefficient for the compressible fluid pressure asymptotes to approximately 1.3%, representing that the error in mean pressure and effective stress can be on the order of approximately 30%, particularly for highly pressure-sensitive permeabilities and compressibilities, further amplifying errors in evaluated reservoir properties. We utilized this volume-averaged pressure and effective stress to correct permeability and compressibility data reported in the literature. Both the corrected initial permeability and the corrected pore compressibility were found to be smaller than the uncorrected values, due to the underestimation of the true mean fluid pressure, resulting in an overestimation of reservoir permeability if not corrected. The correction coefficient for the initial permeability ranges from 0.6 to 0.1 (reservoir values are only approximately 40% to 90% of laboratory values), while the correction coefficient for pore compressibility remains at approximately 0.75 (reservoir values are only approximately 25% of laboratory value). Errors between the uncorrected and corrected parameters are quantified under various factors, such as confining pressure, gas sorption, and temperature. By analyzing the evolutions of the initial permeability and pore compressibility, the coupling mechanisms of mechanical compression, adsorption swelling, and thermal expansion on the pore structure of the coal can be interpreted. These findings can provide insights that are useful for assessing the sensitivity of coal permeability to gas pressure as truly representative of reservoir conditions.
Journal Article