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Base the research of landform, soil erosion and vegetation characteristics, the comprehensive control model of soil and water conservation is summarized in Pisha stone area. The dates shows that: The general idea of this area is to take the construction of gully dam system as the starting point and to strengthen the construction of gully dam system with the main project of gully control. In line with local conditions, we will actively promote the construction of forest and grass vegetation, return farmland to forest and grassland, and implement large areas of closure and control, so as to give full play to the self-repair function of the ecosystem.

Lipid metabolism plays a pivotal role in tumor growth and survival, with altered lipid pathways being associated with cancer progression. Statins, well-known for their cholesterol-lowering properties, have emerged as potential anticancer agents by targeting lipid metabolism in tumors. However, their clinical use is limited due to low bioavailability and stability. Encapsulating statins in polymeric nanocapsules has been suggested to overcome these limitations and enhance therapeutic efficacy. Methods: This systematic review and meta-analysis compiled data from 22 preclinical studies involving 127 animals to evaluate the antitumor efficacy of statin-loaded polymeric nanocapsules. The meta-analysis assessed tumor growth inhibition, tumor weight reduction, and the overall effect size of these nanocapsules compared to non-encapsulated statins. Statistical methods were used to compute Standard Mean Differences (SMD) and evaluate heterogeneity. Results: The meta-analysis showed that statin-loaded polymeric nanocapsules significantly inhibited tumor growth (SMD −1.79; 95% CI −2.21 to −1.38; p  < 0.00001) and reduced tumor weight (SMD –3.53; 95% CI −4.75 to −2.31; p  < 0.0001) across various solid tumor models. Risk of bias assessments indicated moderate to high variability in the quality of the included studies. Conclusions: Statin-loaded polymeric nanocapsules significantly enhance the antitumor efficacy of statins by improving their bioavailability and stability. These findings highlight the potential of nanomedicine in cancer therapy, particularly for tumors dependent on lipid metabolism. Future clinical trials are needed to validate these preclinical results and further explore the clinical applicability of statin-loaded nanocapsules in cancer treatment. Implications for Clinical Practice and Future Research: The development of statin-loaded polymeric nanocapsules offers a promising strategy for enhancing the effectiveness of statins in cancer therapy. Future research should focus on optimizing nanocapsule formulations, conducting clinical trials to assess long-term safety and efficacy, and exploring combination therapies with other anticancer agents.

Background Hydrogen sulfide (H 2 S), a third member of gasotransmitter family along with nitric oxide and carbon monoxide, generated from mainly catalyzed by cystathionine-lyase, possesses important functions in the cardiovascular system. Ischemic post-conditioning (PC) strongly protects against the hypoxia/reoxygenation (H/R)-induced injury and apoptosis of cardiomyocytes. However, PC protection is ineffective in the aging cardiomyocytes. Whether H 2 S restores PC-induced cardioprotection by decrease of reactive oxygen species (ROS) level in the aging cardiomyocytes is unknown. Methods The aging cardiomyocytes were induced by treatment of primary cultures of neonatal cardiomyocytes using d -galactose and were exposed to H/R and PC protocols. Cell viability was observed by CCK-8 kit. Apoptosis was detected by Hoechst 33342 staining and flow cytometry. ROS level was analyzed using spectrofluorimeter. Related protein expressions were detected through Western blot. Results Treatment of NaHS (a H 2 S donor) protected against H/R-induced apoptosis, cell damage, the expression of cleaved caspase-3 and cleaved caspase-9, the release of cytochrome c (Cyt c ). The supplementation of NaHS also decreased the activity of LDH and CK, MDA contents, ROS levels and the phosphorylation of IκBα, NF-κB, JNK2 and STAT3, and increased cell viability, the expression of Bcl-2, the activity of SOD, CAT and GSH-PX. PC alone did not provide cardioprotection in H/R-treated aging cardiomyocytes, which was significantly restored by the addition of NaHS. The beneficial role of NaHS was similar to the supply of N-acetyl-cysteine (NAC, an inhibitor of ROS), Ammonium pyrrolidinedithiocarbamate (PDTC, an inhibitor of NF-κB) and AG 490 (an inhibitor of JNK2), respectively, during PC. Conclusion Our results suggest that exogenous H 2 S contributes to recovery of PC-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2/STAT3 pathways in the aging cardiomyocytes.

Background Hydrogen sulfide (H2S), a third member of gasotransmitter family along with nitric oxide and carbon monoxide, generated from mainly catalyzed by cystathionine-lyase, possesses important functions in the cardiovascular system. Ischemic post-conditioning (PC) strongly protects against the hypoxia/reoxygenation (H/R)-induced injury and apoptosis of cardiomyocytes. However, PC protection is ineffective in the aging cardiomyocytes. Whether H2S restores PC-induced cardioprotection by decrease of reactive oxygen species (ROS) level in the aging cardiomyocytes is unknown. Methods The aging cardiomyocytes were induced by treatment of primary cultures of neonatal cardiomyocytes using d-galactose and were exposed to H/R and PC protocols. Cell viability was observed by CCK-8 kit. Apoptosis was detected by Hoechst 33342 staining and flow cytometry. ROS level was analyzed using spectrofluorimeter. Related protein expressions were detected through Western blot. Results Treatment of NaHS (a H2S donor) protected against H/R-induced apoptosis, cell damage, the expression of cleaved caspase-3 and cleaved caspase-9, the release of cytochrome c (Cyt c). The supplementation of NaHS also decreased the activity of LDH and CK, MDA contents, ROS levels and the phosphorylation of IκBα, NF-κB, JNK2 and STAT3, and increased cell viability, the expression of Bcl-2, the activity of SOD, CAT and GSH-PX. PC alone did not provide cardioprotection in H/R-treated aging cardiomyocytes, which was significantly restored by the addition of NaHS. The beneficial role of NaHS was similar to the supply of N-acetyl-cysteine (NAC, an inhibitor of ROS), Ammonium pyrrolidinedithiocarbamate (PDTC, an inhibitor of NF-κB) and AG 490 (an inhibitor of JNK2), respectively, during PC. Conclusion Our results suggest that exogenous H2S contributes to recovery of PC-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2/STAT3 pathways in the aging cardiomyocytes.

Intra-arterial infusion chemotherapy for locally advanced breast cancer (LABC) has been previously performed. However, the main complications of this type of chemotherapy remain to be clarified. In the present study, catheterization chemotherapy was carried out for 53 LABC cases (stage IIIa-IIIc) between May, 2006 and March, 2007. For IIIB and IIIC patients, the catheters were guided to the opening of the subclavian artery. For stage IIIa patients, the catheters were placed into the thoracic artery through a subcutaneous femoral artery puncture. One to four cycles of chemotherapy (mean, 1.6 cycles) were administered for the patients using taxotere, epidoxorubicin, 5-fluorouracil and/or cyclophosphamide. The interval time between the two cycles was 21 days. Seven cases were identified as complete response (CR, 13.2%), 41 cases were partial response (PR, 77.4%) with a rate of effectiveness of (CR + PR, 90.6%), 5 cases were stable disease (SD, 9.40%) and no case was progressive. Pain of the ipsilateral upper extremity was present in 7 cases. Two cases exhibited ipsilateral upper extremity atrophy following drug administration from the opening of the subclavian artery. One case experienced neck pain and headache, while in one case necrosis of local skin was evident. Hematological toxicity over grade 3 was observed in 6 cases (11.30%). Systemic toxicity was mild and did not affect the quality of life of the patients. Overall survival was identified as 18/51 (35.3%), and free-disease survival as 10/51 (19.6%). In conclusion, intra-arterial infusion chemotherapy is an effective local control treatment for LABC. The main complications are pain of the ipsilateral upper extremity and neck as well as headache. Severe complications are ipsilateral upper extremity atrophy and necrosis of local skin. During the treatment, controlling the pressure of the tourniquet and velocity of drug administration are crucial for reducing local complications.

China has set a goal of large-scale, independent development of nuclear power capacity in the near future. In this context, it becomes very important to establish a pattern of project management for nuclear power engineering that will promote the growth of the nuclear power industry and improve the quality of project management. In this paper, project management in nuclear power engineering is analyzed through interpretative structural modeling. The resulting model shows that the cooperation between the proprietor (utility) and the architect-engineer (AE) company is the key to the validity of the system. If engineering and procurement (and, in the future, construction) are combined in one company, the system structure is simplified, making the management system clear and efficient. The analysis also shows that, to prepare for the upcoming period of large-scale nuclear construction in China, it will be important to encourage the development of Chinese nuclear power AE companies. This analysis has important theoretical and practical significance for optimizing project management systems for construction of nuclear power plants.