Explore the vast range of titles available.

Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn’s Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many intestinal and extraintestinal diseases. As one of the representative bacteria for probiotic-assisted therapy in IBD, multiple strains of Lactobacillus have been proven to alleviate intestinal damage and strengthen the intestinal immunological barrier, epithelial cell barrier, and mucus barrier. Lactobacillus also spares no effort in the alleviation of IBD-related diseases such as Colitis-associated Colorectal cancer (CAC), Alzheimer’s Disease (AD), Depression, Anxiety, Autoimmune Hepatitis (AIH), and so on via gut-brain axis and gut-liver axis. This article aims to discuss the role of Lactobacillus in IBD and IBD-related diseases, including its underlying mechanisms and related curative strategies from the present to the future.

Haze pollution in China is very serious and has become the source of mortality, affecting the health and lives of residents. The Chinese government adopts different policy measures to reduce haze pollution. The impact of different types of environmental regulations on haze pollution has become a hot topic for academics and government departments. Based on panel data from 2005-2017, this paper studies the effect of different types of environmental regulations on haze pollution in 30 provinces of China using a panel quantile model. The results show that when haze pollution changes from a low quantile to a high quantile, the marginal impact of command-and-control environmental regulation on haze pollution changes from 0.122 to -0.332. Command-and-control environmental regulation can reduce haze pollution, but its impact is not significant. The main reason for this finding is that environmental law enforcement is not strict. The marginal impact of economically restrained environmental regulation on haze pollution changes from -14.389 to 49.939. Economically restrained environmental regulation can reduce haze pollution in low quantiles, but not in high quantiles. The collection of sewage charges fees is far less than the total profit, which has no deterrent effect on enterprises. The marginal impact of public participation in environmental regulation on haze pollution changes from 0.154 to -0.002. Public participation in environmental regulation cannot reduce haze pollution in low quantiles, but can in high quantiles; however its impact becomes insignificant. This study reveals the quantile-based discrepancy in the effect of environmental regulation on haze pollution, and offers a new perspective for research on the effects of environmental regulation.

The average annual growth rate of China’s waste emissions from 2007 to 2017 was 2.3%. The main pollutants in the wastewater are chemical oxygen demand, ammonia nitrogen, total ammonia, total phosphorus, and so on which pollute groundwater and destroy ecosystems. Poor water quality reduces the edible value of agricultural products and has an impact on human health. Based on the panel data of 31 provinces in China from 2007 to 2017, this paper uses a dynamic spatial panel lag model to study the impact of China’s water pollution on agricultural economic growth. The results show that the impact of China’s water pollution on agricultural economic growth is significant. If the intensity of wastewater discharge is taken as an input factor in the process of agricultural production, the growth of agricultural economy tends to decline with the increase of water pollution. In the effect analysis, the short-term and long-term effects are significant. The absolute value of the long-term total effect is far greater than the short-term total effect, indicating that the inhibitory effect of water pollution on agricultural economic growth is more obvious. The cumulative effect of water pollution on agricultural economic growth continues to expand, resulting in more and more economic losses. The central and local governments should take various measures to reduce water pollution, guide the green development of agriculture, and increase farmers’ income to realize the rural revitalization plan.

A simulation study was conducted on the hydrogen leakage diffusion process and influencing factors of fuel cell vehicles in enclosed spaces. The results indicate that when hydrogen leakage flows towards the rear of the vehicle, it mainly flows along the rear wall of the space and diffuses to the surrounding areas. Setting ventilation openings of different areas on the top of the carriage did not significantly improve the spatial diffusion speed of the leaked hydrogen, and the impact on the concentration of leaked hydrogen was limited to the vicinity of the ventilation openings. The ventilation opening at the rear can accelerate the diffusion of hydrogen gas to the external environment, significantly reducing the concentration of hydrogen and rate of gas rise. When the leaked hydrogen gas flows towards the front of the vehicle and above the space, the concentration of hydrogen mainly increases along the height direction of the space. The research results have significant safety implications for the use of fuel cell semi-trailer trucks.

Using the panel data of China’s provinces from 2005 to 2016, the paper adopts the ultra-efficiency model to measure the green economy efficiency of each province. Then, the paper used the panel threshold model to study the impact of science and technological input on the green economy efficiency with the energy consumption intensity as a threshold variable. The results show that the green economy efficiency in China’s provinces is low and is in a downward trend. When the energy consumption intensity is the threshold variable, the single-threshold effect is significant. When the energy consumption intensity is lower than the threshold value, the impact of science and technological input on green economic efficiency is not significant, and the energy consumption intensity has a significant impact on green economic efficiency with science and technological input and energy consumption intensity as the core explanatory variables and with energy consumption intensity as the threshold variable. When the energy consumption intensity crosses the threshold value, the impact of science and technological input and energy consumption intensity on green economic efficiency becomes significant. According to the above empirical results, this paper proposes corresponding countermeasures and suggestions.

This study aimed to prepare mitoxantrone thermosensitive liposome (MTX-TSL) to enhance the targeting capability of liposomes and thus improve the therapeutic effect of the drug on prostate cancer. MTX-TSL were prepared using the thin-film hydration method. A single-factor experiment was conducted to optimize the formulation process, and the liposome quality was assessed alongside short-term stability testing. The in vitro efficacy of MTX-TSL was evaluated using RM-1 prostate cancer cell inhibition assays. In vivo experiments were conducted on BDF1 mice inoculated with RM-1 cells to assess the tissue distribution and anticancer activity of MTX-TSL. Quality assessments of MTX-TSL revealed a pH of 6.53 ± 0.02, osmotic pressure of 309 ± 3 mOsmol/Kg, particle size of 100.10 ± 1.50 nm, and encapsulation efficiency of 98.41% ± 0.23%. Stability tests showed no major quality changes for liposome suspensions stored at 2–8 °C for 2 months. In vitro release studies showed that MTX-TSL exhibited good thermosensitive properties. Experiments performed on BDF1 mice indicated that initiating hyperthermia before drug administration was beneficial for drug accumulation in tumor tissue and that MTX-TSL outperformed free drugs in suppressing tumor growth when combined with appropriate hyperthermia. MTX-TSL can effectively inhibit tumor growth while increasing the drug’s therapeutic index.

Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing. We find that lineages begin to split when cells leave the tip HSC population, marked by high Sca-1 and CD201 expression. Downstream, HSCs either retain high Sca-1 expression and the ability to generate lymphocytes, or irreversibly reduce Sca-1 level and enter into erythro-myelopoiesis or thrombopoiesis. Thrombopoiesis is the sum of two pathways that make comparable contributions in steady state, a long route via multipotent progenitors and CD48 hi megakaryocyte progenitors (MkPs), and a short route from HSCs to developmentally distinct CD48 −/lo MkPs. Enhanced thrombopoietin signaling differentially accelerates the short pathway, enabling a rapid response to increasing demand. In sum, we provide a blueprint for mapping physiological differentiation fluxes from HSCs and decipher two functionally distinct pathways of native thrombopoiesis. Hematopoietic stem cells produce diverse cell lineages. Here, the authors apply single-cell RNA-seq, computational integration of non-perturbative approaches for fate-mapping, and mitotic tracking to chart lineage decisions in native hematopoiesis and identify megakaryocyte progenitors that directly link HSCs to megakaryocytes.

The use of agricultural films, pesticides, and fertilizers has increased in China, leading to the degradation of the agricultural ecological environment. Based on the panel data of 30 provinces in China from 2010 to 2021, this paper takes agricultural film usage as the threshold variable to study the impact of pesticide and fertilizer usage on agricultural development. The research results show that a single threshold effect of agricultural film usage is significant. When agricultural film usage is both a core and threshold variable, that is lower than the threshold value, every 1% increase in agricultural film usage will reduce agricultural output value by 0.9862%, and the impact is significant. When agricultural film usage crosses the threshold value, every 1% increase in agricultural film usage will increase agricultural output value by 1.1843%, and the impact is significant. When pesticide usage is the core variable, regardless of whether agricultural film usage is below or above the threshold, pesticide usage promotes agricultural development. Its impact is significant. When fertilizer input is a core variable, regardless of whether agricultural film usage is below or above the threshold, the use of fertilizers hinders agricultural development. The impact of fertilizer input on agricultural development is significant. Through empirical testing, this paper explores the deep relationship between agricultural film usage, pesticide usage and fertilizer input on agricultural development. These can effectively allocate agricultural production factors, transform the mode of agricultural economic growth, achieve the coordinated development of the ecological environment and agricultural economy and provide data support for the formulation of agricultural green development policies.

S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death, self-degradation, cell specialization, aging, and immune system reactions. Autophagy is a meticulously controlled mechanism in which cells repurpose their elements to maintain cellular balance. There are five stages in autophagy: initiation, nucleation, elongation and maturation, fusion, and degradation. New research has provided insight into the complex connection between S1P and autophagy, uncovering their interaction in both normal and abnormal circumstances. Gaining knowledge about the regulatory mechanism of S1P signaling on autophagy can offer a valuable understanding of its function in well-being and illness, potentially leading to innovative therapeutic concepts for diverse ailments. Hence, this review analyzes the essential stages in mammalian autophagy, with a specific emphasis on recent research exploring the control of each stage by S1P. Additionally, it sheds light on the roles of S1P-induced autophagy in various disorders.

A marked elevation of TLR4 was observed in various organs of septic mice. The mechanism of TLR4 in intestinal epithelial cell damage in sepsis remains unclear. CLP mice models were used to assess the role of TLR4 in intestinal Paneth cell damage by histological, polymerase chain reaction, western-blot analyses. The ileal expression of TLR4 was increased by more than five-fold after CLP. CLP significantly increased 7-day mortality and was associated with a higher murine sepsis score (MSS), closely related with increased TLR4 expression. Histological staining revealed that a reduced number of Paneth cells, accompanied by reduced lysozyme and defensin alpha 5(DEF-5) expression as detected by PCR. Of note, the expression levels of ATF6, XBP1 and CHOP increased in the ileal of the sepsis group. Meanwhile, the uncleaved p90 ATF6 was markedly reduced and cleaved p50 ATF6 was increased in the sepsis group. Intriguingly, The TAK-242 had improved intestinal mucosal injury, reduced the expression of ATF6, XBP1 and CHOP and relieved the cleavage of ATF6. We found that increased the expression level of TLR4 in the ileal of CLP mice promoted the depletion of Paneth cell and reduced LYZ and DEF-5 expression. Furthermore, our findings suggested that TLR4-mediated the hyperactivation of ER stress, via activating the ATF6/CHOP pathway, might be one of the mechanisms associated with Paneth cells loss and dysfunction during intestinal barrier impairment of sepsis.