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Cervical cancer is the second leading cause of morbidity and mortality in women worldwide. Traditional treatment methods have become limited. Naringenin, a flavonoid abundant in various fruits and herbal medicines, has demonstrated anti-tumor properties among other effects. This research undertook to elucidate the mechanism of naringenin in the context of cervical cancer treatment by leveraging network pharmacology and performing experimental validation. Initial steps involved predicting potential naringenin targets and subsequently screening for overlaps between these targets and those related to cervical cancer, followed by analysis of their interrelationships. Molecular docking was subsequently utilized to verify the binding effect of the central target. Within the framework of network pharmacology, it was discovered that naringenin might possess anti-cancer properties specific to cervical cancer. Following this, the anti-tumor effects of naringenin on Hela cell viability, migration, and invasion were assessed employing CCK-8, transwell, wound healing assays, and western blotting. Experimental data indicated that naringenin attenuates the migration and invasion of Hela cells via downregulation EGFR/PI3K/AKT signaling pathway. Thus, our findings suggest that naringenin has therapeutic impacts on cervical cancer via multiple mechanisms, primarily by inhibiting the migration and invasion through the EGFR/PI3K/AKT/mTOR pathway. This study offers fresh insights for future clinical studies.

Smallholder farming has in China been viewed as a practice needing transformation. Its relationship with rural development and economic growth has been frequently analyzed in China. Government‐led initiatives promoting the integration of smallholder operations with industrialized agriculture have resulted in collaboration models between smallholders and large‐scale agribusiness. Circular agriculture understood as an agricultural practice that enhances economic and ecological sustainability represents one of the mechanisms through which such collaboration can take place. While this collaboration provides smallholders with opportunities for increased productivity and income, it also carries the risk of marginalization. This study examines the collaboration between agricultural capital and smallholders in southwest China focusing on an integrated pomelo planting and a pig breeding project. The varying interests and risks faced by smallholders, government agencies, agricultural cooperatives, private enterprises, and financial institutions are explored. Findings suggest that local governments play a key role in facilitating the introduction of capital and affording the initial costs of organizing smallholders, while agricultural cooperatives decoupling smallholders from capital are central to the operation of large‐scale production models. However, findings also show that local government involvement is often politically motivated, that smallholders' autonomy and voice in decision‐making are limited, and that a risk of exploiting their interests under the guise of institutional innovation remains. The viability of these collaboration models lies thus rather in its ability to attract new producers and create jobs particularly for returning migrants or local smallholders. The findings could offer a potential pathway for addressing the agricultural transformation challenges facing China. Plain Language Summary Smallholders have long been the backbone of agriculture in China; the central government advocates encouraging smallholders to cooperate with large‐scale agribusinesses to achieve agricultural modernization and improve the productivity and sustainability of smallholders. Circular agriculture is a promising approach in these cooperative models, focusing on reducing waste, recycling by‐products, and achieving economic and environmental benefits. This study observed how smallholders and agribusinesses cooperate in southwest China, focusing on the model of combining pomelo planting with pig farming. The findings highlight the important role of local governments in building platforms with the core function of agricultural cooperatives in managing business. However, the research also shows that government involvement is often politically motivated and smallholders may lose autonomy and fair representation in the decision‐making process. This study provides an in‐depth exploration of how circular agriculture can address the challenges of China's agricultural transformation and create a more inclusive and sustainable future for smallholders. Key Points Circular agriculture models integrating pomelo planting and pig breeding link smallholders with agricultural capital Local government is pivotal in facilitating capital and resources, while agricultural cooperatives decoupled smallholders from capital Viable collaboration attracts producers and protects smallholder interests providing insights for China's agricultural transformation

Improving water retention, erosion resistance and nutrients in desert areas is essential for ecological sustainability. This study evaluated the effects of biochar, polyethylene oxide (PEO), and seaweed fertilizer on the properties of desert sandy soil, focusing on water retention, erosion resistance, and soil nutrients. The sandy soil used in the study was taken from the Tengger Desert in Gansu, China, and an orthogonal experimental design was used to select three different proportions of biochar, PEO, and seaweed fertilizer. Compared with the control, applying of these three substances decreased bulk density by 5.8–9.6%, increased porosity by 8.3–14%, and increased water-holding capacity by 2.2–6.7%. The erosion rate decreased by more than 99%, and water-stable aggregates increased by 9.7–37.4%. Soil nutrients showed varying degrees of increase, and seed germination increased by 26.7%. The results of the principal component analysis showed that B6P0.6S2 had the best overall improvement effect. Therefore, a ratio of 6% biochar, 0.6% PEO, and 2% seaweed fertilizer is recommended to improve the properties of sandy desert soils. Overall, biochar, PEO, and seaweed fertilizer can improve the physical properties of desert sandy soil, enhance soil nutrients, and create a stable and suitable environment for plant growth.

This study aimed to extend the storage time of fresh-cut lotus roots. A quantitative evaluation was conducted using the grey–correlation analysis method based on the variation–coefficient weight to observe the treatment of acetic acid (0, 2%, and 5%) and ozone (0, 0.3 mg/L, and 0.6 mg/L). Their effects on weight loss rate, browning degree, and the content of reducing sugar, ascorbic acid, and free amino acid were determined. Under varied treatments and storage time, the weight loss rate, browning degree, and content of nutritional components in fresh-cut lotus root differed. Result of the weighted correlation degree showed that for fresh-cut lotus root stored for more than 4 days, 0.3 mg/L ozone could be used as preservative to ensure the storage quality. These findings could provide a scientific basis for using acetic acid and ozone as preservative to extend the storage time of fresh-cut lotus root.

Rural entrepreneurship has been seen by the central government of China as a key means to rural vitalization. However, research focus on the long-term developmental status of rural entrepreneurship at local scale has been limited. According to industry types of differentiation, this research describes rural enterprises registered in the administrative area of Mianyang, southwest China, from 2011 to 2020. The spatial-temporal distribution rule of rural entrepreneurship is explored via a quantitative approach focused on spatial analysis and correlation analysis, as well as the application of geocoding on web data. How contexts such as the natural base, socio-economic condition, and institutional arrangements impact this distribution are empirically explored and discussed. The paper adds spatial-temporal insights into the role of the context of rural entrepreneurship. In particular, the paper highlights that rural entrepreneurship is a process potentially best explored at the regional scale and that physical condition and institutional support play central roles in rural entrepreneurship in southwest China.

Introduction: Corydalis yanhusuo total alkaloids (CYTA) are the primary active ingredients in yanhusuo , known for their analgesic and cardioprotective effects. However, the mechanisms underlying the treatment of Myocardial ischemia (MI) with CYTA have not been reported. The purpose of this study was to explore the protective effect of CYTA on MI and its related mechanisms. Methods: A network pharmacology was employed to shed light on the targets and mechanisms of CYTA’s action on MI. The protective effect of CYTA against hypoxia damage was evaluated in H9c2 cells. Furthermore, the effects of CYTA on L-type Ca 2+ current (I Ca-L ), contractile force, and Ca 2+ transient in cardiomyocytes isolated from rats were investigated using the patch clamp technique and IonOptix system. The network pharmacology revealed that CYTA could regulate oxidative stress, apoptosis, and calcium signaling. Cellular experiments demonstrated that CYTA decreased levels of CK, LDH, and MDA, as well as ROS production and Ca 2+ concentration. Additionally, CYTA improved apoptosis and increased the activities of SOD, CAT, and GSH-Px, along with the levels of ATP and Ca 2+ -ATPase content and mitochondrial membrane potential. Moreover, CYTA inhibited I Ca-L , cell contraction, and Ca 2+ transient in cardiomyocytes. Results: These findings suggest that CYTA has a protective effect on MI by inhibiting oxidative stress, mitochondrial damage, apoptosis and Ca 2+ overload. Discussion: The results prove that CYTA might be a potential natural compound in the field of MI treatment, and also provide a new scientific basis for the its utilization.

The dietary supplement industry offers a wide range of orally consumed products that claim to combat skin photoaging, however, there is a lack of research on the proof of safety and effectiveness of dietary supplements in anti-skin photoaging. To further confirm their safety and efficacy, this article provides a detailed review and meta-analysis. Four databases, including PubMed, Embase, Web of Science, and the Cochrane Library (Central Database), were searched for relevant literature up to October 2024. A total of forty English-language randomized controlled trials (RCTs) investigating the relationship between dietary supplements and skin photoaging were screened for an in-depth review and meta-analysis. Collagen, flavanols, and other polyphenol supplements have been found to alleviate skin photoaging and increase MED or overall skin elasticity (R2) when compared to a placebo. However, hyaluronic acid, lycopene, and carotenoids did not show any significant benefits in improving skin photoaging or MED/R2. Due to inconsistent findings and limited research, the effects of dietary supplements on skin photoaging could not be determined in randomized controlled trials with two or fewer studies. It is important to note that, during the study period (typically ≤ 24 weeks), all orally administered dietary supplements were found to be safe. Oral dietary supplements, such as collagen, flavanols, and polyphenols, have demonstrated effectiveness in addressing skin photoaging. However, there is currently insufficient evidence to support the recommendation of other dietary supplements, such as astaxanthin, for the treatment of skin photoaging. This research serves as an initial step in exploring the benefits of dietary supplements in combating skin photoaging. It underscores the need for more focused studies to further investigate the effects of dietary supplements on skin photoaging and gather additional evidence supporting their efficacy. https://www.crd.york.ac.uk/PROSPERO/view/CRD42023472473, identifier CRD42023472473.

Osteoarthritis (OA) is a degenerative disease of cartilage that affects the quality of life and has increased in morbidity and mortality in recent years. Cartilage homeostasis and dysregulation are thought to be important mechanisms involved in the development of OA. Many studies suggest that lncRNAs are involved in cartilage homeostasis in OA and that lncRNAs can be used to diagnose or treat OA. Among the existing therapeutic regimens, lncRNAs are involved in drug-and nondrug-mediated therapeutic mechanisms and are expected to improve the mechanism of adverse effects or drug resistance. Moreover, targeted lncRNA therapy may also prevent or treat OA. The purpose of this review is to summarize the links between lncRNAs and cartilage homeostasis in OA. In addition, we review the potential applications of lncRNAs at multiple levels of adjuvant and targeted therapies. This review highlights that targeting lncRNAs may be a novel therapeutic strategy for improving and modulating cartilage homeostasis in OA patients.

A critical challenge that impedes the application of photocatalytic techniques for organic dye degradation from polluted industrial effluents is that traditional powdery photocatalysts exposed limited photo-absorption sites and exhibited inefficient recyclability. To overcome these challenges, this study designed a one-step process to synthesize a monolithic copper selenide (CuSe)-based photocatalyst. The characterization results fully supported that the maintenance of the copper foam during the selenization process was the prerequisite for the monolithic photocatalyst to keep its structural integrity in photocatalytic reactions. The surface of the monolithic photocatalyst fully covered by active CuSe is crucial for the exposure of photocatalytically active sites and the efficient degradation of methylene blue (MB). It was found that the CuSe-based monolithic photocatalyst exhibited excellent MB degradation performances under harsh pH conditions and high MB concentrations. From these perspectives, it is reasonable to conclude that the CuSe-based monolithic photocatalyst as prepared is a promising alternative to traditional powdery photocatalysts for organic dye degradation and industrial effluent cleaning.

Flood disasters occur frequently and cause great losses. Improving the resilience of urban flood disasters is of great significance to improving disaster prevention and mitigation in the region. The metropolitan area is the center of regional economic development and the key to strengthening the construction of local resilience. However, there is little research on resilience in the metropolitan area. Taking nine cities in the Zhengzhou metropolitan area as the research object, this paper uses the pressure state response (PSR) model to build the evaluation system of the Zhengzhou metropolitan area’s flood disaster resilience and comprehensively uses the entropy weight method, analytic hierarchy process, kernel density estimation method, and factor contribution model to measure the temporal and spatial evolution characteristics of Zhengzhou metropolitan area’s flood disaster resilience from 2010 to 2022, excavating the development trend of the level of flood disaster resilience of members in the Zhengzhou metropolitan area, and explore the driving factors affecting the resilience of the Zhengzhou metropolitan area’s flood disaster. The results show that (1) from 2010 to 2022, the development trend of flood disaster resilience among the Zhengzhou metropolitan area members has obvious differences, the change of pressure resilience is stable, and the state resilience and response resilience increase as a whole; (2) the results show that the resilience of flood disaster in the Zhengzhou metropolitan area has obvious change characteristics in time and space, and the overall trend is to take Zhengzhou as the core to drive the surrounding members’ upward development; (3) in the driving factor analysis, the number of ordinary colleges and universities and the proportion of public security expenditure in fiscal expenditure are the main influencing factors in the resilience evaluation index. The Zhengzhou metropolitan area is the key area of economic development in Henan Province. The research results provide a reference for improving the resilience level of the Zhengzhou metropolitan area and strengthening the prevention and control of flood disasters.