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"Li, Li-Ren"
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The hospitality and tourism industry in ASEAN and East Asian destinations : new growth, trends, and developments
\"This new volume addresses the growing interest to understand tourism and hospitality in Southeast and South Asia, two regions that have seen tremendous growth in international tourists in recent years. It explores the current development of hospitality and tourism industry in the regions of Hong Kong, Macao and Taiwan as well as other key countries in Southeast and South Asia. The Hospitality and Tourism Industry in ASEAN and East Asian Destinations: New Growth, Trends, and Developments provides updated findings and case studies that highlight opportunities and issues of tourism and hospitality development in ASEAN. Chapters cover such diverse topics as online marketing strategies, sustainable hospitality development, diversification efforts of the tourism industry Innovations in independent hotels, wildlife tourism in urban destinations, the Vietnamese national park system, consumers' positive and negative images of certain destinations. While academicians will benefit from the updated research findings summarized by the respected scholars, hospitality professionals will also find the book a valuable source of information as the chapters delve into the most recent topical and industry focused issues.\"-- Provided by publisher.
Book
Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencing on 1015 patients with CRC as part of the ChangKang Project. We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients:
LYST
,
DAPK1
,
CR2
,
KIF16B
,
NPIPB15
,
SYTL2
,
ZNF91
, and
KIAA0586
. With an unsupervised clustering algorithm, we propose a subtyping strategy that classisfies CRC patients into four genomic subtypes with distinct clinical characteristics, including hypermutated, chromosome instability with high risk, chromosome instability with low risk, and genome stability. Analysis of immunogenicity uncover the association of immunogenicity reduction with genomic subtypes and poor prognosis in CRC. Moreover, we find that mitochondrial DNA copy number is an independent factor for predicting the survival outcome of CRCs. Overall, our results provide CRC-related molecular features for clinical practice and a valuable resource for translational research.
The ChangKang (Heathy Bowel) project was established to collect molecular and clinical information of a thousand Chinese colorectal cancer patients. Here, the authors present the genomic landscape of the ChangKang cohort and find a subgroup of patients defined by abnormal mitochondrial copy numbers.
Journal Article
Comparative study on overall, surface and centre compressed solid wood
For more efficient utilisation of low-density solid wood, this study used white poplar (Populus tomentosa) solid wood as the material. Surface, centre, and overall compressed solid wood were subsequently obtained, and a comparative analysis was conducted on their structure, density, modulus of elasticity (MOE), modulus of rupture (MOR), and hardness. The results indicated that different thermos-hydro-mechanical (THM) treatment processes could effectively and accurately control the wood structure. In addition, when the compression rate was the same, an uneven structure was more conducive to improving wood density and bending resistance. Moreover, the higher the surface layer density, the greater the bending properties and hardness. Consequently, surface-compressed wood exhibited the highest compressed layer density, peak density, MOE, MOR, and hardness among the three types of compressed wood. Specifically, when the overall compression rate was 20.0%, its layer density, peak density, MOE, MOR, and hardness were 0.73 g/cm
3
, 0.85 g/cm
3
, 15.97 GPa, 105.19 MPa and 35.60 N/mm
2
, respectively. In summary, in wood applications, positioning the densified layer in the most critical areas could improve the physical and mechanical properties of wood and promote more efficient utilisation.
Journal Article
Business trends in the digital era : evolution of theories and applications
This book introduces 10 mega business trends, ranging from big data to the O2O model. By mining and analyzing mountains of data, the author identifies these 10 emerging trends and goes to great lengths to explain and support his views with up-to-date cases. By incorporating the latest developments, this book allows readers to keep abreast of rapidly advancing digital technologies and business models. In this time of mass entrepreneurship and innovation, acquiring deep insights into business trends and grasping opportunities for innovation give readers (business executives in particular) and their companies a competitive advantage and the potential to become the next success story. The Chinese version of the book has become a hit, with some business schools using it as a textbook for their S & T Innovation and Business Trends programs. It also provides business executives with a practical guide for their investment and operation decisions.
Book
The Immunoscore system predicts prognosis after liver metastasectomy in colorectal cancer liver metastases
BackgroundThe Immunoscore was initially established to evaluate the prognosis of stage I/II/III colorectal cancer patients. However, the feasibility of the Immunoscore for the prognosis of colorectal cancer liver metastases (CRCLM) has not been reported.MethodsLiver metastases in 249 CRCLM patients were retrospectively analyzed. The Immunoscore was assessed according to the counts and densities of CD3+ and CD8+ T cells in the central- and peritumoral areas by immunohistochemistry. The prognostic role of the Immunoscore for relapse–free survival (RFS) and overall survival (OS) was analyzed with Kaplan–Meier curves and Cox multivariate models, and confirmed via an internal validation. Receiver operating characteristic (ROC) curves were plotted to compare the prognostic values of the Immunoscore and the clinical risk score (CRS) system.ResultsCRCLM patients with high Immunoscores (> 2) had significantly longer RFS [median RFS (95% confidence interval; 95% CI) 21.4 (7.8–35.1) vs. 8.7 (6.8–10.5) months, P < 0.001] and OS [median OS (95% CI): not reached vs. 28.7 (23.2–34.2) months, P < 0.001] than those with low Immunoscores (≤ 2). After stratification by CRS, the Immunoscore retained a statistically significant prognostic value for OS. The areas under the ROC curves (AUROCs) of the Immunoscore and the CRS system for RFS were 0.711 [95% CI 0.642–0.781] and 0.675[95% CI 0.601–0.749] (P = 0.492), whereas the AUROC of the Immunoscore system for OS was larger than that of the CRS system [0.759 (95% CI 0.699–0.818) vs. 0.660 (95% CI 0.592–0.727); P = 0.029].ConclusionsThe Immunoscore of liver metastases can be applied to predict the prognosis of CRCLM patients following liver resection.
Journal Article
Modulation of ENSO on Fast and Slow MJO Modes during Boreal Winter
This study investigates modulation of El Niño–Southern Oscillation (ENSO) on the Madden–Julian oscillation (MJO) propagation during boreal winter. Results show that the spatiotemporal evolution of MJO manifests as a fast equatorially symmetric propagation from the Indian Ocean to the equatorial western Pacific (EWP) during El Niño, whereas the MJO during La Niña is very slow and tends to frequently “detour” via the southern Maritime Continent (MC). The westward group velocity of the MJO is also more significant during El Niño. Based on the dynamics-oriented diagnostics, it is found that, during El Niño, the much stronger leading suppressed convection over the EWP excites a significant front Walker cell, which further triggers a larger Kelvin wave easterly wind anomaly and premoistening and heating effects to the east. However, the equatorial Rossby wave to the west tends to decouple with the MJO convection. Both effects can result in fast MJO propagation. The opposite holds during La Niña. A column-integrated moisture budget analysis reveals that the sea surface temperature anomaly driving both the eastward and equatorward gradients of the low-frequency moisture anomaly during El Niño, as opposed to the westward and poleward gradients during La Niña, induces moist advection over the equatorial eastern MC–EWP region due to the intraseasonal wind anomaly and therefore enhances the zonal asymmetry of the moisture tendency, supporting fast propagation. The role of nonlinear advection by synoptic-scale Kelvin waves is also nonnegligible in distinguishing fast and slow MJO modes. This study emphasizes the crucial roles of dynamical wave feedback and moisture–convection feedback in modulating the MJO propagation by ENSO.
Journal Article
Beneficiaries of radical surgery among clinical complete responders to neoadjuvant chemoradiotherapy in rectal cancer
This study aimed to identify patients who benefit from radical surgery among those with rectal cancer who achieved clinical complete response (cCR). Patients with locally advanced rectal cancer (LARC; stage II/III) who achieved cCR after neoadjuvant chemoradiotherapy (nCRT) were included (n = 212). Univariate/multivariate Cox analysis was performed to validate predictors for distant metastasis‐free survival (DMFS). A decision tree was generated using recursive partitioning analysis (RPA) to categorize patients into different risk stratifications. Total mesorectal excision (TME) was compared with the watch‐and‐wait (W&W) strategy in each risk group. Two molecular predicators of CEA and CA19‐9 were selected to establish the RPA‐based risk stratification, categorizing LARC patients into low‐risk (n = 139; CA19‐9 < 35 U/mL and CEA < 5 ng/mL) and high‐risk (n = 73; CA19‐9 ≥ 35 U/mL or CEA ≥5 ng/mL) groups. Superior 5‐y DMFS was observed in the low‐risk group vs. the high‐risk group (92.9% vs. 76.2%, P = .002). Low‐risk LARC patients who underwent TME had significantly improved 5‐y DMFS compared with their counterparts receiving the W&W strategy (95.9% vs. 84.3%; P = .028). No significant survival difference was observed in high‐risk patients receiving the 2 treatment modalities (77.9% vs. 94.1%; P = .143). LARC patients with cCR who had both baseline CA19‐9 < 35 U/mL and CEA < 5 ng/mL may benefit from radical surgery. In total, 212 patients with cCR were retrospectively analyzed and were categorized into low‐risk and high‐risk groups according to their baseline serum concentration of CEA and CA19‐9. Significantly better survival was observed in low‐risk patients when they underwent radical surgery, compared with their counterparts who underwent the watch‐and‐wait strategy.
Journal Article