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Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and the loss of iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress and triggering cell death. Recently, cuproptosis has garnered significant interest in tumor research due to its potential as a crucial therapeutic strategy against cancer. In this review, we summarized the cellular and molecular mechanisms of cuproptosis and its relationship with other types of cell death. Additionally, we reviewed the current drugs or strategies available to induce cuproptosis in tumor cells, including Cu ionophores, small compounds, and nanomedicine. Furthermore, we targeted cell metabolism and specific regulatory genes in cancer therapy to enhance tumor sensitivity to cuproptosis. Finally, we discussed the feasibility of targeting cuproptosis to overcome tumor chemotherapy and immunotherapy resistance and suggested future research directions. This study suggested that targeting cuproptosis could open new avenues for developing tumor therapy.

Children with Tourette Syndrome (TS) commonly experience chronic motor and vocal tics, anxiety, and impaired daily functioning, underscoring the need for accessible, developmentally appropriate interventions. This study evaluated the effects of a 12-week movement-based mindfulness intervention—Mindful Energy Balance Exercise (MEBE)—on self-regulation in children with TS. A total of 135 children aged 4–12 years were randomly assigned to either the MEBE plus standard care group or the standard care group alone, with 121 completing the intervention. The program consisted of 20-minute instructor-led group sessions delivered 5×/week (Weeks 1–3), 3×/week (Weeks 4–9), and 2×/week (Weeks 10–12), plus 10-minute daily home practice, including breathwork, body awareness, and mindful movement. Results showed significant improvements in the intervention group: motor tic frequency and intensity decreased, mindfulness scores increased, and anxiety symptoms—particularly separation and social anxiety—were reduced. Notable gains in daily functioning were observed, with the most robust gains in school-related functioning and a trend toward improvement in physical functioning. These findings support the feasibility and clinical promise of MEBE as a scalable, child-friendly mindfulness intervention with potential to improve psychological and functional outcomes in pediatric TS care.

With the deepening of population aging, the expenditure of basic endowment insurance in China is increasing. The urban employees’ basic endowment insurance(UEBEI) system for is an important part of China’s basic social endowment insurance system, which is the most important institutional guarantee for the basic needs of employees after retirement. It not only relates to the living standards of retired employees but also relates to the stability of the whole society. Especially considering the acceleration of urbanization process, the financial sustainability of the basic endowment insurance for employees is of great significance for safeguarding the pension rights of retired employees and realizing the normal operation of the whole system, and the operation efficiency of urban employees’ basic endowment insurance(UEBEI) fund inevitably becomes the focus of increasing attention. Based on the panel data of 31 provinces in China from 2016 to 2020, this paper established a three-stage DEA-SFA model, and compared the differences of comprehensive technical efficiency, pure technical efficiency and scale efficiency with radar chart, aiming to explore the operating efficiency of the UEBEI in China and how environmental factors affect it. The empirical results show that at present, the overall level of the expenditure efficiency of the UEBEI fund for urban workers is not high, and all provinces have not reached the efficiency frontier level, and there is still a certain space for efficiency improvement. Fiscal autonomy and elderly dependency ratio are negatively correlated with fund expenditure efficiency, while urbanization level and marketization level are positively correlated with fund expenditure efficiency. The regional difference of fund operation efficiency is significant, from high to low, it is East China, Central China and West China. Reasonable control of environmental variables and narrowing of regional economic development and fund expenditure efficiency differences can provide some enlightenment for better realization of common prosperity.

Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to be fully unlocked. This study develops deep-tissue activatable cancer sono-immunotherapy based on the discovery of a semiconducting polymer that generates sonodynamic singlet oxygen ( 1 O 2 ) substantially higher than other sonosensitizers. Conjugation of two immunomodulators via 1 O 2 -cleavable linkers onto this polymer affords semiconducting polymer immunomodulatory nanoparticles (SPINs) whose immunotherapeutic actions are largely inhibited. Under ultrasound irradiation, SPINs generate 1 O 2 not only to directly debulk tumors and reprogram tumor microenvironment to enhance tumor immunogenicity, but also to remotely release the immunomodulators specifically at tumor site. Such a precision sono-immunotherapy eliminates tumors and prevents relapse in pancreatic mouse tumor model. SPINs show effective antitumor efficacy even in a rabbit tumor model. Moreover, the sonodynamic activation of SPINs confines immunotherapeutic action primarily to tumors, reducing the sign of immune-related adverse events. To improve the specificity of immunotherapy, here the authors report the design of a semiconducting polymer immunomodulatory nanoparticle with sonodynamic process to remotely release immune-modulators for deep-tissue precision cancer sono-immunotherapy.

Background School teachers represent an occupational group among which there appears to be a high prevalence of neck and/or shoulder pain (NSP) and low back pain (LBP). Epidemiological data on NSP and LBP in Chinese teachers are limited. The aim of this study was to investigate the prevalence of and risk factors for NSP and LBP among primary, secondary and high school teachers. Methods In a cross-sectional study of teachers from 7 schools, information on participant demographics, work characteristics, occupational factors and musculoskeletal symptoms and pain were collected. Results Among 893 teachers, the prevalence of NSP and LBP was 48.7% and 45.6% respectively. There was significant association between the level and prevalence of NSP and LBP among teachers in different schools. The prevalence of NSP among female teachers was much higher than that for males. Self-reported NSP was associated with physical exercise (OR 0.55, 95% CI 0.35 to 0.86), prolonged standing (1.74, 1.03 to 2.95), sitting (1.76, 1.23 to 2.52) and static posture (2.25, 1.56 to 3.24), and uncomfortable back support (1.77, 1.23 to 2.55). LBP was more consistently associated with twisting posture (1.93, 1.30 to 2.87), uncomfortable back support (1.62, 1.13 to 2.32) and prolonged sitting (1.42, 1.00 to 2.02) and static posture (1.60, 1.11 to 2.31). Conclusions NSP and LBP are common among teachers. There were strong associations with different individual, ergonomic, and occupational factors.

Objectives This study aims to develop sarcopenia risk prediction models for Chinese older adults at different time intervals and to identify and compare modifiable factors contributing to sarcopenia development. Methods This study used data from 3,549 participants aged 60 and older in the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia status was evaluated by the AWGS2019 algorithm. Full models for 2- and 4-year sarcopenia risk, considering multifactorial baseline variables, were compared with modifiable models. Eight machine learning (ML) algorithms were used to build these models, with performance evaluated by the area under the receiver operating characteristic curve (AUC-ROC). SHapley Additive exPlanations (SHAP) was applied for model explanation. Results The average age of participants was 67.0 years (SD = 6.1), with 47.8% being female (1,696 participants). The ML models achieved moderate performance, and eXtreme Gradient Boosting (XGBoost) emerged as the best model for both the full and modifiable models in the 2-year prediction, with AUCs of 0.804 and 0.795, respectively (DeLong test, P  = 0.665). In contrast, in the 4-year prediction, the Light Gradient Boosting Machine (LightGBM) performed best with AUCs of 0.795 and 0.769, respectively ( P  = 0.053). The SHAP analysis highlighted gender and estimated glomerular filtration rate (eGFR) as the most important predictors in both the full and modifiable models. Conclusions Prediction models based on modifiable factors at different time intervals can help identify older Chinese adults at high risk of sarcopenia. These findings highlight the importance of prioritizing functional capacity and psychosocial determinants in sarcopenia prevention strategies.

Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known cell death pathways. The molecular underpinnings of cuproptosis involve the binding of Cu to lipoylated enzymes in the tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating in cell death. The specific mechanism of cuproptosis has yet to be fully elucidated. This newly recognized form of cell death has sparked numerous investigations into its role in tumorigenesis and cancer therapy. In this review, we summarized the current knowledge on Cu metabolism and its link to cancer. Furthermore, we delineated the molecular mechanisms of cuproptosis and summarized the roles of cuproptosis-related genes in cancer. Finally, we offered a comprehensive discussion of the most recent advancements in Cu ionophores and nanoparticle delivery systems that utilize cuproptosis as a cutting-edge strategy for cancer treatment.

Reducing carbon emissions is the key to fulfilling the “double carbon commitment” and promoting the green transformation of the economy. The financial sector is the forerunner of change in economic development. The rapid development of digital finance has disrupted the traditional financial operation mode and has had a significant impact on economic development and environmental quality. This paper explores the impact of digital finance development on carbon emissions using carbon emission data from 2011 to 2017 in China’s counties and combining it with the Digital Inclusive Finance Index of Peking University. The findings are as follows: (1) The development of digital finance can curb carbon emissions, and this causal relationship still holds through a series of robustness tests. The greater the carbon emissions, the better the carbon suppression effect of the development of digital finance. (2) When regions face strict financial regulation and environmental constraints, the development of digital finance can be more effective in reducing carbon emissions. The existence of a digital divide in general can weaken the disincentive effect of the development of digital finance on carbon emissions. (3) The development of digital finance can promote the development of green finance, enhance the level of green technological innovation, improve green total factor productivity, and transform energy structures, thus curbing carbon emissions. This paper not only enriches the literature on the development of digital finance and the environment but also provides a reference for government departments to improve the development strategy of digital finance and achieve “carbon peaking and carbon neutrality.”

Water inrush in karst tunnels usually results in casualties, equipment damage, project delays and other serious consequences. An important measure to ensure the safety of tunnel construction is to provide accurate prediction of water inrush during tunnel excavation. To study the stability of the surrounding rock under effect of a water-bearing cave in front of the tunnel face, a true triaxial geomechanical model test was carried out based on the engineering background of the Xiema Tunnel in Chongqing Province. The response regularities of multivariate physical information of the surrounding rock during rock failure and water inrush were obtained by monitoring the displacement, stress and seepage pressure of different monitoring sections. The results show that some internal connections exist among the kinds of physical information. When the tunnel face was adjacent to the disaster source, the change of displacement and stress was in a decreasing trend, and the seepage pressure increased first and then decreased during the tunnel excavation. In addition, by fusion analysis, the sensitivity priority of precursor information for a rock failure and water inrush disaster in karst tunnels was summarized as stress, displacement and seepage pressure. Finally, the theoretical basis of the prediction of water inrush in karst tunnels had been established, which proved the feasibility of predicting disasters according to the precursor information.

Ulcerative colitis (UC) is increasingly common, and it is gradually become a kind of global epidemic. UC is a type of inflammatory bowel disease (IBD), and it is a lifetime recurrent disease. UC as a common disease has become a financial burden for many people and has the potential to develop into cancer if not prevented or treated. There are multiple factors such as genetic factors, host immune system disorders, and environmental factors to cause UC. A growing body of research have suggested that intestinal microbiota as an environmental factor play an important role in the occurrence and development of UC. Meanwhile, evidence to date suggests that manipulating the gut microbiome may represent effective treatment for the prevention or management of UC. In addition, the main clinical drugs to treat UC are amino salicylate and corticosteroid. These clinical drugs always have some side effects and low success rate when treating patients with UC. Therefore, there is an urgent need for safe and efficient methods to treat UC. Based on this, probiotics and prebiotics may be a valuable treatment for UC. In order to promote the wide clinical application of probiotics and prebiotics in the treatment of UC. This review aims to summarize the recent literature as an aid to better understanding how the probiotics and prebiotics contributes to UC while evaluating and prospecting the therapeutic effect of the probiotics and prebiotics in the treatment of UC based on previous publications.