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"Li, Luo"
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المتاحف الصينية /
يتناول كتاب (المتاحف الصينية) والذي قام بتأليفه (لي شيا نياو، لوه تشهون) في حوالي (195) صفحة من القطع المتوسط موضوع (المتاحف) مستعرضا المحتويات التالية : قراءة حضارة الأمة الصينية من المتاحف-الكنوز في الوطن-المساهمات من الأقليات القومية في الصين-البحث عن أصل التاريخ-كنوز الكهوف الحجرية الصينية-القصورتحت الأرض-الحضارة الصينية-البلوارت الإنسانية-أم الحدائق-موطن الأسلاف-السماء السوداء والأرض الصفراء.
Book
Network text sentiment analysis method combining LDA text representation and GRU-CNN
In order to improve the performance of internet public sentiment analysis, a text sentiment analysis method combining Latent Dirichlet Allocation (LDA) text representation and convolutional neural network (CNN) is proposed. First, the review texts are collected from the network for preprocessing. Then, using the LDA topic model to train the latent semantic space representation (topic distribution) of the short text, and the short text feature vector representation based on the topic distribution is constructed. Finally, the CNN with gated recurrent unit (GRU) is used as a classifier. According to the input feature matrix, the GRU-CNN strengthens the relationship between words and words, text and text, so as to achieve high accurate text classification. The simulation results show that this method can effectively improve the accuracy of text sentiment classification.
Journal Article
Water cycle management : a new paradigm of wastewater reuse and safety control
This book focuses on environmental engineering, and on wastewater treatment and reuse in particular, which is a vital aspect for countries and regions suffering from water shortages. It introduces a new water cycle management concept for designing water systems that mimic the hydrological cycle, where reclaimed water is produced, stored/regulated, supplied and used in a semi-natural manner so that its self-purification capacity and system efficiency can be maximized. To ensure safe water throughout the cycle, emphasis is placed on the control of ecological and pathogenic risks using a series of quality indices associated with bioassays and molecular biological analyses, as well as risk assessments focusing on protecting the environment and human health. Together with theoretical and technological discussions, a real case of a district water system for maximizing water circulation and reuse by means of a sophisticated water cycle is presented. This book introduces readers to essential new concepts and practices and illustrates the future perspectives offered by a new paradigm for design and safety control in the context of wastewater reuse systems.
Book
Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
Resistance development to one chemotherapeutic reagent leads frequently to acquired tolerance to other compounds, limiting the therapeutic options for cancer treatment. Herein, we find that overexpression of Rac1 is associated with multi-drug resistance to the neoadjuvant chemotherapy (NAC). Mechanistically, Rac1 activates aldolase A and ERK signaling which up-regulates glycolysis and especially the non-oxidative pentose phosphate pathway (PPP). This leads to increased nucleotides metabolism which protects breast cancer cells from chemotherapeutic-induced DNA damage. To translate this finding, we develop endosomal pH-responsive nanoparticles (NPs) which deliver Rac1-targeting siRNA together with cisplatin and effectively reverses NAC-chemoresistance in PDXs from NAC-resistant breast cancer patients. Altogether, our findings demonstrate that targeting Rac1 is a potential strategy to overcome acquired chemoresistance in breast cancer.
Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.
Journal Article
تعرف إلى عادات الشعب الصيني
يبين هذا الكتاب الاختلافات الثقافية بين الصينيين والغربيين، لكنه يذكرنا أيضاً بوجود الكثير من أوجه الشبه. فنحن نملك جميعاً أحلاماً وطموحات ورغبات، ونحتاج جميعاً إلى أن نحظى بالحب والاحترام. ونريد جميعاً السلام والاستقرار، وكذلك حياة أفضل لأنفسنا ولعائلاتنا، كل شعار ألعاب بيجيغ الأولمبية لسنة 2008 هو عالم واحد، حلم واحد وهذا يشير إلى أن الأشخاص من ثقافات مختلفة يملكون العديد من الأهداف نفسها، وإنما يستخدمون طرقاً مختلفة لبلوغها.
Book
Covariant chiral kinetic equation in non-Abelian gauge field from “covariant gradient expansion”
A
bstract
We derive the chiral kinetic equation in 8 dimensional phase space in non- Abelian SU(
N
) gauge field within the Wigner function formalism. By using the “covariant gradient expansion”, we disentangle the Wigner equations in four-vector space up to the first order and find that only the time-like component of the chiral Wigner function is independent while other components can be explicit derivative. After further decomposing the Wigner function or equations in color space, we present the non-Abelian covariant chiral kinetic equation for the color singlet and multiplet phase-space distribution functions. These phase-space distribution functions have non-trivial Lorentz transformation rules when we define them in different reference frames. The chiral anomaly from non-Abelian gauge field arises naturally from the Berry monopole in Euclidian momentum space in the vacuum or Dirac sea contribution. The anomalous currents as non-Abelian counterparts of chiral magnetic effect and chiral vortical effect have also been derived from the non-Abelian chiral kinetic equation.
Journal Article
Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
Background
Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) in observational studies, but whether these associations are causal is unclear.
Methods
We performed a univariable and multivariable Mendelian randomization study to evaluate these associations. Genetic instruments associated with exposures at the genome-wide significance level (
P
< 5 × 10
–8
) were selected from corresponding genome-wide associations studies (n = 216,590 to 1,232,091 individuals). Summary-level data for BPH were obtained from the UK Biobank (14,126 cases and 169,762 non-cases) and FinnGen consortium (13,118 cases and 72,799 non-cases). Results from UK Biobank and FinnGen consortium were combined using fixed-effect meta-analysis.
Results
The combined odds ratios (ORs) of BPH were 1.24 (95% confidence interval (CI), 1.07–1.43,
P
= 0.0045), 1.08 (95% CI 1.01–1.17,
P
= 0.0175), 0.94 (95% CI 0.67–1.30,
P
= 0.6891), 1.29 (95% CI 0.88–1.89,
P
= 0.1922), 1.23 (95% CI 0.85–1.78,
P
= 0.2623), and 1.04 (95% CI 0.76–1.42,
P
= 0.8165) for one standard deviation (SD) increase in waist circumference, BMI, and relative carbohydrate, fat, protein and sugar intake, 1.05 (95% CI 0.92–1.20,
P
= 0.4581) for one SD increase in prevalence of smoking initiation, 1.10 (95% CI 0.96–1.26,
P
= 0.1725) and 0.84 (95% CI 0.69–1.02,
P
= 0.0741) for one SD increase of log-transformed smoking per day and drinks per week, and 1.31 (95% CI 1.08–1.58,
P
= 0.0051) for one SD increase in sedentary behavior. Genetically predicted waist circumference (OR = 1.26, 95% CI 1.11–1.43,
P
= 0.0004) and sedentary behavior (OR = 1.14, 95% CI 1.05–1.23,
P
= 0.0021) were associated with BPH after the adjustment of BMI.
Conclusion
This study supports independent causal roles of high waist circumference, BMI and sedentary behavior in BPH.
Journal Article
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling
Astragaloside IV (AsIV), an active ingredient isolated from traditional Chinese medicine astragalus membranaceus, is beneficial to cardiovascular health. This study aimed to characterize the functional role of AsIV against adriamycin (ADR)-induced cardiomyopathy. Here, healthy rats were treated with ADR and/or AsIV for 35 days. We found that AsIV protected the rats against ADR-induced cardiomyopathy characterized by myocardial fibrosis and cardiac dysfunction. Meanwhile, ADR increased type I and III collagens, TGF-β, NOX2, and NOX4 expression and SMAD2/3 activity in the left ventricles of rats, while those effects were countered by AsIV through suppressing oxidative stress. Moreover, ADR was found to promote cardiac ferroptosis, whereas administration of AsIV attenuated the process via activating Nrf2 signaling pathway and the subsequent GPx4 expression increasing. These results suggest that AsIV might play a protective role against ADR-induced myocardial fibrosis, which may partly attribute to its anti-ferroptotic action by enhancing Nrf2 signaling.
Journal Article
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer
Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many develop resistance. Here, we show that aromatase inhibitor (AI)-resistant breast tumors display features of enhanced aerobic glycolysis with upregulation of long noncoding RNA (lncRNA) DIO3OS, which correlates with poor prognosis of breast cancer patients on AI therapies. Long-term estrogen deprivation induces DIO3OS expression in ER-positive breast tumor cells, which further enhances aerobic glycolysis and promotes estrogen-independent cell proliferation in vitro and in vivo. Mechanistically, DIO3OS interacts with polypyrimidine tract binding protein 1 (PTBP1) and stabilizes the mRNA of lactate dehydrogenase A (LDHA) by protecting the integrity of its 3’UTR, and subsequently upregulates LDHA expression and activates glycolytic metabolism in AI-resistant breast cancer cells. Our findings highlight the role of lncRNA in regulating the key enzyme of glycolytic metabolism in response to endocrine therapies and the potential of targeting DIO3OS to reverse AI resistance in ER-positive breast cancer.
While aromatase inhibitors (AI) are an effective treatment for patients with estrogen receptor positive breast cancer, resistance presents a major obstacle. Here, the authors identify DIO3OS, a long noncoding RNA, as a driver of AI-resistance in breast cancer through the enhancement of aerobic glycolysis.
Journal Article
Metallic Co Nanoarray Catalyzes Selective NH3 Production from Electrochemical Nitrate Reduction at Current Densities Exceeding 2 A cm−2
Electrochemical nitrate reduction (NITRR) offers a promising alternative toward nitrogen recycling and ammonia production under ambient conditions, for which highly active and selective electrocatalyst is desired. In this study, metallic cobalt nanoarrays as facilely prepared from the electrochemical reduction of Co(OH)2 nanoarrays (NAs) are demonstrated to exhibit unprecedented NH3 producing capability from catalyzing NITRR. Benefitting from the high intrinsic activity of Co0, intimate contact between active species and conductive substrate and the nanostructure which exposes large number of active sites, the Co‐NAs electrode exhibits current density of −2.2 A cm−2 and NH3 production rate of 10.4 mmol h−1 cm−2 at −0.24 V versus RHE under alkaline condition and significantly surpasses reported counterparts. Moreover, the close‐to‐unity (≥96%) Faradaic efficiency (FE) toward NH3 is achieved over wide application range (potential, NO3− concentration and pH). Density function theory calculation reveals the optimized adsorption energy of NITRR intermediates on Co surface over Co(OH)2. Furthermore, it is proposed that despite the sluggish kinetics of Volmer step (H2O → *H + *OH) which provides protons in conventional hydrogenation mechanism, the proton‐supplying water dissociation process on Co surface is drastically facilitated following a concerted water dissociation–hydrogenation pathway. Metallic Co‐NAs that are electrochemically reduced from Co(OH)2‐NAs exhibit record‐high electrocatalytic activity and close‐to‐unity Faradaic efficiency toward ammonia production from nitrate reduction. DFT calculations reveal that different from the common hydrogenation pathway, fast water dissociation assisted by intermediates with unsaturated N atoms and their concurrent hydrogenation contribute to the superior NITRR activity.
Journal Article