Explore the vast range of titles available.

كان الجو جميلا، فبعد هطول الأمطار، تحول لون القمح إلى اللون الأخضر، وسيطرت على الجو رائحة العشب الأخضر. هذه الرائحة حلوة بعض الشيء ومريرة بعض الشيء، دافئة قليلا وباردة قليلا، كم يُفرح هذا الجوّ القلب وينعش الذهن ! في ذلك الحين، كان قلب \"فان خوا\" يشعر بالراحة والطمأنينية. وفي المساء أثناء موعد عقد الاجتماع شعرت أن رؤوس الحيوانات المفترسة التي تعلو جانبي سقف المسرح جميلة المنظر، وضوء القمر أيضاً ساحر للغاية يشبه ثغر فتاة جميلة تضحك. لذا ابتسمت، إلا أن ضحكتها لم تكن ظاهرة على وجهها، بل كانت مختفية داخل قلبها.

Objectives To evaluate the long‐term biosafety and efficacy of transplantation of human embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage of Stargardt macular degeneration (STGD1). Materials and methods Seven patients participated in this prospective clinical study, where they underwent a single subretinal transplantation of 1 × 105 hESC‐RPE cells in one eye, whereas the fellow eye served as control. These patients were reassessed for a 60‐month follow‐up through systemic and ophthalmic examinations. Results None of the patients experienced adverse reactions systemically or locally, except for two who had transiently high intraocular pressure post‐operation. Functional assessments demonstrated that all of the seven operated eyes had transiently increased or stable visual function 1‐4 months after transplantation. At the last follow‐up visit, two of the seven eyes showed visual function loss than the baseline; however, one of them showed a stable visual acuity when compared with the change of fellow eye. Obvious small high reflective foci in the RPE layer were displayed after the transplantation, and maintained until the last visit. Interestingly, three categories of patients who were classified based on autofluorescence, exhibited distinctive patterns of morphological and functional change. Conclusions Subretinal transplantation of hESC‐RPE in early‐stage STGD1 is safe and tolerated in the long term. Further investigation is needed for choosing proper subjects according to the multi‐model image and function assessments. Transplantation of human embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in the patients with early stage of STGD1 is safe and tolerated in the long term. Objective visual functions test after transplantation were mostly remained as the preoperative levels or improved transiently in some cases. Morphology test showed pigmentation in the fundus and high reflective foci in the RPE layer by OCT. Moreover, a new fundus autofluorescence classification was applied to group the subjects for stem cell transplantation and monitored the clinical outcomes.

يمثل تاريخ التبت جزءا مهما في تاريخ الصين، وتعد التبت التي توصف بأنها سقف العالم لكونها تضم أعلى نقطة من اليابسة على كوكب الأرض، وهي من المناطق تفردا وتميزا في الصين، جغرافيا وثقافيا واجتماعيا، وقد كونت التبت مع غيرها من مناطق القوميات الصينية الأخرى ظروفا مواتية للتبادلات الثقافية والاقتصادية داخل الصين نفسها، وقد اعتمد الكاتب على مؤلفات الكتاب القدامى مرجعا له أثناء تحرير هذا الكتاب.

Colorectal cancer (CRC) is a prevalent form of malignant tumor, and the current clinical treatments are far from satisfactory. Identifying new therapeutic targets is therefore essential for clinical practices. The long intergenic non-protein coding RNA lincROR has been shown to play a significant role in the tumorigenesis of various cancers. However, the molecular mechanism underlying lincROR-mediated CRC tumorigenesis remains unclear. In the present study, we found that knockdown of lincROR significantly inhibited cell viability in vitro , while its overexpression promoted tumor growth in vivo . Mechanistically, lincROR acted as a miRNA sponge for miR-145, thereby elevating the expression of the target genes WNT2B and WNT10A. The overexpression of WNT2B and WNT10A definitely activated the Wnt/β-catenin pathway, thus led to promoting tumorigenesis in CRC. In summary, our findings identified lincROR as a novel activator of the Wnt/β-catenin pathway by serving as a miRNA sponge for miR-145 and facilitating tumorigenesis, which suggests that lincROR may be a potential therapeutic target for CRC patients.

The chemo‐regulation abilities of chemotherapeutic medications are appealing to address the low immunogenicity, immunosuppressive lactate microenvironment, and adaptive immune resistance of colorectal cancer. In this work, the proteolysis targeting chimera (PROTAC) of BRD4 (dBET57) is found to downregulate colorectal cancer glycolysis through the transcription inhibition of c‐Myc, which also inhibits the expression of programmed death ligand 1 (PD‐L1) to reverse immune evasion and avoid adaptive immune resistance. Based on this, self‐delivery nano‐PROTACs (designated as DdLD NPs) are further fabricated by the self‐assembly of doxorubicin (DOX) and dBET57 with the assistance of DSPE‐PEG2000. DdLD NPs can improve the stability, intracellular delivery, and tumor targeting accumulation of DOX and dBET57. Meanwhile, the chemotherapeutic effect of DdLD NPs can efficiently destroy colorectal cancer cells to trigger a robust immunogenic cell death (ICD). More importantly, the chemo‐regulation effects of DdLD NPs can inhibit colorectal cancer glycolysis to reduce the lactate production, and downregulate the PD‐L1 expression through BRD4 degradation. Taking advantages of the chemotherapy and chemo‐regulation ability, DdLD NPs systemically activated the antitumor immunity to suppress the primary and metastatic colorectal cancer progression without inducing any systemic side effects. Such self‐delivery nano‐PROTACs may provide a new insight for chemotherapy‐enabled tumor immunotherapy. Self‐delivery nano‐PROTACs (designated as DdLD NPs) are fabricated by the self‐assembly of doxorubicin and dBET57 with the assistance of DSPE‐PEG2000. Chemo‐regulation effect of DdLD NPs can inhibit glycolysis to improve immunosuppressive lactate microenvironment, and simultaneously downregulate PD‐L1 expression to decrease adaptive immune resistance, thereby systemically activating the immunotherapy of metastatic colorectal cancer.

Objective Thirst is a prevalent adverse effect in individuals undergoing maintenance hemodialysis (MHD), frequently precipitating complications that impair well-being and quality of life. While no gold-standard therapy is currently available for thirst management in MHD patients, sugar-free chewing gum has been proposed as a low-cost behavioral intervention, though its efficacy requires further validation. This meta-analysis evaluated its impact on thirst, xerostomia, and secondary outcomes (salivary flow rate, interdialysis weight gain [IDWG]). Methods Following PRISMA guidelines (PROSPERO: CRD42024550292), ten databases (PubMed, Embase, Web of Science, Cochrane Library, CINAHL, Ovid, CNKI, Wanfang, VIP, and CBM) were systematically searched from inception to July 7, 2025. Two investigators independently conducted literature screening, data extraction, and quality assessment. Statistical analyses were performed using RevMan 5.3. The primary outcomes were thirst intensity, measured using the Visual Analogue Scale (VAS) and the Dialysis Thirst Inventory (DTI), as well as xerostomia, measured using the Summated Xerostomia Inventory (SXI). Secondary outcomes included the salivary flow rate and IDWG. Subgroup analysis was conducted based on the duration of intervention (< 6 weeks vs.≥6 weeks) and the type of intervention in the control group (non-intervention vs. active control). Results Seven studies ( n  = 395) were included in the analysis. Sugar-free gum significantly reduced VAS-assessed thirst (SMD = -0.7, 95% CI: -1.21 to -0.20; P  = 0.006) and xerostomia (MD = -2.21, 95% CI: -2.62 to -1.79; P  < 0.01), with ≥ 6-week interventions showing greater thirst reduction (SMD = -0.84) though without significant duration effect ( P  = 0.62). Control-type subgroup analysis revealed differential DTI effects: a significant reduction compared to non-intervention controls (MD = -2.50) but not active controls (MD = -0.19; P  = 0.006 for interaction). No benefits were observed for salivary flow rate (MD = 0.10, 95% CI: -0.14 to 0.33), IDWG (MD = -0.25, 95% CI: -0.68 to 0.18), or overall DTI scores (MD = -1.57, 95% CI: -3.41 to 0.27). Initial heterogeneity (I²= 64–96%) was resolved after sensitivity analyses. Evidence certainty was very low to low (GRADE). Conclusion Sugar-free chewing gum may reduce xerostomia and the intensity of thirst (measured by VAS), with a more significant effect observed in longer interventions (≥ 6 weeks), but without statistically significant duration effects. It is worth noting that its effectiveness in assessing thirst in DTI seems to depend on the type of control, showing substantial benefits compared to a non-intervention control, but not compared to an active control. Although no benefits were observed in salivary flow rate, overall DTI score, or IDWG, this intervention demonstrates potential as a practical, low-cost adjunct for symptom management. Due to substantial heterogeneity and very low to low-quality evidence (GRADE), these findings should be interpreted with caution. Further high-quality, large-scale randomized controlled trials are warranted to validate these results and optimize thirst management strategies for patients with MHD. Clinical trial number Not applicable.

Ferulasinkins A–D (1–4), four new norlignans, were isolated from the resins of Ferula sinkiangensis, a medicinal plant of the Apiaceae family. All of them were obtained as racemic mixtures, chiral HPLC was used to produce their (+)- and (−)-antipodes. The structures of these new compounds, including their absolute configurations, were elucidated by spectroscopic and computational methods. This isolation provides new insight into the chemical profiling of F. sinkiangensis resins beyond the well-investigated structure types such as sesquiterpene coumarins and disulfides. Compounds 2a and 3a were found to significantly inhibit the invasion and migration of triple-negative breast cancer (TNBC) cell lines via CCK-8 assay. On the other hand, the wound-healing assay also demonstrated that compounds 4a and 4b could promote the proliferation of human umbilical vein endothelial cells (HUVECs). Notably, the promoting effects of 4a and 4b were observed as more significant versus a positive control using basic fibroblast growth factor (bFGF).

Multidrug‐resistant tuberculosis (MDR‐TB), defined as tuberculosis (TB) resistant to at least isoniazid and rifampicin, is a major concern of TB control worldwide. However, the diagnosis of MDR‐TB remains a huge challenge to its prevention and control. To identify new diagnostic methods for MDR‐TB, a mass spectrometry strategy of data‐independent acquisition and parallel reaction monitoring was used to detect and validate differential serum proteins. The bioinformatic analysis showed that the functions of differential serum proteins between the MDR‐TB group and the drug‐sensitive tuberculosis group were significantly correlated to the complement coagulation cascade, surface adhesion and extracellular matrix receptor interaction, suggesting a disorder of coagulation in TB. Here, we identified three potential candidate biomarkers such as sCD14, PGLYRP2 and FGA, and established a diagnostic model using these three candidate biomarkers with a sensitivity of 81.2%, a specificity of 90% and the area under the curve value of 0.934 in receiver operation characteristics curve to diagnose MDR‐TB. Our study has paved the way for a novel method to diagnose MDR‐TB and may contribute to elucidate the mechanisms underlying MDR‐TB.

Organic heterostructures (OHTs) with the desired geometry organization on micro/nanoscale have undergone rapid progress in nanoscience and nanotechnology. However, it is a significant challenge to elucidate the epitaxial-growth process for various OHTs composed of organic units with a lattice mismatching ratio of > 3%, which is unimaginable for inorganic heterostructures. Herein, we have demonstrated a vivid visualization of the morphology evolution of epitaxial-growth based on a doped interfacial-layer, which facilitates the comprehensive understanding of the hierarchical self-assembly of core-shell OHT with precise spatial configuration. Significantly, the barcoded OHT with periodic shells obviously illustrate the shell epitaxial-growth from tips to center parts along the seeded rods for forming the core-shell OHT. Furthermore, the diameter, length, and number of periodic shells were modulated by finely tuning the stoichiometric ratio, crystalline time, and temperature, respectively. This epitaxial-growth process could be generalized to organic systems with facile chemical/structural compatibility for forming the desired OHTs. Organic heterostructures with controlled geometry on the micro and nanoscale are important in nanotechnology, but epitaxial growth processes with high lattice mismatching are challenging to achieve. Here, the authors report a visualisation process for morphology evolution on epitaxial growth.

The aim of this study was to discover novel biomarkers for pulmonary tuberculosis (TB). Differentially expressed proteins in the serum of patients with TB were screened and identified by iTRAQ-two dimensional liquid chromatography tandem mass spectrometry analysis. A total of 79 abnormal proteins were discovered in patients with TB compared with healthy controls. Of these, significant differences were observed in 47 abnormally expressed proteins between patients with TB or pneumonia and chronic obstructive pulmonary disease (COPD). Patients with TB (n = 136) exhibited significantly higher levels of serum amyloid A (SAA), vitamin K-dependent protein Z (PROZ), and C4b-binding protein β chain (C4BPB) than those in healthy controls (n = 66) (P<0.0001 for each) albeit significantly lower levels compared with those in patients with pneumonia (n = 72) (P<0.0001 for each) or COPD (n = 72) (P<0.0001, P<0.0001, P = 0.0016, respectively). After 6 months of treatment, the levels of SAA and PROZ were significantly increased (P = 0.022, P<0.0001, respectively), whereas the level of C4BPB was significantly decreased (P = 0.0038) in treated TB cases (n = 72). Clinical analysis showed that there were significant differences in blood clotting and lipid indices in patients with TB compared with healthy controls, patients with pneumonia or COPD, and treated TB cases (P<0.05). Correlation analysis revealed significant correlations between PROZ and INR (rs = 0.414, P = 0.044), and between C4BPB and FIB (rs = 0.617, P = 0.0002) in patients with TB. Receiver operating characteristic curve analysis revealed that the area under the curve value of the diagnostic model combining SAA, PROZ, and C4BPB to discriminate the TB group from the healthy control, pneumonia, COPD, and cured TB groups was 0.972, 0.928, 0.957, and 0.969, respectively. Together, these results suggested that SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB. Our study may thus provide experimental data for the differential diagnosis of TB.