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Due to its high efficacy as a wide-spectrum disinfectant and its potential for the degradation of pollutants and pesticides, ozone has broad application prospects in agricultural production. In this study, micro/nano bubble technology was applied to achieve a saturation state of bubble nutrient solution, including micro-nano oxygen (O 2 group) and micro-nano ozone (O 3 group) bubble nutrient solutions. The effects of these solutions on lettuce physiological indices as well as changes in the microbial community within the rhizosphere substrate were studied. The application of micro/nano (O 2 and O 3 ) bubble nutrient solutions to substrate-cultured lettuce plants increased the amount of dissolved oxygen in the nutrient solution, increased the lettuce yield, and elevated the net photosynthetic rate, conductance of H 2 O and intercellular carbon dioxide concentration of lettuce plants. Diversity analysis of the rhizosphere microbial community revealed that both the abundance and diversity of bacterial and fungal communities in the substrate increased after plant cultivation and decreased following treatment with micro/nanobubble nutrient solutions. RDA results showed that the microbial community in the S group was positively associated with EC, that in the CK and O 2 groups exhibited a positive correlation with SC, and that in the O 3 group displayed a positive correlation with CAT and POD. Overall, the implementation of micro/nanobubble generation technology in soilless substrates can effectively increase the lettuce growth and yield, and O 3 had a more pronounced effect on lettuce yield and quality and the microbial community structure in the substrate than O 2 . Our study would provide a reference and theoretical basis for developing sustainable and green technology for promoting lettuce production and can be a promising alternative to conventional methods for improving crop yields.

Optical imaging systems using varifocal lenses have been widely used in many applications over the past several decades, such as machine vision devices, consumer electronic products, and medical instruments. Traditional varifocal lenses often consist of multiple solid focal length refractive optical elements. The varifocal ability is obtained by dislocating these optical elements along the optical axis over specific distances using mechanical driving mechanisms. It makes the traditional optical varifocal imaging systems suffer from bulky dimensions, slow response speed, complicated configuration, and discrete magnifications. Adaptive varifocal lenses have been a better choice to address the aforementioned limitations of traditional varifocal lenses. Dielectric elastomer actuators (DEA), which can effectively respond to an electric field and result in shape deformation, have been used to develop various adaptive lenses. This paper aims to give a brief review of adaptive varifocal lenses based on DEA. First, this paper describes the basic physical mechanism of DEA. Second, this paper reviews adaptive varifocal liquid lenses based on DEA and introduces their material, structure, and fabrication process, focusing on their unique advantages, such as fast response speed and compactness. However, despite these merits, the adaptive varifocal liquid lens still has challenges in environment stability and liquid leakage. To address these challenges, adaptive varifocal soft solid lenses based on DEA have been proposed, which are also reviewed. In addition, other adaptive varifocal lenses, including metalens, Fresnel lens, microlens array, and Alvarez lens, are also presented. Finally, the prospects and challenges for the development of adaptive varifocal lenses based on DEA are discussed.

Bullwhip effect is an inevitable phenomenon in supply chain management, because of its objective existence. This phenomenon is very common and harmful to make the operating costs of enterprises double and become one of the main concerns of many enterprises. In this paper, the causes of the bullwhip effect are explored through the methods of literature research and investigated consultation to weaken the bullwhip effect. This paper analyzes the key countermeasures with Wal-Mart successful logistics management case. And according to the reason of bullwhip effect, a mathematical programming model of maximizing the efficiency of supply chain is established, which provides a way to solve the negative effect of bullwhip effect and has certain reference value.

The immune system can monitor tumor development, and DNA methylation is involved in the body’s immune response to tumors. In this work, we investigate whether DNA methylation alterations in peripheral blood mononuclear cells (PBMCs) could be used as markers for early detection of breast cancer (BC) from the perspective of tumor immune alterations. We identify four BC-specific methylation markers by combining Infinium 850 K BeadChips, pyrosequencing and targeted bisulfite sequencing. Based on the four methylation markers in PBMCs of BC, we develop an efficient and convenient multiplex methylation-specific quantitative PCR assay for the detection of BC and validate its diagnostic performance in a multicenter cohort. This assay was able to distinguish early-stage BC patients from normal controls, with an AUC of 0.940, sensitivity of 93.2%, and specificity of 90.4%. More importantly, this assay outperformed existing clinical diagnostic methods, especially in the detection of early-stage and minimal tumors. DNA methylation pattern of immune cells can be altered during tumour development. Here, the authors identify 4 DNA methylation markers in peripheral blood mononuclear cells which are predictive of breast cancer across multiple cohorts.

Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed tomography (LDCT) is a routine clinical examination for early detection of LC, the false-positive rate is over 90%. As one of the intensely studied epigenetic modifications, DNA methylation plays a key role in various diseases, including cancer and other diseases. Hypermethylation in tumor suppressor genes or hypomethylation in oncogenes is an important event in tumorigenesis. Remarkably, DNA methylation usually occurs in the very early stage of malignant tumors. Thus, DNA methylation analysis may provide some useful information about the early detection of LC. In recent years, liquid biopsy has developed rapidly. Liquid biopsy can detect and monitor both primary and metastatic malignant tumors and can reflect tumor heterogeneity. Moreover, it is a minimally invasive procedure, and it causes less pain for patients. This review summarized various liquid biopsies based on DNA methylation for LC. At first, we briefly discussed some emerging technologies for DNA methylation analysis. Subsequently, we outlined cell-free DNA (cfDNA), sputum, bronchoalveolar lavage fluid, bronchial aspirates, and bronchial washings DNA methylation-based liquid biopsy for the early detection of LC. Finally, the prognostic value of DNA methylation in cfDNA and sputum and the diagnostic value of other DNA methylation-based liquid biopsies for LC were also analyzed.

Acute lung injury (ALI) is a life-threatening pathological disease characterized by the damage of pulmonary endothelial cells and epithelial cell barriers by uncontrolled inflammation. During sepsis-induced ALI, multiple cells cooperate and communicate with each other to respond to the stimulation of inflammatory factors. However, the underlying mechanisms of action have not been fully identified, and the modes of communication therein are also being investigated. Extracellular vesicles (EVs) are a heterogeneous population of spherical membrane structures released by almost all types of cells, containing various cellular components. EVs are primary transport vehicles for microRNAs (miRNAs), which play essential roles in physiological and pathological processes in ALI. EV miRNAs from different sources participated in regulating the biological function of pulmonary epithelial cells, endothelial cells, and phagocytes by transferring miRNA through EVs during ALI induced by sepsis, which has great potential diagnostic and therapeutic values. This study aims to summarize the role and mechanism of extracellular vesicle miRNAs from different cells in the regulation of sepsis-induced ALI. It provides ideas for further exploring the role of extracellular miRNA secreted by different cells in the ALI induced by sepsis, to make up for the deficiency of current understanding, and to explore the more optimal scheme for diagnosis and treatment of ALI.

China's historiographical traditions tell of the successful control of a Great Flood leading to the establishment of the Xia dynasty and the beginning of civilization. However, the historicity of the flood and Xia remain controversial. Here, we reconstruct an earthquake-induced landslide dam outburst flood on the Yellow River about 1920 BCE that ranks as one of the largest freshwater floods of the Holocene and could account for the Great Flood. This would place the beginning of Xia at ∼1900 BCE, several centuries later than traditionally thought. This date coincides with the major transition from the Neolithic to Bronze Age in the Yellow River valley and supports hypotheses that the primary state-level society of the Erlitou culture is an archaeological manifestation of the Xia dynasty.

Converting waste biomass into biochar is a means for solving both environmental pollution and energy shortage. Here we transformed Eichhornia crassipes, a harmful floating plant, into a honeycomb-shaped and heteroatoms-rich biochar by KOH activation during carbonization, and we tested this biochar as anode for lithium-ion batteries. Results show that the biochar has a high surface area of 278.56 m2·g−1, a honeycomb-like porous structure, and is rich in heteroatoms, e.g., 3.42% N, 20.82% O, and 0.83% S. Biochar anodes displayed a higher initial reversible specific capacity of 697 mAh·g−1 at 50 mA·g−1, a higher rate capability of 229.7 mAh·g−1 at 3000 mA·g−1, and a better cyclic stability than commercial graphite. The enhanced electrochemical performance could be attributed to the interconnected porous structure that promotes Li+ transfer and electrolyte infiltration, and to the presence of heteroatoms. This approach can be easily industrialized as a substitute of graphite.

This study aims to investigate the relationship between occupational stress and job burnout in female manufacturing workers. A random sample of 1081 female workers in electronic manufacturing in Guangdong Province participated in the present study. An anonymous self-administered questionnaire that covered social-demographic characteristics, the Chinese version of the Job Content Questionnaire, the Chinese version of the Effort-reward Imbalance Questionnaire, and the Maslach Burnout Inventory for the General Survey, was used to assess occupational stress and job burnout. Independent sample t-test, one-way analysis of variance (ANOVA), correlation analysis, hierarchical multiple regression analysis and logistic regression analysis were used in data analysis. Occupational stress was positively correlated with emotional exhaustion and depersonalization and negatively correlated with personal accomplishment. After adjusting for sociodemographic characteristics, job strain was a risk factor for emotional exhaustion ( OR  = 2.27, 95% CI : 1.61–3.20) and depersonalization ( OR  = 1.96 95% CI : 1.45–2.64). Female workers with high effort-reward imbalance had an increased risk of depersonalization ( OR  = 1.96, 95% CI : 1.33–2.90). Furthermore, female workers with high overcommitment had an increased risk of emotional exhaustion ( OR  = 3.07, 95% CI : 2.06–4.58) and depersonalization ( OR  = 2.83, 95% CI : 1.92–4.17), while higher social support reduced the risk of emotional exhaustion ( OR  = 0.37, 95% CI : 0.26–0.53). The job burnout of female manufacturing workers is significantly correlated with their occupational stress. Higher job strain and overcommitment might be important contributors to job burnout. Increased worker social support can reduce job burnout.

As the most frequently occurring cancer worldwide, breast cancer (BC) is the leading cause of cancer-related death in women. The overexpression of HER2 (human epidermal growth factor receptor 2) is found in about 15% of BC patients, and it is often associated with a poor prognosis due to the effect on cell proliferation, migration, invasion, and survival. As a result of the heterogeneity of BC, molecular imaging with HER2 probes can non-invasively, in real time, and quantitatively reflect the expression status of HER2 in tumors. This will provide a new approach for patients to choose treatment options and monitor treatment response. Furthermore, radionuclide molecular imaging has the potential of repetitive measurements, and it can help solve the problem of heterogeneous expression and conversion of HER2 status during disease progression or treatment. Different imaging probes of targeting proteins, such as monoclonal antibodies, antibody fragments, nanobodies, and affibodies, are currently in preclinical and clinical development. Moreover, in recent years, HER2-specific peptides have been widely developed for molecular imaging techniques for HER2-positive cancers. This article summarized different types of molecular probes targeting HER2 used in current clinical applications and the developmental trend of some HER2-specific peptides.